Summary Sexual communication in most species of fireflies is a male±female dialogue of precisely timed flashes of bioluminescent light. The biochemical reactions underlying firefly bioluminescence have been known for 30 years and are now exploited in biomedical assays and other commercial applications. Several aspects of flash regulation are also understood: flash rhythm is controlled by a central pattern generator, and individual flashes are neurally triggered, with octopamine serving as the transmitter. The molecular oxygen needed by the biochemical reactants is delivered (...) by a network of tracheal arborizations extending throughout the light organ (lantern).However, the actual means by which oxygen quickly reaches the reactants packaged within specialized photocytes and the specific event(s) triggered by neural action have not been identified; termination of axons away from the photocytes has exacerbated the latter problem. A recent paper(1) by a consortium of cell and evolutionary biologists, however, reports that nitric oxide (NO), manufactured and released in response to neuronal discharge, is the missing link by which neural action in the firefly lantern yields a sudden flash of light. BioEssays 23:992±995, 2001. ß 2001 John Wiley & Sons, Inc. (shrink)

Why believe in the findings of science? John Ziman argues that scientific knowledge is not uniformly reliable, but rather like a map representing a country we cannot visit. He shows how science has many elements, including alongside its experiments and formulae the language and logic, patterns and preconceptions, facts and fantasies used to illustrate and express its findings. These elements are variously combined by scientists in their explanations of the material world as it lies outside our everyday experience. (...) class='Hi'>John Ziman’s book offers at once a valuably clear account and a radically challenging investigation of the credibility of scientific knowledge, searching widely across a range of disciplines for evidence about the perceptions, paradigms and analogies on which all our understanding depends. (shrink)

Sir John Eccles, a distinguished scientist and Nobel Prize winner who has devoted his scientific life to the study of the mammalian brain, tells the story of how we came to be, not only as animals at the end of the hominid evolutionary line, but also as human persons possessed of reflective consciousness.

Ethically significant consequences of artificially intelligent artifacts will stem from their effects on existing social relations. Artifacts will serve in a variety of socially important roles—as personal companions, in the service of elderly and infirm people, in commercial, educational, and other socially sensitive contexts. The inevitable disruptions that these technologies will cause to social norms, institutions, and communities warrant careful consideration. As we begin to assess these effects, reflection on degrees and kinds of social agency will be required to make (...) properly informed decisions concerning the deployment of artificially intelligent artifacts in important settings. The social agency of these systems is unlike a human social agency, and this paper provides a methodological framework that is more suited for inquiry into artificial social agents than conventional philosophical treatments of the concept of agency. Separate aspects and dimensions of agency can be studied without assuming that agency must always look like adult human agency. This revised approach to the agency of artifacts is conducive to progress in the topics studied by AI ethics. (shrink)

Natural selection comes in degrees. Some biological traits are subjected to stronger selective force than others, selection on particular traits waxes and wanes over time, and some groups can only undergo an attenuated kind of selective process. This has downstream consequences for any notions that are standardly treated as binary but depend on natural selection. For instance, the proper function of a biological structure can be defined as what caused that structure to be retained by natural selection in the past. (...) We usually think of proper functions in binary terms: storing bile is a function of the gall bladder, but making stones is not. However, if functions arise through natural selection, and natural selection comes in degrees, then a binary approach to proper functions is in tension with the biological facts. In order to resolve this tension, we need to revise our standard accounts of proper function. In particular, we may have to seriously consider the possibility that functions themselves come in degrees, in spite of the ramifications this will have for the way we speak about functions and related concepts such as dysfunction, disease, and teleosemantic content. (shrink)

In this short monograph, John Horty explores the difficulties presented for Gottlob Frege's semantic theory, as well as its modern descendents, by the treatment of defined expressions. The book begins by focusing on the psychological constraints governing Frege's notion of sense, or meaning, and argues that, given these constraints, even the treatment of simple stipulative definitions led Frege to important difficulties. Horty is able to suggest ways out of these difficulties that are both philosophically and logically plausible and Fregean (...) in spirit. This discussion is then connected to a number of more familiar topics, such as indexicality and the discussion of concepts in recent theories of mind and language. In the latter part of the book, after introducing a simple semantic model of senses as procedures, Horty considers the problems that definitions present for Frege's idea that the sense of an expression should mirror its grammatical structure. The requirement can be satisfied, he argues, only if defined expressions--and incomplete expressions as well--are assigned senses of their own, rather than treated contextually. He then explores one way in which these senses might be reified within the procedural model, drawing on ideas from work in the semantics of computer programming languages. With its combination of technical semantics and history of philosophy, Horty's book tackles some of the hardest questions in the philosophy of language. It should interest philosophers, logicians, and linguists. (shrink)

Seventeenth-century “chance combinatorics” was a self-contained theory. It had an objective notion of chance derived from physical devices with chance properties, such as casts of dice, combinatorics to count chances and, to interpret their significance, a rule for converting these counts into fair wagers. It lacked a notion of chance as a measure of belief, a precise way to connect chance counts with frequencies and a way to compare chances across different games. These omissions were not needed for the theory’s (...) interpretation of chance counts: determining which are fair wagers. The theory provided a model for how indefinitenesses could be treated with mathematical precision in a special case and stimulated efforts to seek a broader theory. (shrink)

Hegel's Science of Logic is one of the most challenging books in the philosophical library. Its primary text is a mass of abstract terms, woven into sentences that become quite complex. That text avoids illustrations or examples, but plunges on from paragraph to paragraph as the concepts being discussed subtly change their character, develop associations with contrary terms, become part of a complex network of reciprocal interaction, and then collapse into a new integrated thought which then serves as an immediate (...) beginning for the next discussion. (shrink)

Although the last decade has seen a proliferation of ontological approaches to arguments, many of them employ ad hoc solutions to representing arguments, lack interoperability with other ontologies, or cover arguments only as part of a broader approach to evidence. To provide a better ontological representation of arguments, we present the Arguments Ontology (ArgO), a small ontology for arguments that is designed to be imported and easily extended by researchers who work in different upper-level ontology frameworks, different logics, and different (...) approaches to argument evaluation. Unlike most ontological approaches to arguments, ArgO utilizes Basic Formal Ontology (BFO) as an upper-level ontology, and may be used alongside other commonly used ontologies in the BFO framework, including boththe Information Artifact Ontology (IAO), and the Information Entity Ontology (INFO). Critically, our proposal is principled, based on rigorous definitions and formal axioms out of which characterizations of arguments naturally fall. It is our hope that ArgO may assist researchers in many projects, including: integrating heterogeneous sources of evidence, structuring the content of semantic wikis, and enhancing semantic reasoning. (shrink)

In Western political philosophy, democracy is generally the dominant view regarding what the best form of government is, and this holds even in respect to promoting minority rights. However, I argue that there is a better theory for satisfying minority interests and rights. I amass numerous studies from the social sciences demonstrating how democracy does poorly in accounting for minority interests. I then contend that a particular hybrid view that fuses a meritocracy with democracy can do a better job than (...) democracy in accounting for minority interests and in having more equal rights and fair policies coming from the legislative and executive branches. Finally, I defend this thesis from numerous counters. (shrink)

[Editor's introduction: The following are excerpts from three talks given at the conference "Policies and Publics for Science and Technology, " London, April 1990. They introduce a British research initiative in public understanding of science and point to early results. The program was developed and coordinated by the Science Policy Support Group. At the meeting, a new journal for specialists in this area was launched: Public Understanding of Science, to be edited by John Durant, Science Museum, London SW7 2DD, (...) UK. The first issue of the journal is expected to appear in April 1991. Science, Technology, & Human Values reaffirms its long commitment to publishing research on public attitudes toward science and particularly welcomes articles on this topic of general interest to the field of science and technology studies.]. (shrink)

Genetic testing has historically been performed in the context of chronic disease and cancer diagnostics. The timelines for these tests are typically measured in days or weeks, rather than in minutes. As such, the concept that genetic information might be generated and then used to alter management in the acute setting has, thus far, not been feasible. However, recent advances in genetic technologies have the potential to allow genetic information to be generated significantly quicker. The m.1555A>G genetic variant is present (...) in one in 500 individuals and predisposes to profound hearing loss following the administration of aminoglycoside antibiotics. These antibiotics are used frequently in cases of neonatal sepsis and it is estimated that approximately 180 neonates in the UK are at risk of antibiotic induced hearing loss each year because of this genetic change. Knowledge of this variant in the acute setting would allow clinicians to prescribe alternative antibiotics. The Pharmacogenetics to Avoid Loss of Hearing study will implement a genetic point of care test (POCT) for the m.1555A>G variant within two major UK based neonatal intensive care units. This represents the first trial of a genetic POCT aimed at altering management in the acute setting. This round table discussion outlines the novel ethical issues faced in the development of this trial and the legal barriers to implementation. We ask five stakeholders to provide their opinions on this trial and their perspectives on the concept of genetic testing in the acute setting.Trial registration numberISRCTN-13704894. (shrink)

This book examines the different conceptions of the individual that have emerged in recent new approaches in economics, including behavioral economics, experimental economics, social preferences approaches, game theory, neuroeconomics, evolutionary and complexity economics, and the capability approach. These conceptions are classified according to whether they seek to revise the traditional atomist individual conception, put new emphasis on interaction and relations between individuals, account for individuals as evolving and self-organizing, and explain individuals in terms of capabilities. The method of analysis uses (...) two identity criteria for distinguishing and re-identifying individuals to determine whether these different individual conceptions successfully identify individuals. Successful individual conceptions account for sub-personal and supra-personal bounds on single individual explanations. The former concerns the fragmentation of individuals into multiple selves; the latter concerns the dissolution of individuals into the social. The book develops an understanding of bounded individuality, seen as central to the defense of human rights. (shrink)

This is a collection of John Hick's essays on the understanding of the world's religions as different human responses to the same ultimate transcendent reality. Hicks is in dialogue with contemporary philosophers (some of whom contribute new responses); with Evangelicals; with the Vatican and other both Catholic and Protestant theologians. The book is alive with current argument for all interested in contemporary philosophy of religion and theology.

In a wide-ranging, provocative anatomy of modern society and its origins, novelist and historian John Ralston Saul explores the reason for our deepening sense of crisis and confusion. Throughout the Western world we talk endlessly of individual freedom, yet Saul shows that there has never before been such pressure for conformity. Our business leaders describe themselves as capitalists, yet most are corporate employees and financial speculators. We are obsessed with competition, yet the single largest item of international trade is (...) a subsidized market in armaments. We call our governments democracies, yet few of us participate in politics. We complain about "invasive government," yet our legal, educational, financial, social, cultural and legislative systems are breaking down. While most observers view these problems separately, Saul demonstrates that they are largely manifestations of our blind faith in the value of reason. Over the last 400 years, our "rational elites" have gradually instituted reforms in every phase of social life. But Saul shows that they have also been responsible for most of the difficulties and violence of the same period. This paradox arises from a simple truth which our elites deny: far from being a moral force, reason is no more than an administrative method. Their denial has helped to turn the modern West into a vast, incomprehensible, directionless machine, run by process-minded experts - "Voltaire's bastards"--Whose cult of scientific management is bereft of both sense and morality. Whether in politics, art, business, the military, entertainment, science, finance, academia or journalism, these experts share the same outlook and methods. The result, Saul maintains, is a civilization of immense technological power whose peoples increasingly dwell in a world of illusion. Already known to millions of readers as the author of novels which portray the overwhelming effects of this power on the modern individual by weaving together international finance, the oil and arms business, guerrilla warfare, drug traffic, and the world of art, here Saul lays aside the mask of fiction to speak in his own voice. Only by withdrawing from our addiction to "solutions," he argues, reclaiming the citizens' right to question and participate in public life, and recovering a common sense capacity for intelligent panic, can we find a way out of our permanent crisis. (shrink)

I revisit my article, “Why Immortality Is Not So Bad,” in which I argued that Bernard Williams’s thesis that immortality would necessarily be boring for any human being is false. Here I point out various ways in which Williams’s treatment of the issues has tilted and distorted the subsequent debates.

Translated and reprinted by permission of Monthly Review magazine. (c) Monthly Review. All rights reserved. The New Irrationalism by John Bellamy Foster (February 2023, Volume 74, Number 9). Tradução por Lara Nora Portugal Penna. Revisão por Elcemir Paço Cunha.

The Human Condition is a response to the growing disenchantment in the Western world with contemporary life. John Kekes provides rationally justified answers to questions about the meaning of life, the basis of morality, the contingencies of human lives, the prevalence of evil, the nature and extent of human responsibility, and the sources of values we prize. He offers a realistic view of the human condition that rejects both facile optimism and gloomy pessimism; acknowledges that we are vulnerable to (...) contingencies we cannot fully control; defends a humanistic understanding of our condition; recognizes that the values worth pursuing are plural, often conflicting, and that there are many reasonable conceptions of well-being. Kekes emphasizes the importance of facing the fact that man's inhumanity to man is widespread. He rejects as simple-minded both the view that human nature is basically good and that it is basically bad, and argues that our well-being depends on coping with the complex truth that human nature is basically complicated. Finally, Kekes argues that the scheme of things is indifferent to our fortunes and that we can rely only on our own resources to make what we can of our lives. (shrink)

Nowadays, science is treated an instrument of policy, serving the material interests of government and commerce. Traditionally, however, it also has important non-instrumental social functions, such as the creation of critical scenarios and world pictures, the stimulation of rational attitudes, and the production of enlightened practitioners and independent experts. The transition from academic to ‘post-academic’ science threatens the performance of these functions, which are inconsistent with strictly instrumental modes of knowledge production. In particular, expert objectivity is negated by entanglement with (...) political and commercial interests. We cannot go back to the old academic model for science, but need to consider how to maintain its vital non-instrumental roles. (shrink)

Dickens’s relationship with the Arts has confounded or silenced some of the most eminent critics from his day to ours. His own reticence on the topic likewise makes the idea of a book on Dickens and the Arts a little odd or dissonant. Though as this volume makes clear, he was well versed in a range of high and low arts, he was seemingly determined to embrace, if not the wrong side of the cultural track, metaphorically speaking, a different track. (...) The Introduction is structured around four broad areas which are key to an understanding of both the ideological underpinnings of shifting definitions of the Arts, and to an understanding of the reasons for Dickens’s complex relationship to the idea of the Arts: money/materialism; hierarchies of privilege; yardsticks of criticism or artistic judgement; the public good. There is an uneasy relationship between ‘the Arts’ and all four areas, between Dickens and all four, and between Dickens and the Arts understood via these frames, which are commonly invoked in discussions of the Arts. The contention of this volume is that, far from being a philistine who had no interest in the Arts, Dickens’s apparent reticence in an industrial age where the value and function of the Arts was uniquely important in public debate, masks a complex and sophisticated vision (if not theory) of the Arts in the modern era, which is, and was, ahead of its time. Dickens’s philosophy of art in fact works to complicate in subtle ways the idea of an opposition between idealist and integrationist views of the aesthetic, though its most characteristic thrust is integrationist. (shrink)

Does strolling through an art museum, admiring the old masters, improve us morally and spiritually? Would government subsidies of "high art" (such as big-city opera houses) be better spent on local community art projects? In What Good are the Arts? John Carey--one of Britain's most respected literary critics--offers a delightfully skeptical look at the nature of art. In particular, he cuts through the cant surrounding the fine arts, debunking claims that the arts make us better people or that judgements (...) about art are anything more than personal opinion. Indeed, Carey argues that there are no absolute values in the arts and that we cannot call other people's aesthetic choices "mistaken" or "incorrect," however much we dislike them. Along the way, Carey reveals the flaws in the aesthetic theories of everyone from Emanuel Kant to Arthur C. Danto, and he skewers the claims of "high-art advocates" such as Jeannette Winterson. But Carey does argue strongly for the value of art as an activity and for the superiority of one art in particular: literature. Literature, he contends, is the only art capable of reasoning, and the only art that can criticize. Language is the medium that we use to convey ideas, and the usual ingredients of other arts--objects, noises, light effects--cannot replicate this function. Literature has the ability to inspire the mind and the heart towards practical ends far better than any work of conceptual art. Here then is a lively and stimulating invitation to debate the value of art, a provocative book that will pique the interest of anyone who loves painting, music, or literature. (shrink)

In this lively book, John Macnamara shows how a number of important thinkers through the ages have approached problems of mental representation and the ...

Reconstructions of Kant are prominent in the contemporary debate over naturalism. Given that this naturalism rejects a priori principles, Kant's anti-naturalism can best be discerned in the “critical turn” as a response to David Hume. Hume did not awaken Kant to criticize but to defend rational metaphysics. But when Kant went transcendental did he not, in fact, go transcendent? The controversy in the 1990s over John McDowell's Mind and World explored just this suspicion: the questions of the normative force (...) of reason and of the ontological “space of reasons” vis- -vis the world. “Bald naturalism” appears to “extrude” rationality both ontologically and epistemologically from the natural world. Kant sought to discriminate a transcendental middle ground, safe from either extrusion. But was Kant's notion of the autonomy and spontaneity of reason as metaphysically innocent as McDowell's critics would have it? Situating Hume and naturalism in the eighteenth-century German context can help us understand the “critical turn” more accurately. While Hume recognized procedural proprieties for reflection, he did not believe in their a priori necessity. Initially, Kant shared that view. What assimilating Leibniz and Locke in the late 1760s garnered for Kant—the simultaneous spontaneity and self-transparency of reason—seemed to provide a means for overcoming Hume's skepticism and establishing a new foundation for metaphysics. Accordingly, all of the efforts of modern Kantianism notwithstanding, there is more than a whiff of the transcendent in Kant's transcendentalism. (shrink)

Deals with one of the most critical business issues of the century, the question of corporate responsibility. The author reconstructs and critically evaluates the arguments for the maximisation of profits, versus those to be found in the broader context of increased social responsibility.

The theory of evolution by natural selection did not spring fully formed and unprecedented from the brain of Charles Darwin. The idea of evolution had been around, in various guises, since the time of Ancient Greece. And nor did theorizing about evolution stop with what Daniel Dennett called "Darwin's dangerous idea." In this riveting new book, bestselling science writers John and Mary Gribbin explore the history of the idea of evolution, showing how Darwin's theory built on what went before (...) and how it was developed in the twentieth century, through an understanding of genetics and the biochemical basis of evolution, into the so-called "modern synthesis" and beyond. Darwin deserves his recognition as the primary proponent of the idea of natural selection, but as the authors show, his contribution was one link in a chain that extends back into antiquity and is still being forged today. (shrink)

Research scientists are trained to produce specialised bricks of knowledge, but not to look at the whole building. Increasing public concern about the social role of science is forcing science students to think about what they are actually learning to do. What sort of knowledge will they be producing, and how will it be used? Science education now requires serious consideration of these philosophical and ethical questions. But the many different forms of knowledge produced by modern science cannot be covered (...) by any single philosophical principle. Sociology and cognitive psychology are also needed to understand what the sciences have in common and the significance of what they generate. Again, traditional modes of ethical analysis cannot deal adequately with the values, norms and interests activated by present-day technoscience without reference to its sociological, political and economic dimensions. (shrink)

In their thoughtful paper, Shen et al. (2024) discuss optimal solutions to address the challenge of returning individual research results from digital phenotyping in psychiatry. Their conclusion to...

Paul Feyerabend’s 1970 article “Experts in a Free Society” tries to make the case that scientific experts can only be tolerated if they are dilettantes. He uses Galileo, Newton and Kepler as examples of great scientists whose writing is nothing like that of contemporary “experts’, these latter being represented by the authors of the well-known book Human Sexual Response, Bill Masters and Virginia Johnson. He goes on to argue against the idea that the Scientific Revolution represented the triumph of empiricism. (...) I take issue with the way Feyerabend represents Galileo as implacably opposed to empiricism, with his supposition that good science requires a particular personality, and with the way in which he represents the work of Masters and Johnson. (shrink)

This essay explains the prevalence of egalitarian beliefs among academic philosophers, individuals who enjoy significant wealth and privilege. I argue that their egalitarianism does not present a “paradox of conviction,” as G. A. Cohen contends, but follows logically from the institutional structure of academic philosophy. This structure creates a “veil of insignificance” wherein philosophy is a moral performance that incentivizes the adoption of egalitarian beliefs. Philosophers also view the world from behind what is termed a “veil of privilege” that incentivizes (...) a public commitment to egalitarianism as a means of distancing themselves from the role of privilege in their life and encourages the hubristic assumption that the practical problems of socialism can be easily overcome with effort or ingenuity. Identity-protective motivated reasoning means that evidence conflicting with egalitarian beliefs is avoided, ignored, or dismissed. These dynamics are reinforced by established actors who gatekeep the profession. (shrink)

Pursuing Jacques Derrida's reflections on the possibility of "religion without religion," John Llewelyn makes room for a sense of the religious that does not depend on the religions or traditional notions of God or gods. Beginning with Derrida's statement that it was Kierkegaard to whom he remained most faithful, Llewelyn reads Kant, Hegel, Nietzsche, Feuerbach, Heidegger, Sartre, Levinas, Deleuze, Marion, as well as Kierkegaard and Derrida, in original and compelling ways. Llewelyn puts religiousness in vital touch with the struggles (...) of the human condition, finding religious space in the margins between the secular and the religions, transcendence and immanence, faith and knowledge, affirmation and despair, lucidity and madness. This provocative and philosophically rich account shows why and where the religious matters. (shrink)

Elizabeth Anscombe was one of the most gifted and productive philosophers of the decades following the Second World War. Her writings present challenges to readers: some of them are very difficult to comprehend while others seem philosophically-minded yet situated outside of philosophy as such. There are also the issues of whether she had a philosophical method and of the influence of Wittgenstein on the manner of her approach. A summary and estimate of Anscombe’s enduring contributions is presented before exploring the (...) style and aims of her philosophical work. Then two of her writings on religion are examined and their implications for her attitude to philosophy considered. (shrink)

Journal of Political Philosophy, EarlyView.

In this provocative book, John Keane calls for a fresh understanding of the vexed relationship between democracy and violence. Taking issue with the common sense view that 'human nature' is violent, Keane shows why mature democracies do not wage war upon each other, and why they are unusually sensitive to violence. He argues that we need to think more discriminatingly about the origins of violence, its consequences, its uses and remedies. He probes the disputed meanings of the term violence, (...) and asks why violence is the greatest enemy of democracy, and why today's global 'triangle of violence' is tempting politicians to invoke undemocratic emergency powers. Throughout, Keane gives prominence to ethical questions, such as the circumstances in which violence can be justified, and argues that violent behaviour and means of violence can and should be 'democratised' - made publicly accountable to others, so encouraging efforts to erase surplus violence from the world. (shrink)

Thornhill, John Shortly after completing my article, 'Reflections on the Gospel: after Reading Christopher Dawson', I read for the first time, C.H. Dodd's Gospel and Law, lectures given at Columbia University in 1950. This challenging work by a leading scholar prompted me to make the comparison between Protestant and Catholic approaches to the Gospel I have attempted in the present article.