Enzymatic misrepair of ionizing‐radiation‐induced DNA damage can produce large‐scale rearrangements of the genome, such as translocations and dicentrics. These and other chromosome exchange aberrations can cause major phenotypic alterations, including cell death, mutation and neoplasia. Exchange formation requires that two (or more) genomic loci come together spatially. Consequently, the surprisingly rich aberration spectra uncovered by recently developed techniques, when combined with biophysically based computer modeling, help characterize large‐scale chromatin architecture in the interphase nucleus. Most results are consistent with a picture (...) whereby chromosomes are mainly confined to territories, chromatin motion is limited, and interchromosomal interactions involve mainly territory surfaces. Aberration spectra and modeling also help characterize DNA repair/misrepair mechanisms. Quantitative results for mammalian cells are best described by a breakage‐and‐reunion model, suggesting that the dominant recombinational mechanism during the G0/G1 phase of the cell cycle is non‐homologous end‐joining of radiogenic DNA double strand breaks. In turn, better mechanistic and quantitative understanding of aberration formation gives new insights into health‐related applications. BioEssays 24:714–723, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Occupy Wall Street, Indignés, Nuit Debout - plus que jamais la question est posée de définir la vie que nous souhaitons choisir et vivre. Une vie vécue est inséparable de ses formes, de ses modalités, de ses régimes, de ses gestes, de ses façons, de ses allures... qui sont déjà des idées. Le monde, tel que nous le partageons et lui donnons sens, ne se découpe pas seulement en individus, en classes ou en groupes, mais aussi en "styles", qui sont (...) autant de phrasés du vivre, animé de formes attirantes ou repoussantes, habitables ou inhabitables, c'est-à-dire de formes qualifiées : des formes qui comptent, investies de valeurs et de raisons d'y tenir, de s'y tenir, et aussi bien de les combattre. C'est sur ce plan des formes de la vie que se formulent aujourd'hui beaucoup de nos attentes, de nos revendications, et surtout de nos jugements. C'est toujours d'elles que l'on débat, et avec elles ce sont des idées complètes du vivre que l'on défend ou que l'on accuse. Une forme de vie ne s'éprouve que sous l'espèce de l'engagement, là où toute existence, personnelle ou collective, risque son idée. Vouloir défendre sa forme de vie, sans tapage, en la vivant, mais aussi savoir en douter et en exiger de tout autres, voilà à quoi l'histoire la plus contemporaine redonne de la gravité. Bien au-delà du champ de l'art, Marielle Macé propose la construction critique d'une véritable stylistique de l'existence. Cela suppose de s'intéresser sans préjugé à tout ce qu'engagent les variations formelles de la vie sur elle-même - styles, manières, façons - et de ne pas traiter forcément de vies éclatantes, triomphantes, d'apparences prisées ou de corps élégants. Ce n'est pas seulement la littérature mais bien toutes les sciences humaines qui, pour comprendre le monde immédiat, sous nos yeux, doivent s'y rendre vraiment attentives. (shrink)

Should nurses have their own ethics to match specific problems met in their daily routines? How do nurses act in a society that is changing from a 'monocultural' to an 'intercultural' structure? What are the ethical consequences of these changes for their many tasks? How can the ethical aspects be taught to nurses? This article describes the current status of nursing ethics in the curriculum taught in schools of higher education for nurses in The Netherlands. Aspects of the debate on (...) nursing ethics are outlined and ideas about its future as a subject and discipline in nurse education are offered. Est-ce que le personnel infirmier doit avoir son éthique à soi pour faire face aux problèmes spécifiques dans la routine journalière? Et comment les infirmiers/ères se comportent-ils dans une société qui est en train de changer de la 'monoculture' en 'interculture'? Quels sont les conséquences éthiques de leur tâches? Comment peuvent ces aspets éthiques être enseignés aux infirmiers/ères? Cet article parle de l'état courant de l'éthique infirmier dans l'enseignement dans les écoles de l'education supérieure pour infirmiers/ères en Hollande. En plus, il donne une esquisse de la discussion sur l'éthique infirmier et donne quelques idées pour le futur de l'éthique infirmier comme sujet et discipline en soi dans l'éducation des infirmiers/ères. Sollte das Pflegepersonal seine eigene Ethik haben um den spezifischen Problemen seiner täglichen Routine gewachsen zu sein? Wie soll das Pflegepersonal in einer Gesellschaft handeln, die im Wechsel ist von einer 'Monokultur' zu einer 'Interkultur'? Was sind die ethischen Konsequenzen ihres handeln? Wie können diese ethischen Aspekte dem Pflegepersonal gelehrt werden? Dieser Artikel beschreibt den gegenwärtigen Zustand der Krankenpflege-Ethik im Lehrplan der Schulen für Höhere Ausbildung für Pflegepersonal in Holland. Er gibt auch einen Umriss über die Debatte über Krankenpflege-Ethik und formuliert einige Ideen für die Zukunft der Krankenpflege- Ethik als ein Thema und eine Disziplin in der Ausbildung des Pflegepersonals. (shrink)

La Constitución Nacional del año 1994 incorporó el derecho a la salud. Antes dela reforma de 1994, el derecho a la vida no estaba contemplado en el texto constitucional.Esto implica que cualquier persona que perciba que sus derechos fueronvulnerados puede disponer de un inmediato recurso de amparo para que cese tal acciónsobre él. Desde 1994 en adelante, los tratados adquieren carácter supralegal, enel sentido de que ocupan un lugar debajo de la Constitución, pero por encima de lasleyes y resto del (...) derecho interno. Es así, como consecuencia, que Argentina adhiereal Pacto de San José de Costa Rica, que en su artículo 25 establece el derecho de losindividuos a recursos que lo amparen contra cualquier tipo de acto que viole o lesionesus derechos fundamentales reconocidos por la Constitución, la ley o esa mismaconvención. El propósito de este trabajo es abordar la problemática que se presentaen la modalidad de acceso a prestaciones de alto precio a través de la judicializaciónen Argentina, reseñando un breve comentario acerca de las políticas de acceso queposeen otros países a los fines de reflexionar y poder conocer otras alternativasque contribuyan a la sustentabilidad de un sistema de salud. (shrink)

Psychologists, as well as other mental health professionals, face unique demands in the workplace that create increased risk for burnout. This article discusses burnout prevalence and detection, including issues of complexity regarding diagnosis and assessment. An ethical lens is utilized to explore problems that may arise due to burnout, and the ethical responsibility of practicing self-care. Recommendations for graduate clinical training programs as well as practicing professionals are suggested, including strategies for monitoring self and others for warning signs of burnout (...) and implementing self-care. (shrink)

This essay conceptualizes the intersections between contemporary catastrophes and political life by exploring how narratives of catastrophe mediate discursive and objective processes of catastrophization. It argues for the need to counteract catastrophization, a discursive and objective political phenomenon, by not only re-cognizing how catastrophes impinge on political life but by offering a more critical understanding of this intersection. The essay thus calls for the politicization of catastrophe as a response to the “catastrophization of political life.” Apropos of these concerns, it (...) engages with Habermas in order to explore how his political theory and interventions illustrate important aspects of the intersections between narratives of catastrophe and contemporary political life, say, how discursive catastrophization leads to the misrecognition of objective modalities of catastrophe. Overall, this essay offers an account of how to conceptualize catastrophe and catastrophization in order to articulate the broad contours of a political theory of catastrophe. (shrink)

Se realizó la revisión bibliográfica con el objetivo de que los jóvenes profesionales de la salud conozcan acerca de la historia, origen y significado del distintivo que representa a la Medicina en todos sus campos con un carácter humanista y elevados valores éticos y morales: el emblema de Esculapio, al que se le atribuyen dotes para calmar o apaciguar. Esta imagen del bastón con la serpiente es la que ha quedado como un atributo del dios curativo y ha llegado hasta (...) la actualidad como símbolo de la Medicina. The literature review was made in order to young health professionals know about the history, origin and meaning of the emblem that represents the Medicine in all fields with humanist and high ethical values and moral character : the Aesculapius emblem, the feats attributed to him to calm or appease. This image of the snake with the cane has remained as a healing attribute of God and has come to the present as a symbol of medicine. (shrink)

Conscience – a catholic anthropological vision In the catholic tradition conscience always played an important role as visible in the ‘clausula Petri’ (Ac 5,30-33) or in Paul’s belief in its wisdom (Rm 2,14-16). Conscience can break rules (‘epikeia’), but should not stand up against the church as such. Luther’s historical deed left behind a distrust in conscience in the Catholic Church; it took 400 years to restore Paul’s vision of the conscience as the highest authority – if it is formed (...) and reaches the state of maturity. By his conscience, man is called to be as God created him; he is called by others to develop and to respect their dignity. He is also called by the world to form it according to its higher possibilities which cannot be realized but by man. Conscience is God’s voice in the person where his promises can be heard. Though conscience is free, it is the place where responsibility is formed according to what someone can and should do. This is why the conscience will keep its unavoidable and undeniable role – even in a postmodern context. (shrink)

Disparities in maternal morbidity and mortality for Latinx populations are a paradigmatic example of the now widely acknowledged structural racism in U.S. health care that predisposed minorities to...

In their recent Opinion in TiCS, Yildirim and Paul propose that large language models (LLMs) have ‘instrumental knowledge’ and possibly the kind of ‘worldly’ knowledge that humans do. They suggest that the production of appropriate outputs by LLMs is evidence that LLMs infer ‘task structure’ that may reflect ‘causal abstractions of... entities and processes in the real world.' While we agree that LLMs are impressive and potentially interesting for cognitive science, we resist this project on two grounds. First, it casts (...) LLMs as agents rather than as models. Second, it suggests that causal understanding could be acquired from the capacity for mere prediction. (shrink)

Experiential imagination consists in an imaginative projection that aims at simulating the experiences one would undergo in different circumstances. It has been traditionally thought to play a role in how we build our lives, engage with other agents, and appreciate art. Although some philosophers have recently expressed doubts over the capacity of experiential imagination to offer insight into the perspective of someone other than our present-selves, experiential imagination remains a much sought-after tool. This paper substantiates pessimism about the epistemological value (...) of these uses of experiential imagination by developing an embodied approach. Our thesis is that experiential imagination is _robustly embodied_ because the _sociohistorically situated_ body makes an irreducible contribution to the imaginative project, and that, as such, it is constrained by who we are as _concrete_ agents. We argue that experiential imagination is an embodied, virtual exploration of imagined scenarios that depends on our situated history of sensorimotor and affective interactions. We conclude that experiential imagination is much more limited than commonly acknowledged, as it can hardly be divorced from who we are and where we have been. (shrink)

Most decision-making research in economics focuses on individual decisions. Yet, we know, from psychological research in particular, that individual preferences can be sensitive to social pressures. In this paper, we study the impact of a group environment on individual preferences for risky and ambiguous prospects. In our experiment, each participant was invited to make a series of lottery-choice decisions in two different conditions. In the Alone condition, individuals made private choices, whereas in the Group condition, individuals belonged to a three-person (...) group and group members’ choices were aggregated according to either a majority or unanimity rule. This design allows us to study the impact of a group environment on individuals’ attitude towards both risky and ambiguous prospects, while controlling for the decision rule used in the group. Our experimental results show that when individuals are in the Group condition, they tend to be less risk averse and more ambiguity averse than when they are not part of a group. Our experiment also suggests that the decision rule matters as it shows that these two trends tend to be stronger when the group implements a unanimity rule. Specifically, we found that individuals who belong to a group implementing a unanimity rule are significantly less risk averse than individuals who belong to a group that relies on the majority rule. We obtained a similar—but non-significant—result under ambiguity. (shrink)

Advocates of the ethical criticism of art claim that works' ethical defects or merits have an impact on their aesthetic value. Against ethical critics, autonomists claim that moral criteria should not be part of the considerations when evaluating works of art as art. Autonomism refers to the view that an artwork's aesthetic value is independent from its ethical value. The purpose of this paper is to examine how autonomism has been defended in the contemporary discussion in analytic aesthetics. I present (...) three versions of autonomism: Richard Posner's radical autonomism, James C. Anderson and Jeffrey T. Dean, and James Harold's moderate autonomism, and Francisca Pérez Carreño's robust autonomism. I argue that robust autonomism offers a stronger argument against the ethical critic. However, I point to some difficulties for Pérez Carreño's account and conclude by suggesting how further work in autonomism might go around them. (shrink)

This article focusses on corporate attitudes to stakeholder environmental pressures in Argentina. It uses a cross section survey of 505 CEOs of Argentinean firms to gather information on environmental attitudes and a stakeholder theory framework to design and interpret the statistical analyses. It is underpinned by theoretical and empirical findings in the literature on stakeholder management, targeting in particular studies that deal with corporate social responsibility (CSR) in Latin America. Its general aim is to gain a deeper empirical understanding of (...) the coherence between managers' perceptions of stakeholder pressures and the importance they are given in corporate CSR strategies through an empirical investigation of environmental management (EM) decisions. In doing so, it uncovers general differences in the way firms perceive and treat groups of stakeholders. It also detects variations across firms, observing that some are typically proactive in their response to stakeholder pressures whilst others are less responsive. Profiling the various stakeholder networks and the corporate response strategies in this way encourages the development of stakeholder-focussed policies and corporate strategies that emphasise communications, awareness and a clear sense of direction. It concludes that CSR appears to be more effective in the protection of the environment than previously reported. Although this study focusses on EM in Argentina, the findings are more generally applicable. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Respire, Con-spireMarielle Macé (bio)Translated by Alexis Ann StanleyA rather suffocating atmosphere is becoming our customary environment, ecologically, politically, and socially. It is time to affirm "a universal right to breathe"–what Achille Mbembe called the essential demand for justice that escalated during the age of the Anthropocene and is now crudely reemerging in the current pandemic's attack on the respiratory system.But the right to breathe is not "merely" the right (...) to live, to breathe in unpolluted spaces, or to share clean air; it is also the right to a breathable life, a life worth caring for. It is the right to love life, life with and among one another: the right to fraternize in and through breath, the right to detoxify our relationships and breathe with others. To respire with: to con-spire.Because in order to breathe, one needs air, but one especially needs other living beings, a world and landscapes with which to breathe, in which to breathe, and which can breathe through us. To breathe is not only to maintain one's own breath or nourish one's own organic system as if it lived an unconnected life; it is to acquiesce to the world, to the fact that there is a world—this one, precisely—and to participate in it. A person who breathes, in fact, partakes both in and of the world. Moreover, they make a gift to it, contributing to the way of the world in its entirety by a breath that tightly holds the ties binding each of our bodies to the current state of the living._______The lack of air, the feeling of a stifling age, even the fear of overwhelming suffocation—such is our current "natural" condition, the primary characteristic not only of our virtually toxic living environment, but also of our smothering, asphyxiating political condition wrought with violence and discrimination. Such also is the state of our social condition—the way we (rather poorly) create community—or rather, of our distinct social conditions. For there is a very inequitable distribution of the right to air or to breathe determined by which lives "count" and which do not.The Anthropocene is perhaps the age of a new respiratory 'condition.' Toxic fumes, pestilential odors, extensive carbon consumption, agro-chemical [End Page 177] discharge, microparticles, deforestation and soil asphyxiation, radioactive clouds with phantom trajectories and invisible powers of penetration… the history of industrial modernity is that of "the continuous and large-scale alteration of life's atmospheric conditions" (Zimmer 25). Recently, wildfires affecting America and Europe have been adding their horrifying fumes to century-old pollution. Even clouds ("the clouds up there, the marvelous clouds" of Baudelaire) are being targeted: China recently announced the country's intention to accelerate its cloud seeding program1 (in 2008, over one thousand shells loaded with silver iodide were dispersed in order to clear the skies of Beijing and prevent rain from ruining the opening ceremony of the Olympic games. This technique is also used more and more frequently to generate rainfall and avoid agricultural droughts. This type of 'sky colonization' or climate militarization is a profanation of language as much as of nature: to "sow the clouds" (or "grow meat")—even language tells us something is wrong…)It took a great amount of time and much denial before widespread bodily infection and industrial pollution's public health effects could be recognized. Industrialists may object (at times with doctors), but in the most working-class regions, bodies know: "lungs and our sense of smell protest in their own way against any conclusive evidence which would exonerate factories" (Zimmer 23).The history of pollution is, in fact, also a question of exploitation as well as a social history: that of the unequal distribution of air and the inequitable exposure (depending on one's living milieux) to what is oppressive, stifling—in a word, unbreathable. Unsanitary housing, proximity to mines or factories, and lack of access to healthcare are always factors; respiratory diseases are the most prevalent of occupational illnesses2; and the staggering surge in childhood lead poisoning in the very heart of our capitals—the weakest of bodies have... (shrink)

Cet article se penche sur la question des préférences de Gérard Genette, et chez Gérard Genette : sur ses objets de prédilection, c’est-à-dire sur ses « choses » préférées (œuvres, musiques, formes d’art, figures, paysages, personnes) ; mais surtout sur la préférence comme catégorie de la perception, du goût et du jugement, forme sensible de la relationnalité ou de la transcendance esthétique, et sur ce que cette affaire de préférences dit d’un certain rapport sensible aux généralités et aux catégories de (...) l’esprit, qui anime son œuvre et la porte vers nous. (shrink)

Søren Kierkegaard verweigert dezidiert die Standards akademischen Schreibens und betont die Unumgänglichkeit von "indirekter Mitteilung", wenn es um Glaubenswahrheit geht: Das Bemühen um stringente Argumentation und definitorisch gesicherte Termini führe zu Abstraktheit und Fixierung. Damit sei es indifferent gegenüber der einzigartigen und veränderlichen existentiellen Konstellation des Individuums. Kierkegaard geht es vielmehr darum, wie man die eigenständige, persönliche Sinnfindung des Gesprächspartners anregen kann, ohne dies durch die eigene Rede zu beeinflussen. Das Buch untersucht, welche sprachlichen und textuellen Maßnahmen diesem Programm geschuldet (...) sind. Mit Rekurs auf das Denken des theologisch weitgehend abstinenten Ludwig Wittgenstein wird deutlich, daß dieses Problem nicht nur religiöse Rede affiziert und daß das Ideal direkter Mitteilung fragwürdig ist. Es ergeben sich Konvergenzen zwischen den beiden Autoren, die bis in semiotische und epistemologische Implikationen reichen und den Unterschied zwischen Glauben und Wissen neu diskutieren lassen. (shrink)

Se realizó un estudio con el objetivo de ejemplificar los modos de actuación en el trabajo metodológico interdisciplinario que respondan a la formación académica, laboral e investigativa de los estudiantes de la carrera de Medicina de la Facultad de Ciencias Médicas de Camagüey, desde una concepción intra e interdisciplinaria, rectorada por la disciplina Informática Médica. Se elaboraron propuestas de tareas docentes problematizadoras desde una estrategia metodológica a partir de la planificación que cada asignatura del año debe diseñar, las que permitieron (...) la realización de trabajos investigativos por los estudiantes en cada semestre del curso escolar, en las que se combinaron de manera creciente los contenidos y los diversos métodos teóricos y prácticos de las unidades curriculares del plan de estudio de las asignaturas Informática Médica, Metodología de la Investigación, Educación Física, Psicología General y Medicina General Integral como disciplina rectora en la carrera, influyendo en la formación de un profesional más competente. Determining a mode of on-the-job acting interdisciplinary methodologic that the intra answer to Camagüey's academic, labor and investigating formation of the students of the carrier of Medicine of Ciencias Médicas's Faculty, from a conception and interdisciplinary, manager for Information-Technology Medical discipline, he identified the objective of this work. The problem from a strategy elaborated bidding of teaching tasks themselves methodologic as from the planning that he must design each subject of study of the year, the ones that permitted the realization of investigating works for students in each semester of the school year, in the ones that combined of increasing manner the contentses and various theoretic methods themselves and pilots of units curriculares of the curriculum of Information-Technology Medical subjects of study, Methodology of Investigation, Physical Education, Psicología General and Medicine General Integral like ruling discipline in the carrier influencing a more competent professional's formation. (shrink)

El objetivo principal de este artículo es defender, de acuerdo con A. John Simmons, un punto de vista que, normativamente, propone el consentimiento como condición necesaria de legitimidad y fundamento de la obligación política. Pero, descriptivamente, entiende que tal consentimiento, en tanto que autorización personal y voluntaria, todavía no ha tenido lugar en ninguna sociedad, ni siquiera democrática.

Resumen. En el presente análisis se exponen las bases del clásico debate entre Richard Clark y Robert Kozma, autores reconocidos en el campo de Tecnología Instruccional y la Educación a Distancia por la relevancia de sus aportaciones; a partir del argumento inicial presentado por Richard Clark en 1983 contenido en su artículo denominado Reconsidering research on learning from media; dónde describe evidencias suficientes que apoyan su opinión respecto a que los medios instruccionales no ejercen influencia alguna en el nivel de (...) aprovechamiento de los estudiantes durante el proceso de enseñanza-aprendizaje.Palabras claves. Tecnología instruccional, educación a distancia, medios, aprendizaje, enseñanza.. This analysis sets out the basis of the classic debate between Richard Clark and Robert Kozma, known authors in the field of Instructional Technology and Distance Education for the relevance of their contributions, from the initial argument presented by Richard Clark in 1983 contained in his article entitled Reconsidering research on learning from media; in which he describes sufficient evidences supporting his opinion that instructional media have no influence on the level of student achievement in the teaching-learning process.Keywords. Instructional technology, distance education, media, learning, teaching. (shrink)

Decentralized biobanking “de-bi” applies blockchain technology and web3 values to embed the procedural principles of transparency, accountability, and inclusion into the biomedical research ecosyst...

This article examines what constitutes an ethical flaw in artworks and asks which ethical flaws are relevant in determining works. ethical and aesthetic values. I argue that while most of the discussion has simply taken for granted that it is intrinsic ethical flaws that should be taken into account, there are further important differences in the type of intrinsic ethical flaws that artworks display. I identify two different types of ethical defects in artworks, fictional and actual, and argue that this (...) distinction has important consequences for debates surrounding the ethical value of works of fiction. (shrink)

El presente trabajo propone analizar la manera en que Agustín de Hipona recepciona el pensamiento de Tertuliano, autor cristiano latino, también africano, del que lo separan unos 200 años. Las principales menciones al cartaginés tienen lugar en la crítica agustiniana a la concepción de la corporeidad del alma defendida por Tertuliano. A fin de poder analizar los argumentos y los conceptos filosóficos utilizados por el hiponense en el desarrollo de su crítica presentamos, en primer lugar, una breve introducción a Tertuliano (...) (c. 160- c. 220), deteniéndonos en algunos pasajes cruciales de su obra titulada _De anima_ (208/210). En segundo lugar, nos dedicamos a presentar y analizar la discusión que lleva adelante Agustín respecto de la tesis de la corporeidad del alma humana en _De Genesi ad litteram _(finalizado hacia el 415)_,_ y en _De anima et eius origine, _escrita posteriormente, entre 419 y 420. Evaluamos entonces la posición del hiponense respecto de la hipótesis traducionista sobre el alma humana, ciertamente vinculada al corporalismo defendido por Tertuliano. (shrink)

The notion of emergence has accompanied philosophy of science since the late XIX century, claiming that in some systems there are properties in certain levels that cannot be deduced from properties of their components as seen in more fundamental levels. Throughout the XX century, emergence has been characterized by four pillars: unpredictability, novelty, restriction and downward causation. These four pillars have been related to the assumption of a hierarchical order of reality in different levels of organization. In this paper, we (...) show that it is possible to explain the nature of the emergent properties through the nearly-decomposability criterion introduced by Herbert Simon. (shrink)

En este trabajo abordamos la concepción del hombre de Tertuliano, pensador africano del siglo II, en el marco de su inserción en la tradición apologista de Justino e Ireneo. Al igual que ellos, el cartaginés adopta una consideración positiva del cuerpo, más específi camente de la carne, como elemento constitutivo en la definición del hombre, pareciendo asumir, en ocasiones, la carga de la especificidad humana. Sin embargo, Tertuliano atiende a la noción de alma como un aspecto central de su esquema (...) antropológico en un escrito que le dedica especialmente. En este sentido, desarrollamos en el artículo los conceptos de corpus, caro y anima a la luz de la tensión respecto de lo que a veces indica una primacía de un aspecto por sobre el otro. A partir del análisis principalmente de la obra De anima y de algunas menciones al Libro II de Adversus Marcionem, concluimos que prevalece en Tertuliano una perspectiva unitaria sobre el hombre. (shrink)

Time has a highly unstable place between the objective and the subjective. On the one side, there are very well known philosophical arguments trying to show that time has only a subjective reality, even that it is merely a subjective epiphenomenon. On the other side, we are compelled to take points of view as non dispensable elements of reality, at least of a reality capable of containing beings like us. And points of view offer a world of temporal entities existing (...) in an objective way. Moreover, points of view themselves appear to be temporal entities among other temporal entities. We analyse both aspects of time. Our main focus will be McTaggart’s arguments against the reality of a fluent time, what he called temporal series of kind A. We will distinguish three very different arguments in McTaggart works. We analyse them in detail. And we reject their conclusive character. Our final target is to maintain that there is a room for fluent time in what is internal to points of view but external to the subjects adopting those points of view. (shrink)

La denominada “crisis ambiental” que advierte sobre los límites materiales del planeta ha dado lugar a una extensa producción teórica durante décadas. Producción que, como regla general, ha relegado la relectura de los textos clásicos de las ciencias sociales. El presente artículo rescata algunos debates contemporáneos relacionados con la lectura en clave ecológica de la obra de Marx. Obra que adquiere especial importancia al momento de comprender las formas que toma la explotación de la naturaleza bajo el sistema capitalista, problemática (...) resignificada en el marco de las discusiones actuales sobre sustentabilidad ambiental. (shrink)

In this paper Michael Vazquez and Dustin Webster consider the practice of deliberating about ethical case studies as a means to contribute to the professional development of educators. An ongoing debate is whether or not the study of ethical theory should be included in this practice. Vazquez and Webster argue that a popular strategy, known as the Phronetic Approach, is vulnerable to what they call “epistemic blinders” that arise in the absence of the scaffolding provided by theory. They (...) then sketch an alternative approach to case-based reasoning inspired by Barbara Herman's notion of middle theory. The middle theory approach naturally suggests a balanced method for using case studies in teacher professional development: expose educators to some theory, but only to the degree and at the level appropriate for the specific audience and in light of how frequent interactions with that audience will be. (shrink)

Scholars in the humanities and social sciences have turned to ethics to theorize politics in what seems to be an increasingly depoliticized age. Yet the move toward ethics has obscured the ongoing value of political responsibility and the vibrant life it represents as an effective response to power. Sounding the alarm for those who care about robust forms of civic engagement, this book fights for a new conception of political responsibility that meets the challenges of today's democratic practice. Antonio Y. (...) Vázquez-Arroyo forcefully argues against the notion that modern predicaments of power can only be addressed ethically or philosophically through pristine concepts that operate outside of the political realm. By returning to the political, the individual is reintroduced to the binding principles of participatory democracy and the burdens of acting and thinking as a member of a collective. Vázquez-Arroyo historicizes the ethical turn to better understand its ascendence and reworks Adorno's dialectic of responsibility to reassert the political in contemporary thought and theory. (shrink)

I defend, against its more recent critics, a literal, factual, and consistent interpretation of Timaeus’ creation of the cosmos and time. My main purpose is to clarify the assumptions under which a literal interpretation of Timaeus’ cosmology becomes philosophically attractive. I propose five exegetical principles that guide my interpretation. Unlike previous literalists, I argue that assuming a “pre-cosmic time” is a mistake. Instead, I challenge the exegetical assumptions scholars impose on the text and argue that for Timaeus, a mere succession (...) of events and the relations derived from it (before, after, simultaneous with) imply no time, given the narrow definition of the term used in the dialogue. For Timaeus, I explain, time is measurable, regular, and dependent on the motion of the celestial bodies. A mere succession of events like the one needed to understand the creation story and the pre-cosmos requires none of these elements. Readers of Plato erroneously assume that a succession of events implies time, but that is to impose a conception of time absent in the text. The chapter offers a detailed reconstruction of the pre-cosmic stage under a literalist interpretation and argues how it is compatible with the immutable relationship between the Demiurge and the cosmos. -/- This is an open access chapter distributed under the terms of the CC BY-NC 4.0 license. chapter 4. (shrink)

This paper seeks to find possibilities forreconciliation of the implementation of theprecautionary principle and the promotion ofinternational trade of genetically modified organisms,based on the assumption that a sustainabledevelopment is a right objective to strive for. Itstarts with an explanation of the background and therole of the precautionary principle, and describes inwhat way measures based on the precautionary principlecan easily lead to the creation of trade barriers. Thearticle then examines to what extent the WTO (WorldTrade Organisation) Agreements allow theimplementation of the (...) precautionary principle. Inaddition, structural conflicts between the perceptionof the precautionary principle and the concept oftrade liberalisation will be evoked. The last sectionof the paper analyses to what extent the WTO rulesprovide possibilities to avoid or solve theseconflicts in order to attempt to answer the mainquestion: are the precautionary principle and theinternational trade of genetically modified organismsreconcilable? (shrink)

It has been pointed out that Sensorimotor Enactivism, a theory that claims that perception is enacted and brought about by movement, says very little about the neural mechanisms that enable perception. For the proponents of the predictive approach to Sensorimotor Enactivism, this is a challenge that can be met by introducing predictive processing into the picture. However, the compatibility between these theories is not straightforward. Firstly, because they seem to differ in their stand towards representations: while Sensorimotor Enactivism is said (...) to belong to the non-representational wing of cognitive science, predictive processing has a representational profile. And secondly, because they exhibit different explanatory strategies: while Sensorimotor Enactivism prioritizes the interactions of the embodied agent, predictive processing has internalist commitments. The aim of this paper is to address these concerns and show that a predictive approach to Sensorimotor Enactivism is viable. More specifically, I focus on the Free-Energy approach, a theory that falls within the ballpark of predictive processing. In this paper I argue for the following claims. I argue that both Sensorimotor Enactivism and the Free-Energy approach may be understood for some systems in representational terms. The non-representational reading of Sensorimotor Enactivism is not mandatory and neither is the representational reading of the Free-Energy approach. Sensorimotor Enactivism is, in this respect, compatible with both representational and non-representational interpretations of the FEA. So, the position towards representations of these frameworks should not stand in the way of a predictive approach to Sensorimotor Enactivism. I also show that the Free-Energy approach allows for an account that prioritizes the interaction of the embodied agent with the environment. This is the explanatory strategy followed by Sensorimotor Enactivism. To justify this strategy and following other proponents of Sensorimotor Enactivism, I argue that by referring to the interactions of the embodied agent a better account of the phenomena in question is provided. On this basis, I claim that Sensorimotor Enactivism and the Free-Energy approach are compatible in what concerns their explanatory strategy as well. Thus, making the case for the viability of the predictive approach to Sensorimotor Enactivism. (shrink)

The fragility of the subject is a recurring issue in the work of Anne Enright, one of Ireland's most remarkable and innovative writers. It is this specific interest, together with her attempt to make women into subjects, that inevitably links her work to Bracha Lichtenberg-Ettinger's theory of the matrixial borderspace, a feminine sphere that coexists with the Lacanian symbolic order and that, even before our entrance into this linguistic system, informs our subjectivity. By turning to a point in time before (...) language—the encounter between “self” and “other” during pregnancy—both Enright and Ettinger test the boundaries of and the gaps within the linguistic system. It is the going before language that ultimately enables both to go beyond some of the most persistent dualisms present within the linguistic system and to create room for an alternative—a feminine—understanding of the ethical relationality between self and other. (shrink)

One unique challenge in teaching Christian health care ethics involves helping students to appreciate the delicate context of clinical decision-making scenarios. Another challenge involves helping students to empathize with the perspectives and appreciate the expertise of various parties. Finally, students need clear examples of the dangers of reductive medical paradigms. Toward these goals, mock clinical ethics consultations can help students to value respectful ethical discourse and to build necessary virtues for effectively engaging in such dialogue, such as humility, gentleness, and (...) prudence. The goal of mock clinical ethics consultations is to achieve deeper understanding of the moral dimensions of an assigned scenario and the human relationships at stake. This practice can serve as a model for other classroom activities in broad fields of Christian ethics that invite students to cultivate virtues for charitable dialogue, to apply ethical analysis to concrete scenarios, and to consider the relationship of class content to personal vocation. (shrink)

To help eliminate perinatal HIV transmission, the US Department of Health and Human Services recommends against breastfeeding for women living with HIV, regardless of viral load or combined antiretroviral therapy status. However, cART radically improves HIV prognosis and virtually eliminates perinatal transmission, and breastfeeding's health benefits are well-established. In this setting, pregnancy is increasing among American women with HIV, and a harm reduction approach to those who breastfeed despite extensive counseling is suggested. We assess the evidence and ethical justification for (...) current policy, with attention to pertinent racial and health disparities. We first review perinatal transmission and breastfeeding data relevant to US infants. We compare hypothetical risk of HIV transmission from breastmilk to increased mortality from sudden infant death syndrome, necrotizing enterocolitis and sepsis from avoiding breastfeeding, finding that benefits may outweigh risks if mothers maintain undetectable viral load on cART. We then review maternal health considerations. We conclude that avoidance of breastfeeding by women living with HIV may not maximize health outcomes and discuss our recommendation for revising national guidelines in light of autonomy, harm reduction and health inequities. (shrink)