This article discusses the establishment of a governance framework for biomedical research in Singapore. It focuses on the work of the Bioethics Advisory Committee , which has been instrumental in institutionalizing a governance framework, through the provision of recommendations to the government, and through the coordination of efforts among government agencies. However, developing capabilities in biomedical sciences presents challenges that are qualitatively different from those of past technologies. The state has a greater role to play in balancing conflicting and potentially (...) irreconcilable economic, social, and political goals. This article analyzes the various ways by which the BAC has facilitated this. (shrink)

BackgroundAdults with ADHD exhibit a neuropsychological profile that may present deficits in many cognitive domains, particularly attention and executive functions. However, some authors do not consider executive disfunction as an important part of the clinical profile of the syndrome; this could be related to the use of inappropriate neuropsychological tests, probably not adapted and not sufficiently ecological. Moreover, new data are required on specific correlation of attentive-executive symptoms with socio-demographic factors. Therefore, the aim of this study is to analyze the (...) neuropsychological performance of a group of adults with ADHD, also evaluating the influence of gender, age and education level.MethodsWe retrospectively collected health-related personal data of 40 adult ADHD patients, clinically diagnosed and evaluated via a battery of 4 neuropsychological tests and 1 self-administered questionnaire. Gender, age and years of education differences were assessed.ResultsAttention and EFs deficits have been highlighted mainly on the d2-R and 5-point neuropsychological tests, which therefore seem to be more sensitive in measuring the attention-executive dysfunction in an adult ADHD population, than TAP Go/No-go and ROCFT. ADHD patients also manifested subjective behavioral impulsivity disorders on BIS-11. There were no statistically significant gender differences in cognitive performance. On the contrary, younger patients performed worse on subscales TAP Go/No-go errors and 5-points number of drawings, while participants with a higher education level performed better on subscales d2-R speed of execution and d2-R errors. This supports a reduction in the number of errors and the execution time as a function of older age and a higher level of education. Finally, patients with higher education also self-reported greater impulsivity in planning.ConclusionOur preliminary findings suggest that adult ADHD is not a lifelong stable disorder, but it may change over time. Moreover, attention-executive deficits may be influenced and partially counterbalanced by experience and a higher level of education. This could underlie the development of specific psycho-behavioral and cognitive compensatory strategies. The use of self-administered questionnaires is therefore recommended to highlight attentional and executive difficulties that may not result in neuropsychological tests. (shrink)

In this essay, we discuss the relationship between education, human education and ethics in the context of orthodox neoliberalism, as well as some challenges presented to educational policy in Brazil. It is characterized as an exploratory study of a theoretical nature and is part of a set of three research projects at the doctoral level, carried out at a university in southern Brazil from 2017 to 2020. By contextualizing the current moment of neoliberalism in the country and presenting some foundations (...) of a human and ethical formation, we point to the current challenges present for the consolidation of an educational policy whose horizon is full human formation. The studies show that educational policy from the perspective of human formation today needs to guarantee conditions that articulate, within the school, access to scientific knowledge, creativity and self-organization of the subjects of the pedagogical process in its entirety. Keywords: Education. Human formation. Ethics. Neoliberalism. Education policy. (shrink)

O artigo trata de apresentar a obra Oito Capítulos, Shemona Perakim (introdução ao Pirkei Avot, Ética dos Pais, uma das partes integrantes do Comentário de Mishná), de Maimônides (Rabi Moshé Ben Maimon, 1135-1204), procurando estabelecer uma compreensão introdutória dos elementos centrais que se referem ao tema da ética. A metodologia hermenêutica utilizada demonstra o caráter de imersão na obra em questão, traçando uma breve explanação de cada uma das seções componentes do texto maimonidiano, pela qual se procura, como fio condutor, (...) a identificação dos princípios fundamentais sobre os quais se ergue o projeto ético do autor, que o faz por meio de uma reflexão que articula a Torah judaica com elementos da ética aristotélica.Palavras-chave: Oito Capítulos. Introdução ao Pirkei Avot. Ética e fé judaica.ABSTRACTThe article deals with presenting the work Eight Chapters, Shemonah Perakim (introduction to the Pirkei Avot, Ethics of the Fathers, one of the integral parts of the Commentary of Mishnah), from Maimonides(Rabbi Moshe Ben Maimon, 1135-1204), seeking to set up an introductory understanding of the major elements that refer to the theme of ethics. The hermeneutic methodology used shows the attempt at plunging into the work in question, drawing a brief explanation of sections that compound the Maimonidean text, through which it is attempted as a leading thread to find out the fundamental principles on which stands the author’s ethical projectthat is developed through a reflection that articulates the Jewish Torah with elements of Aristotelian ethics.Keywords: Eight Chapters. Introduction to Pirkei Avot. Ethics and Jewish faith. (shrink)

The regional brain networks and the underlying neurophysiological mechanisms subserving the cognition of visual narrative in humans have largely been studied with non-invasive brain recording. In this study, we specifically investigated how regional and cross-regional cortical activities support visual narrative interpretation using intracranial stereotactic electroencephalograms recordings from thirteen human subjects (6 females, and 7 males). Widely distributed recording sites across the brain were sampled while subjects were explicitly instructed to observe images from fables presented in “sequential” order, and a set (...) of images drawn from multiple fables presented in “scrambled” order. Broadband activity mainly within the frontal and temporal lobes were found to encode if a presented image is part of a visual narrative (sequential) or random image set (scrambled). Moreover, the temporal lobe exhibits strong activation in response to visual narratives while the frontal lobe is more engaged when contextually novel stimuli are presented. We also investigated the dynamics of interregional interactions between visual narratives and contextually novel series of images. Interestingly, the interregional connectivity is also altered between sequential and scrambled sequences. Together, these results suggest that both changes in regional neuronal activity and cross-regional interactions subserve visual narrative and contextual novelty processing. (shrink)

Trata-se de uma tradução de um guia sobre como escrever um artigo filosófico, publicado pela Harvard College Writing Center como parte da série Writing Center Brief Guide Series do Writing Program da Harvard University. O texto discorre sobre o que se deve fazer num artigo propriamente filosófico, apresentando critérios sobre como se deve elaborar teses e argumentos filosóficos, e as possíveis objeções contra esses.

Palabras de agradecimiento al promotor del Congreso Internacional y a los participantes en él. Asimismo, a la persona que ha trabajado en la labor de transcripción de mis escritos y a otros colaboradores míos. También a quienes han tomado en cuenta mis ideas para elaborar sus tesis doctorales, y a otros colegas cuyos planteamientos filosóficos distan de los míos. Como la filosofía es una actividad interminable, queda abierta la sucesiva investigación en mis propuestas.

Fast food companies like Siam Burger that participate in health awareness campaigns create a conflict of interest between the social responsibility of promoting health and the business interest of increasing sales through marketing strategies like advertising. Alternative options of raising health awareness without mitigating the involvement of fast food companies either by denying advertisements or having a third party foundation should be explored.

Resumen Este artículo examina siete concepciones filosóficas acerca de la libertad -incluyendo la distinción entre libertad negativa y positiva, liberal y republicana-, ejemplificándolas con representantes de la historia de la filosofía. Por otra parte, para enriquecer la mirada desde un texto jurídico concreto, examinamos la Constitución ecuatoriana de 2008. El propósito principal que ha animado esta investigación es el de sondear las distintas visiones que se han propuesto sobre la libertad, en su triple relación con: 1) los valores, tales como (...) el bien común y la igualdad; 2) el tipo de deber correspondiente que tienen que cumplir los particulares y la sociedad con respecto al sujeto portador del derecho a la libertad; y 3) el Estado y las leyes. Aspiramos a que los resultados alcanzados aporten mayor claridad en aquellos debates de la filosofía normativa en los que está involucrada la libertad.The paper examines seven philosophical conceptions of freedom -including the distinctions between positive and negative liberty, and liberal and republican liberty-, exemplifying them with great authors in the history of philosophy. On the other hand, in order to enrich the vision with a concrete legal document, we examine the Ecuadorian Constitution of 2008. The central aim of the research is to probe the use made by those who participated in the drafting of that Constitution of philosophical ideas concerning liberty in its threefold relation to: 1) values, such as common good and equality; 2) the correlative duties imposed on individuals and the society at large with respect to the holder of the right to freedom; and 3) the state and its laws. We hope that the results provide greater clarity in those debates of normative philosophy in which freedom is involved. (shrink)

Despite numerous and increasing attempts to define what life is, there is no consensus on necessary and sufficient conditions for life. Accordingly, some scholars have questioned the value of definitions of life and encouraged scientists and philosophers alike to discard the project. As an alternative to this pessimistic conclusion, we argue that critically rethinking the nature and uses of definitions can provide new insights into the epistemic roles of definitions of life for different research practices. This paper examines the possible (...) contributions of definitions of life in scientific domains where such definitions are used most (e.g., Synthetic Biology, Origins of Life, Alife, and Astrobiology). Rather than as classificatory tools for demarcation of natural kinds, we highlight the pragmatic utility of what we call operational definitions that serve as theoretical and epistemic tools in scientific practice. In particular, we examine contexts where definitions integrate criteria for life into theoretical models that involve or enable observable operations. We show how these definitions of life play important roles in influencing research agendas and evaluating results, and we argue that to discard the project of defining life is neither sufficiently motivated, nor possible without dismissing important theoretical and practical research. (shrink)

En este artículo, mostramos ciertos supuestos no explicitados en la noción de individuo humano en la que se basan los enfoques teóricos de la neuroeconomía y la economía conductual para desarrollar sus programas de investigación e intervención. También abordamos los compromisos epistemológicos, ideológicos y políticos desde los cuales conciben, estudian e intervienen en la conducta humana. En lugar de un individuo producto de un proceso de socialización, lo que se presenta es un cerebro aislado con numerosas funciones cognitivas atribuidas, cuya (...) conducta puede ser alterada debido a “accidentes” en su evolución como órgano rector del comportamiento. Este enfoque permite la construcción de propuestas de políticas públicas basadas en el llamado “paternalismo libertario”. Se destaca un potencial mecanismo de control cuyo objetivo es configurar los distintos espacios de la vida cotidiana de los individuos de manera que sus conductas agregadas se alineen lo más posible con los entes racionales ideales del modelo económico neoclásico. (shrink)

El objetivo de este trabajo es realizar una crítica al concepto hegemónico-dominante de ciencia a través de un análisis de la construcción discursiva del paradigma de la simplificación heredado de la Modernidad. Se problematizan las exclusiones político-epistemológicas de la tradición del pensamien..

Organization figures centrally in the understanding of biological systems advanced by both new mechanists and proponents of the autonomy framework. The new mechanists focus on how components of mechanisms are organized to produce a phenomenon and emphasize productive continuity between these components. The autonomy framework focuses on how the components of a biological system are organized in such a way that they contribute to the maintenance of the organisms that produce them. In this paper we analyze and compare these two (...) accounts of organization and argue that understanding biological organisms as cohesively integrated systems benefits from insights from both. To bring together the two accounts, we focus on the notions of control and regulation as bridge concepts. We start from a characterization of biological mechanisms in terms of constraints and focus on a specific type of mechanism, control mechanisms, that operate on other mechanisms on the basis of measurements of variables in the system and its environment. Control mechanisms are characterized by their own set of constraints that enable them to sense conditions, convey signals, and effect changes on constraints in the controlled mechanism. They thereby allow living organisms to adapt to internal and external variations and to coordinate their parts in such a manner as to maintain viability. Because living organisms contain a vast number of control mechanisms, a central challenge is to understand how they are themselves organized. With the support of examples from both unicellular and multicellular systems we argue that control mechanisms are organized heterarchically, and we discuss how this type of control architecture can, without invoking top-down and centralized forms of organizations, succeed in coordinating internal activities of organisms. (shrink)

Biological regulation is what allows an organism to handle the effects of a perturbation, modulating its own constitutive dynamics in response to particular changes in internal and external conditions. With the central focus of analysis on the case of minimal living systems, we argue that regulation consists in a specific form of second-order control, exerted over the core regime of production and maintenance of the components that actually put together the organism. The main argument is that regulation requires a distinctive (...) architecture of functional relationships, and specifically the action of a dedicated subsystem whose activity is dynamically decoupled from that of the constitutive regime. We distinguish between two major ways in which control mechanisms contribute to the maintenance of a biological organisation in response to internal and external perturbations: dynamic stability and regulation. Based on this distinction an explicit definition and a set of organisational requirements for regulation are provided, and thoroughly illustrated through the examples of bacterial chemotaxis and the lac-operon. The analysis enables us to mark out the differences between regulation and closely related concepts such as feedback, robustness and homeostasis. (shrink)

Com recuerdo y fiel homenaje a nuestro genial compatrinta, el ingeniero e inventar santanderino Leonardo Torres Quevedo, THEORIA quiere reeoger hoy en sus páginas dos breves, claros y luminosostextos -el primero sobre máquinas algébricas (1901) y el segundo sobre el alcance de una nueva ciencia: la Automática (1915)- de aquel español itinerante e infatigable que, como muy contadascompatriotas, supo aliar claridad y rlgor lógico en las definiciones de los conceptos básicos y desbordante inventiva creadora en la estricta y audaz (...) aplicación técnica de los mismos.Acompaña a estos textos la inolvidable imagen del primer ajedrecista automático (electromagnetico) concebido y construido por Torres Quevedo, anticipador también en la era electromecanica de los que habían de seguirle en la electrónica e informática y triunfador póstumo, en 1951, en el primer Congreso Cibernético de París, donde fué examinado por el hijo del inventor español y el padre de la Cibernética, Norbert Wiener, tres años después de la aparición en el M.I.T. de la primera edición inglesa de la obra de éste último Cybemetics, or control and communication in the animal and the machine (1948) que iba a inaugurar la era de la Cibernética, anticipada en tantas ideas, muchos decenios antes, por la Automática de nuestro Torres Quevedo. (shrink)

En los últimos tiempos, destacadas figuras del horizonte filosófico y teológico español se han declarado partidarias de lo que ha dado en llamarse ética civil. El propósito de este trabajo es exponer las razones por las que no puedo compartir la postura de mis distinguidos colegas. El estudio de algunos de sus textos -que serán citados abundantemente en lo que sigue- me ha empujado a la conclusión de que bajo el nombre de ética civil circulan confundidas dos propuestas morales diferentes, (...) a las que llamare concepción estática y concepción dinámica de la ética civil, respectivamente. Y no se trata, según creo, de dos teorías complementarias (de suerte que pudieran combinarse en una unidad teórica superior), sino de dos teorías incompatibles. Por si esta ambigüedad fuera poco, hay razones para pensar que ambas son inaceptables. (shrink)

El artículo indaga si es posible caracterizar como expresión del irredentismo el ethos palestino de Retorno a territories donde fueron expulsados en la guerra con Israel en 1948-49. Después de una reseña histórica sobre los campos de refugiados palestinos, y el rol de la UNRWA, se compara cuál fue el destino de refugiados de otras naciones irredentistas tras guerras de descolonización y poscoloniales. Finalmente, se reflexiona sobre el dilema identitario y político acerca del Irredentismo palestino sin estado o la alternativa (...) de un “sionismo palestino” en su propio estado-nacional. Palabras clave : irredentismo, descolonizacion, conflicto Israel-Palestina, nacionalismo The article assesses if it is possible to characterize the Palestinian ethos as an expression of irredentism of an extra-territorial nation, whose young generations long to return to territories from where their families were expelled in the 1948-49 war. After making a historical account of the Palestinian refugee camps and the role of UNRWA, the article compares the fate of refugees from other irredentist nations expelled by decolonization and postcolonial wars. Finally, identity and political dilemmas are raised about stateless Palestinian Irredentism or the alternative of a “Palestinian Zionism” in its own nation-state. Kaywords: irredentism, decolonization, Israel-Palestine conflict, nationalism. (shrink)

Spinoza is often described as an ethical perfectionist—one who accepts an account of the good centered on the development of our natural capacities. Perfectionists typically accept a perfectionist theory of value, in which the properties of good and evil are grounded in a normative property of perfection. Yet I argue that Spinoza rejects a perfectionist theory of value because he believes it conflicts with the doctrine of necessitarianism. This leads him to conclude that attributions of perfection in ethical contexts must (...) be regarded as fictions. If Spinoza is indeed an ethical perfectionist, his perfectionism must be grounded in a theory of value that is not itself perfectionist. (shrink)

Living organisms act as integrated wholes to maintain themselves. Individual actions can each be explained by characterizing the mechanisms that perform the activity. But these alone do not explain how various activities are coordinated and performed versatilely. We argue that this depends on a specific type of mechanism, a control mechanism. We develop an account of control by examining several extensively studied control mechanisms operative in the bacterium E. coli. On our analysis, what distinguishes a control mechanism from other mechanisms (...) is that it relies on measuring one or more variables, which results in setting constraints in the control mechanism that determine its action on flexible constraints in other mechanisms. In the most basic arrangement, the measurement process directly determines the action of the control mechanism, but in more complex arrangements signals mediate between measurements and effectors. This opens the possibility of multiple responses to the same measurement and responses based on multiple measurements. It also allows crosstalk, resulting in networks of control mechanisms. Such networks integrate the behaviors of the organism but also present a challenge in tailoring responses to particular measurements. We discuss how integrated activity can still result in differential, versatile, responses. (shrink)

In this article we analyse the problem of emergence in its diachronic dimension. In other words, we intend to deal with the generation of novelties in natural processes. Our approach aims at integrating some insights coming from Whitehead’s Philosophy of the Process with the epistemological framework developed by the “autopoietic” tradition. Our thesis is that the emergence of new entities and rules of interaction (new “fields of relatedness”) requires the development of discontinuous models of change. From this standpoint natural evolution (...) can be conceived as a succession of emergences — each one realizing a novel “extended” present, described by distinct models — rather than as a single and continuous dynamics. This theoretical and epistemological framework is particularly suitable to the investigation of the origin of life, an emblematic example of this kind of processes. (shrink)

El uso de un conocimiento invariante para alcanzar propósitos intervencionistas o de política es comúnmente aceptado por los enfoques manipulabilistas. Sin embargo, dicho uso plantea dos problemáticas filosóficas que serán examinadas en el presente trabajo. El primer problema es ontológico, y refiere a la dificultad de encontrar genuinos factores causales estables en ciencias sociales. En este sentido, se mostrará que los fenómenos sociales no responden a una lógica de factores estables como los mecanismos o las «capacidades», sino que se adecúan (...) más a una lógica de «árboles de posibilidades” o «resultados de final abierto». El otro problema es de índole epistemológico y refiere a que, incluso si se encuentran contribuciones sociales estables, nada garantiza que dicha estabilidad prevalezca en el futuro. Diferentes tesis que avalan esta problemática serán examinadas, tales como la denominada «crítica de Lucas» o la «teoría del cisne negro». (shrink)

RESUMENEl objetivo de este artículo es contrastar las posturas filosóficas y políticas de Alain Badiou y Jacques Rancière, y aplicar los resultados de ese análisis al ámbito educativo. Para ello abordamos inicialmente las diferencias entre ambos autores respecto de sus teorías del sujeto, sus relaciones con Platón y sus propuestas ontológicas. A continuación consideramos, en primer lugar, una coincidencia acerca del carácter prescriptivo del concepto de «igualdad», y en segundo lugar, una divergencia respecto del «sujeto» y de las consecuencias disruptivas (...) acontecidas a partir de la declaración igualitaria en la educación. PALABRAS CLAVESABER Y PODER –EDUCACIÓN POR VERDADES –IGUALDAD–SUJETO EDUCATIVO. ABSTRACTThe aim of this paper is to contrast the philosophical and political positions of Alain Badiou and Jacques Rancière, and apply the results of this review to education. For this, we initially regard the differences between the two authors about their theories of the subject, its relations with Plato and their ontological proposals. Next, we considered, firstly, a coincidence about the prescriptive concept of «equality», and secondly, a difference with respect to the «subject» and the disruptive consequences from the equalitarian statement in education. KEYWORDSKNOWLEDGE AND POWER –EDUCATION BY TRUTHS –EQUALITY–SUBJECT OF EDUCATION. (shrink)

The main models of scientific explanation assume the need for some kind of stable knowledge for assembling a good explanatory argument. While these approaches are useful in the natural sciences, it is doubtful that they are similarly applicable in the socioeconomic realm. In this paper it is expected to show that the logic of socioeconomic processes of being "possibility trees" or "open-ended results" makes regularities the exception rather than the rule. Alternatively, a mode of explanation that focuses on contextual factors (...) and people actions is proposed. Los principales modelos de explicación científica asumen la necesidad de utilizar algún tipo de conocimiento estable para el armado de un buen argumento explicativo. Si bien estos enfoques son muy útiles en las ciencias naturales, es dudoso que sean similarmente aplicables en el reino de lo socioeconómico. En el presente trabajo se prevé mostrar que la lógica de los “árboles de posibilidades” o “resultados de final abierto” propias de los procesos socioeconómicos hace que las regularidades sean más la excepción que la regla. Como alternativa, se propone un modo de explicación que focalice en los factores contextuales y en las acciones de las personas en el momento en que aconteció el fenómeno a explicar. (shrink)

From its origins, cybernetics has based its desire on the concept of transverse nature, today transdisciplinary. Within its history, the breaking point is unquestionably Stafford Beer and the VMS applied in Salvador Allende's government. Chile's historical conditions and context undoubtedly allowed a series of conceptual emergencies that were not necessarily developed after the 1973 coup d'état. Beer's design, as he claims, could serve both a socialist vision and a fascist command. This tells us that the tool depends on the hand (...) of the administrator. On the other hand, good but insufficient attempts have been made in the field of biologies, such as the theory of autopoiesis and epistemological positions concerning the observer, which have not been able to add value to the VMS. The errors in the design of the VMS can be summarized as follows: confusion of interactions with relationships, confusing co-autonomy with self-organization, confusion of centrism and centralities necessarily as central and establish isomorphisms in a mathematical system aiming at conceptual homologation. As is the case with Information and Entropy. This work shows that the VMS must obligatorily migrate to a Relational Viable system, whose bases are the relations of cooperation and reciprocity based on heterarchical structures for limited or scarce material energy resources. This is the basis of the socialist design which forces the economy to reduce the production of Non-Required Variety. (shrink)