Leydig cells, traditionally known as the steroidogenic workhorses of the testis, are now known to synthesize significant amounts of non‐steroid products including some potent bioactive proteins and peptides. These products are currently being investigated for their potential role in the paracrine regulation of spermatogenesis in the nearby seminiferous tubules and in the autocrine regulation of Leydig cell function.

Human beings are essentially vulnerable in the view that their existence qua humans is not given but construed. This vulnerability receives basic protection from the State, expressed in the form of the universal rights all citizens are meant to enjoy. In addition, many individuals fall prey to destitution and deprivation, requiring social action aimed at recognising the specific harms they suffer and providing remedial assistance to palliate or remove their plights.Citizens receive protection against their biologic vulnerability by means of an (...) in rem right to health [care], which is more an attitude of protection than a specific programme. When individuals become susceptible, that is, biologically weak or diseased, they also increase their predisposition to additional harm, and require social actions to treat their demeaned condition. Such assistance takes the form of positive healthcare rights.Research on human beings has been slow to observe that the subjects recruited are susceptible, especially so if research is done in less developed countries. By mislabelling them as vulnerable – a characteristic they share with all humans – sponsors avoid registering the deprivation these people suffer, and the ethical obligation to offer them remedial help.The distinction between vulnerability and susceptibility also marks the difference between being intact but fragile – vulnerable – and being injured and predisposed to compound additional harm – susceptible. Awareness of this difference should give additional force to the rejection of double standards in research ethics. (shrink)

The so-called European principles of bioethicsare a welcome enrichment of principlistbioethics. Nevertheless, vulnerability, dignityand integrity can perhaps be moreaccurately understood as anthropologicaldescriptions of the human condition. Theymay inspire a normative language, but they donot contain it primarily lest a naturalisticfallacy be committed. These anthropologicalfeatures strongly suggest the need todevelop deontic arguments in support of theprotection such essential attributes ofhumanity require. Protection is to beuniversalized, since all human beings sharevulnerability, integrity and dignity, thusfundamenting a mandate requiring justice andrespect for fundamental human (...) rights.Being a feature of all humanity, vulnerabilityis improperly extended to designatedestitute individuals and populations. Rather,they are in a state of fallen vulnerability,for they already are harmed in some way, andhave become deprived of their range ofcapabilities. These individuals are destituteand are no longer in command of theirfundamental human rights. They have lost thestatus of unharmed vulnerability;identifying them as susceptible – vulnerated andno longer only vulnerable – stresses thepoint that bioethics demands specific socialaction to palliate or remove their distress.When harm does occur – in the form of disease,for example –, individuals are no longervulnerable – for they have ceased to be intact–, they become susceptible to additionaldeprivations and sickness; integrity isdemeaned and dignity is offended, leading tostates of dysfunction that require specificremedial social practices, aimed at treatingand removing injuries.The main point this paper addresses is thatvulnerability – as well as dignity and integrity – are descriptive characteristics ofhuman beings qua humans, which are not normative in themselves, but fundamental enoughto inspire bioethical requirements of protection and respect for human rights in thewake of social justice. A clear distinction must be made in regard to human beings who areinjured by poverty, sickness, discriminating deprivations or suffer otherdestitutions, having ceased to be only vulnerable for they are no longer intact. Theseindividuals and populations require more than protection, their needs must be met byspecific care and remedial measures to be identified and instigated by bioethics quaapplied ethics. (shrink)

One of the most influential studies in all expertise research is de Groot’s (1946) study of chess players, which suggested that pattern recognition, rather than search, was the key determinant of expertise. Many changes have occurred in the chess world since de Groot’s study, leading some authors to argue that the cognitive mechanisms underlying expertise have also changed. We decided to replicate de Groot’s study to empirically test these claims and to examine whether the trends in the data have changed (...) over time. Six Grandmasters, five International Masters, six Experts, and five Class A players completed the think-aloud procedure for two chess positions. Findings indicate that Grandmasters and International Masters search more quickly than Experts and Class A players, and that both groups today search substantially faster than players in previous studies. The findings, however, support de Groot’s overall conclusions and are consistent with predictions made by pattern recognition models. (shrink)

Wicked problems—that is, problems that can be framed in a number of different ways, depending on who is looking at them—pose ethical challenges for professionals that have scarcely been recognized as such. Even though wicked problems are all around us, they are rarely addressed in education. A reason for this failure might be that wicked problems pose almost insurmountable challenges in educational settings. This contribution shows how students can learn to cope with wicked problems in problem-based learning projects that are (...) structured by the Reflect! platform. (shrink)

Although there is increasing interest in philosophy of science in transcendental reasoning, there is hardly any discussion about transcendental arguments. Since this might be related to the dominant understanding of transcendental arguments as a tool to defeat epistemological skepticism, and since the power of transcendental arguments to achieve this goal has convincingly been disputed by Barry Stroud, this contribution proposes, first, a new definition of the transcendental argument which allows its presentation in a simple modus ponens and, second, a pragmatist (...) re-interpretation of this argument form that leaves it to the scientific community to debate, criticize, refine, or reaffirm its core claim: a premise which claims that the truth of a certain assumption is a necessary condition for something that is generally accepted. The proposed “logico-pragmatist interpretation” highlights the role of transcendental arguments as a methodological step to move science forward, just as abduction and inference to the best explanation do. (shrink)

Among the many problems posed by Peirce's concept of abduction is how to determine the scope of this form of inference, and how to distinguish different types of abduction. This problem can be illustrated by taking a look at one of his best known definitions of the term:Abduction is the process of forming an explanatory hypothesis. It is the only logical operation which introduces any new idea; for induction does nothing but determine a value, and deduction merely evolves the necessary (...) consequences of a pure hypothesis.The second half of this quote is not part of the definition, but an explanation of it. However, it adds something to this definition because it says implicitly that there are only three logical.. (shrink)

Few studies examine plagiarism in a Middle Eastern context, specifically from the perspectives of preservice teachers. As future gatekeepers of academic integrity, preservice teachers need to understand plagiarism. This study surveyed 128 female preservice teachers in one university in the Gulf Cooperation Council (GCC) countries. The survey explores preservice teachers regarding their understandings and reasons for academic plagiarism and their responses to particular scenarios. Findings indicate that preservice teachers have a thorough comprehension of plagiarism and suggest a lack of knowledge (...) of citing sources, weak writing skills, a lack of time, and not knowing the research process as reasons for plagiarism. Informants' responses to six scenarios are presented to illustrate their perspectives further. Discussion addresses language and cultural issues to contextualize the study. (shrink)

We define a rich model to be one which contains a proper elementary substructure isomorphic to itself. Existence, nonstructure, and categoricity theorems for rich models are proved. A theory T which has fewer than $\min(2^\lambda,\beth_2)$ rich models of cardinality $\lambda(\lambda > |T|)$ is totally transcendental. We show that a countable theory with a unique rich model in some uncountable cardinal is categorical in ℵ 1 and also has a unique countable rich model. We also consider a stronger notion of richness, (...) and use it to characterize superstable theories. (shrink)

Anatomy of an Argument Michael H. Mitias. FOUR LOVE AS THE BASIS OF THE FAMILY Let us grant, for the sake of argument, my critic would object, that Hegel has made a distinction between a universal or natural law and a human law, ...

This critical study of Arendt explores the sources and dangers of political alienation in the West from the citizen republics of classical antiquity to the consumer societies of modern liberal democracies. It is a sympathetic appraisal of the high promise and great perils of the political life.

The last decade has experienced a vivid enthusiasm to unravel the mystery of consciousness believed to be one of the major puzzles of human kind. We share this enthusiasm. Still, we feel that current models are incomplete suffering from a problem that we call the “small network argument”.

A presentation of the major themes of Teilhard's works and their relationship to traditional biblical and theological concepts.

This volume provides a critical survey of the major figures and ideas of 20th century political philosophy.

This paper is a critical analysis of the conditions under which a decent world order is possible, an order in which the different peoples of the world can thrive under the conditions of peace, cooperation, freedom, justice, and prosperity. This analysis is done from the standpoint of Janusz Kuczyński’s philosophy of universalism as a metaphilosophy. More than any other in the contemporary period, this philosophy has advanced a focused, systematic, and comprehensive analysis of these conditions on the basis of a (...) universal vision of nature, human nature, and the meaning of human life and destiny. The paper is composed of three parts. The first part is devoted to a short overview of activism in the history of philosophy. The second part is devoted to an analysis of the main elements of universalism as a metaphilosophy, especially the theoretical conditions of establishing a decent world order. The third part is devoted to a discussion of the practical steps that should be taken to establish a decent world order. (shrink)

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Most of the epistemological debate on disagreement tries to develop standards that describe which actions or beliefs would be rational under specific circumstances in a controversy. To build things on a firm foundation, much work starts from certain idealizations—for example the assumption that parties in a disagreement share all the evidence that is relevant and are equal with regard to their abilities and dispositions. This contribution, by contrast, focuses on a different question and takes a different route. The question is: (...) What should people actually do who find themselves in deep disagreement with others? And instead of building theory on some “firm foundation,” the paper starts from a specific goal—building consensus by creating new proposals—and asks, first, which actions are suitable to achieve this goal and, second, what are the epistemic conditions of these actions. With regard to the latter, the paper focuses on what has been called framing and reframing in conflict research, and argues that both metaphors need and deserve a suitable epistemological conceptualization. (shrink)

Robert Fogelin formulated the thesis “that deep disagreements cannot be resolved through the use of argument, for they undercut the conditions essential to arguing.” The possibility of arguing presupposes “a shared background of beliefs and preferences,” and if such a background is not given, there is no way of “rational” dispute resolution. By contrast to this pessimistic view, I will propose a method that has been developed to overcome difficulties as described by Fogelin.

Parties are back, and many are cheering. Party polarization has voters seeing stark differences between Democrats and Republicans and demonstrating more ideological constraint than previous generations. But these signs of a more “responsible” electorate are an illusion, because the public is no more knowledgeable than ever about the type of “information” it needs if it is to exercise effective control over the public‐policy outcomes it cares the most about. Indeed, polarization has produced a political environment where both voters and policy (...) makers may be less likely to learn about the potential consequences of their governing choices. The result is that holding elected politicians to account for policies treated as divisive ends in themselves has become easier—but that holding them accountable for policies intended as means to the achievement of consensual ends has become harder. (shrink)

: To honor Bernard Goldstein, this article highlights in the "Defense of Theon against George of Trebizond" by Regiomontanus (1436-1476) themes that resonate with leading strands of Goldstein's scholarship. I argue that, in this poorly-known work, Regiomontanus's mastery of Ptolemy's mathematical astronomy, his interest in making astronomy physical, and his homocentric ideals stand in unresolved tension. Each of these themes resonates with Gold- stein's fundamental work on the Almagest, the Planetary Hypotheses, and al-Bitruji's Principles of Astronomy. I flesh out these (...) tensions with an intriguing interpretation of the history of astronomy, in which Regiomontanus contrasts the two-dimensional "eccentric astronomy" attributed to the Almagest and the Arabs with the three-dimensional spheres of the "later" astronomers. A similar contrast reappears when Regiomontanus portrays as a "fictitious art" an astronomy that does not go beyond the accommodation of computations to the appearances. To conclude, I use Regiomontanus's expression to reinstate (pace Goldstein and Barker in this journal, 1998) fictionalism as an actor's category in Osiander and sixteenth-century astronomy. (shrink)