The primary objective was to review pediatric ethics consultations at a large academic health center over a nine year period, assessing demographics, ethical issues, and consultant intervention. The secondary objective was to describe the evolution of PECs at our institution. This was a retrospective review of Consultation Summary Sheets compiled for PECs at our Academic Health Center between January 2008 and April 2017. There were 165 PECs reviewed during the study period. Most consult requests came from the inpatient setting, with (...) the Pediatric and Neonatal Intensive Care Units being the highest utilizers. Consultation utilization increased over the study period. The most common patient age was less than one year. Physicians were most likely to request consultation. Patient Best Interest, Withholding/Withdrawing of Life Sustaining Therapy, and Provider Moral Distress were ethical issues most commonly identified by the consultants. Making recommendations was the most common consultant intervention. The ethics consultation process evolved over time from informal provider discussions, to a hospital infant care review committee, to a pediatric only consultation service, to a combined adult/pediatric consultation service, with variable levels of salary support for consultants. Ethics consultation requests are growing at our institution. Similarities in identified ethical issues exist between our findings and existing literature, however meaningful comparisons remains elusive secondary to variability in approaches to investigation and reporting. A combined paid/volunteer/trainee ethics consultation service model appears sustainable and real time ethics consultation is feasible using this approach. (shrink)

The global array may be a useful concept in studying behavior in a complex environment, especially in the context of dynamical systems theory. However, Stoffregen & Bardy's arguments are weakened by the conflation of sensation and perception, and by the lack of evidence for synergy between stimulus energy arrays; strong evidence places the convergence of sensory stimuli inside the head.

Dieser Band ist der erste Teil einer Lekture von Hegels Phanomenologie des Geistes, in dem die ersten drei Hauptkapitel - d.h. -Bewusstsein-, -Selbstbewusstsein- und -Vernunft- - von Hegels erstem Hauptwerk umfassend kommentiert werden. Der Text entstand dabei wahrend eines uber viele Jahre laufenden Seminars, welches am Institut fur Philosophie der Universitat Wien unter Leitung von Professor Dr. Friedrich Grimmlinger abgehalten wurde und in dem der Hegelsche Text gemeinsam Satz fur Satz gelesen und ausgelegt wurde.".

This personal account traces a series of studies that led from DNA physical chemistry to anticancer drug mechanisms. Chemical crosslinking as a basis for anticancer drug actions had been suspected since the time of the first clinical reports of the effectiveness of nitrogen mustard in 1946. After the elucidation of the DNA helix‐coil transition, several nearly concurrent findings in the early 1960s established the paradigm of DNA interstrand crosslinking. The DNA filter elution phenomenon was discovered in the early 1970s, and (...) lent itself to the development of practical assays for DNA crosslinks and other DNA lesions in mammalian cells. The assays allowed studies of the effects of DNA damaging agents at pharmacologically or toxicologically relevant doses, and have been widely applied in studies of mutagenic and chemotherapeutic agents. During the period 1979–1986, DNA filter elution studies led to the paradigm of DNA topoisomerases as targets of anticancer drug action, and this has become one of the most active areas of anticancer drug development. (shrink)

In the Critique of Pure Reason, Kant uses the term “logic” in a bewildering variety of ways, at times making it close to impossible to determine whether he is referring to (among others) general logic, transcendental logic, transcendental analytic, a "special" logic relative to a specific science, a "natural" logic, a logic intended for the "learned" (Gelehrter), some hybrid of these logics, or even some still-more abstract notion that ranges over all of these uses. This paper seeks to come to (...) grips with Kant's complex use of "logic." Kant is standardly regarded as saying that since Aristotle, there need be no more concern about logic as a discipline or a field of study, and that Aristotle (with some minor embellishments, in terms of presentation) is the last word in logic. I argue here that, in spite of Hegel, Peirce, Strawson, and others, one must take into consideration Kant’s sophisticated critique of Aristotle’s logic in order to see Kant’s own conception of logic in contrast to that of Aristotle’s. In this way, Kant's strategy in the First Critique—grounded as it is in logic—becomes more plausible, defensible, and, consequently, more attractive. (shrink)

The Marxian critics of ideologies is an important stage within the process of demystification of history. This near relationship to positivism does not alter the main difference between both points of view which consists in answering the question to which objects the method of criticism of ideologies should refer. While most of the positivistic theories neglect the psychological and the sociological sources of ideologies, Marx too reflects on the concrete social conditions to which he imputes the causation of « false (...) consciousness » . While Comte supposes that history also is ruled by natural laws, Marx emphasizes the difference between natural laws and the laws of history. Only in this way it is possible to him to assume that « Naturwüchsigkeit » of history could be overcome by human activity.First in the latest positivism, history is eliminated from sociological analysis . Finally with R. Dahrendorf there is to be found an attempt to include the consistency of social change in society and in sociological theory. (shrink)

Tomus 1. Schriften zur Intellekttheorie.

The policy projected by the Eighth Congress of the Socialist Unity Party of Germany rests on two cornerstones. First, there is the task of further raising the material and cultural living standard of the people on the basis of the higher rates of development of socialist production which result from increased efficiency, scientific-technological progress, and a rise in labor productivity. Second, there is the foreign policy task decided jointly with the Soviet Union and other fraternal socialist countries: "to create favorable (...) external conditions for the building of socialism, to further the strengthening of the community of socialist states, to strengthen international solidarity with peoples fighting for their freedom, to realize the Leninist principles of peaceful coexistence between states having different social systems, and to struggle actively against aggressive imperialism." (1. (shrink)

Excerpt from Norm und Verfall des Staates Wohl wußte Nietzsche, daß die physiologischen Grund kenntnisse, denen er doch so großen Wert beimaß, ihm fehlten. Schwankte er doch, ob er die südliche Einsamkeitmit der Luft deutscher Universitäten vertauschen sollte; aber damals würde er diese Grundlagen vergeblich in der Wissenschaft gesucht haben. Heute würde er eher finden, was er brauchte. Die Vor stellung, daß anerz'ogene Eigenschaften sich vererben, ist fast überwunden. Züchtung und Erziehung sind scharfe Gegensätze geworden, die der Bildner des Volkes (...) streng auseinanderhalten muß. Weniger durchdacht sind aber bisher die Folgerungen, daß der Kampf gegen die phy sisehe E nt a r t u n g des einzelnen und der Rasse ganz verschieden ist von dem Kampf gegen den V e r f all des Geistes und des Staates. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

Im Ausgang von Ernst Cassirers methodischen Überlegungen zur Geschichtsschreibung werden dichterische, ästhetische und künstlerische Intentionen der geschichtlichen Darstellung bei David Hume, Wilhelm von Humboldt, Heinrich von Treitschke, Benedetto Croce und Hayden White hinsichtlich ihrer Möglichkeiten und Gefahren nachgezeichnet. Die Abhandlung schließt mit kritischen Stellungnahmen von Thomas Nipperdey und Joachim Fest zur gegenwärtigen Geschichtsschreibung. Zur Diskussion steht, ob die Aufnahme ästhetischer Kriterien in die Geschichtsschreibung den Anspruch einlösen kann, Wahrheit in der Geschichte darzustellen, ob diese Kriterien nicht eher zu einer Abschwächung (...) und Verdunkelung dieses Anspruchs beitragen, und ob nicht vielmehr davon auszugehen ist, daß sich ästhetische und wissenschaftliche Kategorien geschichtlicher Darstellung gegenseitig ausschließen. (shrink)

In der philosophischen Tradition nehmen geschichtsphilosophische Gesichtspunkte wie die Wahrnehmung von Geschichte, der Begriff von Wissen und Vernunft, das sich daraus ergebende Folgeproblem von Einheit und Vielheit und die Rolle und Funktion des Subjektes eine grundlegende Bedeutung ein. In der Postmoderne erfahren diese Aspekte in ihrem philosophischen Stellenwert eine deutliche Profilveränderung. Diese Veränderung, die auf ein ,,entdifferenzierendes Denken" innerhalb der Postmoderne zurückzuführen ist, wird kritisch überprüft.