Overview The evolution of multicellularity raises questions regarding genomic and developmental commonalities and discordances, selective advantages and disadvantages, physical determinants of development, and the origins of morphological novelties. It also represents a change in the definition of individuality, because a new organism emerges from interactions among single cells. This volume considers these and other questions, with contributions that explore the origins and consequences of the evolution of multicellularity, addressing a range of topics, organisms, and experimental protocols. Each section focuses on (...) selected topics or particular lineages that present a significant insight or challenge. The contributors consider the fossil record of the paleontological circumstances in which animal multicellularity evolved; cooptation, recurrent patterns, modularity, and plausible pathways for multicellular evolution in plants; theoretical approaches to the amoebozoa and fungi (cellular slime molds having long provided a robust model system for exploring the evolution of multicellularity), plants, and animals; genomic toolkits of metazoan multicellularity; and philosophical aspects of the meaning of individuality in light of multicellular evolution. Contributors Maja Adamska, Argyris Arnellos, Juan A. Arias, Eugenio Azpeitia, Mariana Benítez, Adriano Bonforti, John Tyler Bonner, Peter L. Conlin, A. Keith Dunker, Salva Duran-Nebreda, Ana E. Escalante, Valeria Hernández-Hernández, Kunihiko Kaneko, Andrew H. Knoll, Stephan G. König, Daniel J. G. Lahr, Ottoline Leyser, Alan C. Love, Raul Montañez, Emilio Mora van Cauwelaert, Alvaro Moreno, Vidyanand Nanjundiah, Aurora M. Nedelcu, Stuart A. Newman, Karl J. Niklas, William C. Ratcliff, Iñaki Ruiz-Trillo, Ricard Solé . (shrink)

This book explores the main stages and key concepts in the development of Kant's critical philosophy, from the early 1760s to the 1790s. Karl Ameriks provides a detailed and concise account of the main ways in which the later critical works provide a plausible defense of the conception of humanity's fundamental end that Kant turned to after reading Rousseau in the 1760s. Separate essays are devoted to each of the three Critiques, as well as to earlier notes and lectures (...) and several of Kant's later writings on history and religion. A final section devotes three chapters to post-Kantian developments in German Romanticism, accounts of tragedy up through Nietzsche, and contemporary philosophy. The theme of an elliptical path is shown to be relevant to these writers as well as to many aspects of Kant's own life and work. The topics of the book include fundamental issues in epistemology and metaphysics, with a new defense of the Amerik's 'moderate' interpretation of transcendental idealism. (shrink)

There is a steadily growing literature on the role of the immune system in psychiatric disorders. So far, these advances have largely taken the form of correlations between specific aspects of inflammation (e.g. blood plasma levels of inflammatory markers, genetic mutations in immune pathways, viral or bacterial infection) with the development of neuropsychiatric conditions such as autism, bipolar disorder, schizophrenia and depression. A fundamental question remains open: why are psychiatric disorders and immune responses intertwined? To address this would require a (...) step back from a historical mind–body dualism that has created such a dichotomy. We propose three contributions of active inference when addressing this question: translation, unification, and simulation. To illustrate these contributions, we consider the following questions. Is there an immunological analogue of sensory attenuation? Is there a common generative model that the brain and immune system jointly optimise? Can the immune response and psychiatric illness both be explained in terms of self-organising systems responding to threatening stimuli in their external environment, whether those stimuli happen to be pathogens, predators, or people? Does false inference at an immunological level alter the message passing at a psychological level (or vice versa) through a principled exchange between the two systems? (shrink)

Despite claims from prominent scientists that SARS‐CoV‐2 indubitably emerged naturally, the etiology of this novel coronavirus remains a pressing and open question: Without knowing the true nature of a disease, it is impossible for clinicians to appropriately shape their care, for policy‐makers to correctly gauge the nature and extent of the threat, and for the public to appropriately modify their behavior. Unless the intermediate host necessary for completing a natural zoonotic jump is identified, the dual‐use gain‐of‐function research practice of viral (...) serial passage should be considered a viable route by which the novel coronavirus arose. The practice of serial passage mimics a natural zoonotic jump, and offers explanations for SARS‐CoV‐2's distinctive spike‐protein region and its unexpectedly high affinity for angiotensin converting enzyme (ACE2), as well as the notable polybasic furin cleavage site within it. Additional molecular clues raise further questions, all of which warrant full investigation into the novel coronavirus's origins and a re‐examination of the risks and rewards of dual‐use gain‐of‐function research. (shrink)

The intent of Jaspers' philosophizing then is simply to recall us to our authentic situation. This recall is not itself a doctrine; it is only the stimulus to an inward action each must perform for himself in communication with others. Jaspers' Existenz-philosophy is thus an attempt to consider and enact human honesty; it is philosophy, not as wisdom, but as the love of wisdom.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

This paper argues that a guaranteed income is not only consistent with the principle of reciprocity but is required for reciprocity. This conclusion follows from a three-part argument. First, if a guaranteed income is in place, all individuals have the same opportunity to live without working. Therefore, those who choose not to work do not take advantage of a privilege that is unavailable to everyone else. Second, in the absence of an unconditional income, society is, in effect, applying the principle, (...) “(S)he who does not work, will not eat.” If the application of this principle is to be consistent with reciprocity, it must be applied to everyone. Most modern industrial societies exempt many citizens from that choice. For example, the owners of external assets do not face the work-or-starve choice and do take advantage of a privilege that is not available to others. An unconditional guaranteed income is one way to eliminate that violation of reciprocity. Third, this paper addresses the criticism that the guaranteed income exploits middle-class workers by demonstrating that a basic income will have a positive effect on wages, which will at least partially counteract the effect of the taxes needed to pay for it. (shrink)

We describe new results in parametrized complexity theory. In particular, we prove a number of concrete hardness results for W[P], the top level of the hardness hierarchy introduced by Downey and Fellows in a series of earlier papers. We also study the parametrized complexity of analogues of PSPACE via certain natural problems concerning k-move games. Finally, we examine several aspects of the structural complexity of W [P] and related classes. For instance, we show that W[P] can be characterized in terms (...) of the DTIME ) and NP. (shrink)

This essay develops an interpretation of Kant’s conception of the faculty of reason as the capacity for what he calls "comprehension" (Begreifen). In doing so, it first discusses Kant's characterizations of reason in relation to what he describes as the two highest grades of cognition—insight and comprehension. Then it discusses how the resulting conception of reason relates to more familiar characterizations as the faculty for inference and the faculty of principles. In doing so, it focuses on how the idea of (...) reason as aiming at comprehension expresses the modesty about reason that is essential to Kant’s critical philosophy. It concludes by showing how this grounds an elegant account of the unity of theoretical and practical reason—one that does justice both to the "primacy" that Kant assigns to practical reason and the fact that this "primacy" is grounded in a more basic unity. (shrink)

Karl Hahn, Jahrgang 1937, war bis zu seiner Emeritierung im Jahr 2003 Professor für Politische Theorie und Ideengeschichte an der Westfälischen Wilhelms-Universität Münster. Hierbei hat er die Klassiker der abendländischen Geistesgeschichte nicht in einem kanonisch-schematischen Profil gelehrt, sondern die jeweiligen Themen und Theoreme mit lebensfüllender Leidenschaft vermittelt. Seine Vorlesungen und Seminare an der Universität zeugen, wie auch seine Vorträge und Tagungsbeiträge, von einem streitbaren Geist, der stets auch um die aktualisierende Bezugnahme bemüht war. Stets hat er pointiert Stellung bezogen, (...) auch gegen den Mainstream des Faches, das er kritisch hinterfragt hat. Ob Platon, Fichte oder auch Simone Weil: Bei Karl Hahn stehen philosophische Überlegungen für eine Suche nach der Vollendung des Daseins in seinen unendlich vielen und offenen Aussagemöglichkeiten. Hahns großes Lebensthema war und ist hierbei das tragische Element des menschlichen Wesens, dessen Kleinheit und Begrenztheit angesichts der großen Fragen der menschlichen Existenz. Das hat er seinen Studierenden mit auf den Weg gegeben. Und auch den Kolleginnen und Kollegen, die bereit waren, zuzuhören. Mit dem vorliegenden Band wird der Wissenschaftler zum Anlass seines 80. Geburtstages geehrt, der seine Verdienste nicht in der flüchtigen Wertschätzung des Feuilletons, sondern grundsätzlich im Diskurs der Seminarräume und Kongressveranstaltungen erworben hat. (shrink)

Provides a thorough background study of the postmodern assault on the standpoint of the subject as a foundation for philosophy, and assesses what remains today of the philosophy of subjectivity.

Karl Pfeifer argues against Searle's "Connection Principle" which requires that unconscious intentional mental states must be in principle accessible to consciousness.