Much of what we need to plan for our survival is already known, but what we know, how we know, and who knows is divided up between disciplines. Thus much of the problem of ensuring our survival is a matter of learning across the disciplines. We identify four modes through which we bring disciplinary knowledge together: the unity of science, integrated assessment, heuristic models, and distributed learning networks. Although none of them are perfect, we can learn how to put our (...) knowledge together across the disciplines much better than we do. (shrink)

In this essay, I argue for four related claims. First, Richard Levins’ classic “The Strategy of Model Building in Population Biology” was a statement and defense of theoretical population biology growing out of collaborations between Robert MacArthur, Richard Lewontin, E. O. Wilson, and others. Second, I argue that the essay served as a response to the rise of systems ecology especially as pioneered by Kenneth Watt. Third, the arguments offered by Levins against systems ecology and in favor of (...) his own methodological program are best construed as “pragmatic”. Fourth, I consider limitations of Levins’ arguments given contemporary population biology. (shrink)

Evolutionary processes such as natural selection and random drift are commonly regarded as causes of population-level change. We respond to a recent challenge that drift and selection are best understood as statistical trends, not causes. Our reply appeals to manipulation as a strategy for uncovering causal relationships: if you can systematically manipulate variable A to bring about a change in variable B, then A is a cause of B. We argue that selection and drift can be systematically manipulated to produce (...) different kinds of population-level change. They should therefore be regarded as causes. (shrink)

The three classic regress problems (the Extensive Regress of states, the Intensive Regress of contents, and the Fichte-Henrich-Shoemaker Regress of de se beliefs) related to the Self-Awareness Thesis (that one’s conscious states are the ones that one is aware of being in) can all be elegantly resolved by a self-acquaintance postulate. This resolution, however, entails that consciousness has an irreducibly circular structure and that self-acquaintance should not be conceived of in terms of an independent entity bearing an external or mediated (...) relation to itself but rather in terms of a realized relation-instance relating to itself as well as to something other than itself. Consciousness, on this account, has a categorially curious status. It is like a relation-particular hybrid. This can be formalized in terms of the theory of hypersets, which in turn can be used to elucidate the problem of individuality, one source of the conceptual difficulty with adequately characterizing de se content. (shrink)

The Systematicity Arguments is the only book-length treatment of the systematicity and productivity arguments.

This essay looks at the concept of AKEDAH, the essence of which is the travail of the human condition and the trust in vindication and victory, as a salient and deep metaphor for bioethics. The author first delineates the symbol, then shows its theological and ethical significance, and finally suggests its bioethical applications.The LORD said, “Go get Isaac, your only son, the one you dearly love! Take him to the land of Moriah, and I will show you a mountain where (...) you must sacrifice him to me on the fires of an altar.” So Abraham got up early the next morning and chopped wood for the fire. He put a saddle on his donkey and left with Isaac and two servants for the place where God had told him to go.Genesis 22There is silence all around. The Baptist appears, and cries: “Repent, for the Kingdom of Heaven is at hand.” Soon after that comes Jesus, and in the knowledge that He is the coming Son of Man lays hold of the wheel of the world to set it moving on that last revolution which is to bring all ordinary history to a close. It refuses to turn, and He throws Himself upon it. Then it does turn; and crushes Him. The wheel rolls onward, and the mangled body of the one immeasurably great Man, who was strong enough to think of Himself as the spiritual ruler of mankind and to bend history to His purpose, is hanging upon it still. That is His victory and His reign. (shrink)

This article considers claims that biology should seek general theories similar to those found in physics but argues for an alternative framework for biological theories as collections of prototypical interlevel models that can be extrapolated by analogy to different organisms. This position is exemplified in the development of the Hodgkin‐Huxley giant squid model for action potentials, which uses equations in specialized ways. This model is viewed as an “emergent unifier.” Such unifiers, which require various simplifications, involve the types of heuristics (...) discussed in Wimsatt’s writings on reduction, but with a twist. Here, the heuristics are used to generate emergent rather than reductive explanations. †To contact the author, please write to: Department of History and Philosophy of Science, University of Pittsburgh, 1017 Cathedral of Learning, Pittsburgh, PA 15260; e‐mail: [email protected]. (shrink)

I have argued in other work that emotion, attentional functions, and executive functions are three interpenetrant global state variables, essentially differential slices of the consciousness pie. This paper will outline the columnar architecture and connectivities of the PAG (periaqueductal gray), its role in organizing prototype states of emotion, and the re-entry of PAG with the extended reticular thalamic activating system (“ERTAS”). At the end we will outline some potential implications of these connectivities for possible functional correlates of PAG networks that (...) are just starting to be mapped. Overall, we will look at many lines of evidence that PAG should be conceptualized as a peri-reticular structure that has a foundational role in emotion, in generating the meaningful organization of behavior by the brain through prototype emotional states, and in allowing the various emotional systems to globally influence and tune both the forebrain and brainstem. Finally, we address implications of these concepts for what is currently understood about consciousness, underlining the need for somewhat more humility within consciousness studies about our current level of understanding of consciousness in the brain, combined with a deeper appreciation of the intrinsic connections between emotion and consciousness. One hopes that more concerted empirical interest in structures underneath the thalamus, combined with a deeper appreciation for the fundamental role that organismic and social value must have in bootstrapping awareness in the developing brain, would begin more widely to influence the fundamental lines of neuroscientific research in both emotion studies and consciousness studies. (shrink)

In the summer of 1998, the Wisconsin State legislature amended its child protection laws. Under new child abuse provisions, Wisconsin judges can confine pregnant women who abuse alcohol or drugs for the duration of their pregnancies. South Dakota enacted similar legislation almost simultaneously. The South Dakota statute requires mandatory drug and alcohol treatment for pregnant women who abuse those substances and classifies such activity as child abuse. In addition, the South Dakota legislation gives relatives the power to commit pregnant women (...) involuntarily for two days; a court order can place the pregnant women in custody for up to nine months. These recent legislative “successes” follow scores of failed attempts by legislators in other states to establish fetal protection laws aimed at women who use and abuse drugs and alcohol during pregnancy. (shrink)

The presence of a human being/organism—a living human ‘whole’, with the defining tendency to promote its own welfare—has value in itself, as do the functions which compose it. Life is inseparable from health, since without some degree of healthy functionality the living whole would not exist. The value of life differs both within a single life and between lives. As with any other form of human flourishing, the value of life-and-health must be distinguished from the moral importance of human beings: (...) less fulfilled means not less important morally, but more in need of being fulfilled. That said, to say that life and health has value is not to say exactly what—if anything—that value requires by way of active promotion at a given time. Many factors must be taken into account in making health care decisions, even if the worth of all lives, and the dignity of all human beings, must in every case be acknowledged. (shrink)

Characterizations of the Anthropocene often indicate both the challenges that our new epoch poses for human well-being and a sense of loss that comes from a compromised environment. In this paper I explore a deeper problem underpinning both issues, namely, that decoupling humanity from the world with which we are familiar compromises human flourishing. The environmental conditions characteristic of the Anthropocene do so, I claim, by compromising flourishing on two fronts. First, the comparatively novel conditions of the Anthropocene risk rupturing (...) our narratives, putting at risk our sense of self and connections to familiar environments. Second, by undermining the connections between our environmental background and the sense of well-being conditioned by that background our ability to exercise options that constitute a recognizable good life are compromised. This paper argues that to the extent humanity is decoupled from their environments humans are not only less able to access opportunities our understanding of who we are, our identities, and our capacity to make sense of the world around us through those identities is compromised. I conclude that the Anthropocene does more than challenge our ability to utilize resources, it challenges our understanding of who we are in the world. (shrink)

This lucid and wide-ranging volume constitutes a self-contained introduction to the elements and key issues of the philosophy of language.

Despite the considerable attention that the systematicity argument has enjoyed, it is worthwhile examining the argument within the context of similar explanatory arguments from the history of science. This kind of analysis helps show that Connectionism, qua Connectionism, really does not have an explanation of systematicity. Second, and more surprisingly, one finds that the systematicity argument sets such a high explanatory standard that not even Classicism can explain the systematicity of thought.

_The Ethics of Pregnancy, Abortion and Childbirth_ addresses the unique moral questions raised by pregnancy and its intimate bodily nature. From assisted reproduction to abortion and ‘vital conflict’ resolution to more everyday concerns of the pregnant woman, this book argues for pregnancy as a close human relationship with the woman as guardian or custodian. Four approaches to pregnancy are explored: ‘uni-personal’, ‘neighborly’, ‘maternal’ and ‘spousal’. The author challenges not only the view that there is only one moral subject to consider (...) in pregnancy, but also the idea that the location of the fetus lacks all inherent, unique significance. It is argued that the pregnant woman is not a mere ‘neighbor’ or helpful stranger to the fetus but is rather already in a real familial relationship bringing real familial rights and obligations. If the status of the fetus is conclusive for at least some moral questions raised by pregnancy, so too are facts about its bodily relationship with, and presence in, the woman who supports it. This lucid, accessible and original book explores fundamental ethical issues in a rich and often neglected area of philosophy in ways of interest also to those from other disciplines. (shrink)

Within the philosophy of sport, the phenomenon of practising has received very little attention, whereas other related aspects of sport such as excellence and competition have been subjected to many and thorough studies. This essay will attempt to clarify this particular phenomenon of practising through the notion of athletic ascetics, which will be analysed as a special variant of askēsis. Drawing especially on Foucault’s lectures on ascetics in ancient philosophy and Sloterdijk’s anthropology of the practising life, the essay outlines and (...) interrogates the potential relevance of an ascetological understanding of sport. Through both descriptive and normative analysis, it is argued that athletic ascetics can refine our understanding of performance in sport and comprise an embodied account of the formative aspect of ethics, with implications for ethical considerations related to performance enhancement. (shrink)

Biological sex should be “acknowledged” and “accepted”—but which responses to gender dysphoria might this preclude? Trans-identified people may factually acknowledge their biological sex and regard transition as purely palliative. While generally some level of self-deception and even a high level of nonlying deception of others are sometimes justified, biological sex is important, and there is a nontrivial onus against even palliative, nonsexually motivated cross-dressing. The onus is higher against co-opting the body, even in a minor and/or reversible way, to make (...) a false communication concerning one’s sex. Hardest to defend is the destruction of sexual–reproductive functions and causally downstream functions such as lactation: due to the transcendent nature of sexual–reproductive functions, an appeal to the “principle of totality” here is misplaced. This is not to say that social, and milder medical, transition is absolutely excluded even for severe unmanageable dysphoria, nor that subsequent to any transition, detransition is necessarily required. (shrink)

This target article argues that the Turing test implicitly rests on a "naive psychology," a naturally evolved psychological faculty which is used to predict and understand the behaviour of others in complex societies. This natural faculty is an important and implicit bias in the observer's tendency to ascribe mentality to the system in the test. The paper analyses the effects of this naive psychology on the Turing test, both from the side of the system and the side of the observer, (...) and then proposes and justifies an inverted version of the test which allows the processes of ascription to be analysed more directly than in the standard version. (shrink)

Ernst Mayr proposed a distinction between “proximate”, mechanistic, and “ultimate”, evolutionary, causes of biological phenomena. This dichotomy has influenced the thinking of many biologists, but it is increasingly perceived as impeding modern studies of evolutionary processes, including study of “niche construction” in which organisms alter their environments in ways supportive of their evolutionary success. Some still find value for this dichotomy in its separation of answers to “how?” versus “why?”questions about evolution. But “why is A?” questions about evolution necessarily take (...) the form “how does A occur?”, so this separation is illusory. Moreover, the dichotomy distorts our view of evolutionary causality, in that, contra Mayr, the action of natural selection, driven by genotype-phenotype-environment interactions which constitute adaptations, is no less “proximate” than the biological mechanisms which are altered by naturally selected genetic variants. Mayr’s dichotomy thus needs replacement by more realistic, mechanistic views of evolution. From a mechanistic viewpoint, there is a continuum of adaptations from those evolving as responses to unchanging environmental pressures to those evolving as the capacity for niche construction, and intermediate stages of this can be identified. Some biologists postulate an association of “phenotypic plasticity” (phenotype-environment covariation with genotype held constant) with capacity for niche construction. Both “plasticity” and niche construction comprise wide ranges of adaptive mechanisms, often fully heritable and resulting from case-specific evolution. Association of “plasticity” with niche construction is most likely to arise in systems wherein capacity for complex learning and behavioral flexibility have already evolved. (shrink)

The endoplasmic reticulum (ER) organelle is the key intracellular site of both protein and lipid biosynthesis. ER dysfunction, termed ER stress, can result in protein accretion within the ER and cell death; a pathophysiological process contributing to a range of metabolic diseases and cancers. ER stress leads to the activation of a protective signalling cascade termed the Unfolded Protein Response (UPR). However, chronic UPR activation can ultimately result in cellular apoptosis. Emerging evidence suggests that cells undergoing ER stress and UPR (...) activation can release extracellular signals that can propagate UPR activation to target tissues in a cell non‐autonomous signalling mechanism. Separately, studies have determined that the UPR plays a key regulatory role in the biosynthesis of bioactive signalling lipids including sphingolipids and ceramides. Here we weigh the evidence to combine these concepts and propose that during ER stress, UPR activation drives the biosynthesis of ceramide lipids, which are exported and function as cell non‐autonomous signals to propagate UPR activation in target cells and tissues. (shrink)

Discusses human sexuality, population contral, women's rights, genetic research, abortion, AIDS, and childcare.

Once Queen of the Medieval court of sciences, dethroned theology may be able in our time to play a strategic servant role in rightly humiliating, elevating, and ordering the disciplines, in gadflying like a mutant honeybee, generating surprise and serendipity through the intermediacy of social science, and in offering ethical homing direction to the disciplines in their applied endeavors.

Some form of potential or "capacity" is often seen as evidence of human moral status. Opinions differ as to whether the potential of the embryo should be regarded as such evidence. In this paper, I discuss some common arguments against regarding the embryo's potential as a sign of human status, together with some less common arguments in favour of regarding the embryo's potential in this way.

Cooperation in wrongdoing is an everyday matter for all of us, though we need to discern when such cooperation is morally excluded as constituting formal cooperation, as opposed to material (unintended) cooperation whether justified or otherwise. In this paper, I offer examples of formal cooperation such as referral of patients for certain procedures where the cooperating doctor intends an intrinsically wrongful plan of action on the part of the patient and a medical colleague. I also consider a case of formal (...) cooperation where the cooperator intends a choice on the part of another person that is not intrinsically wrong, but wrong in the circumstances because the person believes it will cause serious uncompensated harm. (shrink)

The term “value of life” can refer to life’s intrinsic dignity: something nonincremental and time-unaffected in contrast to the fluctuating, incremental “value” of our lives, as they are longer or shorter and more or less flourishing. Human beings are equal in their basic moral importance: the moral indignities we condemn in the treatment of e.g. those with dementia reflect the ongoing human dignity that is being violated. Indignities licensed by the person in advance remain indignities, as when people might volunteer (...) their living, unconscious bodies for surrogacy or training in amputation techniques. Respect for someone’s dignity is significantly impacted by a failure to value that person’s very existence, whatever genuine respect and good will is shown by wanting the person’s life to go well. Valuing and respecting life is not, however, vitalism: there can be good and compelling reasons for eschewing some means of prolonging life. (shrink)

The Umayyad period. The beginnings of sectarianism ; The Khārijites ; The Shīʻtes ; The Murjiʼites and other moderates -- The first wave of Hellenism 750-950. The historical background ; The translators and the first philosophers ; The expansion of Shīʻism ; The Muʻtazilites ; The consolidation of Sunnism ; Al-Ashʻarī -- The second wave of Hellenism 950-1258. The historical background ;The flowering of philosophy ; The vicissitudes of Shīʻism ; The progress of Sunnite theology ; Al-Ghazālī ; Sunnite theology (...) from 1100 to 1250 ; Theology and philosophy in the Islamic west -- The period of darkness. The historical background ; The sclerosis of philosophical theology ; The vitality of the Ḥanbalites ; The transformation of Shīʻism -- The new dawn. The prospect for theology. (shrink)

00 In this innovative analysis, Plato's four eleatic dialogues are treated as a continuous argument. In Kenneth Dorter's view, Plato reconsiders the theory of forms propounded in his earlier dialogues and through an examination of the theory's limitations reaffirms and proves it essential. Contradicted are both those philosophers who argue that Plato espoused his theory of forms uncritically and those who argue that Plato in some sense rejected the theory and moved toward the categorical analysis developed byAristotle. Dorter's reexamination (...) of Plato's insights implies an important new direction for modern philosophical inquiry. In this innovative analysis, Plato's four eleatic dialogues are treated as a continuous argument. In Kenneth Dorter's view, Plato reconsiders the theory of forms propounded in his earlier dialogues and through an examination of the theory's limitations reaffirms and proves it essential. Contradicted are both those philosophers who argue that Plato espoused his theory of forms uncritically and those who argue that Plato in some sense rejected the theory and moved toward the categorical analysis developed byAristotle. Dorter's reexamination of Plato's insights implies an important new direction for modern philosophical inquiry. (shrink)