Cellular interactions in the mammalian ovarian follicle between its germ‐line and somatic cell components are crucial for its development and function. These interactions are mediated by both membrane gap junctions and paracrine factors. Somatic cell‐to‐oocyte communication is essential for oocyte growth and the regulation of meiotic maturation. In particular, granulosa cells provide nutrients and molecular signals that regulate oocyte development. Oocytes, on the other hand, promote the organization of the follicle, the proliferation of granulosa cells, and the differentiation and function (...) of cumulus cells, a subset of granulosa cells. Determining the nature of the oocyte‐to‐granulosa cell signals remains a key challenge for future work. (shrink)

This is done through a chronology, an introductory essay, an extensive bibliography, and hundreds of cross-referenced dictionary entries on key terms and ...

This book examines Aristotle's critical reaction to the mathematical cosmology of Plato's Academy, and traces the aporetic method by which he developed his own ...

In this paper I refute the chief arguments for cultural relativism, meaning the moral (not the descriptive) theory that goes by that name. In doing this I walk some oft-trodden paths, but I also break new ones. For instance, I take unusual pains to produce an adequate formulation of cultural relativism, and I distinguish that thesis from the relativism of present-day anthropologists, with which it is often conflated. In addition, I address not one or two, but eleven arguments for cultural (...) relativism, many of which contribute to its popularity but receive scant attention from its critics. To elicit the failings of these arguments I deploy a host of pertinent but often neglected distinctions. (shrink)

A significant effect of China’s rejection of a planned economy for a free market is the stimulus this has given to discussion of therelationship between morality and the market. Some Chinese believe that the introduction of a market economy has had a negative effect on public morality. Others disagree and maintain that it has had only a positive effect. Besides this particular debate there are two others. In the first of these debates, it is maintained on the one side that (...) conduct in the market is amoral and essentially contractual or transactional in nature: a boundary must be drawn between economic conduct and conduct in other spheres of social life. Against this it is argued that ethical norms apply equally to all aspects of social life including the economy. In the second debate one side holds that the market engenders its own “ethical” norms. In opposition it is argued that the moral categories articulated in moral philosophy are applicable to behaviour in the market. (shrink)

This article surveys arguments for the claim that employees have a right to strong forms of decision-making participation. Itconsiders objections to employee participation based on shareholders' property rights and it claims that those objections are flawed. In particular, it argues the employee participation rights are grounded on the same values as are property rights. The articlesuggests that the conflict between these two competing rights claims is best resolved by limiting the scope of corporate property rightsand by recognizing a strong employee (...) right to co-determine corporate decisions. (shrink)

Pragmatism, Postmodernism and the Future of Philosophy is a vigorous and dynamic confrontation with the task and temperament of philosophy today. In this energetic and far-reaching new book, Stuhr draws persuasively on the resources of the pragmatist tradition of James and Dewey, and critically engages the work of Continental philosophers like Adorno, Foucault, and Deleuze, to explore fundamental questions of how we might think and live differently in the future. Along the way, the book addresses important issues in public policy, (...) university administration, spirituality, and the notion of community and its meaning in a global world of difference. This book is essential reading for anyone concerned with the future of philosophy, and the ways in which philosophical thinking can help us live better, more fulfilling lives. (shrink)

This paper explores the emergence of the distinctions between the transcendental and the psychological and, correlatively, between phenomenology and psychology that emerge in The Idea of Phenomenology. It is argued that this first attempt to draw these distinctions reveals that the conception of transcendental phenomenology remains infected by elements of the earlier conception of descriptive psychology and that only later does Husserl move to a more adequate—but perhaps not yet fully purified—conception of the transcendental.

Discussions of moral relativism commonly distinguish between normative relativism (NR) and moral judgment relativism (MJR) without highlighting the differences between the two. One significant difference—a difference between normative relativism and the most prevalent type of moral judgment relativism—is not immediately obvious and has not been discussed in print. This paper explains it and draws out some of its philosophical consequences.

The key problem for normative (or moral) cultural relativism arises as soon as we try to formulate it. It resists formulations that are (1) clear, precise, and intelligible; (2) plausible enough to warrant serious attention; and (3) faithful to the aims of leading cultural relativists, one such aim being to produce an important alternative to moral universalism. Meeting one or two of these conditions is easy; meeting all three is not. I discuss twenty-four candidates for the label "cultural relativism," showing (...) that not one meets all three conditions. In the end I conclude that cultural relativists have produced nothing that threatens universalism. (shrink)

As the only nation in the western world without a national health insurance program, the United States faces ongoing issues of access and fairness in health care coverage. The Clinton administration tried and failed to address the problem of universal coverage. Since then we have focused on the narrower, but nonetheless real, issues of fairness and equity in the benefits package provided in insurance plans. The LORAN Commission spent two years trying to devise agreed-upon principles to govern such issues. The (...) lesson learned was the same as that of the Ethics Force study: there was no possibility of getting agreement, let alone consensus, among the participants on how to decide what should be a covered benefit. There were, however, two generally agreed upon principles that emerged regarding health care: “Every individual should be treated alike,” and “When it comes to health, cost cannot be a consideration.” That formula translated into providing everyone with everything. The only certain outcome from such a policy would be fiscal insolvency and ultimately bankruptcy. (shrink)

Rosoff and Schneiderman's essay “Irrational Exuberance: Cardiopulmonary Resuscitation as Fetish” (2017) raises an issue first posed by the then Chairman of the Federal Reserve Board, Alan Greenspan...

What I say here has been said before on many days and nights by reflective persons, for centuries long and planetary wide. Why, then, say it again, Sam? Is it because Heraclitus was onto something when he told us the Logos speaks but few hear? Or is the situation that of the Hassidic tale as recounted by Martin Buber? A man took it upon himself to convey the message of the high and holy one. He found no response and so (...) went directly, petulantly, to the author of the message. "Why are you here?" asked the high and holy one. "I have offered your message and no one hears me." "But," comes the response, "there is no hearing here for you. I have sunk my hearing in the deafness of mortals." More directly we can recall .. (shrink)

Both William James and Gilles Deleuze labeled their philosophies "radical empiricism." In this context, this essay explores the similarities and differences between James's radical empiricism and Deleuze's "transcendental empiricism". These accounts then inform a view of philosophy understood as a creative art. This art demands flexible habits--what James termed "genius"--in a changing world. Accordingly, radically empirical accounts of creativity and genius are sketched.

Certain passages in the Meditations indicate a silence of Descartes before the mystery of God. These passages underscore the inadequacy of reason to penetrate God’s attributes. Descartes underlines the incomprehensibility of God’s infinity and God’s purposes. He evokes an intuitive knowledge of God which transcends the conceptual. Relevant passages in the correspondence of Descartes indicate Descartes’s repeated concern with the limits of philosophical theology and support a deconstruction of the Medítations which privileges its recurrent theologia negativa. Such an interpretation of (...) the religious theory in public and private Cartesian texts contests the persistent “rationalist” interpretation of Descartes, which reduces the theology of the Meditations to a series of deductive proofs. (shrink)

Modern medicine has produced many wonderful technological breakthroughs that have extended the limits of the frail human body. However, much of the focus of this medical research has been on the physical, often reducing the human being to a biological machine to be examined, understood, and controlled. This book begins by asking whether the modern medical milieu has overly objectified the body, unwittingly or not, and whether current studies in bioethics are up to the task of restoring a fuller understanding (...) of the human person. In response, various authors here suggest that a more theological/religious approach would be helpful, or perhaps even necessary. Presenting specific perspectives from Judaism, Christianity and Islam, the book is divided into three parts: "Understanding the Body," "Respecting the Body," and "The Body at the End of Life." A panel of expert contributors—including philosophers, physicians, and theologians and scholars of religion— answer key questions such as: What is the relationship between body and soul? What are our obligations toward human bodies? How should medicine respond to suffering and death? The resulting text is an interdisciplinary treatise on how medicine can best function in our societies. Offering a new way to approach the medical humanities, this book will be of keen interest to any scholars with an interest in contemporary religious perspectives on medicine and the body. (shrink)

The proposal to add the behavioral momentum metaphor to Skinnerian psychology and the use of other borrowed physical explanatory concepts such as velocity and inertial mass has only superficial value. The basic problem is that, in contrast to Newtonian physics, the “laws” do not apply to a significant proportion of the phenomena to be explained, and these evidential discrepancies are ignored, rather than being used to modify the scientific explanations and improve technological applications that are based on those explanations.

How does a self-described “simple teacher of religion” at the College of the Holy Cross get involved in bioethics? Nothing in my training or experience had prepared me for involvement in medicine. Much like that of my moral theology professor and then mentor, Richard McCormick, my training was in moral theology and social ethics. I also had an abiding interest in the courts and constitutional law. That interest led to a doctoral dissertation at the University of Southern California's Program in (...) Social Ethics on “The Supreme Court's Understanding of Religion in Conscientious Objector Cases.” Interestingly, doctoral work in the late 1960s on the ethical dimension of war was the starting point for other ethicists such as Leroy Walters and James Childress who subsequently became early voices in bioethics. (shrink)

These questions-in essence 'What are flourishing lives and how can we lead them?'-are long central to philosophy. Now, however, can be addressed in light of new insights in positive psychology, psychiatry, evolutionary biology, cognitive science, and behavioral economics as well new research in philosophy itself, including feminist theory, critical race studies, philosophical psychology, neuro-ethics, and more. The thirteen contributors chart new directions for understanding and securing human flourishing. Reflecting the fact that lives and cultures differ, the perspectives are pluralistic. Part (...) One considers the meaning of human flourishing through analyses of: the nature of purposeful, mattering lives; biological, psychological, and social levels of homeostasis; the nature of human agency and the role of narrative in it; the nature of the self and self-fulfillment; the centrality of subjective values and non-subjective conditions that make possible these values; and the need to encompass the wide diversity of human lives. Part Two considers conditions on which flourishing depends. These include: habits flexible enough to confront ever-changing realities; conditions of social justice rather than supposed self-help; epistemic responsibility and sensitivity to social relations; civility and values literacy; educational reconstruction, particularly in the humanities; a cultural focus on eudaimonic values rather than mere technical efficiency and marketplace consumerism; and the role of creative arts in transforming our abilities, promoting genuine self-government, and providing consolation in the face of loss. (shrink)

Collagen is the most abundant vertebrate protein and forms a stable fibrous architecture in connective tissues, such as bone, cartilage, skin and tendon. Much recent research has been directed towards an understanding of the molecular and cellular mechanisms involved in the synthesis and degradation of collagen, because a change in the normal balance, or an increased destruction of collagen, can cause loss of function of specialized tissues. This short review attempts to summarize present knowledge about the proteolytic destruction of collagen (...) and the exciting new work on the factors that are emerging as important controlling agents. An understanding of the regulatory processes is yielding some important clues regarding the levels at which they can fail in pathological conditions and we speculate about evolving strategies for preventing uncontrolled resorption. (shrink)

(2008). Book Review: “Dimensions of Apeiron: A Topological Phenomenology of Space, Time, and Individuation”. World Futures: Vol. 64, No. 8, pp. 631-633.

The rift which has long divided the philosophical world into opposed schools-the "Continental" school owing its origins to the phenomenology of Husserl and the "analytic" school derived from Frege-is finally closing.

_A major theoretical statement by a distinguished political scholar explains why a policy of liberal hegemony is doomed to fail_ In this major statement, the renowned international-relations scholar John Mearsheimer argues that liberal hegemony, the foreign policy pursued by the United States since the Cold War ended, is doomed to fail. It makes far more sense, he maintains, for Washington to adopt a more restrained foreign policy based on a sound understanding of how nationalism and realism constrain great powers (...) abroad. It is widely believed in the West that the United States should spread liberal democracy across the world, foster an open international economy, and build institutions. This policy of remaking the world in America’s image is supposed to protect human rights, promote peace, and make the world safe for democracy. But this is not what has happened. Instead, the United States has ended up as a highly militarized state fighting wars that undermine peace, harm human rights, and threaten liberal values at home. Mearsheimer tells us why this has happened. (shrink)

Towards the conclusion of the First Section of the Groundwork of the Metaphysics of Morals, Kant describes a process whereby a subject can undergo a kind of moral corruption. This process, which he calls a “natural dialectic”, can cause one to undermine one’s own or¬dinary grasp of the demands of morality. Kant also claims that this natural dialectic is the basis of the need for moral philosophy itself, since first-order moral reasoning is insufficient to protect against it. I show that (...) this passage is closely related to another in the First Section, one where Kant warns against the threat of “misology”, or the hatred of reason. I argue that both these passages must be read as engaging with specific claims from Rousseau’s writings. Uncovering the historical context and rhetorical function of Kant’s account of moral self-deception can re-orient the reader to his ambitions for the Groundwork itself. (shrink)

This paper approaches the intentional structure of the emotions by considering three claims about that structure. The paper departs from the Brentanian and Husserlian ‘priority of presentation claim’. The PPC comprises two theses: intentional feelings and emotions are founded on presenting acts and intentional feelings and emotions are directed specifically to the value-attributes of the presented objects. The paper then considers two challenges to this claim: the equiprimordial claim and the priority of feeling claim. The EC asserts that the presentational (...) and affective dimensions of intentional feelings and emotions are equiprimordial. I respond to this challenge to the PPC by revising it, claiming instead that the founding relations exist between the presentational and affective senses in an experience whose presenting and affective aspects are equiprimordial. The PFC grants priority to the affective, a grant which presupposes the independence of the affective from the presentational. I argue that the PFC is mistaken, and that the revision of the PPC can handle the examples on which the PFC is based. (shrink)

Charles S. Peirce, William James, Josiah Royce, George Santayana, John Dewey, and George Herbert Mead: each of these individuals is an original and historically important thinker; each is an essential contributor to the period, perspective, and tradition of classical American philosophy; and each speaks directly, imaginatively, critically, and wisely to our contemporary global society, its distant possibilities for improvement, and its massive, pressing problems. From the initiative of pragmatism in approximately 1870 to Dewey's final work after World War II, (...) classical American philosophy has come to represent the critical articulation of attitudes, outlooks, and forms of life imbedded in the culture from which it arose. John Stuhr brings together the works of these foremost thinkers to present a comprehensive collection in American philosophy. Extensive introductory essays, written especially for this volume by leading scholars of the subject, provide not only the bibliographical and cultural contexts necessary to a full appreciation of each thinker, but also original critical and interpretive philosophical observations. (shrink)

From the "New York Times" bestselling author of "If I Stay" Allyson Healeys life is exactly like her suitcase--packed, planned, ordered. Then on the last day of her three-week post-graduation European tour, she meets Willem. A free-spirited, roving actor, Willem is everything shes not, and when he invites her to abandon her plans and come to Paris with him, Allyson says yes. This uncharacteristic decision leads to a day of risk and romance, liberation and intimacy: 24 hours that will transform (...) Allysons life. A book about love, heartbreak, travel, identity, and the "accidents" of fate, "Just One Day" shows us how sometimes in order to get found, you first have to get lost... and how often the people we are seeking are much closer than we know. The first in a sweepingly romantic duet of novels. Willems story--"Just One Year"--is coming soon. (shrink)

"It has long been known that Dreiser devoted much effort during the final two decades of his lfe to the preparation of a major philosophical work which remained unfinished at his death....The best evidence of Dreiser's later thought would appear to be [t]his treatise, and it is appropriate that Marguerite Tjader and John J. McAleer--the two Dreiserians most sympathetic to the mystical religiosity of the later Dreiser--should make it available in published form." --_American Literary Realism_.