Plants have evolved systems analogous to animal innate immunity that recognise pathogen‐associated molecular patterns (PAMPs). PAMP detection is an important component of non‐host resistance in plants and serves as an early warning system for the presence of potential pathogens. Binding of a PAMP to the appropriate pattern recognition receptor leads to downstream signalling events and, ultimately, to the induction of basal defence systems. To overcome non‐host resistance, pathogens have evolved effectors that target specific regulatory components of the basal defence system. (...) In turn, this has led to the evolution in plants of cultivar‐specific resistance mediated by R proteins, which guard the targets of effectors against pathogen manipulation; the arms race continues. BioEssays 28: 880–889, 2006. © 2006 Wiley periodicals, Inc. (shrink)

This paper looks at the commodification of interferon, marketed by Hoffmann La Roche as Roferon A in 1986, as a case study that helps us understand the role of pharmaceutical industry in cancer research, the impact of molecular biology on cancer therapy, and the relationships between biotech start-ups and established pharmaceutical firms. Drawing extensively on materials from the Roche company archives, the paper traces interferon’s trajectory from observed phenomenon to product. Roche embraced molecular biology in the late 1960s to prepare (...) for the moment when the patents on some of its bestselling drugs were going to expire. The company funded two basic science institutes to gain direct access to talents and scientific leads. These investments, I argue, were crucial for Roche’s success with recombinant interferon, along with more mundane, technical and regulatory know-how held at Roche’s Nutley base. The paper analyses in some detail the development process following the initial success of cloning the interferon gene in collaboration with Genentech. It looks at the factors necessary to scale up the production sufficiently for clinical trials. Using Alfred Chandler’s concept of ‘organizational capabilities’, I argue that the process is better described as ‘mobilisation’ than as ‘translation’. (shrink)

This is a bilingual edition of the selected peer-reviewed papers that were submitted for the International Symposium on Jesuit Studies on the thought of the Jesuit Francisco Suárez. The symposium was co-organized in Seville in 2018 by the Departamento de Humanidades y Filosofía at Universidad Loyola Andalucía and the Institute for Advanced Jesuit Studies at Boston College.

Representative for contemporary attempts to establish a science of consciousness we examine Chalmers' statement and resolution of the 'hard problem of consciousness'. Agreeing with him that in order to account for subjectivity it is necessary to expand the ontology of the natural sciences, we argue that it is not sufficient to just add conscious experience to the list of fundamental features of the world. Instead, we turn to phenomenology as the philosophy of conscious experience and give an outline of Merleau-Ponty's (...) critique of the objectivist ontology underlying science which excludes subjectivity from the world. We reconstruct his proposal for a revised ontology in The Visible and the Invisible aiming at an extended understanding of Being including subjectivity, which takes on the form of a constellation of new ontological terms centered around the concept of the 'flesh of the world'. Trying to spell out the consequences of Merleau-Ponty's ontological considerations for scientific practice and especially the science of consciousness, we notice that his philosophy of subjectivity-in-the-world on its part is unable to connect to the insights of the natural sciences. The phenomenological critique of the 'hard problem' reveals a deeper disparity which, at present, limits its practical implications. (shrink)

SummaryAt the end of 1910, when the Qing dynasty was on the verge of collapse and the whole Chinese empire in a process of transformation, North Manchuria was devastated by a large pneumonic plague epidemic. The Russian and Japanese governments wanted to use the outbreak of the disease as a pretext to invade north-east China, making plague an issue of international politics. At this dramatic moment the empire relied on the skills of the young Chinese doctor Wu Lien-teh, the first (...) Chinese medical graduate from Cambridge. Wu investigated the disease on the spot, chaired an international plague conference in Shenyang (Manchuria) in April 1911, and, later on, became the figurehead of fundamental public health reforms in Republican China. Highly ambitious, striving for personal fame and international renown for China, supported by an excellent network of personal connections, and equipped with a medical training considered the best in the world at the time, he launched on a startling career as one of China's key medical reformers and international representatives. His history is an example of the inseparable links between personal fate and historical events, and between the interests of scientists, medical men, politicians, and businessmen on the national and international stages. (shrink)

This is a bilingual edition of the selected peer-reviewed papers that were submitted for the International Symposium on Jesuit Studies on the thought of the Jesuit Francisco Suárez (1548-1617). The symposium was co-organized in Seville in 2018 by the Departamento de Humanidades y Filosofía at Universidad Loyola Andalucía and the Institute for Advanced Jesuit Studies at Boston College. Suárez was a theologian, philosopher and jurist who had a significant cultural impact on the development of modernity. Commemorating the four-hundredth anniversary of (...) his death, the symposium studied the work of Suárez and other Jesuits of his time in the context of diverse traditions that came together in Europe between the late Middle Ages, the Renaissance, and early modernity. (shrink)

Kants Anliegen, Erfahrung zu begr nden als eine Verbindung von Anschauung und Begriff, erweist sich als ein komplexes Unterfangen, insofern hierzu viele Synthesisleistungen des Verstandes und der Einbildungskraft strukturell notwendig sind. Die Arbeit setzt sich zum Ziel, diese isoliert und in ihrer Bezogenheit aufeinander zu untersuchen. Ausgehend von einer Betrachtung der Anschauungsformen Raum und Zeit und einer Analyse der urspr nglich-synthetischen Einheit der Apperzeption, wird der Bogen geschlagen zu den einzelnen Synthesen der Einbildungskraft und der synthetischen Reflexion durch den Verstand. (...) Dabei hat insbesondere das Kapitel zum Schematismus der reinen Verstandesbegriffe eine tragende Bedeutung; hier soll ein neues Licht auf die Schemata als Schnittstelle zwischen Begriff und Anschauung geworfen werden. Trotz der mittlerweile schwer zu berschauenden Zahl an Forschungsliteratur finden sich nur wenige Untersuchungen speziell zur Synthesis, weshalb die Arbeit als ein Desiderat der Kant-Forschung gelten kann. Ein Desiderat ist sie auch deshalb, weil Kants Theorie seit Strawson immer wieder Angriffen speziell sprachanalytischer Interpretationen ausgesetzt ist, die "Synthesis" f r obsolet erkl ren wollen. (shrink)

This intra-view explores a number of productive junctions between contemporary Deleuzoguattarian and new materialist praxes via a series of questions and provocations. Productive tensions are explored via questions of epistemological, ontological, ethical, and political intra-sections as well as notions of difference, transversal contamination, ecosophical practices, diffraction, and, lastly, schizoanalysis. Various irruptions around biophilosophy, transduction, becomology, cartography, power relations, hyperobjects as events, individuation, as well as dyschronia and disorientation, take the discussion further into the wild pedagogical spaces that both praxes have (...) in common. -/- . (shrink)

PurposeThe paper aims to explore future and emerging information and communication technologies. It gives a general overview of the social consequences and ethical issues arising from technologies that can currently be reasonably expected. This overview is used to present recommendations and integrate these in a framework of responsible innovation.Design/methodology/approachThe identification of emerging ICTs and their ethical consequences is based on the review and analysis if several different bodies of literature. The individual features of the ICTs and the ethical issues identified (...) this way are then aggregated and analysed.FindingsThe paper outlines the 11 ICTs identified. Some of the shared features that are likely to have social relevance include an increase in natural interaction, the invisibility of technology, direct links between humans and technology, detailed models and data of humans and an increasing autonomy of technology that may lead to power over the user. Ethical issues include several current topics such as privacy, data protection, intellectual property and digital divides. New problems may include changes to the way humans are perceived and the role of humans and technology in society. This includes changing power structures and different ways of treating humans.Research limitations/implicationsThe paper presents a piece of foresight research which cannot claim exact knowledge of the future. However, by developing a detailed understanding of possible futures it provides an important basis for current decisions relating to future technology development and governance.Practical implicationsThe paper spells out a range of recommendations for both policy makers and researchers/industry. These refer to the framework within which technology is developed and how such a framework could be designed to allow the development of ethical reflexivity.Social implicationsThe work described here is likely to influence EU policy on ICT research and technology research and innovation more broadly. This may have implications for the type of technologies funded and broad implications for the social use of emerging technologies.Originality/valueThe paper presents a novel and important broad view of the future of ICTs that is required in order to inform current policy decisions. (shrink)

Wie viele der monumentalen Fotoarbeiten Jeff Walls ist The Flooded Grave (1998- 2000) ein Werk, dem das Medium Fotografie selbst zum Thema wird – auf gedan- kenweckend paradoxe, Gesten dokumentarischer Kontingenz und Markierungen fiktionalen Arrangements amalgamierende Weise. Analysen, die vorrangig oder exklusiv auf diesen Befund abstellen, können die Komplexität und Individualität der Bilderfindung Walls freilich nicht angemessen erfassen. Hierfür bedarf es viel- mehr der Einsicht in allusiv fundierte Reflexionsstrukturen, die The Flooded Grave auf ikonografischer und bildtypologischer Ebene zu historisch indizierten (...) Formen christlicher Kunst in Beziehung setzen. Der vorliegende Beitrag unternimmt den Versuch, sie zu identifizieren, ihre werk-interne Synergie zu beschreiben und im Wege »denkender Betrachtung« (Hegel) über ihre ästhetische, künstlerische und spirituelle Bedeutung Auskunft zu geben. (shrink)

Laudan famously argued that neither truth nor approximate truth can be part of an explanation of a scientific theory's predictive success because in the history of science there were theories that enjoyed some limited success but now are considered outright false. The power of his argument lay in the many historic examples he listed . Realists have disputed that all theories on Laudan's list can be regarded as predictively successful but let's suppose momentarily that at least some exist that support (...) his point. In this case, there are historic false theories that made some true predictions. We are aiming for a general explanation of a theory's predictive success and hence these false theories necessarily are on board. Now, Laudan also argues that historic false theories – the downright false ones and the ones we nowadays judge as strictly false, but approximately true – do not in any principled sense differ from the ones we presently accept. These theories seem to present a good basis for inductively inferring that any presently accepted scientific theory is actually false. Many presently accepted theories certainly are predictively successful to a great extent and certainly their success should be covered by an acceptable explanation. Since there seems to be inductive support for the conclusion that …. (shrink)

By bringing feminist science studies scholar Donna J. Haraway’s A manifesto for cyborgs (1985) and Situated knowledges (1988) in line with contemporary critical new materialist thought (see Colman & Van der Tuin, 2024; Dolphijn & Van der Tuin, 2012; Geerts, 2022), this critical pedagogical and philosophical think piece tackles the problematic of Anthropocenic disruptions of the planetary biosphere for critical pedagogies and higher education (also see Carstens, 2016). It additionally encourages its readers to think through their own pedagogical conceptions (...) and praxes by means of irruptive (Geerts & Carstens, 2024; Koro-Ljungberg, 2015) selfreflection- stimulating questions. Our situated – and thus limited and open-ended – response to this all-encompassing Anthropocenic crisis is rooted in a rethinking of Harawayan cyborgian and situated knowledges and the critical pedagogical lessons drawn from the latter. Rereading Haraway’s work through contemporary critical new materialist and related scholarship reveals that it already contained an ecofeminist onto-epistemological shift toward more-than-human agency and relationality. This shift has major consequences for all things critical pedagogical and educational, as our pedagogical thinking-doings are deeply embedded in today’s crisis-ridden lifeworld. This rereading exercise furthermore underlines the necessity of an updated critical new materialist pedagogical praxis for learning and teaching, inspired by Harawayan ecofeminism, that takes the entanglements between human, dehumanised, and more-than-human actors seriously. (shrink)

Research methods and their developers play a crucial role in bringing together scientific fields. Scientists, who wish to have their methods acknowledged and used in another discipline have to bridge the gaps between different practices and worldviews, and they often experience hostility, incredulity, and in general feelings of ‘otherness’, while changing the established practice in a scientific field. Researchers representing newly emerging fields such as materials science have to overcome obstacles that are caused more by feelings of threat and fear (...) than by arguments rooted in epistemic or social considerations. In using the habitus concept of Pierre Bourdieu, I analyze in this article statements and observations of the scientists who in the 1950s and 1960s have introduced physical methods into chemistry and in so doing merged characteristic features of research communities into a new unit. The habitus of physicists, chemists and method-oriented researchers are shaped by hierarchical relationships inside the disciplines, and between them. Studying emotional expressions in interviews and self-descriptions gives access to hitherto neglected parts of the historical processes leading to new disciplines and fields. The brief case studies presented are seen as exemplars, and the analysis offered is intended more to provide a possible model for further research than as giving conclusive answers. (shrink)

The linkages and interactions of scientific disciplines with industry, politics, and society have long been a staple in the history of science, the history of technology, and science studies. However, it is arguable that the impact of this intertwining on the epistemic and social core of scientific disciplines has not yet been sufficiently explored. Chemistry is an ideal case in point, given that it has emerged as one of the largest scientific disciplines while at the same time becoming one of (...) the world’s most powerful technologies. Specifically, chemistry’s power lies in its ability to gain knowledge of the natural world by transforming it, along with the society in which it is embedded. The four contributions to this Focus section all address chemistry’s border permeability, based on its transformative powers; they focus on the feedback mechanisms that transformed chemistry and thereby altered the very concept of a scientific discipline. So successful has this “nonclassical approach” become that, in the opinion of the contributors to this Focus section, it is now both necessary and advisable to study the history of chemistry’s embeddedness and power in science and technology. (shrink)

During the Covid-19 pandemic, funerals have been conducted consistently in Norway, but, of course, the ceremonies were subject to rules and regulations, while digitization was on the increase. Against the background of already ongoing discussions, both in contexts related to the Church of Norway and in practical-theological discourses, this article analyses scenes and excerpts from interviews conducted in 2021 and asks: What does the sociologist Hartmut Rosa’s concept of resonance convey in the pandemic situation? – This concept aims at a (...) mode of relating that empowers fulfilling, resonant relationships between subjects and between subject and world; the aim here is to bring it into play as a sensitizing concept, in a situation of supposedly increased distance and unaffectedness between people. The article discusses where the concept conveys the need for stable frameworks, and where it conveys the need for ongoing work with an ecclesiastical-theological self-understanding in the field of church funerals. (shrink)