Complexes of two or more proteins form many, if not most, of the intracellular “machines” that execute physical and chemical work, and transmit information. Complexes can form from stochastic post‐translational interactions of fully formed proteins, but recent attention has shifted to co‐translational interactions in which the most common mechanism involves binding of a mature constituent to an incomplete polypeptide emerging from a translating ribosome. Studies in yeast have revealed co‐translational interactions during formation of multiple major complexes, and together with recent (...) mammalian cell studies, suggest widespread utilization of the mechanism. These translation‐dependent interactions can involve a single or multiple mRNA templates, can be uni‐ or bi‐directional, and can use multi‐protein sub‐complexes as a binding component. Here, we discuss benefits of co‐translational complex assembly including accuracy and efficiency, overcoming hidden interfaces, localized and hierarchical assembly, and reduction of orphan protein degradation, toxicity, and dominant‐negative pathogenesis, all serving to improve cell fitness. (shrink)

This article wrestles with the question of the relationship between the digits of our hands and the digital in a dispersed but connected world. What can be held and what fails our grasp in such a universe? How the everyday and habitual skills of cooking and cleaning come into consciousness or vanish into habit, in a constant choreography of remembering and forgetting, with the digital as aid or hindrance. In the process of thinking through posture, gesture, and infrastructure, it reflects (...) on the enduring contemporary challenge of doing ethnographic work at multiple transnational locations, by an ethnographer with a passport that does not travel well, made worse by the restrictions of a pandemic. In the process, it shows how the same hands that can heal, can also hurt. (shrink)

This article wrestles with the question of the relationship between the digits of our hands and the digital in a dispersed but connected world. What can be held and what fails our grasp in such a universe? How the everyday and habitual skills of cooking and cleaning come into consciousness or vanish into habit, in a constant choreography of remembering and forgetting, with the digital as aid or hindrance. In the process of thinking through posture, gesture, and infrastructure, it reflects (...) on the enduring contemporary challenge of doing ethnographic work at multiple transnational locations, by an ethnographer with a passport that does not travel well, made worse by the restrictions of a pandemic. In the process, it shows how the same hands that can heal, can also hurt. (shrink)

Recently a prospective, observational clinical study was carried out in the department of ophthalmology, at a district general hospital. The main purpose of the study was to evaluate the medicolegal and ethical implication of consent and confidentiality in ophthalmic practice, in accordance with the guidelines provided by medical law. One hundred patients, who had been referred by optometrists to ophthalmologists, were included in the study. The general ophthalmic services (GOS) 18 form, a referral form used by optometrists for referring patients (...) to ophthalmologists, which allows optometrists to share a patient's medical information with ophthalmologists, was used as a …. (shrink)

Green innovation plays a critical role in mitigating environmental issues and balancing the interaction between economic growth and the natural environment. Drawing on social network and resource-dependence theory, this article scrutinises the relationship between independent director interlocks and corporate green innovation. Using the data from listed Chinese companies from 2010 to 2022, this study finds that independent director interlocks can significantly promote corporate green processes and product innovation. This research further finds that internal corporate contexts can also influence the relationship (...) between independent director interlocks and green innovation. Moreover, the results indicate that corporate environmental commitment positively moderates the relationships between independent director interlocks and corporate green innovation. This study also provides significant implications for firms seeking green innovation performance and for policymakers seeking ways to fulfill the mission of carbon dioxide abatement. (shrink)

Mostly consists of works composed in Tibetan, with translations into Mongolian, on the Soyombo script.

On Western philosophy from the point of view of Burmese philosophers.

This paper raises the question of how ethical issues arising out of social inequities involving international business in developing countries can be represented, and articulates a conceptual framework that identifies and maps four different approaches to representing or making sense of such issues. A fieldwork-based case study on the child labor issue in Pakistan’s soccer ball industry illustrates the argument that representational practices do matter, and that when representational approaches go awry, they end up savaging the well-being of the poor (...) in the developing world. (shrink)

Within the Ideological Surround Model of the social sciences and religion, so-called “universal” perspectives within the psychology of religion can dialogically clarify and be clarified by the “particular” elements of Muslim commitment. This study developed new scales for operationalizing the experience and behavior of Pakistani Muslims during Ramadan. In a sample of university students, one set of experiential factors apparently facilitated, whereas another interfered with the practices of Ramadan. Intrinsic and Extrinsic Personal Religious Orientations correlated with greater and the Extrinsic (...) Social motivation with lower levels of involvement in Ramadan. Relative to these religious orientation measures, Ramadan experience scales displayed incremental validity by explaining additional variance in Ramadan behavior. Women proved to be more religious than men. At the most general level, these data further supported the dialogic assumptions of the Ideological Surround Model of research in the psychology of religion. (shrink)

A Theory of Universal Democracy empowers cultures and communities across the world to custom design democracy in consonance with their traditional values. For example, the book makes concrete proposals for Muslim countries to democratize their constitutions without accepting Western values and without violating the principles of Islamic law. More importantly, Universal Democracy further develops the idea of Free State, which the author first presented in his previous book, The Extinction of Nation-States (Kluwer, 1996). The proposed fusion of Universal Democracy and (...) Free State is designed to revolutionize the classical theory of government and to offer a new paradigm that accommodates both universality and uniqueness. Scholars, teachers and students of international law, constitutional law, legal theory, and Islamic law will find this book a source of valuable ideas. (shrink)

Moral foundations theory provides a theoretical framework for understanding the universal and societal aspects of morality. The focus thus far has been on understanding the influence of group categories on moral foundations by controlling for relevant factors and then examining the unique contribution of a single factor. Although this type of analysis was critical to demonstrate the efficacy of the Moral Foundations Theory and Moral Foundations Questionnaire, the current study examines moral responses from the intersection of culture, ethnic identity and (...) gender group membership in the United States and India. Significant results suggest that moral foundations are better understood through a multiple group identity perspective and that the MFQ is equipped to capture differences in moral foundations within subgroups. (shrink)

Aesthetics of art and literature; articles.

It is no secret that one of the biggest public health challenges facing this nation is the obesity epidemic. Two-thirds of adults and one-third of children and teens are either obese or overweight. For adults, the number of obese has doubled since 1980, and for children age 6-11 the number of obese has quadrupled. The epidemic has changed what we thought we knew about medicine. For example, until fairly recently, type 2 diabetes was known as “adult-onset” diabetes. But doctors have (...) dropped this moniker as youth account for almost half of new type 2 diabetes in certain communities. Further, there has always been an assumption that life spans and health would improve with advancements in medicine and technology. However, obesity is related to over 20 major chronic diseases, and therefore obese children are more than twice as likely to die before the age of 55 compared to healthy-weight children. In other words, if trends are not reversed, America’s current generation of children are likely to have shorter life spans than their parents. (shrink)

Jensen’s inequality is one of the fundamental inequalities which has several applications in almost every field of science. In 2003, Mercer gave a variant of Jensen’s inequality which is known as Jensen–Mercer’s inequality. The purpose of this article is to propose new bounds for Csiszár and related divergences by means of Jensen–Mercer’s inequality. Also, we investigate several new bounds for Zipf–Mandelbrot entropy. The idea of this article may further stimulate research on information theory with the help of Jensen–Mercer’s inequality.

Code switching is defined as the use of two or more languages or varieties of language in conversation. It is a general phenomenon in Pakistani society. This research was conducted through a qualitative descriptive method; it produces descriptive data in the form of code switched sentences from editorial of Urdu newspaper. In this research paper I discussed code switching in editorial of an Urdu newspaper. Daily Khabrain Newspaper was selected for this purpose. One week newspapers were collected for research from (...) 1st January, 2020 to 7th January, 2020 to analyze code switching in editorial. In this research paper I discussed code switching in editorial of an Urdu newspaper. Aims and Objectives are; in this research paper I discussed code switching in editorial of an Urdu newspaper. Research Question was what type of code switching is in editorial in Daily Khabrain Newspaper? Daily Khabrain Newspaper from first January 2020 to 7th January 2020 was collected for the analysis of language or code switching and its type in editorial. Through the analysis of data of newspaper it can be concluded that the type of code switching was intra sentential, word code switching and total integrated Urdu. (shrink)

The expropriation of marginalized women’s labor is a key issue in business ethics in these times of global outsourcing and informal work arrangements. This has led to a transnational advocacy movement for securing the labor rights of homeworkers, who are poor women working on piece-rate contracts out of their homes. Drawing on materialist feminism, our paper critically explores the homeworker network in Pakistan, that was set up as part of a global push by international institutions and networks to localize the (...) issue across geographies. Our focus is the national women’s NGO that leads advocacy efforts on the issue in the country and its relationship with other actors. Through fieldwork spanning 3 years we find that the network employs a top-down ‘us versus them’ approach in advocacy and mobilization. The race-to-the-bottom between the network’s national and district-level actors for donor funding further undermines prospects for developing indigenous narratives of resistance. The network, while mission bound to enhance the collective agency of its constituency, has depoliticized what should have been a class-based feminist struggle. From a materialist perspective, we conclude that the NGOized network rests upon and feeds off of its constituency, creating an additional layer of primitive accumulation over the workers it represents. (shrink)

: The modern era may be deemed as that of scientific and technologicaldevelopment but peace and harmony among the people remain elusive. Thetwo world wars, Palestinian problem, bombing of world twin towers, invasionof Muslim countries by Americans and allied forces, and the continuous bloodshedding of humanity in one form or another in different parts of the world, allthese horrifying phenomena prove lack of political will on the part of UnitedNations. Had religions in the strife-torn regions played their crucial role, therewould (...) never have occurred bloodshed of the humanity. Judaism, Christianity,and Islam account for the big majority in the world today and have so manythings in common, especially essential human values guided by two universalprinciples, unity of God and unity of man. The Ten Commandments in theTorah, confirmation of the Mosaic Law in the Bible, and reconfirmation of theMosaic and Biblical instructions in the Qur’an still hold the significance forcreating peace and harmony among people of the three creeds. (shrink)

Jürgen Habermas’s theory of ‘discourse ethics’ has been an important source of inspiration for theories of deliberative democracy and is typically contrasted with agonistic conceptions of democracy represented by theorists such as Chantal Mouffe. In this article I show that this contrast is overstated. By focusing on the different philosophical traditions that underpin Mouffe’s and Habermas’s respective approaches, commentators have generally overlooked the political similarities between these thinkers. I examine Habermas’s and Mouffe’s respective conceptions of democratic politics and argue that (...) they cannot be so neatly distinguished from each other. I show that much of Mouffe’s criticism of Habermas’s theory does not hold up to careful scrutiny, and discourse ethics shares important points of similarity with her own democratic theory. By using critical republican theory to show the similarities in their work, I push beyond the agonistic versus deliberative debate, and show that at the heart of both of these approaches is a critical republican emphasis on the need for civic solidarity, on the constructive role of conflict in democratic politics and on the vital importance of self-government. These are crucial ingredients for the regeneration of democracy in contemporary pluralistic societies. (shrink)

This paper draws a correlation between processes of research and drawing by analyzing the formation of emotional content and stylistic representation in art. The paper suggests that research process fundamentally involves a systematic development of understanding on a particular issue through a process of rational inquiry. The research outcome or an intellectual understanding is therefore nothing more than a thoroughly investigated form of a hypothesis/ premise/ theory/ idea that has undergone a careful process of scrutiny, comparison and evaluation. On similar (...) grounds, drawing process also involves a systematic development of form in which adjustments are made with the help of nonverbal reasoning till the final form is evolved. The development of form in drawing becomes a systematic rational process but operates at a subconscious plane; reason is substituted by aesthetic sensibility. It is suggested that aesthetic sensibility is a judgment that the human mind tailors through the use of non-verbal criteria of evaluating the beautiful and ugly. The paper develops a theoretical model in the light of above and then applies it to analyze various drawing conventions used by Sadequain in figurative treatment. (shrink)

Our objective is to examine the effects of Big Five personality traits on ethical ideologies using a time-lagged design of 406 employees of higher education institutions in Pakistan. Based on low/high idealism versus relativism, we investigate the conceptual linkage between each of the personality traits and moral philosophy. The results illustrate that extraversion and openness to experience believed on subjectivism moral philosophy, agreeableness believed on situationism, and neuroticism believed on absolutism moral philosophies. In addition, contentiousness believed on exceptionism moral philosophy. (...) Furthermore, managerial implications and future research directions are suggested. (shrink)

This investigation examined Pakistani Muslim understandings of the animal sacrifice that occurs during Eid-ul-Adha at the end of the Hajj. Pakistani university students responded to a number of items expressing possible interpretations of this ritual. A Faithful Sacrifice factor operationalized sincere religious reasons for the sacrifice and correlated positively with an Intrinsic Religious Orientation and with Muslim Experiential Religiousness. Extrinsic and Troublesome Sacrifice factors recorded nonreligious implications of the practice and displayed direct associations with the Extrinsic Social Religious Orientation and (...) inverse linkages with Muslim Experiential Religiousness. Extrinsic Sacrifice also correlated negatively with the Intrinsic Orientation. These results further documented the complexity of Muslim beliefs and practices and once again illustrated how a dialectic between tradition-specific and more general social scientific perspectives can promote progress in the psychology of religion. (shrink)

On November 2019, the world commemorated the 30th anniversary of the United Nations’ Convention on the Rights of the Child. The UNCRC noted that “the press and other media have essential fu...

This article deals with the complex personality and legacy of a mysterious saint known both as a Sufī (Ḥājji Ratan) and a Nāth Yogī (Ratannāth) and links his multiple identity as well as the religious movement originated from him, to the specific cultural context of the former North-West Indian provinces. The first part is devoted to Ratan in the Nāth Yogī tradition, the second to his many facets in the Muslim tradition, in connection with his dargāh in the Panjabi town (...) of Bhatinda. The third and main part explores a particular movement, the Har Śri Nāth tradition. Presently centered around a “ dargāh mandir ” in Delhi, this movement, with its two branches issued from Ratan and from his “son” Kāyānāth, was rooted in what is now Pakistan. The influence of location and history has led to many peculiarities which lead us to stress the blurred boundaries between Islam and Hinduism and the essential part played by charismatic figures in the construction of religious identities. (shrink)