Many sophisticated essays and books have been written about the topic of consciousness. My own contributions date back some twenty-five years in an essay entitled 'Problems concerning the structure of consciousness' (Pribram 1976), and five years before that in delineating the difference between brain processes that are coordinate with awareness and those that are coordinate with habitual behavior (Pribram 1971a). I have been intrigued by what has been written since and take this occasion to reassess a few of the major (...) issues that have arisen. (shrink)

The roles played by physics in the study of the life sciences have taken many forms over the past 100 years. Here we analyze how physics can be brought to bear on the contemporary study of morphogenesis, where new tissue-scale forms arise out of simpler, more homogenous, initial structures. We characterize how morphogenesis has been studied through reductionist approaches and discuss their limitations. We suggest that an alternative way of approaching morphogenesis that begins with a consideration of the whole may (...) also serve as a fruitful mode of scientific inquiry. Through historical analysis of concepts relevant for contemporary systems biology, we illustrate how physical thinking oriented toward the biological whole (“holistic biophysical thinking”) was exemplified in the biological theories presented earlier by D’Arcy Thompson (1860–1948) and Pere Alberch (1954–1998). We contrast the use of physics to develop the conceptual foundations of holistically oriented systems biology with the more prevalent contemporary use of physics that focuses on technological development and quantification, embedded within reductionist strategies. As an in-depth contemporary case study, we describe how in our research we have used holistic biophysical thinking to develop biological theories of vertebrate morphogenesis that account for and extend beyond genetic, molecular, and cellular processes. We propose a theory of skin development where _both_ molecular _and_ morphological patterns are orchestrated by emergent physical processes at the supracellular scale. We further posit that holistic biophysical thinking at the supracellular scale may advance theories of diseases such as cancer. (shrink)

In the context of this publication on blindsight, I want to address further the brain processes critically responsible for organizing our conscious experience. As in a previous related publication , I am restricting myself to brain and conscious experience, not the fuller topic of ‘consciousness’ as this might be determined by genetic and environmental factors, nor as it is defined in Eastern traditions and in esoteric Western religion and philosophy. For my thoughts on this broader topic the reader is referred (...) to a recent publication prepared for the centennial celebration of Norbert Wiener's birth. That paper is entitled: ‘What is Mind that the Brain May Order It? (shrink)

The result of the second Appalachian conference on neurodynamics, this volume focuses on the problem of "order," its origins, evolution, and future.