IntroductionCognitive impairment is a highly prevalent non-motor feature of Parkinson’s disease. A better understanding of the underlying pathophysiology may help in identifying therapeutic targets to prevent or treat dementia. This study sought to identify metabolic alterations in the prefrontal cortex, a key region for cognitive functioning that has been implicated in cognitive dysfunction in PD.MethodsProton Magnetic Resonance Spectroscopy was used to investigate metabolic changes in the PFC of a cohort of cognitively normal individuals without PD, as well as PD participants (...) with either normal cognition, mild cognitive impairment, or dementia. Ratios to Creatine resonance were obtained for glutamate, glutamine and glutamate combined, N-acetylaspartate, myoinositol, and total choline, and correlated with cognitive scores across multiple domains administered to the PD participants only.ResultsWhen individuals retain cognitive capabilities, the presence of Parkinson’s disease does not create metabolic disturbances in the PFC. However, when cognitive symptoms are present, PFC Glu/Cre ratios decrease with significant differences between the PD-NC and PPD groups. In addition, Glu/Cre ratios and memory scores were marginally associated, but not after Bonferroni correction.ConclusionThese preliminary findings indicate that fluctuations in prefrontal glutamate may constitute a biomarker for the progression of cognitive impairments in PD. We caution for larger MRS investigations of carefully defined PD groups. (shrink)

We all have moral beliefs. But what if one beleif conflicts with another? DePaul argues that we have to make our beliefs cohere, but that the current coherence methods are seriously flawed. It is not just the arguments that need to be considered in moral enquiry. DePaul asserts that the ability to make sensitive moral judgements is vital to any philosophical inquiry into morality. The inquirer must consider how her life experiences and experiences with literature, film and theatre have influenced (...) her capacity for making moral judgments and attempt to ensure that this capacity is neither naive nor corrupted. (shrink)

Consideration of the counting and reidentification of particulars leads naturally enough to the orthodox doctrine that, “on pain of indefiniteness,” an identity statement in some way involves or presupposes a general term or “covering concept”: i.e., that the principium individuationis or criterion of identity implied depends upon the kind of thing in question. Thus it is said that an auditor understands the question whether A is the same as B only in so far as he knows, however informally or implicitly, (...) the answer to the supplementary question, “The same what?”. (shrink)

In this book, Michael R. Slater provides a new assessment of pragmatist views in the philosophy of religion. Focusing on the tension between naturalist and anti-naturalist versions of pragmatism, he argues that the anti-naturalist religious views of philosophers such as William James and Charles Peirce provide a powerful alternative to the naturalism and secularism of later pragmatists such as John Dewey and Richard Rorty. Slater first examines the writings of the 'classical pragmatists' - James, Peirce, and Dewey - and (...) argues for the relevance of their views for thinking about such topics as the nature of religion and the viability of natural theology. His final three chapters engage with the religious views of later pragmatists such as Rorty and Philip Kitcher, and with current philosophical debates over metaphysical realism, naturalism, and evidentialism. His book will be of particular interest to philosophers of religion, theologians, and specialists in American philosophy. (shrink)

One merit claimed for john rawls's coherence method, Wide reflective equilibrium, Is that it transcends the traditional two tiered approach to moral inquiry according to which one must choose as one's starting points either particular moral judgments or general moral principles. The two tiered conception of philosophical method is not limited to ethics. The most detailed exposition of the conception can be found in r m chisholm's various discussions of the problem of the criterion. While chisholm's work has played a (...) major role in structuring the way epistemologists think about method, It has not similarly influenced the deliberations of moral theorists. But moral philosophers are not the only ones with myopia, For neither rawls's coherentist method nor classical moral intuitionism figure in chisholm's taxonomy. One aim is to correct the vision of both parties by expanding chisholm's taxonomy in order to make clear how intuitionism and rawls's coherentist method are related to the methods identified by chisholm. My other aim is to argue for coherentism of the sort defended by rawls against the other non-Skeptical methods I consider. (shrink)

What is the Moral Problem? NORMATIVE ETHICS VS. META-ETHICS It is a common fact of everyday life that we appraise each others' behaviour and attitudes from ...

In the 1960s molecular population geneticists used Monte Carlo experiments to evaluate particular diffusion equation models. In this paper I examine the nature of this comparative evaluation and argue for three claims: first, Monte Carlo experiments are genuine experiments: second, Monte Carlo experiments can provide an important meansfor evaluating the adequacy of highly idealized theoretical models; and, third, the evaluation of the computational adequacy of a diffusion model with Monte Carlo experiments is significantlydifferent from the evaluation of the emperical adequacy (...) of the same diffusion model. (shrink)

This article offers three contrasting cases of the use of neutrality and drift in molecular evolution. In the first, neutrality is assumed as a simplest case for modeling. In the second and third, concepts of drift and neutrality are developed within the context of population genetics testing and the development and application of the molecular clock.

This book explores the problem of time and immanence for phenomenology in the work of Edmund Husserl, Martin Heidegger, Maurice Merleau-Ponty, and Jacques Derrida. Detailed readings of immanence in light of the more familiar problems of time-consciousness and temporality provide the framework for evaluating both Husserl's efforts to break free of modern philosophy's notions of immanence, and the influence Heidegger's criticism of Husserl exercised over Merleau-Ponty's and Derrida's alternatives to Husserl's phenomenology. Ultimately exploring various notions of intentionality, these in-depth analyses (...) of immanence and temporality suggest a new perspective on themes central to phenomenology's development as a movement and raise for debate the question of where phenomenology begins and ends. (shrink)

There is widespread belief that connectionist networks are dramatically different from classical or symbolic models. However, connectionists rarely test this belief by interpreting the internal structure of their nets. A new approach to interpreting networks was recently introduced by Berkeley et al. (1995). The current paper examines two implications of applying this method: (1) that the internal structure of a connectionist network can have a very classical appearance, and (2) that this interpretation can provide a cognitive theory that cannot be (...) dismissed as a mere implementation. (shrink)

In their article Beyond Suppressing Testosterone: A Categorical System to Achieve a “Level Playing Field” in Sport, Jennings and Braun (2024) accurately display how the World Athletics’ (WA) restri...

This chapter contains section titled: The Neutral Theory of Molecular Evolution The Molecular Clock The Neutral Null Model Controversy in Molecular Evolution Acknowledgment References Further Reading.

This essay examines one of the most important but understudied aspects of William James’s philosophy, his doctrine of pluralism. It aims to shed new light on the complex and sometimes ambiguous relationship between James’s pluralism and his doctrines of pragmatism and radical empiricism, and shows that his pluralism is a much more pervasive feature of his philosophy than has usually been thought. In particular, the essay shows that James was a pluralist not only in his metaphysical views, but also in (...) his epistemological, ethical, and religious views, and that these latter views are not always clearly dependent upon his pluralistic metaphysics. (shrink)

This paper presents Anthony Steinbock's broad theory of moral emotions and specifically the distinction he draws between the temporal orientation and the temporal meaning of emotions. The latter distinction is used in order to provide phenomenological descriptions of, and distinctions between, patience and impatience. The paper takes leading clues from Steinbock’s work in an effort to “do” phenomenology in a way that clarifies these specific natural attitude intentionalities.

Throughout the 1930s two of Germany’s most senior geneticists were caught up in controversy as they tried to enter the distinctly American culture of Drosophila genetics. When Richard Goldschmidt and Victor Jollos were forced by the Nazis to leave Germany in 1936 and 1933, respectively, this type of conflict intensified. The experiences of Goldschmidt and Jollos as émigré scientists are interpreted in terms of a conflict of scientific styles of thought. Their Americanization, I claim, involved the modification of their scientific (...) styles and consequently the ways in which they conceived of and presented their scientific work. (shrink)

The past decade has seen a renewed interest in moral psychology. A unique feature of the present endeavor is its unprecedented interdisciplinarity. For the first time, cognitive, social, and developmental psychologists, neuroscientists, experimental philosophers, evolutionary biologists, and anthropologists collaborate to study the same or overlapping phenomena. This review focuses on moral judgments and is written from the perspective of cognitive psychologists interested in theories of the cognitive and affective processes underlying judgments in moral domains. The review will first present and (...) discuss a variety of different theoretical and empirical approaches, including both behavioral and neuroscientific studies. We will then show how these theories can be applied to a selected number of specific research topics that have attracted particular interest in recent years, including the distinction between moral and conventional rules, moral dilemmas, the role of intention, and sacred/protected values. One overarching question we will address throughout the chapter is whether moral cognitions are distinct and special, or whether they can be subsumed under more domain-general mechanisms. (shrink)

History, Philosophy and Science Teaching argues that science teaching and science teacher education can be improved if teachers know something of the history and philosophy of science and if these topics are included in the science curriculum. The history and philosophy of science have important roles in many of the theoretical issues that science educators need to address: the goals of science education; what constitutes an appropriate science curriculum for all students; how science should be taught in traditional cultures; what (...) integrated science is; how scientific literacy can be promoted; and the conflict which can occur between science curriculum and deep-seated religious or cultural values and knowledge. In part, answers to these questions hinge on views about the nature of science, views that are best informed by historical and philosophical study. Outlining the history of liberal, or contextual, approaches to the teaching of science, Michael Matthews elaborates contemporary curriculum developments that explicitly address questions about the nature and the history of science. He provides examples of classroom teaching and develops useful arguments on constructivism, multicultural science education and teacher education. The book will appeal to school and university science teachers, educators of science teachers, and historians and philosophers of science. (shrink)

I’m not sure one even needs to think a state of affairs is true for us to take attitudinal pleasure in it. We surely take pleasure in imagining states of affairs. In such a case, we are well aware that the state of affairs that is the object of our enjoyment does not obtain. What is the proper account of the pleasure we take from imagining? I am fairly sure this is not a type of sensory pleasure. Would it make (...) sense to say that what S is attitudinally pleased by is the state of affairs consisting of S’s imagining p rather than p? I don’t think this will do. It seems possible for S to take pleasure in the imagined state of affairs, p, but not in the state of affairs of S’s imagining p. Consider the case of Chastity, who has had a puritanical upbringing. One day Chastity imagines a torrid romantic encounter with one of her co-workers. Quite in spite of herself, Chastity is pleased by the state of affairs which she merely imagines. But her upbringing has left its mark on her, so she feels very guilty about allowing her thoughts to run in such an unwholesome direction. Chastity is pained by the state of affairs consisting in her imagining the encounter. (shrink)

In this paper I offer a re-reading of "The Moral Philosopher and the Moral Life," William James's most well known work on ethics. I show that while James defends a naturalistic account of the basis of morality in the essay, he also makes a practical argument for religious faith, one that closely connects the piece to such works as "The Will to Believe" and The Varieties of Religious Experience. After discussing some of the strengths and weaknesses of James's moral theory (...) and metaethical views, I argue that the religious aspect of the essay—which has tended to be either ignored or downplayed by previous interpreters—is of crucial importance for understanding James's ethics, and that his practical argument is valid and worthy of serious consideration. (shrink)

David Hume and James Madison believed that a republic can secure domestic tranquility by discouraging the development of factions. Modern computer technology shatters these hopes, which rest on the idea that factions will not grow because great distance makes it difficult for individuals to discover that others share their interests or grievances. Today, technology renders geographical distance increasingly irrelevant to communication with others. If Madison and Hume were right about the effects of distance prior to the current development of computer (...) technology, then we may experience the growth of factions and associated violence that Hume and Madison feared. Increased domestic terrorism made more effective by technologically developed weapons of mass death could be the way of the future. I contend that education can modify such developments by giving priority to Jane Roland Martin's suggestion that we adopt an educational aim intent on securing domestic tranquility. I revise the content of her proposal to include features of communicative rationality as an indispensable element of political dialogue. This provides resources by which factional elements can access and influence political discussion. If we are to enjoy a decent degree of domestic tranquility in the future, we must integrate potentially factious elements into the political process. To marginalize such elements, no matter how repugnant their political views, will merely serve to legitimate their use of terror as the only option available to them for political expression. (shrink)