Actin plays several essential roles in cellular processes and is a vital component in the contractile apparatus. To accomplish its many cellular tasks, actin must interact with a wide range of other proteins in addition to self‐assembling into filaments. Characterization of these functional domains and localized binding regions on the actin monomer is therefore an important undertaking. Strategies for elucidating the many interaction sites include X‐ray diffraction, NMR and fluorescence spectroscopy, chemical modification, chemical cross‐linking, protein cleavage, and the study of (...) sequence homologies between the many isotypes of actin. Based on these varied data, we discuss the possible spatial relationships between the interaction sites. (shrink)

Reprint. Originally published: 1959; 1st Princeton/Bollingen pbk. ed. published: 1970.

G. E. M. Anscombe; I *—The Presidential Address: Existence and Truth, Proceedings of the Aristotelian Society, Volume 88, Issue 1, 1 June 1988, Pages 1–12, http.

Fabvla misere mutila: this notice in the Oxford edition, reinforced in the critical apparatus, warns the reader against the transmitted text of the Heradidae. It tends to perpetuate the view which Wilamowitz, following up the hints of G. Hermann and A. Kirchhoff, propounded in 1882. The sweeping assurance of his famous article gave it a publicity which makes a detailed rehearsal superfluous. Wilamowitz throughout his life stuck to the opinion that ‘wir lesen die Herakliden in der Bearbeitung eines Regisseurs’. Dissentient (...) voices have been raised from time to time. M. Pohlenz in 1930 even proposed an interpretation of the Heradidae which quietly discarded the thesis of Wilamowitz. Nevertheless the latter appears still to hold the field at least in the English-speaking countries. If it is correct, the Heradidae of Euripides is beyond our reach. This conclusion has indeed, quite recently, been drawn by H. D. F. Kitto. (shrink)

How should religion and ethics be studied if we want to understand what people believe and why they act the way they do? An energetic guide to the study of religion and ethics, rejecting theories from postmodernism and cognitive science in favour of a return to pragmatic enquiry.

In the article "The Epistemological Nature of Information Modeling" [Gnoseologicheskaia priroda informatsionnogo modelirovaniia], Voprosy filosofii, 1963, No. 10, Academician V. M. Glushkov examines two important methodological aspects of the modeling of natural objects and phenomena in the contemporary natural sciences. The first consists of the informational nature of the models created, and the second of their dynamism. The dynamic nature of today's models in the natural sciences means that it is not so much the material structure of the object that (...) is modeled as its behavior and functions in some sphere of natural phenomena. In this sense, the models under examination may also be termed functional, as distinct from the structural models pertaining to a static description of objects. (shrink)

This book offers the first comprehensive introduction to wave scattering in nonstationary materials. G. F. Roach's aim is to provide an accessible, self-contained resource for newcomers to this important field of research that has applications across a broad range of areas, including radar, sonar, diagnostics in engineering and manufacturing, geophysical prospecting, and ultrasonic medicine such as sonograms. New methods in recent years have been developed to assess the structure and properties of materials and surfaces. When light, sound, or some other (...) wave energy is directed at the material in question, "imperfections" in the resulting echo can reveal a tremendous amount of valuable diagnostic information. The mathematics behind such analysis is sophisticated and complex. However, while problems involving stationary materials are quite well understood, there is still much to learn about those in which the material is moving or changes over time. These so-called non-autonomous problems are the subject of this fascinating book. Roach develops practical strategies, techniques, and solutions for mathematicians and applied scientists working in or seeking entry into the field of modern scattering theory and its applications. Wave Scattering by Time-Dependent Perturbations is destined to become a classic in this rapidly evolving area of inquiry. (shrink)

More than twenty-five years after the first signs of potential harm, the US remains locked in the grip of an opioid epidemic, with more Americans dying from overdoses than ever before.1 Diversion of prescription opioids plays an important role in opioid-related harms. Much of the scientific and public health focus on diversion has been on end-users, given how commonly non-medical prescription opioid use occurs, as well as the proportion of individuals who report that their source of non-medical opioids was friends (...) or family. However, diversion of opioids, as well as their rampant oversupply, can be discerned higher up the supply chain, including among wholesalers, pharmacies and rogue prescribers whose behavior may trigger well-described “flags” warranting further evaluation and action. (shrink)

The main experiments concerning the Aharonov–Bohm phase shifts, seen in an electron interference pattern, and their Boyer semiclassical explanations are reviewed. A new experiment is also presented which emphasizes the subtleties involved in the interpretations of the magnetic Aharonov–Bohm phase shift as a result of a non-dispersive or dispersive effect.

The social aspects of causality in medicine and healthcare have been emphasized in recent debates in the philosophy of science as crucial factors that need to be considered to enable, among others, appropriate interventions in public health. Therefore, it seems central to recognize the bearing of social causes (broadly understood, e.g., social inequalities and socio-economic status) in bringing about certain concrete pathologies. Being aware of the relevance of social causes in medicine and healthcare is particularly important in the face of (...) the role that artificial intelligence-based systems (such as machine learning algorithms) are increasingly playing in these high-stakes fields. In fact, these systems bear the dangerous potential of concealing relevant social causes. This is highly problematic not only because it reinforces issues of distributive injustice but also because it can pave the way for issues of epistemic injustice. The central aim of this chapter is to make a first effort to point out possible connections between the importance of recognizing social causes in medicine and healthcare and forms of epistemic injustice. (shrink)

I present the current experimental and theoretical work on interference in complementary spaces. These ideas are applicable to both light and matter waves. I give a detailed treatment for classical light beams in frequency and time domains. I also present a description which gives the totality of interferences.