The H19 gene produces a non‐coding RNA, which is abundantly expressed during embryonic development and down‐regulated after birth. Although this gene was discovered over 20 years ago, its function has remained unclear. Only recently a role was identified for the non‐coding RNA and/or its microRNA partner, first as a tumour suppressor gene in mice, then as a trans‐regulator of a group of co‐expressed genes belonging to the imprinted gene network that is likely to control foetal and early postnatal growth in (...) mice. The mechanisms underlying this transcriptional or post‐transcriptional regulation remain to be discovered, perhaps by identifying the protein partners of the full‐length H19 RNA or the targets of the microRNA. This first in vivo evidence of a functional role for the H19 locus provides new insights into how genomic imprinting helps to control embryonic growth. (shrink)

We highlight that the connection of well-foundedness and recursive definitions is more than just convenience. While the consequences of making well-foundedness a sufficient condition for the existence of hierarchies have been extensively studied, we point out that well-foundedness is a necessary condition for the existence of hierarchies e.g. that even in an intuitionistic setting α⊢wfwhereα\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${_\alpha \vdash \mathsf{wf}\, {\rm where}\, _\alpha}$$\end{document} stands for the iteration of Π10\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} (...) \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\Pi^0_1}$$\end{document} comprehension along some ordinal α\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\alpha}$$\end{document} and wf\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathsf{wf}}$$\end{document} stands for the well-foundedness of α\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\alpha}$$\end{document}. (shrink)

An important debate in the current literature is whether “all truth-conditional effects of extra-linguistic context can be traced to [a variable at; LM] logical form” (Stanley, ‘Context and Logical Form’, Linguistics and Philosophy, 23 (2000) 391). That is, according to Stanley, the only truth-conditional effects that extra-linguistic context has are localizable in (potentially silent) variable-denoting pronouns or pronoun-like items, which are represented in the syntax/at logical form (pure indexicals like I or today are put aside in this discussion). According to (...) Recanati (‘Unarticulated Constituents’, Linguistics and Philosophy, 25 (2002) 299), extra-linguistic context can have additional truth-conditional effects, in the form of optional pragmatic processes like ‘free enrichment’. This paper shows that Recanati’s position is not warranted, since there is an alternative line of analysis that obviates the need to assume free enrichment. In the alternative analysis, we need Stanley’s variables, but we need to give them the freedom to be or not to be generated in the syntax/present at logical form, a kind of optionality that has nothing to do with the pragmatics-related optionality of free enrichment. (shrink)

In this article we tackle the core question of machine emotion research – “Can machines have emotions?” – in the context of “social robots”, a new class of machines designed to function as “social partners” for humans. Our aim, however, is not to provide an answer to the question “Can robots have emotions?” Rather we argue that the “robotics of emotion” moves us to reformulate it into a different one – “Can robots affectively coordinate with humans?” Developing a series of (...) arguments relevant to theory of emotion, philosophy of AI, and the epistemology of synthetic models, we argue that the answer to this different question is positive, and that it lays grounds for an innovative ethical approach to emotional robots. This ethical project, which we introduced elsewhere as “synthetic ethics”, rejects the diffused ethical condemnation of emotional robots as “cheating” technology. Synthetic ethics focuses not on an ideological refusal, but on the concrete sustainability of the emerging mixed human-robot social ecologies. On this basis, in contrast to a purely negative ethical approach to social robotics it promotes an analytical case by case ethical inquiry into the type of human flourishing that can result from human-robot affective coordination. (shrink)

This paper investigates young children's knowledge of scalar implicatures and downward entailment. In previous experimental work, we have shown that young children access the full range of truth-conditions associated with logical words in classical logic, including the disjunction operator, as well as the indefinite article. The present study extends this research in three ways, taking disjunction as a case study. Experiment 1 draws upon the observation that scalar implicatures (SIs) are cancelled (or reversed) in downward entailing (DE) linguistic environments, e.g., (...) in the scope of negation (Chierchia, 2000). Experiment 2 was designed to determine if scalar implicatures are used by children, like adults, to influence the interpretation of disjunction in non-DE contexts, yielding an implicature of exclusivity for disjunction. Whereas adult controls always rejected assertions of the form A or B in positive (non-DE) contexts in which assertions of the form A and B were also true, many children accepted assertions with disjunction in such contexts. To provide an interpretation to the findings from Experiment 2, a new experimental technique was devised and used in Experiment 3. The new technique presents pairs of assertions to children, who are asked to judge which assertion is a ‘better’ description of the context. The findings from Experiment 3 demonstrated children's awareness that A and B is more informative than A or B in positive contexts, where both statements are true. Taken together, the findings of Experiments 2 and 3 are compatible with the view that some children lack the computational resources to apply scalar implicatures when a single assertion is presented alone (see Reinhart, 1999). (shrink)

Smell can be understood as a cultural phenomenon, historically signified, enforcing social structures or transgressing them, creating social bonds – empowering or disempowering people. The perception of smell consists not only of the sensation of the odours themselves, but of the experiences and emotions associated with them. Odours, unlike colours, for instance, cannot be named, only described; in the realm of olfaction, we must make do with descriptions, analogies and recollections. It is an elusive phenomenon. From natural environments to urban (...) spaces, the large variety of odours can stimulate our olfactory senses and evoke experiences, in which pleasant and unpleasant, and even non-smelling scents, can be combined as parameters of spatial limits and social bounds. Thus, smell can be used to structure and classify different aspects of the world, from time and space to gender and selfhood. The aim of this text is to comprehend some chemical and cultural aspects of smells and odours, and their potential to elaborate social connections and configure spatial orientations. Based on some examples from the Bororo of Brazil and the aboriginal inhabitants of the Andaman Islands, odours are understood as cultural classification systems and means of ordering the world. At the end, some artists – such as Usman Haque, Rion Willard and Jenny Marketou – will be presented since their art works proposals of mapping and describing physical spaces through smells and odours can be apprehended as a medium to create evocative experiences. (shrink)

L’article de Luisa Simonutti traite de la critique et de la reprise de certains concepts clés de la pensée de Socin (liberté, volonté, responsabilité) par des arminiens de Hollande. Cet héritage complexe est plus qu’un épisode de la réaction vaste et articulée qui se manifesta à la fin du XVIe siècle – et qui s’étendit sur tout le XVIIe siècle – contre les œuvres et les idées du Siennois. Cet événement doit aussi être interprété comme le moment d’une confrontation (...) plus large en défense de la libertas prophetandi et du libre arbitre de l’homme face aux lois et à la volonté divines. (shrink)

Pensando no instigante sucesso do desenho animado "A Bela e a Fera", da Walt Disney, que teve grande repercussão mundial na época em que fora exibido, este artigo propõe-se a compreender o desenvolvimento psicológico da personagem Bela. Para tanto, algumas cenas do filme foram escolhidas para anális..

From Gerdil to Marugi: Malebranchean Revival and Lockean Readings. For the Cardinal Gerdil, the only philosophical reflection able to combine aspects of Post-Cartesian philosophy with Augustinian Platonism and to provide an explanation of the spirituality of the soul and of the philosophically plausible and pragmatic mind-body interaction in an apologetic reflection on religion was the philosophy of Malebranche. Committed to the defence of the immortality of the soul and the vision of all things in God which found favour in English (...) neo-Platonic thinking, Gerdil becomes one of the protagonists of Italian culture engaged in the European philosophical debate developed against Lockean reason and in defence of Neoplatonism and Cartesianism. To form an emblem of rationalistic rationalism and materialism in metaphysics and religion was a task of certain Italian thinkers, including Muratori, Francesco Zanotti, Marugi and Francesco Soave, and in particular Cardinal Gerdil. (shrink)

Depressive mood can be involved in the moral judgments made by people with depression. Here, we focus on the negative judgments depressed patients have of themselves and the world. Possibly, the alterations in moral judgment in subjects with depression can be understood by taking into account the neural basis of depression.

Not unlike the Catholics, the English Reformed circles—the Church of England—upheld the legitimacy of the Revelation and miracles, recognised the Mosaic account of creation, original sin and the Trinity, the non-corporeal nature of spiritual substance, the eternity of punishment or reward and the primacy of Church over State. And so where did Locke’s hermeneutics fit into this complex panorama in terms of the interpretations of Christian anthropology and the resurrection? As underscored in the early chapters of The Reasonableness of Christianity, (...) Locke does not appear to consider that the sin of Adam has to fall on the whole of posterity, and again there is no positive affirmation of the Trinity in this work which, although it is not named, in effect proves to be incompatible with the definitions of person and individual identity which he provides in the Essay concerning human understanding. (shrink)

It is widely assumed that the scope of indefinites is island insensitive, i.e., that, generally, an indefinite inside of a syntactic island, such as an adjunct clause, is capable of taking scope outside of that island. This paper challenges this assumption by studying the scope behaviour of the Spanish plural indefinite algunos ’). It presents an experimental study that shows that the scope of algunos is not free and depends on its syntactic environment, at least in the dialect of Spanish (...) studied here. The paper discusses some of the implications of the study for current theories of indefinite scope: it points out the problems that choice functions and singleton indefinites have with the Spanish data, and it also discusses the implications for Schwarzschild's solution to the so-called ‘Donald Duck’ problem. (shrink)

The aim of the present study was to investigate the effects of communicative intention on action. In Experiment 1 participants were requested to reach towards an object, grasp it, and either simply lift it or lift it with the intent to communicate a meaning to a partner . Movement kinematics were recorded using a three-dimensional motion analysis system. The results indicate that kinematics was sensitive to communicative intention. Although the to-be-grasped object remained the same, movements performed for the ‘communicative’ condition (...) were characterized by a kinematic pattern which differed from those obtained for the ‘individual’ condition. These findings were confirmed in a subsequent experiment in which the communicative condition was compared to a control condition, in which the communicative exchange was prevented. Results are discussed in terms of cognitive pragmatics and current knowledge on how social behavior shapes action kinematics. (shrink)

Damaris Cudworth Masham was convinced that the “useful knowledge” has a theoretical, practical and pedagogic content. Man has a social destiny and we cannot offend the divine wisdom assuming that religion precludes this approach and expects the breakdown of society. Reason therefore has a prominent character on the will and free will is the pillar of moral practice. This thought reveals an affinity with the Lockean concept of “person” and “identity” and the central role of individual liberty for love of (...) God and for an ordered and social life. Thanks also to her intellectual relationship with Locke, her “philosophical salon” at Oates become the meeting point for overseas and English scholars, such as Jean Le Clerc, Pierre Des Maizeaux, Pierre Coste, the III Earl of Shaftesbury. Through original sources the paper focus the intellectual legacy of Damaris Masham. (shrink)

"Cover " -- "Title Page " -- "Copyright " -- "Contents " -- "Preface to the English Edition" -- "Introduction" -- "1. The Substitute" -- "2. Animals, Machines, Cyborgs, and the Taxi " -- "3. Mind, Emotions, and Artificial Empathy " -- "4. The Other Otherwise " -- "5. From Moral and Lethal Machines to Synthetic Ethics " -- "Notes" -- "Works Cited" -- "Acknowledgments" -- "Credits.

Social robotics entertains a particular relationship with anthropomorphism, which it neither sees as a cognitive error, nor as a sign of immaturity. Rather it considers that this common human tendency, which is hypothesized to have evolved because it favored cooperation among early humans, can be used today to facilitate social interactions between humans and a new type of cooperative and interactive agents - social robots. This approach leads social robotics to focus research on the engineering of robots that activate anthropomorphic (...) projections in users. The objective is to give robots "social presence" and "social behaviors" that are sufficiently credible for human users to engage in comfortable and potentially long-lasting relations with these machines. This choice of ’applied anthropomorphism’ as a research methodology exposes the artifacts produced by social robotics to ethical condemnation: social robots are judged to be a "cheating" technology, as they generate in users the illusion of reciprocal social and affective relations. This article takes position in this debate, not only developing a series of arguments relevant to philosophy of mind, cognitive sciences, and robotic AI, but also asking what social robotics can teach us about anthropomorphism. On this basis, we propose a theoretical perspective that characterizes anthropomorphism as a basic mechanism of interaction, and rebuts the ethical reflections that a priori condemns "anthropomorphism-based" social robots. To address the relevant ethical issues, we promote a critical experimentally based ethical approach to social robotics, "synthetic ethics," which aims at allowing humans to use social robots for two main goals: self-knowledge and moral growth. (shrink)

Many experimental investigations of human sentence processing have shown that listeners do not wait until they reach the end of a sentence before they begin to compute an interpretation. Rather, listeners incrementally make commitments to an interpretation as the linguistic input unfolds in real time. A consequence of this property of sentence comprehension is that it sometimes gives rise to so-called garden-path effects. In the presence of a temporary ambiguity, listeners may assign an interpretation that later turns out to be (...) unviable and must, therefore, be abandoned in favor of an alternative interpretation. Various explanations have been proposed to account for garden- path effects that have been documented in certain experimental contexts (Frazier and Rayner, 1982; Trueswell and Tanenhaus, 1994; MacDonald, 1994, among others). One line of research has claimed, however, that the referential contexts in which sentences ordinarily appear often mitigate, or even completely eliminate, garden-path effects. This is the Referential Theory proposed by Crain and Steedman (1985) and extended by Altmann and Steedman (1988). According to the Referential Theory, people experience garden-path effects primarily when sentences are interpreted outside any referential context or in infelicitous contexts. If the Referential Theory is correct, garden-path effects are largely experimental artifacts. Recent work by Trueswell, Sekerina, Hill and Logrip, (1999) suggests that children might not be sensitive to features of the referential context to the same.. (shrink)

El secreto en todas sus vertientes, en todas sus facetas, vericuetos, senderos. Pero sobre todo el Secreto en la literatura, pues como dice Luisa Valenzuela, en su estilo mordaz, agudo, siempre entre guinos y complicidades: "No hay literatura sin secreto."Detras de cada palabra se esconde el misterio, un laberinto en el que todo puede suceder: de la pasion a la ternura; del crimen a la sublimacion. Encontrar el hilo conductor, salvador, descifrador, o ahondar sus diversidades, es papel de quien (...) aspira a lo literario, bien como escritor, bien como lector.Precisas, directas, divertidas, las palabras de Luisa Valenzuela se deslizan sobre las paginas de un libro lleno de humor del mas fino, de ironia inteligente, como sucede en sus novelas, en sus cuentos, pero ahora provenientes del ciclo de conferencias y el dinamico taller de escritura breve que impartio en el marco de la Catedra Alfonso Reyes del Instituto Tecnologico y de Estudios Superiores de Monterrey, Mexico. (shrink)

Argues that affirming the irreducible differences between men and women can lead to more transformative politics than the struggle for abstract equality between the sexes. In The Symbolic Order of the Mother Luisa Muraro identifies the bond between mother and child as ontologically fundamental to the development of culture and politics, and therefore as key to achieving truly emancipatory political change. Both corporeal development and language acquisition, which are the sources of all thinking, begin in this relationship. However, Western (...) civilization has been defined by men, and Muraro recalls the admiration and envy she felt for the great philosophers as she strove to become one herself, as well as the desire for independence that opposed her to her mother. This conflict between philosophy and culture on the one hand and the relationship with the mother on the other constitutes the root of patriarchy’s symbolic disorder, which blocks women’s (and men’s) access to genuine freedom. Muraro appeals to the feminist practice of gratitude to the mother and the recognition of her authority as a model of unconditional nurture and support that must be restored. This, she argues, is the symbolic order of the mother that must overcome the disorder of patriarchy. The mediating power of the mother tongue constitutes a symbolic order that comes before all others, for both women and men. Luisa Muraro is Professor Emeritus of Philosophy at the University of Verona, Italy. Francesca Novello is an instructor at the University of Oklahoma. Timothy S. Murphy is Houston-Truax-Wentz Professor and Regents Professor of English at Oklahoma State University. (shrink)

At the end of the 1960s “Supports/Surfaces” artists start deconstructing paintings to jeopardize their representational qualities. Claude Viallat and Daniel Dezeuze, for example, process canvases and frames to highlight their phisical aspect as opposed to the illusionistic realm or representation. This way polarities such as form/space and illusionistic space/real space start having a new, dialectic relationship.

The views of Celia Amorós, which are dealt with here, originate in the ideas which appeared, especially in the Enlightenment, and which demanded equality for women. Following this line of thought she studies some of the most powerful theories of Western philosophical tradition in order to carry out a critical feminist deconstruction. Since her work is a critique of the philosophical critique of the Enlightenment, one can identify traces , today almost forgotten, of a feminist tradition of thought which can (...) be considered as a discourse of emancipation. Furthermore, this critical exercise becomes an intellectual and social non-patriarchal project of a society free from gender restrictions. In this sense, Celia Amoros’ philosophical work develops into philosophical feminism, not only in terms of being critical revision of the history of ideas, but also and principally because it takes shape as critical reflection and as direct dialogue with present-day philosophical discourse. (shrink)

This article puts forward the following thesis: the legitimation of school subjects stems from an acknowledged epistemic field, from a science in its broadest sense. The more school subjects deviate from the science from which they originate the more they become weaken and disfigured. A focus on the Estado Novo period in Portugal allows for a particular understanding and emphasis placed on the context which legitimises Philosophy as a school subject in middle school. Thus, this article examines the avenues followed (...) by Philosophy as a school subject in this particular historical period, accounting for and explaining the link between educational and instructional plans, the interference of ideology and education policy, and the transformation of school into an instrument of political, ideological education. (shrink)

Every philosophy has a conceptualisation which demarcares it and defines a net of signification, even in the field of filiation or proximity relations. Ricœur’s hermeneutics is admittedly close to Gadamer’s hermeneutics, due to the aim of integrating and rectifying it and to its identical or equivalent conceptualisation (in some cases). My topic concerns the difference between the two hermeneutics, which mainly emerges through the relevance attached to dialogue. The chief question I ask is whether that difference is insignificant and sporadic (...) or, in contrast, is determinant to the description of Ricœur’s hermeneutics, which would mark it out against Gadamer’s. The former establishes a link between dialogue and oralism, which allow us a coherent understanding of not only his opposition to romantic hermeneutics, but also the development of his epistemological project. By analysing these matters we will, therefore, realise the consistency of the hermeneutic paradigm put forward by Ricœur, as well as the progressively clear cut between the two hermeneutical models. (shrink)

Uneasiness is an issue of our time that has strongly resurfaced under the pressure of the pandemic. It is a kind of anxiety which is not caused only by the lack of something: it rather contains a push for change, releasing the power to choose and to act.

ABSTRACTThe Dutch history of the golden century, a formula which had effectively imposed this interpretative paradigm well beyond the seventeenth century, has been analysed in a more conscientious manner by more recent historiography. This has tempered the hagiographic reading and confirmed the fact that, in the second half of the century, the question of tolerance had become primarily a political conquest and a value shared by other nations. A supernational, European value, but which had also begun to cross the Atlantic (...) several decades earlier. It is interesting to explore how writers facing each other across the two shores of the Channel, on one side observed and interpreted and on the other side presented themselves, offering to foreign eyes the concept of tolerance that had been consolidated in the Netherlands. In the appendix to the essay, besides sinignifcative images, is transcribed the rare and meaningful pamphlet titled ‘A LETTER from HOLLAND, touching Liberty of Conscience, &c.’. (shrink)

O pensamento utópico é um modo de vislumbrar as virtualidades ocultas na realidade imediata e de sonhar com uma outra realidade, uma sociedade idealmente mais perfeita do que aquela em que vivemos. É a esperança e o desejo de superar o imediato, no qual estamos mergulhados, que alimenta a utopia. Tratar-se-á de mera ficção? Qual a relação entre o real dado e esse mundo outro, idealizado? Será possível o retorno dessas cidades utópicas ao mundo real para o transformar? Se isso (...) é possível, como parece transparecer da Utopia de More, a relação utopia/mundo real transformar-se-ia numa interminável espiral, configurada pelo jogo das categorias modais da realidade e possibilidade. (shrink)

Catholicism played a main role in the long and controversial process of constructing the Spanish national identity. as a consequence, the christian creed ended up becoming a condition sine qua non for “being Spanish”. Marcelino Menéndez Pelayo (1856-1912) and his Historia de los Heterodoxos Españoles were to become a basic milestone in the conformation of this peculiar case of Spanish catholicism, to whom we direct our attention at the present study.