While the research programs in early cognitive science and artificial intelligence aimed to articulate what cognition was in ideal terms, much research in contemporary computational neuroscience looks at how and why brains fail to function as they should ideally. This focus on impairment affects how we understand David Marr's hypothesized three levels of understanding. In this essay, we suggest some refinements to Marr's distinctions using a population activity model of cortico-striatal circuitry exploring impulsivity and behavioral inhibition as a case study. (...) In particular, we urge that Marr's computational level should be redefined to include a description of how systems break down. We also underscore that feed-forward processing, cognition disconnected from behavioral context, and representations do not always drive cognition in the way that Marr originally assumed. (shrink)

We present a population density and moment-based description of the stochastic dynamics of domain $${\text{Ca}}^{2+}$$ -mediated inactivation of L-type $${\text{Ca}}^{2+}$$ channels. Our approach accounts for the effect of heterogeneity of local $${\text{Ca}}^{2+}$$ signals on whole cell $${\text{Ca}}^{2+}$$ currents; however, in contrast with prior work, e.g., Sherman et al. :985–995, 1990), we do not assume that $${\text{Ca}}^{2+}$$ domain formation and collapse are fast compared to channel gating. We demonstrate the population density and moment-based modeling approaches using a 12-state Markov chain model (...) of an L-type $${\text{Ca}}^{2+}$$ channel introduced by Greenstein and Winslow :2918–2945, 2002). Simulated whole cell voltage clamp responses yield an inactivation function for the whole cell $${\text{Ca}}^{2+}$$ current that agrees with the traditional approach when domain dynamics are fast. We analyze the voltage-dependence of $${\text{Ca}}^{2+}$$ inactivation that may occur via slow heterogeneous domain [ $${\text{Ca}}^{2+}$$ ]. Next, we find that when channel permeability is held constant, $${\text{Ca}}^{2+}$$ -mediated inactivation of L-type channels increases as the domain time constant increases, because a slow domain collapse rate leads to increased mean domain [ $${\text{Ca}}^{2+}$$ ] near open channels; conversely, when the maximum domain [ $${\text{Ca}}^{2+}$$ ] is held constant, inactivation decreases as the domain time constant increases. Comparison of simulation results using population densities and moment equations confirms the computational efficiency of the moment-based approach, and enables the validation of two distinct methods of truncating and closing the open system of moment equations. In general, a slow domain time constant requires higher order moment truncation for agreement between moment-based and population density simulations. (shrink)

We describe a simple, flexible exercise that can be implemented in the philosophy of science classroom: students are asked to determine the contents of a closed container without opening it. This exercise has revealed itself as a useful platform from which to examine a wide range of issues in the philosophy of science and may, we suggest, even help us think about improving the public understanding of science.

Anthony Giddens’ theory of structuration is a theory of social action, which claims that society should be understood in terms of action and structure; a duality rather than two separate entities. This paper introduces some of the central characteristics of structuration theory, presenting a conceptual framework that helps to explore how people produce the systems and structures that shape their practice. By understanding how people produce and reproduce structures, then there is the potential for changing them. Criticisms that have been (...) raised about the theory are introduced, followed by examples of how the theory might be useful to nursing research. Structuration theory can be employed to explore how nurses produce, reproduce, and transform nursing practice through social interaction across time and space. (shrink)

This paper provides new insights into the food security performance of long and short food chains, through an analysis of the resilience of such chains during the severe weather events that occurred in the Australian State of Queensland in early 2011. Widespread flooding cut roads and highways, isolated towns, and resulted in the deaths of people and animals. Farmlands were inundated and there were food shortages in many towns. We found clear evidence that the supermarket-based food chain delivery system experienced (...) significant difficulties in supplying food to flood-affected towns. In contrast, more localized food supply chains—which relied upon supply from growers in peri-urban areas and community-based food initiatives—remained largely intact, and provided food at a time when the supermarkets were limited in their ability to respond to consumer demand. However, on closer examination of food distribution during flooding in the regional city of Rockhampton and in the State capital, Brisbane, the demarcation of success between “long” and “short” food chains became blurred. Both types of food supply chains shared some key resilience characteristics in responding to crisis but diverged in other important ways. We argue that conceptualizing food chains in terms of key elements of resilience—scale, diversity, flexibility and cohesion—may be more fruitful than the short-long dichotomy alone. This approach is particularly useful when prioritizing food security as the basis for evaluating food system sustainability in a context of predicted increases in extreme weather events and future climate change. (shrink)

or Browse over 3500 reviews in " by Valerie Hardcastle, Ph.D. " _Metapsychology_.

This book is perhaps the first to open a dialogue between the two disciplines.

In 2020, the International Association for the Study of Pain (IASP) changed its definition of pain to just an "an unpleasant sensory and emotional experience. " Since then, several philosophers have attempted to reaffirm the impossibility of reducing pain to neurobiology from a variety of approaches, including eliminativism, multiple realizability, and intersubjectivity. All of their arguments assume that there are no specific biomarkers for pain. I adumbrate a more ecumenical path: that while these approaches have some merit, they also misstate (...) how brains function. Once we shift our view regarding how brains operate, then pain processing is just as "mysterious" as other types of complex brain processes. (shrink)

In this article, I argue that as we learn more about how we might intervene in the brain in ways that impact human behavior, the scope of what counts as “moral behavior” becomes smaller and smaller because things we successfully manipulate using evidence-based science are often things that fall outside the sphere of morality. Consequently, the argument that we are morally obligated to morally enhance our neighbors starts to fall apart, not because humans should be free to make terrible choices, (...) but because morality is not something subject to such manipulation. To illustrate my argument, I shall use the rise of veteran diversion courts in the United States as a putative instance of an intervention designed to change human behavior for the better. Part of my purpose in working my way through this case study is to demonstrate that many philosophers have the psychology of immoral action wrong. (shrink)

Although Redish et al. have pulled together a large number of approaches to understanding decision-making and common errors in cognition, they have outlined neither the necessary nor the sufficient attributes of addiction. They are correct in claiming that addiction is multifaceted and probably more akin to a syndrome than a genuine disease. But grasping what that multifaceted syndrome is still eludes us.

"An essential overview of an important intellectual movement, Logical Empiricism in North America offers the first significant, sustained, and multidisciplinary attempt to understand the intellectual, cultural, and political dimensions of ...

An account of scientific explanation is presented according to which (1) scientific explanation consists in solving “insight” problems (Metcalfe and Wiebe 1984) and (2) understanding is the result of solving such problems. The theory is pragmatic; it draws upon van Fraassen’s (1977, 1980) insights, avoids the objections to pragmatic accounts offered by Kitcher and Salmon (1987), and relates scientific explanation directly to understanding. The theory also accommodates cases of explanatory asymmetry and intuitively legitimate rejections of explanation requests.

In this essay, we present three case studies which suggest that sometimes we are better off supporting a so–called irrational suicide, and that emotional or psychological distress – even if medically controllable – might justify a suicide. We underscore how complicated these decisions are and how murky a physician's moral role can be. We advocate a more individualized route to end–of–life care, eschewing well–meaning, principled, generalizations in favor of a highly contextualized, patient–centered, approach. We conclude that our Western traditions of (...) promoting reasoned behavior and life themselves may at times be counter–productive. (shrink)

In this essay, I hope to make clearer what the points of division between the materialists and the sceptics are. I argue that the rifts are quite deep and turn on basic differences in understanding the scientific enterprise. In section I, I outline the disagreements between David Chalmers and me, arguing that consciousness is not a brute fact about the world. In section II, I point out the fundamental difference between the materialists and the sceptics, suggesting that this difference is (...) not something that further discussion or argumentation can overcome. In the final section, I outline one view of scientific explanation and conclude that the source of conflict really turns on a difference in the rules each side has adopted in playing the game. (shrink)

Heath care and public health are typically conceptualized as separate, albeit overlapping, systems. Health care’s goal is the improvement of individual patient outcomes through the provision of medical services. In contrast, public health is devoted to improving health outcomes in the population as a whole through health promotion and disease prevention. Health care services receive the bulk of funding and political support, while public health is chronically starved of resources. In order to reduce morbidity and mortality, policymakers must shift their (...) attention to public health services and to the improved integration of health care and public health. In other words, health care and public health should be treated as two parts of a single integrated health system. Furthermore, in order to maximize improvements in health status, policymakers must consider the impact of all governmental policies on health. (shrink)

Some theorists have argued that we should understand the notion of free will from a functional perspective: free will just is our ability to choose effectively and adaptively in an ever-changing environment. Although far from what many philosophers normally mean by free will, those who adopt this biological-evolutionary perspective can clearly define and defend a notion of personal responsibility. One consequenceof this point of view is that addicts become responsible for their actions, for at each choice point, there is a (...) real sense in which the addict could have elected not to use or abuse. As a result, it has been argued that addiction is not a disease, that addictive behavior is voluntary, and that sometimes it is even rational. This paper defends a different way of thinking about addiction, one that aligns it with other complex chronic illnesses. The perspective put forth here suggests that these discussions about responsibility and free will represent an over-simplified and neuropsychologically inaccurate portrait of basic human capacities for behavioral choice. (shrink)

What is required to be an interdisciplinary theory in cognitive science is for it to span more than one traditional domain. Generally speaking, as I discuss ...

Despite influencing the social sciences since the 1930s, S. S. Stevens' "operationist" philosophy of science has yet to be adequately understood. I reconstruct Stevens' operationism from his early work and assess the influence of various views (logical positivism, behaviorism and the "operational viewpoint" of P. W. Bridgman, among others) on Stevens. Stevens' operationism emerges, on my reconstruction, as a naturalistic methodological directive aimed at agreement, founded in turn on the belief that agreement is constitutive of science, the scientific community, and (...) objectivity. Further, I show that operationism is historically and philosophically independent of the views mentioned above. (shrink)

There is a bias in neuroscience toward localizing and modularizing brain functions. Single cell recording, imaging studies, and the study of neurological deficits all feed into the Gallian view that different brain areas do different things and the things being done are confined to particular processing streams. At the same time, there is a growing sentiment that brains probably don’t work like that after all; it is better to conceive of them as fundamentally distributed units, multi‐tasking at every level. This (...) sentiment, however, is much less congenial to the tried‐and‐true experimental protocols available today and to theorizing about the brain in general. This essay examines the tension between current experimental methods and large-scale views of the brain. We argue that this disconnection between experiment and what really are guiding theoretical metaphors seriously impedes progress in neuroscience. (shrink)

O'Regan & Noë mistakenly identify visual processing with visual experience. I outline some reasons why this is a mistake, taking my data and arguments mainly from the literature on subliminal processing.

Newly developed Bayesian perspectives on schizophrenia hold out the promise that a common underlying mechanism can account for many, if not all, of the positive symptoms of schizophrenia. If this is the case, then understanding how schizophrenic minds go awry could shine light on how healthy minds maintain a sense of self. This article investigates this Bayesian promise by examining whether the approach can indeed account for the difficulties with self-awareness experienced in schizophrenia. While I conclude that it cannot, I (...) nonetheless maintain that understanding how the self breaks down in schizophrenia tells us much about how and why the self functions in normal human circumstances. I proceed first by recounting in some detail a Bayesian interpretation of perception, schizophrenia, and self-awareness, as well as some of the empirical data supporting this interpretation, then by exploring aspects of schizophrenia that this approach leaves out. I conclude by discussing what the “left out” aspects tell us about self-awareness, thereby convincing the reader that studying patients with schizophrenia is indeed a useful avenue for understanding awareness of self. (shrink)

Fred Suppe claims that the refereed journal article is an appropriate unit of scientific debate for philosophical analysis. He also claims that when we regiment scientific papers correctly, we can see that the hypothetico-deductive method, Baysian induction, and inference to the best explanation fail to capture the structure of scientific articles adequately. In what follows I demonstrate that the coding scheme Suppe used for uncovering the structure of a scientific paper is not appropriate under all circumstances, illustrate alternative structures found (...) in various scientific articles, and show that the hypothetico-deductive method can accommodate the alternative structures I find. My conclusions are that the article that Suppe analyzed is not paradigmatic of published scientific articles, that different papers have different structures, that the structure depends upon the rhetorical goals of the article, and that, because of the different structures and different goals, no one philosophical account of testing is going to suffice. (shrink)

Connectionist views in psychology and neuroscience give the impression that there is no one place in the brain into which all information funnels. If these impression are accurate, then we will have great difficulty picking out a point in neuronal or psychological time at which phenomena become conscious. If so, pointing to one place in which we are conscious of a particular event and expecting a psychophysical correlation between qualitative and neural events seems hopeless. In response to this worry, I (...) argue that ERP research can bridge the psychology and neuroscience such that we can identify when qualitative experiences occur relative to other cognitive events. I present data suggesting that accessing an early implicit priming system gives rise to a qualitatively different kind of ERP wave than does accessing a later episodic memory system. These results illustrate how it is possible to parse psychological events finely enough in (neuro-)psychological investigations in order to determine when particular psychological events occur in the head. So, if we could align consciousness with some psychological event, then we should be able to articulate when that event occurs in the processing stream (relative to other events) as long as that event can be correlated with some ERP waveform. (shrink)

Helen Neville has gathered ERP data suggesting that accessing an “implicit” memory system produces a qualitatively different kind of ERP wave than does accessing our “explicit” conscious memory system. These results corroborate the hypothesis that an early anterior priming effect indexes activity of a system specialized for words, while a later posterior priming effect indexes access to general, episodic representations of words. Moreover, she saw no effects in the masked paradigms using pseudo-words, further supporting the notion of an early lexicon. (...) However, we might not see any effects because the tasks use stimuli too complicated for an early automatic system to encode rapidly. Hence, masked priming effects for novel stimuli might be seen immediately with very simple input patterns. The following series of experiments was designed to test this hypothesis, as well as to try to differentiate the supposed early lexicon from other sorts of early access memory systems and to characterize more fully the capabilities of these early systems. In particular, ERP waveforms are compared for unmasked and masked priming conditions using simple 5-line visual patterns in experiments requiring subjects to make rapid decisions concerning the physical structure of the shapes. (shrink)

This chapter contains sections titled: Abstract Introduction The Inscrutability of Objectual Reference Empiricism, Naturalism, and Provincialism References.

This paper challenges a central tenet of constructive empiricism, namely that empirical adequacy has a privileged epistemic status. I argue that perceptions of observables are theory-wrought, and theory-wrought in the same ways as the observation sentences we use to describe those perceptions, van Fraassen can draw no privileged or fundamental distinction between what we observe and interpreting those observations through theory. Since empirical adequacy depends upon accurately describing what we observe, and we have no theory-independent reason to believe that what (...) we ‘observe’ is a reflection of what is true, then empirical adequacy can inherit no special connection to what is real via what we observe. The epistemological significance of empirical adequacy is thereby reduced. (shrink)

Spelling out in detail what we do and do not know about phenomenological experience, this book denies the common view of consciousness as a central decision...

In this essay, I home in on the difficulties with group-to-individual (G2i) inferences in neuroscience and how they impact the legal system. I briefly outline how cognitive shortcutting can distort legal decisions, and then turn my attention to G2i inferences, with a special focus on issues of intellectual disability and brain damage. I argue that judges and juries are not situated to appreciate the nuances in brain data and that they are required to make clinical decisions without clinical training. As (...) a result, they effectively ignore those responsibilities and simply decide cases in virtue of what they already believe to be true. How judges actually make decisions in highstakes criminal cases is troubling, but they are also hamstrung in a variety of ways. (shrink)

Given what we know about the segregated nature of the brain and the relative absence of multi-modal association areas in the cortex, how percepts become unified is not clear. However, if we could work out how and where the brain joins together segregated outputs, we would have a start in localizing the neuronal processes that correlate with conscious perceptual experiences. In this essay, I critically examine data relevant for understanding the neurophysiological underpinnings of perception. In particular, I examine the possibility (...) that 40 Hz. oscillatory firing patterns in cortex are important lower-level neuronal events related to perceptual experiences. I suggest that `binding' - understood as a process of hooking together disparate psychological units - reduces to a property inherent in the structure of our brain's firing patterns. However, this reduction may not reflect the firing rates of individual cells, but instead a `higher level' order superimposed on individual cells' activity. (shrink)

Evolutionary biologists who are also naturalists believe that natural selection is a purely causal interaction that follows basic rules discovered and understood by science. Hence, they believe that the evolution of humans from other organisms has a purely natural story that is really no different in kind from any other scientific account of the appearance and evolution of any other entity or process. However, a majority of the general population in the United States believes that the evolution of humans in (...) fact requires supernatural intervention. This chapter takes a brief look at the history of the Western conflict between evolutionary biology and Christianity and then examines a contemporary argument for why hypothesizing the creation of humans without also positing the existence of some supernatural being is a mistake. It closes by recounting the most recent skirmishes in the United States regarding how evolution should be articulated and understood in the public arena, and tries to answer the question of whether or not evolution is a scientific theory. (shrink)

The data discussed strongly suggest that neural imaging does not unduly sway judges and jurors; in fact, it is often counterproductive. The percentage of appellate cases in which the decision was favorable to defendants with brain scan data mirrored those of decisions without such proffered evidence. Moreover, fully two-thirds of the scans admitted were either inconclusive or showed normal brain structures. In decisions referencing brain scans, judges mentioned defendant behavior significantly more often than they referred to the defendant’s brain. Finally, (...) in the actual decisions themselves, judges often ignored relevant imaging data in favor of case precedent or misinterpreted the data so that they would fit with the judges’ initial reactions and opinions. (shrink)