Personalised medicine has been discussed as a medical paradigm shift that will improve health while reducing inefficiency and waste. At the same time, it raises new practical, regulatory, and ethical challenges. In this paper, we examine PM strategies epistemologically in order to develop capacities to address these challenges, focusing on a recently proposed strategy for developing patient-specific models from induced pluripotent stem cells so as to make individualised treatment predictions. We compare this strategy to two main PM strategies—stratified medicine and (...) computational models. Drawing on epistemological work in the philosophy of medicine, we explain why these two methods, while powerful, are neither truly personalised nor, epistemologically speaking, novel strategies. Both are forms of correlational black box. We then argue that the iPSC models would count as a new kind of black box. They would not rely entirely on mechanistic knowledge, and they would utilise correlational evidence in a different way from other strategies—a way that would enable personalised predictions. In arguing that the iPSC models would present a novel method of gaining evidence for clinical practice, we provide an epistemic analysis that can help to inform the practical, regulatory, and ethical challenges of developing an iPSC system. (shrink)

In this paper, I argue that absences pose a challenge to our understanding of physicalism that has not been properly appreciated. I do this by setting out a thought experiment involving a being in whom absence properties occupy the causal roles that functionalists take to define mental properties, in which case these absence properties realize the being’s mental properties. Such a being should be compatible with the truth of physicalism, I argue, even though its mental properties are neither themselves physical (...) properties nor are they realized/grounded in physical properties—instead, they are realized/grounded in (nonphysical) absence properties. I argue that the case serves as a counterexample to leading formulations of physicalism that appeal to realization or grounding, but not to standard supervenience-based formulations of physicalism, because the latter typically include negative truths in their supervenience base in addition to physical truths. I show how realization- and grounding-based formulations of physicalism might be revised to handle the problem, but also recommend that we rethink how we understand physicalism and the role that negative entities can play for physicalists. (shrink)

I present Ned Markosian's episodic account of identity under a sortal, and then use it to sketch a new model of the Trinity. I show that the model can be used to solve at least three important Trinitarian puzzles: the traditional ‘logical problem of the Trinity’, a less-discussed problem that has been dubbed the ‘problem of triunity’, and a problem about the divine processions that has been enjoying increased attention in the recent literature.

Do philosophers and ordinary people conceive of subjective experience in the same way? In this article, we argue that they do not and that the philosophical concept of phenomenal consciousness does not coincide with the folk conception. We first offer experimental support for the hypothesis that philosophers and ordinary people conceive of subjective experience in markedly different ways. We then explore experimentally the folk conception, proposing that for the folk, subjective experience is closely linked to valence. We conclude by considering (...) the implications of our findings for a central issue in the philosophy of mind, the hard problem of consciousness. (shrink)

There is a certain metaphor that has enjoyed tremendous longevity in the evolution of ageing literature. According to this metaphor, nature has a certain goal or purpose, the perpetuation of the species, or, alternatively, the reproductive success of the individual. In relation to this goal, the individual organism has a function, job, or task, namely, to breed and, in some species, to raise its brood to maturity. On this picture, those who cannot, or can no longer, reproduce are somehow invisible (...) to, or even dispensable to, the evolutionary process. Here, I argue that the metaphor should be discarded, not on the grounds that it is a metaphor, but on the grounds that this particular metaphor distorts our understanding of the evolution of ageing. One reason the metaphor is problematic is that it frames senescence and death as nature’s verdict on the value of older individuals. Instead, we should explore a different metaphor: the lengthy post-reproductive period in humans and some other animals is not an accident of culture, but designed by nature for the purpose of supporting and guiding younger generations. On this alternate picture, different stages of life have their own evolutionary rationales, their distinctive design features, their special mandates. (shrink)

Originally published in 1992 this book attacks many recent philosophical and psychological theories of the emotions and argues that our emotions themselves have intrinsic moral significance. He demonstrates that a proper understanding of the emotions reveals the fundamental role they play in our moral lives and the practical consequences that arise from being morally responsible for our emotions.

The world is swimming in misinformation. Conflicting messages bombard us every day with news on everything from politics and world events to investments and alternative health. The daily paper, nightly news, websites, and social media each compete for our attention and each often insist on a different version of the facts. Inevitably, we have questions: Who is telling the truth? How would we know? How did we get here? What can we do? Beyond Fake News answers these and other queries. (...) It offers a technological and market-based explanation for how our informational environment became so polluted. It shows how purveyors of news often have incentives to mislead us, and how consumers of information often have incentives to be misled. And it chronicles how, as technology improves and the regulatory burdens drop, our information-scape becomes ever more littered with misinformation. Beyond Fake News argues that even when we really want the truth, our minds are built in such a way so as to be incapable of grasping many facts, and blind spots mar our view of the world. But we can do better, both as individuals and as a society. As individuals, we can improve the accuracy of our understanding of the world by knowing who to trust and recognizing our limitations. And as a society, we can take important steps to reduce the quantity and effects of misinformation. (shrink)

Rahel Jaeggi’s theory of alienation has received less attention than her work on forms of life and capitalism. This theory avoids the problems of traditional theories of alienation: objectivism, paternalism, and essentialism. It also sidesteps post-structuralist criticisms of the theory of alienation. However, Jaeggi’s theory is flawed in two ways: it is not historically specific, and so cannot explain why alienation is a problem for modernity rather than other historical periods, and it is difficult to connect to social critique. I (...) argue that Karl Marx’s later theory of alienation, as interpreted by Moishe Postone and others, is able to avoid the problems that Jaeggi’s theory avoids, and is also able to avoid the flaws in her theory. This suggests that critical theory should focus on a theory of capitalism rather than normative social theory. (shrink)

With the expansion of multinational corporations (MNCs), the alarming upsurge in widely publicized and notable corporate scandals involving MNCs in emerging markets has begun to draw both academic and managerial attention to look beyond home market practices to the pressing concern of CSR in emerging markets. Previous studies on CSR have focused primarily on Western markets, reserving limited discussions in addressing the issue of MNC attitudes and CSR practices in their emerging host markets abroad. Despite this incongruity in academic response (...) to CSR in emerging markets, managers of multinational companies continue to face mounting and most often conflicting pressures to weigh among multiple strategic CSR responses in emerging markets. Such a task is often further complicated by the complexity of varying business norms and standards, regulatory environments, and stakeholder demands for CSR across national boundaries. With such a challenge in mind, I attempt to examine the explanatory factors in leading MNCs, otherwise recognized for accountability and integrity in their home markets, to employ inconsistent or negligent practices under CSR pressure in Chinese emerging economy. Preliminary findings reveal that discrepancies exist in how MNCs perform in CSR in home countries versus in host countries. While MNCs do have much to improve, the institutional environment in the emerging market, including the legal framework and the ethical culture, also needs to be improved by the host country governments, the industry associations, and local firms. Meanwhile, media interest and journalists, NGOs, third party monitors, industry stakeholders as well as consumer advocacy groups can raise the visibility of MNC's contradictory practices between their origin nations and countries with emerging economies and offer the pressures and incentives for MNCs to amend their ethical short-comings. This article also suggests implications for both theory and practice. (shrink)

Mechanisms, in the prominent biological sense of the term, are historical entities. That is, whether or not something is a mechanism for something depends on its history. Put differently, while your spontaneously-generated molecule-for-molecule double has a heart, and its heart pumps blood around its body, its heart does not have a mechanism for pumping, since it does not have the right history. My argument for this claim is that mechanisms have proper functions; proper functions are historical entities; so, mechanisms are (...) historical entities, too. This thesis runs against the mainstream new mechanist way of thinking about mechanisms, where mechanisms are generally thought of in an ahistorical way. After arguing for this thesis, I draw out some consequences for philosophy of science and metaphysics. (shrink)

I develop a reduction of grounding to essence. My approach is to think about the relation between grounding and essence on the model of a certain conceptof existential dependence. I extend this concept of existential dependence in a coupleof ways and argue that these extensions provide a reduction of grounding to essenceif we use sorted variables that range over facts and take it that for a fact to obtain is forit to exist. I then use the account to resolve various (...) issues surrounding the concept of grounding and its connection with essence; apply the account to paradigm cases andto the impure logic of grounding; and respond to objections. (shrink)

We live in an increasingly globalizing world, in which countries are closely linked by international trade and investment ties. Cross-cultural comparative studies of national values and ethics have attracted growing research interest in recent years, because shared practices, values and ethical standards depend on shared beliefs. However, the findings of such studies have been unable to reach a consensus on the impact of culture on ethics-related attitudes and behavior. Empirically, many "cross–cultural" differences reported by previous studies might actually stem from (...) cross-national differences. In order to partially fill this gap, this study advocates an analytical framework that isolates the role of cultural and national differences in order to test their relationship to individual level variables. Within this framework, we test competing hypotheses based on both cultural and national contexts by comparing groups of Chinese and American respondents together with a "bridging group" of Chinese Chinese-Americans. Theoretically, this contextual approach helps resolve the debate on the role of culture, by showing that culture plays a far more important role in shaping value orientations than the national background. Specifically, the two ethnic Chinese groups had many cultural values in common, and differed significantly from the Caucasian group. Implications are discussed. (shrink)

_The first unabridged English translation of the correspondence between Gottfried Wilhelm Leibniz and Georg Ernst Stahl detailing their opposing philosophies_ The correspondence between the eighteenth-century mathematician and philosopher G. W. Leibniz and G. E. Stahl, a chemist and physician at the court of King Friedrich Wilhelm I of Prussia, known as the Leibniz-Stahl Controversy, is one of the most important intellectual contributions on theoretical issues concerning pre-biological thinking. Editors François Duchesneau and Justin E. H. Smith offer readers the first (...) fully annotated English translation of this fascinating exchange of philosophical views on divine action, the order of nature, causality and teleology, and the soul-body relationship. (shrink)

This article argues that the controversy over genetically modified crops is best understood not in terms of the supposed bias, dishonesty, irrationality, or ignorance on the part of proponents or critics, but rather in terms of differences in values. To do this, the article draws on and extends recent work of the role of values and interests in science, focusing particularly on inductive risk and epistemic risk, and it shows how the GMO debate can help to further our understanding of (...) the various epistemic risks that are present in science and how these risks might be managed. (shrink)

At the beginning of the twentieth century, the French philosopher of science Edmond Goblot wrote three prescient papers on function and teleology. He advanced the remarkable thesis that functions are, as a matter of conceptual analysis, selected effects. He also argued that “selection” must be understood broadly to include both evolutionary natural selection and intelligent design. Here, I do three things. First, I give an overview of Goblot’s thought. Second, I identify his core thesis about function. Third, I argue that, (...) despite its ingenuity, Goblot’s expansive construal of function cannot be right. Still, Goblot deserves long-overdue credit for his work. (shrink)

The practice of conceptual analysis has undergone a revival in recent years. Although the extent of its role in philosophy is controversial, many now accept that conceptual analysis has at least some role to play. Granting this, I consider the relevance of empirical investigation to conceptual analysis. I do so by contrasting an extreme position (anti-empirical conceptual analysis) with a more moderate position (non-empirical conceptual analysis). I argue that anti-empirical conceptual analysis is not a viable position because it has no (...) means for resolving conceptual disputes that arise between seemingly competent speakers of the language. This is illustrated by considering one such dispute that has been pressed by a prominent advocate of anti-empirical conceptual analysis: Bennett and Hacker ( 2003 ) assert that psychological predicates only logically apply to whole living animals, but many scientists and philosophers use the terms more broadly. I argue that to resolve such disputes we need to empirically investigate the common understanding of the terms at issue. I then show how this can be done by presenting the results of three studies concerning the application of “calculates” to computers. (shrink)

When studying historical thinkers, it helps enormously to know on which issues they had philosophically systematic views. For example, if attributing to Mencius the view that all existence is process-like rather than substance-like, it is very useful to know whether Mencius had philosophically systematic views about the (process-like or substance-like) nature of existence in the first place, or whether speculation about this particular issue is more constructive on the part of interpreters. In this paper, I offer a rough-and-ready account of (...) philosophical systematicity, talk about what would count as evidence of this sort of systematicity, and what implications it should have for one's interpretation if one can or cannot provide such evidence. The historical tradition that I am most concerned with is the pre-modern Chinese one, but my conclusions should hold for philosophical interpretations of thinkers of most times and traditions. (shrink)

Leading researchers in the philosophy of mind present and explore cutting edge research in the exciting new field of experimental philosophy.

To explore 3- to 7-year-old children's developing understanding of human and non-human minds, a battery of "background knowledge" tasks was administered to 51 American children. The children were asked to speculate about how three other intentional agents would understand various visual displays. First, children answered when they themselves did not understand the displays, then they answered after they had been given information necessary to understand the displays. Results revealed that children begin to understand the role of background knowledge around the (...) same age that they pass false-belief tasks; and that before thoroughly understanding the role of background knowledge they already begin to discriminate between different types of minds. By age four, children began to show some understanding that because of having different minds than people, God is more able and dogs are less able to understand some visual displays even with full visual access. (shrink)

Many observers now acknowledge that there are serious problems with the way in which pharmaceutical research is currently practiced. These problems include the suppression of undesirable results, bias in the design of studies and in the interpretation of results, and neglect of diseases that afflict the poor in developing countries. These problems can be traced at least in part to the influence of commercial interests on research. In what follows, I will discuss some of the main deficiencies of current pharmaceutical (...) research, and I will argue that an important one is inadequate dissent. As many have argued, rigorous scientific research requires dissent, or what Robert Merton called “organized skepticism” (1942). .. (shrink)

I defend a novel interpretation of Kant's conceptualism regarding the contents of our perceptual experiences. Conceptualist interpreters agree that Kant's Deduction aims to prove that intuitions require the categories for their spatiality and temporality. But conceptualists disagree as to which features of space and time make intuitions require the categories. Interpreters have cited the singularity, unity, infinity, and homogeneity of space and time. But this is incompatible with Kant's Aesthetic, which aims to prove that these same features qualify space and (...) time as intuitions, not concepts. On my interpretation, the feature is objectivity. Space and time are objective, in that they ground our judgments in geometry and mechanics. (shrink)

What is the significance of Arendt considering the title Amor Mundi for what we now are familiar with as The Human Condition? Read alongside Native American philosophers, it is clear that The Human Condition does not explain what it is like to love the world. Instead, it is a powerful genealogy of world alienation and earth alienation in the Western tradition. In other words, The Human Condition shows how Western thought lost and/or undermines amor mundi. By comparing and contrasting Arendt (...) with Vine Deloria Jr. and Daniel Wildcat, we can better understand what Arendt means by the distinction between ‘world’ and ‘earth’ and see the limitations of her concept of world. My claim is that reading these thinkers together enriches our understanding of world alienation, earth alienation, and amor mundi. (shrink)

‘Epistocracy’ is the name of a type of political power structure in which the power is held by the knowledgable—for example, by restricting the right to vote to those who can demonstrate sufficient knowledge. Though Plato and Mill defended epistocratic views, it has found few contemporary advocates. In a recent book, however, Jason Brennan argues that epistocratic power structures are capable of outperforming democratic ones. His argument is two-pronged: first, he argues that democratic procedures with universal suffrage allow poorly-informed voters (...) to pollute the electorate, and that doing so has negative policy-related consequences that are easily avoidable. Second, he argues that voting does not possess any non-intrinsic value, and so restricting suffrage to the educated does not result in a loss of status or standing for less well-educated persons in any meaningful way. I argue that epistocratic techniques are impossible to implement fairly, and represent an ineffective solution for the problems they are designed to solve. On these bases, I recommend rejecting it. (shrink)

According to long-standing orthodoxy in contemporary analytic philosophy of language, the content of a sentence (that is, the information it encodes and what on.

I outline a theory of moral motivation which is compatible with the metaphysical claims of strong emotionism—a sentimentalist account of morality first outlined by Jesse Prinz and supported by myself which construes moral concepts and properties as a subset of emotion-dispositional properties. Given these claims, it follows that sincere moral judgements are necessarily motivating in virtue of their emotional constitution. I defend an indefeasible version of judgement motivational internalism which takes into consideration both positively and negatively valenced affective states and (...) how they promote both approach and avoidance motivation, respectively. On this view, in making sincere moral judgements agents are antecedently motivated by standing Desires to avoid or approach the stimuli picked out by their judgements. I also defend internalism against the objections from defeating circumstances and amoralists. As regards the former, I claim that the tendency of philosophers to frame the motivation debate in terms of positive moral judgements makes the argument from defeating circumstances appear more plausible than it is; as regards the latter, I claim the amoralist argument only has force if it is empirically well supported and that psychological data has hitherto been unconvincing. (shrink)

Recently, philosophers have investigated the emergence and evolution of the social contract. Yet extant work is limited as it focuses on the use of simple behavioral norms in rather rigid strategic settings. Drawing on axiomatic bargaining theory, we explore the dynamics of more sophisticated norms capable of guiding behavior in a wide range of scenarios. Overall, our investigation suggests the utilitarian bargaining solution has a privileged status as it has certain stability properties other social arrangements lack.

In a recent paper in this journal, Jason Brennan correctly notes that libertarians struggle to justify a policy of compulsory vaccination. The most straightforward argument that justifies compulsory vaccination is that such a policy promotes welfare. But libertarians cannot make this argument because they claim that the state is justified only in protecting negative rights, not in promoting welfare. I consider two representative libertarian attempts to justify compulsory vaccination, and I argue that such arguments are unsuccessful. They either fail to (...) show that the state is justified in implementing the policy or overgeneralise. I suggest that Brennan's solution is especially well motivated insofar as it addresses the shortcomings of these arguments. Brennan argues that we violate the rights of others by participating in an activity that imposes an unacceptable collective risk of harm. Going unvaccinated is an activity that imposes an unacceptable collective risk of harm, and thus amounts to a rights violation. So, the state can implement a policy of compulsory vaccination I object, however, that Brennan's delineation of acceptable and unacceptable risk implicitly rests on classical liberal rather than libertarian principles; he justifies compulsory vaccination on the grounds that it promotes welfare. I also object that Brennan's argument would entail significant departures from libertarian institutional arrangements. This leaves libertarians with a choice: they can develop new arguments to demonstrate that their position is compatible with compulsory vaccination, or they can accept that their view entails the impermissibility of compulsory vaccination, and argue that this is not an unpalatable implication of their view. (shrink)

More and more businesses are aligning their activities with the principles of sustainable development. Therefore they need to adapt their ways of measuring corporate performance. However, it includes issues which may be outside the direct control of the organisation, that are difficult to characterise and often are based on value judgements rather than hard data. The difficulty in measuring performance is further complicated by the fact that many corporations have a complex organisational structure, with different business streams, functions and projects. (...) This paper has used two case studies to explore how the appropriate use of indicators can be a powerful tool in addressing the sustainability of businesses both at a corporate wide level and at a project level. (shrink)

This case study documents a high-profile incident involving the world-famous auto maker Daimler Benz with its customers in China. On the one hand, angry customers felt victimized by the auto maker's lack of willingness to take responsibility and its double standard between industrialized markets and emerging economies in dealing with customer complaints; on the other hand, the auto maker also felt frustrated at how this product warranty matter quickly escalated into a public relations nightmare. The case illustrates the complexity of (...) operating in emerging markets where institutional environments are vastly different, and the difficulty of balancing business interests with social responsibility. It also illustrates the urgent needs for emerging markets to develop institutional infrastructure to protect consumer rights, and to offer proper channel for conflict resolution. (shrink)

This paper examines James Conant’s pragmatic theory of science – a theory that has been neglected by most commentators on the history of 20th-century philosophy of science – and it argues that this theory occupied an important place in Conant’s strategic thinking about the Cold War. Conant drew upon his wartime science policy work, the history of science, and Quine’s epistemological holism to argue that there is no strict distinction between science and technology, that there is no such thing as (...) “the scientific method,” and that theories are better interpreted as policies rather than creeds. An important consequence that he drew from these arguments is that science is both a thoroughly value-laden, and an intrinsically social, enterprise. These results led him to develop novel proposals for reorganizing scientific and technological research – proposals that he believed could help to win the Cold War. Interestingly, the Cold War had a different impact upon Conant’s thinking than it did upon many other theorists of science in postwar America. Instead of leading him to “the icy slopes of logic,” it led him to develop a socially- and politically-engaged theory that was explicitly in the service of the American Cold War effort. (shrink)

Despite the role women play in job creation, economic growth and society revitalization, especially in economies undergoing fundamental transformations, issues emerging from women in entrepreneurship have not received adequate attention in academic research. As a result, our understanding of women entrepreneurship in emerging markets as well as in nontraditional industries is even more limited. In this study, I attempt to partially fill the gap by comparing entrepreneurial orientations and venture performance between men and women entrepreneurs in electronics industry in Chinese (...) transition economy. I offer insights gained from statistical analyses based on a survey as well as case study. Results reveal that while women are influenced by the same factors that affect decision making among men and exhibit some similarities, they differ from men in their willingness to take more risks and make bolder moves in pursuit of greater returns and future competitive advantage. In addition, women entrepreneurs outperform their male counterparts. I compare these findings with existing literature and offer suggestions for future research. (shrink)

Three distinct reasons that Plato calls the rational part of the soul “divine” are analyzed: its metaphysical kinship with the Forms, its epistemological ability to know the Forms, and its ethical capacity to live by them. Supposing these three divine aspects of the rational part are unified in the life of each person, they naturally suggest a process of divinization or “becoming like god” according to which a person, by living more virtuously, which requires increasingly better knowledge of the Forms, (...) gradually becomes united with them. This process of divinization is in fact found throughout the middle and late dialogues, including the Phaedo, Republic, Symposium, Phaedrus, Timaeus, and the Laws. This synoptic view of the Platonic idea of divinization provides a standard according to which misplaced emphasis, flaws, and tension created by other interpretations are criticized and corrected. (shrink)

Evolutionary accounts of morality consider behavior in rather simple scenarios. Evolutionary work on fairness focuses on the division of a windfall and, importantly, assumes that the positions of those involved are entirely symmetric. I consider more complicated strategic settings and find that there is a strong tendency for evolution to produce divisions consistent with the so-called Nash bargaining solution. I also uncover the evolutionary importance of comprehensiveness, an often-overlooked feature of division problems.

It is often asserted that we should believe that phenomenal consciousness exists because it is pretheoretically obvious. If this is the case, then we should expect lay people to categorize mental states in roughly the way that philosophers do, treating prototypical examples of phenomenally conscious mental states similarly. Sytsma and Machery present preliminary evidence that this is not the case. They found that participants happily ascribed seeing red to a simple robot but denied that the robot felt pain. The most (...) prominent response to this work has been the ambiguity objection, which charges that participants were interpreting ascriptions of seeing red in a purely informational way, such that their attributions of “seeing red” to the robot do not speak to the question of whether they recognize the phenomenality of this state. Peressini pushes an especially interesting version of the objection, presenting new empirical evidence and suggesting that lay people do in fact have a concept of phenomenality. In this paper, I respond to Peressini’s objections, and the ambiguity objection more generally, arguing that the new data does not undermine Sytsma and Machery’s conclusion. (shrink)

This volume examines the implications of developments in the science of ethics for philosophical theorizing about moral psychology and human agency. These ten new essays in empirically informed philosophy illuminate such topics as responsibility, the self, and the role in morality of mental states such as desire, emotion, and moral judgement.

In the opening paragraph of “Computing Machinery and Intelligence” Alan Turing famously notes that “if the meaning of the words ‘machine’ and ‘think’ are to be found by examining how they are commonly used it is difficult to escape the conclusion that the meaning and the answer to the question, ‘Can machines think?’ is to be sought in a statistical survey such as a Gallup poll.” He then immediately responds, “But this is absurd.” But why is this absurd, if indeed (...) it is? We think that the suggested method is absurd because the answer to the question might not follow from the meaning of the words alone—it might critically depend on what machines can be built to do. Further, the ordinary use of the terms might display shallow biases or superstitions that we want to set aside, or overcome, in pursuing a science or philosophy of mind. However, we do not think that the method is absurd insofar as we are interested in getting clear on “the normal use of the words,” as Turing puts it. And we believe that getting clear on the normal use of words like “machine” and “think” is relevant even if we then want to move beyond the ordinary usage in our theorizing. But the best way to figure out how ordinary people use language is via empirical investigation. (shrink)