This article explores the use of model organisms in studying the cognitive phenomenon of decision-making. Drawing on the framework of biological control to develop a skeletal conception of decision-making, we show that two core features of decision-making mechanisms can be identified by studying model organisms, such as E. coli, jellyfish, C. elegans, lamprey, and so on. First, decision mechanisms are distributed and heterarchically structured. Second, they depend heavily on chemical information processing, such as that involving neuromodulators. We end by discussing (...) the implications for studying distinctively human decision-making. (shrink)

RESUMEN Largamente desatendida o malinterpretada, la noción de caos en la filosofía de Nietzsche es una pieza constitutiva de la particular concepción del ser que este autor habría dejado apenas esbozada. El artículo se propone elaborar este concepto en la obra nietzscheana, siguiendo algunas de las metáforas que lo iluminan. Desde allí se busca plantear los rasgos centrales de una ontologia del caos, de sesgo no metafísico, que, al afirmar el carácter acontecimental de la realidad, puede verse como precursora de (...) la ontología hermenéutica contemporánea. ABSTRACT The notion of chaos, which has long been neglected or misinterpreted, is a constitutive element of a peculiar conception of being that the philosopher only had time to outline. The objective of this article is to elaborate on this concept in Nietzschean philosophy, guided by some of the metaphors that shed light on it. This serves as the basis to set forth the main characteristics of a non-metaphysical ontology of chaos that asserts the eventful nature of reality and can thus be seen as a precursor of contemporary hermeneutic ontology. (shrink)

The purpose of this paper is less ambitious than its title might suggest, since it does not deal with everything that Plato has said on time and on eternity. Rather, it attempts to clarify some issues which have arisen in the controversy as to whether Parmenides or Plato was the first Western philosopher to grasp the notion of atemporal eternity. It is particularly concerned with some publications on the subject that have appeared within the last twelve years or so. G. (...) E. L. Owen, in a paper published in this journal, has defended his earlier interpretation that Parmenides discovered the notion of atemporal eternity. J. Whittaker for his part has contended that both Parmenides and Plato failed to grasp it, and would ascribe its discovery to some later thinker. Yet another scholar, G. Reale, believes that there is no essential difference between the position of Parmenides as reconstructed by Owen and others and that of Melissus. For Reale maintains that Melissus’ formula “it is and always was and always will be” does not exclude atemporality, that it means the same thing as the alleged tenseless ‘is’ predicated of Parmenides’ Being. (shrink)

This important new editio maior of Aristotle's Poetics is based on all the primary sources and is accompanied by a details critical apparatus. The introductory chapters provide important new insights about the transmission of the text to the present day and especially the significance of the Syro-Arabic tradition.

Palabras de agradecimiento al promotor del Congreso Internacional y a los participantes en él. Asimismo, a la persona que ha trabajado en la labor de transcripción de mis escritos y a otros colaboradores míos. También a quienes han tomado en cuenta mis ideas para elaborar sus tesis doctorales, y a otros colegas cuyos planteamientos filosóficos distan de los míos. Como la filosofía es una actividad interminable, queda abierta la sucesiva investigación en mis propuestas.

In this pathbreaking study, Micaela di Leonardo reveals the face of power within the mask of cultural difference. From the 1893 World's Fair to Body Shop advertisements, di Leonardo focuses on the intimate and shifting relations between popular portrayals of exotic Others and the practice of anthropology. In so doing, she casts new light on gender, race, and the public sphere in America's past and present. "An impressive work of scholarship that is mordantly witty, passionately argued, and takes (...) no prisoners."--Lesley Gill, News Politics "[Micaela] di Leonardo eloquently argues for the importance of empirical, interdisciplinary social science in addressing the tragedy that is urban America at the end of the century."--Jonathan Spencer, Times Literary Supplement "In her quirky new contribution to the American culture brawl, feminist anthropologist Micaela di Leonardo explains how anthropologists, 'technicians of the sacred,' have distorted American popular debate and social life."--Rachel Mattson, Voice Literary Supplement "At the end of di Leonardo's analyses one is struck by her rare combination of rigor and passion. Simply, [she] is a marvelous iconoclast."--Matthew T. McGuire, Boston Book Review. (shrink)

BackgroundMinorities are an underrepresented population in clinical trials. A potential explanation for this underrepresentation could be lack of willingness to participate. The aim of our study was to evaluate willingness to participate in different hypothetical clinical research scenarios and to evaluate the role that predictors could have on the willingness of minorities to participate in clinical research studies.MethodsWe conducted a mixed-methods study at the Miami VA Healthcare system and included primary care patients with hypertension. We measured willingness to participate as (...) a survey of four clinical research scenarios that evaluated common study designs encountered in clinical research and that differed in degree of complexity. Our qualitative portion included comments about the scenarios.ResultsWe included 123 patients with hypertension in our study. Of the entire sample, ninety-three patients were minorities. Seventy per cent of the minorities were willing to participate, compared to 60 per cent of the non-minorities. The odds ratio of willingness to participate in simple studies was 0.58; 95 per cent CI 0.18–1.88 p=0.37 and the OR of willingness to participate in complex studies was 5.8; 95 per cent CI 1.10–1.31 p=0.03. In complex studies, minorities with low health literacy cited obtaining benefits as the most common reason to be willing to participate. Minorities who were not willing to participate, cited fear of unintended outcomes as the main reason.ConclusionsMinorities were more likely to be willing to participate in complex studies compared to non-minorities. Low health literacy and therapeutic misconception are important mediators when considering willingness to participate in clinical research. (shrink)

The article examines education in the information age, proposing an informational perspective. By analyzing the epistemology of informational learning, I offer a framework for understanding how individuals acquire knowledge, highlighting the role of design and models in active and constructive learning. Following this, the paper presents the UDL and ODDE educational models, outlining their key features and potential contributions. I then showcase the practical application of these models through case studies focusing on the use of AI to develop personalized learning (...) tools and inclusive environments. I propose EIML as a competence to address the abundance of information in learning and the need for the concept of reciprocity. (shrink)

Living systems employ several mechanisms and behaviors to achieve robustness and maintain themselves under changing internal and external conditions. Regulation stands out from them as a specific form of higher-order control, exerted over the basic regime responsible for the production and maintenance of the organism, and provides the system with the capacity to act on its own constitutive dynamics. It consists in the capability to selectively shift between different available regimes of self-production and self-maintenance in response to specific signals and (...) perturbations, due to the action of a dedicated subsystem which is operationally distinct from the regulated ones. The role of regulation, however, is not exhausted by its contribution to maintain a living system’s viability. While enhancing robustness, regulatory mechanisms play a fundamental role in the realization of an autonomous biological organization. Specifically, they are at the basis of the remarkable integration of biological systems, insofar as they coordinate and modulate the activity of distinct functional subsystems. Moreover, by implementing complex and hierarchically organized control architectures, they allow for an increase in structural and organizational complexity while minimizing fragility. Finally, they endow living systems, from their most basic unicellular instances, with the capability to control their own internal dynamics to adaptively respond to specific features of their interaction with the environment, thus providing the basis for the emergence of minimal forms of cognition. (shrink)

Com recuerdo y fiel homenaje a nuestro genial compatrinta, el ingeniero e inventar santanderino Leonardo Torres Quevedo, THEORIA quiere reeoger hoy en sus páginas dos breves, claros y luminosostextos -el primero sobre máquinas algébricas (1901) y el segundo sobre el alcance de una nueva ciencia: la Automática (1915)- de aquel español itinerante e infatigable que, como muy contadascompatriotas, supo aliar claridad y rlgor lógico en las definiciones de los conceptos básicos y desbordante inventiva creadora en la estricta y audaz (...) aplicación técnica de los mismos.Acompaña a estos textos la inolvidable imagen del primer ajedrecista automático (electromagnetico) concebido y construido por Torres Quevedo, anticipador también en la era electromecanica de los que habían de seguirle en la electrónica e informática y triunfador póstumo, en 1951, en el primer Congreso Cibernético de París, donde fué examinado por el hijo del inventor español y el padre de la Cibernética, Norbert Wiener, tres años después de la aparición en el M.I.T. de la primera edición inglesa de la obra de éste último Cybemetics, or control and communication in the animal and the machine (1948) que iba a inaugurar la era de la Cibernética, anticipada en tantas ideas, muchos decenios antes, por la Automática de nuestro Torres Quevedo. (shrink)

Living organisms act as integrated wholes to maintain themselves. Individual actions can each be explained by characterizing the mechanisms that perform the activity. But these alone do not explain how various activities are coordinated and performed versatilely. We argue that this depends on a specific type of mechanism, a control mechanism. We develop an account of control by examining several extensively studied control mechanisms operative in the bacterium E. coli. On our analysis, what distinguishes a control mechanism from other mechanisms (...) is that it relies on measuring one or more variables, which results in setting constraints in the control mechanism that determine its action on flexible constraints in other mechanisms. In the most basic arrangement, the measurement process directly determines the action of the control mechanism, but in more complex arrangements signals mediate between measurements and effectors. This opens the possibility of multiple responses to the same measurement and responses based on multiple measurements. It also allows crosstalk, resulting in networks of control mechanisms. Such networks integrate the behaviors of the organism but also present a challenge in tailoring responses to particular measurements. We discuss how integrated activity can still result in differential, versatile, responses. (shrink)

An approach which has the purpose to catch what characterizes the specificity of a living system, pointing out what makes it different with respect to physical and artificial systems, needs to find a new point of view – new descriptive modalities. In particular it needs to be able to describe not only the single processes which can be observed in an organism, but what integrates them in a unitary system. In order to do so, it is necessary to consider a (...) higher level of description which takes into consideration the relations between these processes, that is the organization rather than the structure of the system. Once on this level of analysis we can focus on an abstract relational order that does not belong to the individual components and does not show itself as a pattern, but is realized and maintained in the continuous flux of processes of transformation of the constituents. Using Tibor Ganti’s words we call it “Order in the Nothing”. In order to explain this approach we analyse the historical path that generated the distinction between organization and structure and produced its most mature theoretical expression in the autopoietic biology of Humberto Maturana and Francisco Varela. We then briefly analyse Robert Rosen’s (M,R)-Systems, a formal model conceptually built with the aim to catch the organization of living beings, and which can be considered coherent with the autopoietic theory. In conclusion we will propose some remarks on these relational descriptions, pointing out their limits and their possible developments with respect to the structural thermodynamical description. -/- . (shrink)

Endocrinologists apply the idea of feedback loops to explain how hormones regulate certain bodily functions such as glucose metabolism. In particular, feedback loops focus on the maintenance of the plasma concentrations of glucose within a narrow range. Here, we put forward a different, organicist perspective on the endocrine regulation of glycaemia, by relying on the pivotal concept of closure of constraints. From this perspective, biological systems are understood as organized ones, which means that they are constituted of a set of (...) mutually dependent functional structures acting as constraints, whose maintenance depends on their reciprocal interactions. Closure refers specifically to the mutual dependence among functional constraints in an organism. We show that, when compared to feedback loops, organizational closure can generate much richer descriptions of the processes and constraints at play in the metabolism and regulation of glycaemia, by making explicit the different hierarchical orders involved. We expect that the proposed theoretical framework will open the way to the construction of original mathematical models, which would provide a better understanding of endocrine regulation from an organicist perspective. (shrink)

Esta obra procura celebrar a conclusão do restauro de 56 pinturas da paisagem urbana carioca, que se encontram desde o Caju à Rodoviária Novo Rio. No livro, os autores registram o processo e documentam as imagens, além de trazer as versões das mensagens do Profeta em inglês e espanhol.

In this paper we criticize the “Ashbyan interpretation” (Froese & Stewart, 2010) of autopoietic theory by showing that Ashby’s framework and the autopoietic one are based on distinct, often incompatible, assumptions and that they aim at addressing different issues. We also suggest that in order to better understand autopoiesis and its implications, a different and wider set of theoretical contributions, developed previously or at the time autopoiesis was formulated, needs to be taken into consideration: among the others, the works of (...) Rosen, Weiss and Piaget. By analyzing the concepts of organization and closure, the idea of components, and the role of materiality in the theory proposed by Maturana and Varela, we advocate the view that autopoiesis necessarily entails self-production and intrinsic instability and can be realized only in domains characterized by the same transformative and processual properties exhibited by the molecular domain. From this theoretical standpoint it can be demonstrated that autopoietic theory neither commits to a sharp dualism between organization and structure nor to a reflexive view of downward causation, thus avoiding the respective strong criticisms. (shrink)

Organization figures centrally in the understanding of biological systems advanced by both new mechanists and proponents of the autonomy framework. The new mechanists focus on how components of mechanisms are organized to produce a phenomenon and emphasize productive continuity between these components. The autonomy framework focuses on how the components of a biological system are organized in such a way that they contribute to the maintenance of the organisms that produce them. In this paper we analyze and compare these two (...) accounts of organization and argue that understanding biological organisms as cohesively integrated systems benefits from insights from both. To bring together the two accounts, we focus on the notions of control and regulation as bridge concepts. We start from a characterization of biological mechanisms in terms of constraints and focus on a specific type of mechanism, control mechanisms, that operate on other mechanisms on the basis of measurements of variables in the system and its environment. Control mechanisms are characterized by their own set of constraints that enable them to sense conditions, convey signals, and effect changes on constraints in the controlled mechanism. They thereby allow living organisms to adapt to internal and external variations and to coordinate their parts in such a manner as to maintain viability. Because living organisms contain a vast number of control mechanisms, a central challenge is to understand how they are themselves organized. With the support of examples from both unicellular and multicellular systems we argue that control mechanisms are organized heterarchically, and we discuss how this type of control architecture can, without invoking top-down and centralized forms of organizations, succeed in coordinating internal activities of organisms. (shrink)

This paper analyses conceptual and experimental work in synthetic biology on different types of interactions considered as minimal examples or models of communication. It discusses their pertinence and relevance for the wider understanding of this biological and cognitive phenomenon. It critically analyses their limits and it argues that a conceptual framework is needed. As a possible solution, it provides a theoretical account of communication based on the notion of organisation, and characterised in terms of the functional influence exerted by the (...) sender upon the receiver. It shows that this account can be operationalised in synthetic biology, and that it can supply criteria and guidelines for the design and evaluation of synthetic models. (shrink)

Habermas se ha valido a menudo de la expresión "sociedad postsecular" para referirse al proceso de aprendizaje mutuo entre la razón ilustrada y la conciencia religiosa en el seno de las sociedades modernas. Esa expresión es utilizada por el pensador alemán en dos acepciones distintas. Unas veces la emplea como categoría sociológica descriptiva y otras como categoría filosófica de carácter normativo. En este trabajo rechazamos el uso descriptivo del concepto de sociedad postsecular, haciéndonos eco de las críticas que contra él (...) se han vertido desde la sociología de la religión contemporánea. A la vez, reconocemos el interés que reviste la propuesta normativa de Habermas. Tras exponer el sentido preciso de esa propuesta, examinamos la principal acusación que contra ella cabe formular: la de funcionalismo religioso. (shrink)

Este artigo visa apresentar uma taxonomia original dos argumentos mais difundidos contra o Princípio de Identidade dos Indiscerníveis ao longo da história da Filosofia, mas focando em versões defendidas no século XX e XXI; bem como uma taxonomia das respostas mais efetivas para esses argumentos usados no início do século XXI com uma breve avaliação sobre quais são as mais efetivas para cada argumento de ataque. O leitor também encontrará uma bibliografia atualizada sobre os debates envolvendo esses argumentos e contra-argumentos (...) nas seções correspondentes. Palavras-chave: identidade; indiscernibilidade; Princípio de Identidade dos Indiscerníveis; concebilidade. (shrink)

This paper criticises the ideological dimension of the AI narrative. It does so by questioning the implicit assumptions behind its vision, which promises a world that automatically adapts to our desires before we even know them. These assumptions hinge on a misconception of the value of desire as residing exclusively with its fulfilment, warranting human manipulation for increased predictability. This social trajectory towards algorithmic governance, rather than delivering on the promised fulfilment, undermines our capacity to sustain the same desire that (...) it uses to justify its enterprise. (shrink)

Despite numerous and increasing attempts to define what life is, there is no consensus on necessary and sufficient conditions for life. Accordingly, some scholars have questioned the value of definitions of life and encouraged scientists and philosophers alike to discard the project. As an alternative to this pessimistic conclusion, we argue that critically rethinking the nature and uses of definitions can provide new insights into the epistemic roles of definitions of life for different research practices. This paper examines the possible (...) contributions of definitions of life in scientific domains where such definitions are used most (e.g., Synthetic Biology, Origins of Life, Alife, and Astrobiology). Rather than as classificatory tools for demarcation of natural kinds, we highlight the pragmatic utility of what we call operational definitions that serve as theoretical and epistemic tools in scientific practice. In particular, we examine contexts where definitions integrate criteria for life into theoretical models that involve or enable observable operations. We show how these definitions of life play important roles in influencing research agendas and evaluating results, and we argue that to discard the project of defining life is neither sufficiently motivated, nor possible without dismissing important theoretical and practical research. (shrink)