In nature, cells face a variety of stresses that cause physical damage to the plasma membrane and cell wall. It is well established that evolutionarily conserved cell cycle checkpoints monitor various cellular perturbations, including DNA damage and spindle misalignment. However, the ability of these cell cycle checkpoints to sense a damaged plasma membrane/cell wall is poorly understood. To the best of our knowledge, our recent paper described the first example of such a checkpoint, using budding yeast as a model. In (...) this review, we will discuss this important question as well as provide hypothetical explanations to be tested in the future. (shrink)

“Myth” comprises the first chapter of the book, The Logic of the Imagination, by Miki Kiyoshi.In this chapter Miki analyzes the significance of myth (shinwa) as possessing a certain reality despite being “fictions.” He begins by broadening the meaning of the imagination to argue for a logic of the imagination that involves expressive action or poiesis (production) in general, of which myth is one important product. The imagination gathers in myth material from the environing world lived by the social (...) collectivity. Its formation of images (Bilder) expresses the pathos of a people vis-a-vis their environment, but myth also contains elements of logos in the form of intellectual representations and figures. And their combination becomes expressed externally by stimulating and guiding action. In this way Miki argues that myths contain both emotive and kinetic elements, which by moving people to action, are capable of making history. Thus rooted in the symbiosis between individual and social and between society and environment, myth possesses a “historical creativity.” And he also argues that myths can be present with a sense of reality at any epoch in history, even today, wherever and whenever their primeval power is felt to function, “drawing out” a new reality, a new world, out of the natural world. (shrink)

“Myth” comprises the first chapter of the book, The Logic of the Imagination, by Miki Kiyoshi. In this chapter Miki analyzes the significance of myth (shinwa) as possessing a certain reality despite being “fictions.” He begins by broadening the meaning of the imagination to argue for a logic of the imagination that involves expressive action or poiesis (production) in general, of which myth is one important product. The imagination gathers in myth material from the environing world lived by the (...) social collectivity. Its formation of images (Bilder) expresses the pathos of a people vis-à-vis their environment, but myth also contains elements of logos in the form of intellectual representations and figures. And their combination becomes expressed externally by stimulating and guiding action. In this way Miki argues that myths contain both emotive and kinetic elements, which by moving people to action, are capable of making history. Thus rooted in the symbiosis between individual and social and between society and environment, myth possesses a “historical creativity.” And he also argues that myths can be present with a sense of reality at any epoch in history, even today, wherever and whenever their primeval power is felt to function, “drawing out” a new reality, a new world, out of the natural world. (shrink)

The members of the Six gene family were identified as homologues of Drosophila sine oculis which is essential for compound-eye formation. The Six proteins are characterized by the Six domain and the Six-type homeodomain, both of which are essential for specific DNA binding and for cooperative interactions with Eya proteins. Mammals possess six Six genes which can be subdivided into three subclasses, and mutations of Six genes have been identified in human genetic disorders. Characterization of Six genes from various animal (...) phyla revealed the antiquity of this gene family and roles of its members in several different developmental contexts. Some members retain conserved roles as components of the Pax-Six-Eya-Dach regulatory network, which may have been established in the common ancestor of all bilaterians as a toolbox controlling cell proliferation and cell movement during embryogenesis. Gene duplications and cis-regulatory changes may have provided a basis for diverse functions of Six genes in different animal lineages. (shrink)

The lifeworld is, according to Husserl, the horizon of all our experiences, in the sense that it is the background environment of human being’s competences, practices, and attitudes. The lifeworld is the intersubjective, pre-given in the ontic sense, and immediately perceived world of everyday life. Although Husserl has distinguished the lifeworld from the objective world that natural science describes with mathematical methods, we cannot divide the world on the practical level into the perceived world of ordinary life and the scientific (...) world. The characteristic of human beings is that they live in the environment which they have enormously changed. Modern science has accelerated this tendency: the contemporary world is constructed so deeply scientifically and technologically. Accordingly, as Ulrich Beck pointed out, the risk of the technologically constructed world is often invisible/unperceivable. The disaster at Fukushima nuclear power plants is a terrible testament of this kind of risk. In order for a land to become the lifeworld of meaningful human interactions, the land should be first of all safe and livable for all of us. The risk calculation made by Tokyo Electric Power Company was shown to be sloppy and deceptive. The contemporary techno-science should be democratically governed and watched by all kinds of stakeholders, and never be left it to the specialists of science. For re-establishing the livable and sustainable lifeworld, safety, resilience, and vulnerability should be the fundamental values. And, the autonomy of the local residents, including the most vulnerable people, through the democratization of the techno-science must be the fundamental value to establish and protect such a safe environment. (shrink)

古代西洋より伝わったとされる対称美の分析―黄金比。しかし、本書では葛飾北斎、歌川広重など偉大な日本の先人たちはすでに、黄金比を会得していたことを証明しています。なぜ、北斎がすばらしいのか?なぜ、俳句は 5・7・5なのか?富士山はどの角度から眺めるのが一番美しいのか?すべては黄金比を使い、美の世界を数値化することで見える新たな世界。初めて黄金比を用い、実例を分析した本書は日本初の試み。.

Diese Abhandlung verteidigt gegen die heute vorherrschenden realistischen Interpretationen des kantischen transzendentalen Idealismus eine anti-realistische Zwei-Welten-Interpretation. Durch konkrete Textanalysen wird gezeigt, dass die realistische Interpretation an der Antinomienlehre und dem vierten Paralogismus (A) scheitern muss, während die anti-realistische Interpretation erlaubt, die Kritik der reinen Vernunft im Ganzen zu einer kohärenten Sinneinheit zu strukturieren. Anschließend wird der konkrete Gehalt von Kants anti-realistischer Ontologie der raumzeitlichen Wirklichkeit erhellt. Dafür entwickelt der Verfasser eine intuitionistische Wahrheitskonzeption (ein empirisches Gegenstück der Wahrheitskonzeption des mathematischen Intuitionismus), (...) kombiniert mit der Superassertibilität à la Crispin Wright. Die von Michael Dummett bereit gestellte Begrifflichkeit "Realismus/Anti-Realismus‟ erweist sich als fruchtbar nicht nur für die Analyse der kantischen Position selbst, sondern auch für ein klares Verständnis der mannigfaltigen Interpretationsansätze des transzendentalen Idealismus. (shrink)

Since the 1980s, a number of discourses have celebrated the coming of the information society in Japan. In those discourses, enabling media interactivity has been emphasized as the objective of technological innovations, creating a sort of `myth' of media interactivity. This article tries to investigate the close relationship between media interactivity and surveillance modality in newly emergent information and communication technologies, especially SNS (social networking services) on the Internet. While the traditional image of surveillance society is gloomy and repressive, contemporary, (...) ubiquitous surveillance appears brighter and more fun, since people voluntarily engage with interactive media whilst acknowledging its surveillance modality. In that sense, the logic of surveillance is not merely repressive but also seductive for users of interactive media. Given the rising desire for public security after 9/11, the logic of surveillance is becoming more prevalent and dominant all over the world. With the rise of globalized security, philosophical and social scientific interrogations of security-obsessed contemporary society have become indispensable for critical academic discourse. In order to critically interrogate rising surveillance and media interactivity, this article tries to analyze the liberating potentials of the ideal of hospitality, which is expected to offer a counter-logic against surveillance. (shrink)

Quantum Systems in Chemistry and Physics: Progress in Methods and Applications is a collection of 33 selected papers from the scientific contributions presented at the 16th International Workshop on Quantum Systems in Chemistry and Physics (QSCP-XVI), held at Ishikawa Prefecture Museum of Art in Kanazawa, Japan, from September 11th to 17th, 2011. The volume discusses the state of the art, new trends, and the future of methods in molecular quantum mechanics and their applications to a wide range of problems in (...) physics, chemistry, and biology. The breadth and depth of the scientific topics discussed during QSCP-XVI appears in the classification of the contributions in six parts: I. Fundamental Theory II. Molecular Processes III. Molecular Structure IV. Molecular Properties V. Condensed Matter VI. Biosystems. Quantum Systems in Chemistry and Physics: Progress in Methods and Applications is written for advanced graduate students as well as for professionals in theoretical chemical physics and physical chemistry. The book covers current scientific topics in molecular, nano, material, and bio sciences and provides insights into methodological developments and applications of quantum theory in physics, chemistry, and biology that have become feasible at end of 2011. (shrink)

Vertebrate haemoglobin (Hb), the oxygen‐carrying protein of the blood, consists of two α‐ and two β‐subunits, each containing one haem, and shows cooperative oxygen binding known as the haem–haem interaction. The amino‐acid sequences of Hbs found in different species have diverged considerably and the homology in the most distantly related ones is only 40%. How can such varied amino‐acid sequences give rise to similar three‐dimensional structures and functional properties? To what extent do amino‐acid replacements affect the structure of haemoglobin? Which (...) mutations are responsible for the functional differences between haemoglobins from different species? Expression of α‐ and β‐globins in Escherichia coli has enabled us to introduce any mutations in the haemoglobin molecule at will. By X‐ray crystallographic and functional studies of the engineered mutants, we are trying to answer these questions. (shrink)

PurposeThis paper aims to deal with the attitudes towards and social impact of Edward Snowden’s revelations in Japan, taking the Japanese socio-cultural and political environment surrounding privacy and state surveillance into account.Design/methodology/approachA questionnaire survey of 1,820 university students and semi-structured follow-up interviews with 56 respondents were conducted, in addition to reviews of the literature on privacy and state surveillance in Japan. The outcomes of the survey were statistically analysed, and qualitative analyses of the interview results were also performed.FindingsSnowden’s revelations have (...) had little influence over Japanese youngsters’ attitudes towards privacy and state surveillance, mainly due to their low level of awareness of the revelations and high level of confidence in government agencies.Practical implicationsThe study results imply a need for reviewing educational programmes for civic education in lower and upper secondary education.Social implicationsThe results of this study based on a large-scale questionnaire survey indicate an urgent necessity for providing Japanese youngsters with opportunities to learn more about privacy, liberty, individual autonomy and national security.Originality/valueThis study is the first attempt to investigate the social impact of Snowden’s revelations on Japanese youngsters’ attitudes towards privacy and state surveillance as part of cross-cultural analyses between eight countries. (shrink)