Among the niftiest arguments for scientific anti-realism is the ‘pessimistic induction’ (also sometimes called ‘the disastrous historical meta-induction’). Although various versions of this argument differ in their details (see, for example, Poincare 1952: 160, Putnam 1978: 25, and Laudan 1981), the argument generally begins by recalling the many scientific theories that posit unobservable entities and that at one time or another were widely accepted. The anti-realist then argues that when these old theories were accepted, the evidence for them was quite (...) persuasive – roughly as compelling as our current evidence is for our best scientific theories positing various unobservable entities. Nevertheless, the anti-realist argues, most of these old theories turned out to be incorrect in the unobservables they posited. Therefore, the anti-realist concludes that with regard to the theories we currently accept, we should believe that probably, most of them are likewise incorrect in the unobservable entities they posit. (This argument appeals to what our best current theories say about unobservables in order to show that the entities posited by some earlier theory are not real. So the argument takes the form of a reductio of the view that the apparent success of some scientific theory justifies our believing in its accuracy regarding unobservables.) Of course, this argument has been criticized on many grounds. Some have argued, for instance, that the scientific theories we currently accept are much better supported than were earlier scientific theories at the time they were accepted. In addition, some have argued that many scientific theories accepted justly in the past were in fact accurate.. (shrink)

This article argues that the misalignment of private profit-maximizing objectives with public health needs causes institutional corruption in the pharmaceutical sector and systematically leads firms to act contrary to public heath. The article analyzes how financial incentives generate a business model promoting harmful practices and explores several means of realigning financial incentives in order to foster therapeutic innovation and promote the rational use of medicines.

The Food and Drug Administration authorizes the marketing of a drug only for uses that the manufacturer has demonstrated to be safe and effective, based on evidence from at least two clinical trials. However, the FDA does not regulate the practice of medicine, so physicians may prescribe drugs in any manner they choose. Prescribing drugs in ways that deviate from the uses specified in the FDA-approved drug label, package insert, and marketing authorization is referred to as off-label prescribing. This occurs (...) when physicians prescribe a drug for a therapeutic purpose other than the one approved by the FDA; treat patients in a different age cohort or gender than the population on which it was tested; or prescribe a different dose, for a different duration of use, or a different mode of administration than indicated on the label. (shrink)

I have two concerns about Pugh et al ’s case that vaccine requirements without a natural immunity exception are unjustified.1 First, the scientific question they suggest must be answered to justify the policy is in my view the wrong one, or at least not the only relevant one. Second, the authors set up a standard for public health regulation that will be often unattainable, risking paralysis of public health authorities. Pugh et al suggest two legitimate bases for vaccine mandates: ‘the (...) prevention of severe outcomes from COVID-19 and the reduction of viral transmission.’ Governments and employers have a legitimate interest in protecting the health of their citizens and workers, respectively. To maximally accomplish these goals, the relevant scientific question for whether people with prior infection should be subject to a vaccine mandate is: in persons who have been previously infected, does vaccination enhances protection against severe disease and/or infection and transmission? The relevant comparison, if one is trying to maximise protection in the population, is not vaccination vs prior infection, but vs prior infection alone. I am unaware of a systematic review of this question, but the answer in two recent studies appears to be that the combination is more protective.2,3 The comparison the authors propose, in contrast, seems to be one based on an unstated conception of fairness and adequacy: if vaccination alone provides some level of protection, and prior infection can’t be shown to provide an inferior level, then prior infection should be an acceptable alternative to vaccination to satisfy mandates. No argument is given to support the greater relevance of the comparison the authors emphasise. A second and independent concern is that the authors’ proposal …. (shrink)

In a series of papers, Bence Nanay has recently put forward and defended a new theory of function, which he calls the ‘Modal Theory of Function’. In this article, I critically address this theory and argue that it fails to fulfill some key desiderata that a satisfactory theory of function must comply with. As a result, I conclude that, whatever property Nanay’s notion of function refers to, it is not the property having the function that is standardly attributed in science.

The French philosopher, Gilles Deleuze, is emerging as one of the most important and influential philosophers of the 20th century, having published widely on philosophy, literature, language, psychoanalysis, art, politics, and cinema. However, because of the ‘experimental’ nature of certain works, combined with the manner in which he draws upon a variety of sources from various disciplines, his work can seem difficult, obscure, and even ‘willfully obstructive’. In an attempt to resist such impressions, this paper will seek to provide an (...) accessible introduction to Deleuze's work, and to begin to discuss how it can be employed to provide a significant critique and reconceptualization of the theoretical foundations and therapeutic practices of psychiatry, psychotherapy, and mental health nursing. In order to do this, the paper will focus upon Deleuze's masterwork, and the cornerstone to his philosophy as a whole, Difference and Repetition; in particular, it will discuss how his innovative and challenging account of time can be employed to provide a conception of human life as a ‘continuity’, rather than as a series of distinct ‘moments’ or ‘events’. As well as discussing the manner in which his work can provide us with an understanding of how life is different and significant for each human being, this paper will also highlight the potential importance of Deleuze's work for logotherapy, for the recent ‘turn’ to ‘narrative’ as a psychotherapeutic approach and for contemporary mental health care's growing interest in ‘social constructionism’. As such, this paper also seeks to stimulate further discussion and research into the importance and the relevance of Deleuze's work for the theory and practice of psychiatry, psychotherapy, and mental health nursing. (shrink)

Scientific realism is the view that one can be justified in believing, of some theory about unobservable entities, that the entities it posits are real and accurately described by the theory, in the same sense as one can be justified in believing that the theory’s empirical predictions are accurate, and that so to believe is what it means for a scientist to “accept” that theory, because the goal of science is to describe reality, even its unobservable features. The first part (...) is an epistemic claim, whereas the second concerns the rational reconstruction of scientific practice. Together they suggest that evidence justifying scientific acceptance of a theory justifies belief that the unobservable entities it posits are real and as the theory purports them to be. Anti-realism denies ; it holds that claims about unobservables are either unjustified or justified in a different sense from predictions of observations. It also denies ; it maintains that in her scientific work, as rationally reconstructed, a scientist who accepts a claim about unobservables believes that it yields accurate predictions of observables, not that it describes unobservables. (shrink)

In recent years, there has been an increasing interest on the notion of freedom as non-domination, according to which a subject is free to the extent that no agent has the capacity to arbitrarily interfere on his actions. Now, the most common way of interpreting the notion of freedom as non-domination restricts its applicability to cases where particular agents can intentionally and arbitrarily interfere on a subject�s affairs. In this paper, I present an argument which shows that the standard conception (...) of freedom as non-domination is too restrictive, and that this notion can be extended so as to as to ground a critical point of view on economic and social inequalities. (shrink)

This book is the first comprehensive examination of the psychological development of deaf children. Because the majority of young deaf children are reared in language-impoverished environments, their social and cognitive development may differ markedly from hearing children. The author here details those potential differences, giving special attention to how the psychological development of deaf children is affected by their interpersonal communication with parents, peers, and teachers. This careful and balanced consideration of existing evidence and research provides a new psychological perspective (...) on deaf children and deafness while debunking a number of popular notions about the hearing impaired. In light of recent findings concerning manual communication, parent-child interactions, and intellectual and academic assessments of hearing-impaired children, the author has forged an integrated understanding of social, language, and cognitive development as they are affected by childhood deafness. Empirical evaluations of deaf children's intellectual and academic abilities are stressed throughout. The Psychological Development of Deaf Children will be of great interest to students, teachers, and researchers studying deafness and how it relates to speech and hearing; developmental, social, and cognitive psychology; social work; and medicine. (shrink)

Selectional preferences have a long history in both generative and computational linguistics. However, since the publication of Resnik's dissertation in 1993, a new approach has surfaced in the computational linguistics community. This new line of research combines knowledge represented in a pre‐defined semantic class hierarchy with statistical tools including information theory, statistical modeling, and Bayesian inference. These tools are used to learn selectional preferences from examples in a corpus. Instead of simple sets of semantic classes, selectional preferences are viewed as (...) probability distributions over various entities. We survey research that extends Resnik's initial work, discuss the strengths and weaknesses of each approach, and show how they together form a cohesive line of research. (shrink)

This chapter presents arguments positing that there is an important sense in which it takes more than all of the actual kinds to make a world, contrary to the popular saying that goes “it takes all kinds to make a world.” In a variety of ways, the various species of elementary particles are ideal cases of natural kinds since each belongs to exactly one of these natural kinds and it essentially belongs to that kind. There exists perfect uniformities within each (...) species and sharp distinctions between the species with respect to certain properties. Some of these properties are essential and suffice to give necessary and adequate conditions for species-membership, while others derive from the fundamental properties via exceptionless uniformities with no ceteris paribus escape clauses. (shrink)

Pickard’s contribution reminds me that conceptualizing choice is no simple matter. Pickard sees choice as entirely voluntary, while I argue that choice is only partially voluntary. Choices are based on appraisals of situations, which fluctuate due to external circumstances and internal states such as emotion and mood. Habit itself competes with volition, and all these parameters vary with development. Psychological factors such as delay discounting and especially one's belief in one's agency are critical for volitional choice as well.

Darwin offered an intriguing answer to the species problem. He doubted the existence of the species category as a real category in nature, but he did not doubt the existence of those taxa called ‘‘species’’. And despite his scepticism of the species category, Darwin continued using the word ‘‘species’’. Many have said that Darwin did not understand the nature of species. Yet his answer to the species problem is both theoretically sound and practical. On the theoretical side, DarwinÕs answer is (...) confirmed by contemporary biology, and it offers a more satisfactory answer to the species problem than recent attempts to save the species category. On the practical side, DarwinÕs answer frees us from the search for the correct theoretical definition of ‘‘species’’. But at the same time it does not require that we banish the word ‘‘species’’ from biology as some recent sceptics of the species category advocate. Ó The Willi Hennig Society 2010. (shrink)

texte aujourd’hui fameux, repose sur un document connu également de la Vie latine d’Adam et Ève et que l’auteur qoumrânien a remanié. nowadays a famous text, depends on a document which is also known from the Latin Life of Adam and Eve, and which has been reworked by the author from Qumran.

Ce texte vise à explorer la contribution de Paul Ric?ur à une réflexion phénoménologique sur le vivant. Il s?agit notamment, à partir du débat avec Jean-Pierre Changeux, de faire ressortir l?insistance avec laquelle il s?efforce de distinguer l?approche phénoménologique du vécu de l?ap­proche objectivante des sciences du vivant, de façon à soutenir la thèse d?un dualisme sémantique entre les deux ordres de discours. Tout le travail de Ric?ur est alors d?ouvrir le discours philosophique à l?apport des sciences de la vie, (...) sans soumettre le projet phénoménologique à une naturalisation. Con­trairement à Jean-Luc Petit, qui voit dans la phénoménologie eidétique de la volonté du jeune Ric?ur ce qu?il y a de plus prometteur pour aborder la question du vivant, nous soutenons plutôt que la position originale de Ric?ur sur le vivant se laisse comprendre à partir de sa triple allégeance à la phéno­ménologie, à l?herméneutique et à la philosophie réflexive. (shrink)

Introduction -- The legal aspects -- Corporate governance and corporate performance -- Complexity and corporate governance -- Conclusion.

In early embryonic development, the cell cycle is paced by a biochemical oscillator involving cyclins and cyclin-dependent kinases (cdks). Essentially the same machinery operates in all eukaryotic cells, although after the first few divisions various braking mechanisms (the so-called checkpoints) become significant. Haase and Reed have recently shown that yeast cells have a second, independent oscillator which coordinates some of the events of the G1 phase of the cell cycle.(1) Although the biochemical nature of this oscillator is not known,it seems (...) unlikely to be a redundant cyclin/cdk system. BioEssays 22:3–5, 2000. ©2000 John Wiley & Sons, Inc. (shrink)