Polypeptide growth factors (mitogens) which stimulate proliferation of fibroblasts and epithelial cells also rapidly activate transmembrane ion transport systems. The mitogen‐induced Na+ influx is due to the activation of a Na+/H+ antiport. Recent methodological developments allow, for the first time, precise measurements of the factors that control activation of the Na+/H+ antiport by these agents, and provide the tools needed to assess the physiological significance of this exchange mechanism.

In this novel account of global citizenship, Luis Cabrera argues that all individuals have a global duty to contribute directly to human rights protections and to promote rights-enhancing political integration between states. The Practice of Global Citizenship blends careful moral argument with compelling narratives from field research among unauthorized immigrants, activists seeking to protect their rights, and the 'Minuteman' activists striving to keep them out. Immigrant-rights activists, especially those conducting humanitarian patrols for border-crossers stranded in the brutal Arizona desert, (...) are shown as embodying aspects of global citizenship. Unauthorized immigrants themselves are shown to be enacting a form of global 'civil' disobedience, claiming the economic rights central to the emerging global normative charter while challenging the restrictive membership regimes that are the norm in the current global system. Cabrera also examines the European Union, seeing it as a crucial laboratory for studying the challenges inherent in expanding citizen membership. (shrink)

The representation of physics problems in relation to the organization of physics knowledge is investigated in experts and novices. Four experiments examine the existence of problem categories as a basis for representation; differences in the categories used by experts and novices; differences in the knowledge associated with the categories; and features in the problems that contribute to problem categorization and representation. Results from sorting tasks and protocols reveal that experts and novices begin their problem representations with specifiably different problem categories, (...) and completion of the representations depends on the knowledge associated with the categories. For, the experts initially abstract physics principles to approach and solve a problem representation, whereas novices base their representation and approaches on the problem's literal features. (shrink)

Cosmopolitanism is said by many critics to be arrogant. In emphasizing universal principles and granting no fundamental moral significance to national or other group belonging, it wrongly treats those making non-universalist claims as not authorized to speak, while treating those in non-Western societies as not qualified. This book works to address such objections. It does so in part by engaging the work of B.R. Ambedkar, architect of India's 1950 Constitution and revered champion of the country's Dalits (formerly "untouchables"). Ambedkar cited (...) universal principles of equality and rights in confronting domestic exclusions and the "arrogance" of caste. He sought to advance forms of political humility, or the affirmation of equal standing within political institutions and openness to input and challenge within them. This book examines how an "institutional global citizenship" approach to cosmopolitanism could similarly advance political humility, in supporting the development of input and challenge mechanisms beyond the state. It employs a grounded normative theory method, taking insights for the model from field research among Dalit activists pressing for domestic reforms through the UN human rights regime, and from their critics in the Hindu nationalist Bharatiya Janata Party. Insights also are taken from Turkish protesters challenging a rising domestic authoritarianism, and from UK Independence Party members demanding "Brexit" from the European Union-in part because of possibilities that predominantly Muslim Turkey will join. Overall, it is shown, an appropriately configured institutional cosmopolitanism should orient fundamentally to political humility rather than arrogance, while holding significant potential for advancing global rights protections and more equitable rights specifications. (shrink)

El presente artículo aborda las consideraciones de la alteridad del otro en las elaboraciones tempranas de Heidegger. Entendidas como condición de posibilidad para un abordaje propio de las cuestiones éticas, aquí analizamos tensiones y limitaciones en la tematización del otro, con el objetivo de dar cuenta de la transición hacia una comprensión radical de la alteridad en sus trabajos posteriores a 1930, más allá de las limitaciones antropológicas y subjetivas de las elaboraciones de Husserl. Para dar cuenta de ello, en (...) primer lugar, analizamos los tratamientos respectivos en la fenomenología de Husserl, poniendo énfasis en los límites de su enfoque. En segundo lugar, abordamos las elaboraciones en torno a la alteridad del otro en los trabajos de Heidegger, para dilucidar el carácter transicional de la comprensión de base, a partir de sus desplazamientos y limitaciones propias. Finalmente, circunscribimos su enfoque sobre las estructuras relacionales, destacando algunas discusiones sobre implicancias éticas. De este modo, nos proponemos dar cuenta del carácter fronterizo de una comprensión filosófica del otro, en su empuje hacia su radicalización en el pensamiento contemporáneo. (shrink)

This paper studies the possible influences on Boole's logic of the writings related to the controversy over the quantification of the predicate between the philosopher William Hamilton and the mathematician Augustus De Morgan. As Boole himself testified in the introduction to his book The mathematical analysis of logic , this controversy was the external agent that stimulated him into writing up his earlier thoughts about a new conception of logic. But in addition to the external role that was played by (...) the controversy, it seems that other kinds of influences on Boole of Hamilton's and De Morgan's ideas about logic, which were made explicit in writings related to the controversy, can also be traced. (shrink)

En este trabajo indagaremos en torno al estatuto de la acción y la praxis en la obra de Heidegger a partir de un análisis de la figura del despertar relativa al aburrimiento profundo, en su trabajo de 1929-1930. Con ello, buscaremos demostrar que las implicancias relativas al actuar, pensar y filosofar allí expuestas, permiten cotejar continuidades y diferencias de tipo fronterizo tanto con sus elaboraciones anteriores, como respecto a su perspectiva posterior a la kehre. Para dar cuenta de ello, primero (...) abordaremos aspectos fundamentales de su interpretación de la filosofía práctica aristotélica y sus reelaboraciones hasta Sein und Zeit. (shrink)

En el siguiente trabajo nos detendremos en un análisis y reconstrucción de las relaciones entre singularización y tiempo, respecto de sus especificaciones en torno al instante, a partir de una relación entre las elaboraciones de Heidegger en _Sein und Zeit_ y su curso de 1929-1930. En ese marco, nos proponemos demostrar que sus consideraciones en torno a la relación dinámica Dasein-temporeidad-singularización profundizan la comprensión de fondo en la que se articulan, a partir de un cambio de acento que permite precisar (...) con mayor claridad el concepto relacional de Dasein frente a las perspectivas subjetivistas tradicionales. De esta manera, buscamos desarrollar las relaciones entre singularización-tiempo en la obra de Heidegger y cotejar desde allí las condiciones para un marco interpretativo y recepción acorde al marco comprensivo de su obra. (shrink)

Ao percorrermos as páginas das histórias da educação e da pedagogia não podemos ficar surpreendidos ao verificar que não existe nelas lugar para Spinoza. O que neste breve ensaio se vai tentar descobrir é que a questão pedagógica em geral e a do ensino da filosofia não são tratadas com desprezo pelo pensador de Amsterdão, nem em relação a elas existem sinais de indiferença. Pretende-se mostrar de que modo algumas atitudes do filósofo juntamente com tópicos do seu pensamento servem para (...) explicar a ausência de efetiva preocupação com a temática pedagógica. No entanto, o sistema espinosano encerra princípios pedagógicos de primordial relevância para o processo educativo. (shrink)

One of the potentially most significant objections to a cosmopolitan moral approach charges an essential arrogance: cosmopolitanism disdains particularist moral insights even while – in what is said to be its most coherent form – it seeks to bind all persons within global political institutions. It is argued here that adopting a form of institutional cosmopolitanism actually helps to meet this sort of objection. An appropriately configured such approach will have a conception of equal global citizenship at its core. It (...) will seek to place individuals in relations of political humility, understood not as plain deference to competing moral claims, but as concrete recognition of the equal moral status of others. It will seek to progressively empower as actual citizen equals those whose interests are often ‘arrogantly’ neglected in the current system, and to multiply mechanisms of input and challenge for them over time. (shrink)

Information is a peculiar quantity. Unlike matter and energy, which are conserved by the laws of physics, the aggregation of knowledge from many sources can in fact produce more information (synergy) or less (redundancy) than the sum of its parts. This feature can endow groups with problem‐solving strategies that are superior to those possible among noninteracting individuals and, in turn, may provide a selection drive toward collective cooperation and coordination. Here we explore the formal properties of information aggregation as a (...) general principle for explaining features of social organization. We quantify information in terms of the general formalism of information theory, which also prescribes the rules of how different pieces of evidence inform the solution of a given problem. We then show how several canonical examples of collective cognition and coordination can be understood through principles of minimization of uncertainty (maximization of predictability) under information pooling over many individuals. We discuss in some detail how collective coordination in swarms, markets, natural language processing, and collaborative filtering may be guided by the optimal aggregation of information in social collectives. We also identify circumstances when these processes fail, leading, for example, to inefficient markets. The contrast to approaches to understand coordination and collaboration via decision and game theory is also briefly discussed. (shrink)

Resumen Este artículo proponemos un abordaje de las elaboraciones en torno a la singularización en la época de Sein und Zeit. Mediante un recorrido por sus consideraciones respecto al Dasein y las especificaciones sobre las dinámicas de mismidad, tanto en su carácter primario y cotidiano, como en su modalidad propia, buscaremos demostrar el carácter correlativo entre el tratamiento de la singularización en la analítica y la propia articulación discursiva de Heidegger en sus relaciones con la tradición, destacando algunas tensiones y (...) discusiones respectivas. Junto a ello, distinguiremos en qué medida estas caracterizaciones pueden condicionar la modalidad de abordaje y lectura de su obra. De esta manera, esperamos desplegar una articulación comprensiva fundamental del existente humano en vistas de sus continuidades y derivas en el pensamiento contemporáneo.In this article we propose an approach to the elaborations around the singularization at the time of Sein und Zeit. Through a tour of their considerations regarding Dasein and the specifications on the dynamics of sameness, both in their primary and daily character, and in their own modality, we will try demonstrate the correlative character between the treatment of the singularization in the analytics and the articulation itself Heidegger's discourse in his relations with tradition, highlighting some tensions and respective discussions. Along with this, we will distinguish to what extent these characterizations can condition the approach and reading modality of his work. In this way, we hope to display a fundamental comprehensive articulation of the existing human in view of its continuities and drifts in contemporary thinking. (shrink)

The following article addresses Heidegger’s considerations on tradition and philosophical legacy in two fundamental periods of his thought. I seek to demonstrate that the notion of tradition is articulated in different ways in the Sein und Zeit period and in his post-Kehre considerations. I show irreducible connections that manifest this understanding with his considerations on language and temporal dynamics. For this purpose, firstly, I analyze the destructive strategies that Heidegger deploys during the former period within the framework of his considerations (...) on history. Secondly, I address his ideas on metaphysics and their consequences in works published after 1930. Finally, I distinguish some links with his ideas on language. (shrink)

The trinitarian theology of Karl Rahner has been the object of much discussion that has concentrated above all on two points: the «fundamental axiom» of the trinitarian theology and the problems surrounding the concept ofthe divine person. The fundamental axiom has helped to reclaim the central place of the mystery of the Trinity in the Christian faith and the need to set out from the economy of salvation as the only way to search more deeply into the mystery of God. (...) If the first part of the axiom, «the economic Trinity is the immanent Trinity», has been commonly accepted, the second, «and vice versa», has been the object of criticism. It must be emphasized in each case that the economy of salvation does not constitute or perfect the triune God and that He acts in it with full freedom. With these provisos, the second part of the axiom becomes not only legitimate but necessary to guarantee the universal mediation of Christ in whom God has reconciled the world to Himself. The concrete development of the trinitarian theology of Karl Rahner is not without its problems. It has been accused of tending toward modalism, in that the «personal» character of the divine hypostases in the immanent Trinity is much diminished. The article reviews the criticisms of various types that have been made and tries to offer a balanced interpretation of the thought of the German theologian that bears in mind its various aspects. (shrink)

Algumas abordagens antirrepresentacionalistas da cognição têm se tornado cada vez mais populares, e muitos de seus defensores as veem como promissoras de um novo paradigma para a ciência cognitiva. Neste manuscrito, concentro-me em duas dessas abordagens para argumentar que elas não contêm uma explicação adequada das ilusões perceptuais - e que talvez não possam fornecê-la. Minha alegação é que, sem um tratamento adequado de um fenômeno perceptual tão comum, elas dificilmente podem ser vistas como parte de um novo paradigma. Começo (...) descrevendo o contexto em que essas abordagens surgiram e se desenvolveram e, na segunda parte, apresento três tratamentos de ilusões perceptuais provenientes das abordagens em questão. A terceira parte faz um desvio sobre a noção de ilusão perceptual, já que a avaliação dessas explicações das ilusões parece exigir isso. Em seguida, a quarta parte é dedicada à avaliação dessas explicações das ilusões, discutindo a introdução da linguagem normativa, o apelo a noções como propriedade “dependente da situação” e se uma definição proposta de ilusão se ajusta à nossa compreensão atual delas, bem como a rejeição de inferências de comportamento inadequado que parecem abdutivamente legítimas. Argumento que esses relatos de ilusões perceptuais não atingem seu objetivo. Traduzido com a versão gratuita do tradutor - DeepL.com. (shrink)

There are currently serious concerns that published scientific findings often fail to be reproducible, and that some solutions may be gleaned by attending the several methodological and sociological recommendations that could be found in the literature. However, researchers would also arrive at some answers by considering the advice of the philosophy of science, particularly semantics, about theses on truth related to scientific realism. Sometimes scientists understand the correspondence thesis of truth as asserting that the next unique empirical confirmation of a (...) hypothesis suffices to attribute truth to it provisionally. Such empiricist bias is not necessarily at the core of CTT, but Mario Bunge proposed the synthetic thesis of truth, based on CTT, to explicitly avoid the bias. STT requires considering a hypothesis corroborated, both by purely empirical confirmation and external consistency or compatibility with the bulk of existing background knowledge. While a capricious understanding of CTT could be rigged to recommend the “one shot game” in hypothesis testing, STT clearly demands the use of multiple approaches, empirical as well as theoretical, and it asserts that a scientific test is effective to the extent to which it is neither purely empirical, nor viewed in isolation. Pattern consistency together with an understanding of causal relations make confirmed hypotheses robust and more reliable. The militancy of the double mechanism of hypothesis control of STT can help mitigate the reproducibility crisis. Earl Werner’s research program in community ecology is an example of the use of STT criteria, which leads to the development of reliable, cross-checked, ecological results, with high predictive capacity. (shrink)

Existe un consenso general en torno a la condena de los textos de Foucault sobre la revolución iraní, a los que se considera un error manifiesto, ya sea debido a que el entusiasmo por la revolución islámica lo habría alejado imprudentemente de sus verdaderos intereses teóricos, ya sea debido a que ellos revelan un trasfondo totalitario, ingenuo y hasta misógino de su filosofía, lo cual, por supuesto, ahorra a los comentadores un trabajo hermenéutico sobre la inserción de tales escritos en (...) una obra cuya apuesta general aún es objeto de disputa académica. En este trabajo proponemos una vía alternativa de comprensión que no toma estos textos como un error, sino como parte de un diagnóstico al que se busca echar luz a través de la dimensión del viaje, el periodismo radical y la heterotopología como elementos fundamentales de una apuesta filosófica por la alteridad. There is consensus in disapproving the journalistic articles written by Foucault about the Iranian revolution. They are considered clear mistakes. Some say that this is so because the enthusiasm of Foucault towards the Islamic revolution moved him away from his true theoretical interests; others say that what those texts reveal is a totalitarian, naive, and even misogynistic background of his philosophy. By doing this, commentators spear themselves a hermeneutical work on the incorporation of those texts into a work whose general bet remains the subject of academic discussion. In this paper, we propose an alternative approach to the issue; one in which the texts are not considered a mistake but rather they are seen as part of a diagnosis that can get some light from the ideas of travel, radical journalism and heterotopology. These considered as fundamental elements of a philosophical bet on alterity. (shrink)

El artículo indaga y compara diferentes posturas que se tiene sobre la informalidad comercial en Latinoamérica, en donde se realiza una revisión detallada y analítica de este fenómeno; que se define como el conjunto de actividades comerciales no reguladas, que en estos países desborda la institucionalidad, generando un deterioro de la estructura social, económica, política e inclusive humana. Estas dificultades tienen su origen en una serie de situaciones como la pobreza, el desempleo, el desplazamiento, la migración, el analfabetismo, entre otros; (...) las cuales son importantes conocer y analizar a fin de generar soluciones reales a estas profundas dificultades. (shrink)

Recent years have seen a remarkable resurgence in rigorous thought on global government by leading thinkers in international relations, economics, and political theory. Not since the immediate post-World War II period have so many scholars given serious attention to possibilities for global political integration.This book will be of interest to students of international relations, political theory, international economics, secuity and gender studies. It pulls together some of the leading current thinkers on global government into a conversation about provocative global institutional (...) visions. Chapters here explore whether a world state should be viewed as inevitable, ways in which global moral and political communities might be sustained, and reasons to reject world government in favor of improvements to governance in the United Nations and other institutions. (shrink)

Volume 16, Issue 1, April 2020, Page 110-115.

Tomando como punto de partida el artículo 27.7 de la Constitución Española, que reconoce expresamente que "los profesores, los padres y, en su caso, los alumnos intervendrán en el control y gestión de todos los Centros sostenidos por la Administración con fondos públicos, en los términos que la ley establezca", nuestro sistema jurídico educativo ha venido estableciendo un marco de actuación de los conocidos Consejos Escolares de los Centros, marco que lejos de haber permanecido inalterado desde la Ley Orgánica reguladora (...) del Derecho a la Educación (19885), he evolucionado llamativamente con el transcurso de los años, a través de las sucesivas Leyes orgánicas: Ley Orgánica de Participación, Evaluación y Gobierno de los Centros (LOPEG, 1995), Ley Orgánica de Calidad de la Educación (LOCE, 2002) y Ley Orgánica de Educación (LOE, 2006. (shrink)

Suprastate policy formation in such bodies as the WTO remains fundamentally exclusive of individuals within states. This article critiques the "don't kill the goose" arguments commonly offered in defense of such exclusions.

El cultivo de la filosofía, particularmente el de la metafísica, constituye el fin último del hombre y cuyo acto tiene por objeto la contemplación de Dios ut auctornaturae. Ahora bien, la Revelación cristiana introduce dos factores determinantes que modificaron la condición pura de nuestra naturaleza: la elevación al orden sobrenatural y la intromisión del pecado original. De allí que, por un lado, el fin último del hombre consistirá en la visión sobrenatural de Dios ut auctor gratiae y, por otro, la (...) necesidad de la gracia sanadora y elevadora para llegar a esa visión. No obstante, Santiago Ramírez siguiendo a Santo Tomás de Aquino, explicará que el hombre actual –es decir, caído por el pecado– es impotente incluso para alcanzar su fin connatural sin la ayuda de la gracia. (shrink)

Sophocles' Antigone, written around 441-440 B.C. is the most studied and interpreted tragedy in the history of classical theater. There are diverse interpretive angles and analysis that at 2500 BCE challenge exegetes and scholars from the various fields of human knowledge. The way the play is, interpretatively, received varies according to the interests of the time in which it is studied and staged. The objective of this work, by means of a hermeneutic-dialectic analysis of literature review, is to present possible (...) impacts that the non-compliance with the civil law that prevented the young princess Antigone from giving a dignified burial to her brother, Polynices, has on the formation of an educational and emancipating ethos of citizens who seek, in their praxis, full social justice in the face of laws woven by the excluding logic of a state power that aims only to perpetuate itself in power. The main characters are analyzed and contextualized in the light of the understanding of a formative ethos that prioritizes the logic of justice over the cold logic of legal law. We conclude that Creon's interdict is still alive in our times, and education is one of the main instruments to transform the status quo that unjustly victimizes many people in the name of a state reason divorced from ethical and moral principles. (shrink)

Based on the hypothesis that modified human beings will have successful life projects, the biopolitical presuppositions of genetic manipulation in modern society are reflected. Considering the theories presented by Michel Foucault, Jürgen Habermas, Michael J. Sandel, Hans Jonas and Achille Mbembe, a genetic Africanization of the economically disadvantaged population is identified. In this scenario, concepts of class and race are confused and social prejudice increases. Faced with the new technologies of genetic engineering, gene manipulation presents itself as a new face (...) of biopower, since science now has the power to give life from the selection of characteristics considered superior. It is argued that the criticism surrounding the process of genetic manipulation is necessary as it opens the possibility of debating mutual recognition as a condition of life, above the identification of race or class, geographic location or other characteristics of the individuals that make up society. (shrink)

Em tempos em que os sistemas humanos aceleram as esferas de descuido, de caos, faz-se necessário buscar novos princípios que fundamentem as bases essenciais da existência e das relações humanas. Nesse viés, a reflexão sobre o caminho da pessoa que busca entender-se como ser de Cuidado torna-se cada vez mais urgente, haja vista que pode promover uma compreensão profunda sobre as próprias atitudes e ações em relação ao todo da vida existente. Dessa forma, toda ação humana para ser boa deve (...) adotar os princípios de Cuidado, e sua reflexão em nível de essência religiosa tem como base a narrativa da Criação na busca de encontrar fundamentos para uma ética necessária e essencial, e que seja norma de conduta responsável, visto que só pela moral do Cuidado com a terra a pessoa manifesta a sua realidade e assume o seu ser em imagem e semelhança ao Criador. (shrink)

A Quinta das Meditações Metafísicas desafia, ainda hoje, seus intérpretes, dado que nesta parte de sua obra-prima, Descartes discute as implicações do conhecimento das essências dentro de seu projeto fundacionista do conhecimento em bases metafísicas. O objetivo de nosso trabalho é mostrar algumas tensões dentro do argumento cartesiano, sobremaneira, as originadas pela apresentação de uma nova prova da existência de Deus - o argumento ontológico, que teve grandes defensores, mutatis mutandis - na história da filosofia: São Boaventura, Duns Scott, Descartes, (...) Leibniz e Hegel. Através do método de revisão bibliográfica, dialogar-se-á com alguns dos principais comentaristas que abordaram esta temática, mostrando que o argumento cartesiano pode ter limitações, contudo as objeções advindas de matrizes tomistas, como as de Caterus, ou da filosofia transcendental como a de Kant demonstram mais uma incompreensão do novo conceito de existência, enquanto ideia, do que uma verdadeira crítica ao argumento ontológico de Descartes. (shrink)