SUMMARYBy examining the use of tissue culture in post-war American biomedicine, this paper investigates how scientists experience and manage failure. I study how Leonard Hayflick forged his new definition of failure and ways of managing it by refuting Alexis Carrel's definition of failure alongside his theory of the immortality of cultured cells. Unlike Carrel, Hayflick claimed that every vertebrate somatic cell should eventually die, unless it transformed into a tumour cell. This claim defined cell death, which had (...) been a problem leading to a laboratory failure, as a normal phenomenon. On the other hand, permanent life, which had been considered a normal cellular characteristic, became a major factor causing scientific failure, since it implied malignant transformation that scientists hoped to control. Hayflick then asserted that his cell strains and method would partly enable scientists to manage this factor—especially that occurred through viral infection—alongside other causes of failure in routine tasks, including bacterial contamination. I argue that the growing biomedical enterprise fostered this work of Hayflick's, which had repercussions in both his career and the uses of cells in diverse investigations. His redefinition of failure in the age of biomedicine resulted in the broad dissemination of his cells, medium, and method as well as his long struggle with the National Institutes of Health, which caused his temporarily failed career. (shrink)

Classic analysis of the subject and the development of personal probability; one of the greatest controversies in modern statistcal thought.

Four principal papers and a total of 43 peer commentaries on the evolutionary origins of morality. To what extent is human morality the outcome of a continuous development from motives, emotions and social behaviour found in nonhuman animals? Jerome Kagan, Hans Kummer, Peter Railton and others discuss the first principal paper by primatologists Jessica Flack and Frans de Waal. The second paper, by cultural anthropologist Christopher Boehm, synthesizes social science and biological evidence to support his theory of how our hominid (...) ancestors became moral. In the third paper philosopher Elliott Sober and evolutionary biologist David Sloan Wilson argue that an evolutionary understanding of human nature allows sacrifice for others and ultimate desires for another's good. Finally Brian Skyrms argues that game theory based on adaptive dynamics must join the social scientist's use of rational choice and classical game theory to explain cooperation. (shrink)

Pleasure, in the inclusive usages most important in moral psychology, ethical theory, and the studies of mind, includes all joy and gladness — all our feeling good, or happy. It is often contrasted with similarly inclusive pain, or suffering, which is similarly thought of as including all our feeling bad. Contemporary psychology similarly distinguishes between positive affect and negative affect.[1..

The annual cost of healthcare in the United States reached $2.5 trillion in 2009 (about 17.6% of GDP) with projections to 2019 of about $4.5 trillion (about 20% of likely GDP).

Rule consequentialism (RC) holds that the rightness and wrongness of actions is determined by an ideal moral code, i.e., the set of rules whose internalization would have the best consequences. But just how many moral codes are there supposed to be? Absolute RC holds that there is a single morally ideal code for everyone, while Relative RC holds that there are different codes for different groups or individuals. I argue that Relative RC better meets the test of reflective equilibrium than (...) Absolute RC. In particular, I contend that Relative RC is superior because it accommodates our convictions about costless benefits. Some have charged that Relative RC threatens our convictions about the generality of moral codes and that it leads inevitably to what Brad Hooker calls “runaway relativism.” I argue that Relative RC has principled reasons for stopping this imagined slide down the slippery slope. (shrink)

This book, first published in 1953, was one of the first written in English that attempted to provide a sympathetic analysis of the new movement of Existentialism. In the attempt to bring out what is of permanent value in what was at the time a study yet to gain academic recognition, it is a valuable work that presents a clear-eyed analysis from the ground up.

Health reform must include health care rationing, both for reasons of fairness and efficiency. Few politicians are willing to accept this claim, including the Clinton Administration. Brown and others have argued that enormous waste and inefficiency must be wrung out of our health care system before morally problematic cost constraining options, such as rationing, can be justifiably adopted. However, I argue that most of the policies and practices that would diminish waste and inefficiency include implicit (and therefore morally problematic) rationing. (...) Critics of rationing see as its most morally and psychologically troubling feature that an identified individual is denied potentially beneficial care. That psychic anguish may not be eliminable, and perhaps ought not be eliminated. But if rationing protocols are fairly adopted through a process of free and informed rational democratic deliberation to which all have access, the moral objections are largely overcome. Such a process is possible only if implicit rationing is recognized and rejected. Keywords: Justice, health care rationing, health reform, democratic decision-making CiteULike Connotea Del.icio.us What's this? (shrink)

Translated from German. Includes bibliographical references. Includes index.

My task is to provide some critical commentary on the preceding essays. My unfortunate conclusion will be that the issues that are their primary focus are more likely to become more ethically intractable over the next several years as medicine progresses. I do not see any easy or obvious way to avoid this conclusion.

I begin this paper by discussing the difference between outweighing and canceling in conflicts of normativity. I then introduce a thought experiment that I call Crash Drive,and I use it to explain the nature of a certain kind of moral conflict as well as the appropriate emotional response – regret – on the part of the primary agent in this case. Having done this, I turn to a line of criticism opened by Bernard Williams and recently expanded by Jonathan Dancy (...) according to which archetypal examples of modern moral philosophies such as Kantianism cannot make sense of conflict and regret. Finally, I examine the general structure of such theories and explain how at least some of them can avoid this line of criticism. (shrink)

Ethics, Policy & Environment, Volume 15, Issue 2, Page 241-243, June 2012.

One recently proposed solution to the Liar paradox is the contextual theory of truth. Tyler Burge (1979) argues that truth is an indexical notion and that the extension of the truth predicate shifts during Liar reasoning. A Liar sentence might be true in one context and false in another. To many, contextualism seems to capture our pre-theoretic intuitions about the semantic paradoxes; this is especially due to its reliance on the so-called Revenge phenomenon. I, however, show that Super-Liar sentences (where (...) a Super-Liar sentence is a sentence which says of itself that it is not true in any context) generate a significant problem for Burge’s contextual theory of truth. (shrink)

This XIIIth volume comprises all the articles published by Benjamin Constant in 1819–1820, that is almost 120 contributions. Featured in the most influential liberal newspapers of the time, these texts shed light on an essential but little known aspect of Constant's political and intellectual commitment under the French Restauration.

Thus the radical character of Hume's causal theory lies far more in its denial of externality to necessary causal connection than in any change he made in the character or status of the connection. It is obvious Hume did not mean his sceptical denial of the "reality" of the causal connection to imply that there is no association or connection between causes and effects. For to him the anarchy of chance, or "liberty," was the only alternative to the truth of (...) causal necessity; and his own "habit" necessity is designed to account for the fact that the universe and human life are not in reality anarchic. Yet in making causal connection a matter of mental association Hume came very close to subverting the idea of necessity despite himself. Had he developed his notion that necessity consists in the unopposable habit our minds form of passing from the idea of the cause to the idea of its effect, he might have seen that causal theory can be divested altogether of the idea of necessity without loss of order and regularity on either the mental or physical levels. Even though he did not do so, Hume's idea of necessity based on habit seems a somewhat attenuated version of causal necessity, since habit is not an inexorable force, and past conjunctions of a given cause and its effect in our experience do not in the least imply that future conjunctions will be the same. For when we anticipate the issue of an effect similar to past effects because the cause is similar to past causes, it is only by a mental presumption that we do so, a "determination of the mind to pass from one object to its usual attendant.". (shrink)