Ravelingien et al1 argue that, given the restrictions that must be imposed on recipients of xenotransplanted organs, we should conduct clinical trials of xenotransplantation only on patients in a persistent vegetative state. I argue that there is no ethical barrier to using terminally ill patients instead. Such patients can choose to waive their rights to the liberties that xenotransplantation would probably restrict; it is surely rational to prefer to waive your rights rather than to die, and permissible to allow patients (...) to make this choice.Perhaps the single most important advance in the history of moral thought occurred when it came to be generally recognised that all people are protected by rights that are inviolable, at least without their consent. The precise nature and content of these rights is controversial, but there is a consensus among reasonable people over their core. We all have a right to life, to liberty, to security of person and to equality before the law. Other rights—so-called positive rights, such as the right to economic security, or cultural rights, for instance—may be controversial, but we all agree at least on these.Ravelingien et al1 therefore seem to be on solid ground when they conclude that it would not be permissible to use living persons as subjects in clinical trials of xenotransplantation, as such trials, potentially or actually, result in the violation of the core human rights of the subjects. Their argument is as follows:" Xenotransplantation carries with it a currently unquantifiable risk of the transmission of viruses, from the animal that is the source of the organ transplanted, to the human recipient. Such viruses could have potentially catastrophic consequences, up to and including triggering a global and devastating pandemic. Therefore, it would be necessary to monitor the health status of recipients of … ". (shrink)

Context: Immunity includes cognitive concepts: the organism is thought to specifically recognize foreign materials and develop a memory of these encounters. Vaccines are thought to work by enhancing this immunological memory. Lymphocytes are key cells and specific antibodies are key molecules in immune recognition. Antibodies are blood proteins called “immunoglobulins.” Spontaneously formed immunoglobulins are seen as “natural” antibodies to dietary components and commensal bacteria. Immune cognition is used simply as a didactic metaphor. Problem: Do the cognitive aspects of immunology stem (...) from the activities of cells and molecules, or are they ascribed by the immunologist operating as a human observer? (1) An immense variety of immunoglobulins may bind to the same antigen with different binding energies. It is the immunologist who arbitrates the boundary between those that are specific (and declared antibodies) and those that are not. Specific antibodies serve as functional labels pasted onto natural immunoglobulins, as if they were recognizing elements. Is this “arbitration” the true cognitive event ascribed to immunoglobulins and lymphocytes? (2) A major impasse exists between progress in experimental immunology and its translation into clinical results. A proper understanding of immunological activity demands a wider view of an organism’s biology and, also, of the interference of human observers in delineating experimental realities, such as the specificity of immune recognition. Maturana’s biology of cognition and language provides one such approach. Method: Use of Maturana’s biology of cognition and language concepts to describe immunological activity. Results: A whole new understanding of immunological activity is suggested. Implications: A major change in the way of seeing is proposed that may eventually help the translation of this knowledge into clinical results. Furthermore, the immune system may also become a proper model for cognitive analyses. (shrink)

Leibniz said with a mixture of admiration and inspiration that the Duchess Sophie of Hannover always wanted to know the reason why behind the reason why. And that is just how rationality works: it wants to leave no loose ends to understanding, seeking to enable us to understand things through to the bitter end. In the twelve chapters that make up Satisfying Reason, Rescher develops and defends the following perspective: That rationality is a cardinal virtue in cognitive matters. That this (...) is not something simple and cut-and-dried: in the pursuit of truth through the development of knowledge we face obstacles -- sometimes even insuperable ones. All that we can do is the best we can, realizing that even our very best may still be imperfect. Nevertheless, the venture is far from hopeless. While absolutes are unattainable in the cognitive venture, some solutions are situationally optimal, being comparatively the best that can be managed under the circumstances. That reason itself enables us to come to terms with this state of affairs, urging us to accept the best we can do as good enough. Satisfying Reason is an explanation of the presuppositions and methods of rational enquiry, an original exercise in metaknowledge, developing a systematic body of knowledge about the scope and limits of knowledge itself. (shrink)

Die Herrschaft des Behaviorismus in der Psychologie ist gebrochen! Das ist die Ausgangsthese dieses Buches, die im Rahmen des Modells revolutionärer Wissenschaftsentwicklung (Kuhn) als Behauptung eines Paradigmawechsels präzisiert wird. Die Argumentation beschränkt sich nicht nur auf den Nachweis des Niedergangs des Behaviorismus, sondern gibt auch konstruktiv das mögliche neue Paradigma an: als Psychologie des reflexiven Subjekts, das wie der Wissenschaftler (subjektive) Theorien aufstellt, überprüft, bewertet. Der Aufriss einer solchen Psychologie des epistemischen Subjekts unter allgemein-, sozial-, pädagogisch- und klinisch-psychologischem Aspekt thematisiert (...) vor allem: die Rationalität der Reflexionen, Normenkritik und -begründung im Austausch von wissenschaftlichen und naiven Theorien sowie die Berücksichtigung von Reflexivität in der therapeutischen Praxis. Die Rückwendung dieser pychologisch-metatheoretischen Perspektiven auf die Wissenschaftstheorie führt auch zu einer neu. (shrink)

Ibn Masarra y su escuela -- El místico Abū-l-ʻAbbās ibn al-ʻArīf de Almería y su "Mahāsin al-Maŷālis" -- Un precursor hispanomusulmán de San Juan de la Cruz.

qism 1. Fī al-qānūn. al-Ṭabʻah 5., mazīdah wa-munaqqaḥah wafqan lil-qawānīn al-jadīdah, 1966 -- qism 2. Fī al-ḥuqūq. al-Ṭabʻah 4., mazīdah wa-munaqqaḥah wafqan lil-qawānīn al-jadīdah, 1961.

"The twelve chapters of this volume all began their existence as contributions to workshops held between 2009 and 2011 by a Danish-Swedish research network called The Aristotelian Tradition: The reception of Aristotle's works on logic and metaphysics in the Middle Ages, headquartered in Gothenburg and funded by the Bank of Sweden Tercentenary Foundation. Most of them were written by members of the network, some by invited speakers. While the volume amply illustrates the set of scholarly approaches characteristic of the "Copenhagen (...) School of Medieval Philosophy" (notably a strong philological foundation and an interest in ancient as well as medieval and Greek as well as Latin texts), its thematic diversity reflects the network's breadth of interests. What unites the chapters in this respect is simply a concern with different historical manifestations of Aristotelian thought on logical and metaphysical matters. The volume includes studies of texts by, among others, Apuleius, Boethius, Anonymus Aurelianensis III, Michael of Ephesus, Averroes, Anonymus Cantabrigiensis, Nicholas of Paris, Robert Kilwardby, Anonymus O, Thomas Aquinas, William of Ockham, and Francisco Suárez, relating to themes and passages in Aristotle's Categories, On Interpretation, Prior Analytics 1, Posterior Analytics 1, Sophistical Refutations and Metaphysics A and Z. The last two chapters consist of a new edition, with English translation and commentary, of the first part of a fiercely anti-Aristotelian work, which has been described as the starting-point for Renaissance Platonism and Aristotelianism alike: George Gemistos Plethon's On Aristotle's Departures from Plato."--. (shrink)