Error‐free genome duplication and accurate cell division are critical for cell survival. In all three domains of life, bacteria, archaea, and eukaryotes, initiator proteins bind replication origins in an ATP‐dependent manner, play critical roles in replisome assembly, and coordinate cell‐cycle regulation. We discuss how the eukaryotic initiator, Origin recognition complex (ORC), coordinates different events during the cell cycle. We propose that ORC is the maestro driving the orchestra to coordinately perform the musical pieces of replication, chromatin organization, and repair.

: Nagarjuna seems willing to embrace contradictions while at the same time making use of classic reductio arguments. He asserts that he rejects all philosophical views including his own-that he asserts nothing-and appears to mean it. It is argued here that he, like many philosophers in the West and, indeed, like many of his Buddhist colleagues, discovers and explores true contradictions arising at the limits of thought. For those who share a dialetheist's comfort with the possibility of true contradictions commanding (...) rational assent, for Nagarjuna to endorse such contradictions would not undermine but instead confirm the impression that he is indeed a highly rational thinker. It is argued that the contradictions he discovers are structurally analogous to many discovered by Western philosophers and mathematicians. (shrink)

Ecologist Richard Levins argues population biologists must trade‐off the generality, realism, and precision of their models since biological systems are complex and our limitations are severe. Steven Orzack and Elliott Sober argue that there are cases where these model properties cannot be varied independently of one another. If this is correct, then Levins's thesis that there is a necessary trade‐off between generality, precision, and realism in mathematical models in biology is false. I argue that Orzack and Sober's arguments fail since (...) Levins's thesis concerns the pragmatic features of model building not just the formal properties of models. (shrink)

Theory of Mind (ToM) is the cognitive achievement that enables us to report our propositional attitudes, to attribute such attitudes to others, and to use such postulated or observed mental states in the prediction and explanation of behavior. Most normally developing children acquire ToM between the ages of 3 and 5 years, but serious delays beyond this chronological and mental age have been observed in children with autism, as well as in those with severe sensory impairments. We examine data from (...) studies of ToM in normally developing children and those with deafness, blindness, autism and Williams syndrome, as well as data from lower primates, in a search for answers to key theoretical questions concerning the origins, nature and representation of knowledge about the mind. In answer to these, we offer a framework according to which ToM is jointly dependent upon language and social experience, and is produced by a conjunction of language acquisition with children's growing social understanding, acquired through conversation and interaction with others. We argue that adequate language and adequate social skills are jointly causally sufficient, and individually causally necessary, for producing ToM. Thus our account supports a social developmental theory of the genesis of human cognition, inspired by the work of Sellars and Vygotsky. How are we to decide whether to take reason to be an essentially private thing that can, however, turn on a public display when it chooses to do so, or, like conversing, to be an essentially social skill, which can, however, be retained a while through periods of solitary confinement? (Annette Baier, The Commons of the Mind, p. 5). The squirrel does not infer by induction that it is going to need stores next winter as well (Wittgenstein, On Certainty§ 287). The problem of thought and language thus extends beyond the limits of natural science and becomes the focal problem of historical human psychology, i.e. of social psychology. Consequently, it must be posed in a different way (Vygotsky, Thought and Language, p. 51). From the very first days of the child's development his activities acquire a meaning of their own in a system of social behaviour and, being directed towards a definite purpose, are refracted through the prism of the child's environment. The path from object to child and from child to object passes through another person. This complex human structure is the product of a developmental process deeply rooted in the links between individual and social history (Vygotsky, Mind in Society, p. 30). (shrink)

This paper addresses some connections between conceptions of the will and the theory of practical reason. The first two sections argue against the idea that volitional commitments should be understood along the lines of endorsement of normative principles. A normative account of volition cannot make sense of akrasia, and it obscures an important difference between belief and intention. Sections three and four draw on the non-normative conception of the will in an account of instrumental rationality. The central problem is to (...) explain the grip of instrumental requirements even in cases in which agents do not fully endorse the ends they are pursuing. The solution I propose appeals to coherence constraints on the beliefs that condition the distinctive volitional stance of intention. (shrink)

The doctrine of informed consent, borrowed from the law of torts, cannot be readily transplanted into therapeutic settings. The broader, as yet unrealized, idea of informed consent, which suggests that parties must make decisions jointly, should guide interactions between physicians and patients or investigators and subjects.

In this essay, I argue for four related claims. First, Richard Levins’ classic “The Strategy of Model Building in Population Biology” was a statement and defense of theoretical population biology growing out of collaborations between Robert MacArthur, Richard Lewontin, E. O. Wilson, and others. Second, I argue that the essay served as a response to the rise of systems ecology especially as pioneered by Kenneth Watt. Third, the arguments offered by Levins against systems ecology and in favor of his own (...) methodological program are best construed as “pragmatic”. Fourth, I consider limitations of Levins’ arguments given contemporary population biology. (shrink)

People do not choose to suffer from catastrophic illnesses, but considerable human choice is involved in the ways in which the participants in the process treat and conduct research on these diseases. Catastrophic Diseases draws a powerful and humane portrait of the patients who suffer from these illnesses as well as of the physician-investigators who treat them, and describes the major pressures, conflicts, and decisions which confront all of them. By integrating a discussion of "facts" and "values," the authors highlight (...) the forces which affect new developments in medicine—such as kidney and heart transplants—and the controversial issues they generate. Katz and Capron explore these issues through the use of dual conceptual perspectives. Their study first examines and evaluates the authority which should be vested in each of the chief participants in the catastrophic disease process—the physician-investigator, the patient-subject and his relatives, the professionals, and the state. Challenging questions are raised concerning medical education, informed consent, and professional responsibility. The authors next explore how the roles and capacities of the participants vary not only according to the basic issues they face but also according to the point in decision-making at which these issues arise. The process of investigating and treating catastrophic diseases, the authors believe, can thus usefully be divided into three decision-making stages—the formulation of policy, the administration of research and therapy, and the review of the decisions and their consequences. In conclusion, Katz and Capron demonstrate the need for a variety of individuals and groups with diverse values to be involved in decision-making in a manner which will not unnecessarily impede the scientific investigation of these diseases. (shrink)

‘Ju Mipham Rinpoche, (1846-1912) an important figure in the _Ris med_, or non- sectarian movement influential in Tibet in the late 19^th and early 20^th Centuries, was an unusual scholar in that he was a prominent _Nying ma_ scholar and _rDzog_ _chen_ practitioner with a solid dGe lugs education. He took dGe lugs scholars like Tsong khapa and his followers seriously, appreciated their arguments and positions, but also sometimes took issue with them directly. In his commentary to Candrak¥rti’s _Madhyamakåvatåra, _Mi (...) pham argues that Tsong khapa is wrong to take Candrak¥rti’s rejection of the reflexive character of consciousness to be a rejection of the _conventional _existence of reflexive awareness. Instead, he argues, Candrak¥rti only intends to reject the reflexivity of awareness _ultimately_, and, indeed, Mipham argues, it is simply _obvious _that conventionally, consciousness is reflexive. (shrink)

In this paper I argue for the Atlas-Kempson Thesis that sentences of the form The A is not B are not ambiguous but rather semantically general (Quine), non-specific (Zwicky and Sadock), or vague (G. Lakoff). This observation refutes the 1970 Davidson-Harman hypothesis that underlying structures, as full semantic representations, are logical forms. It undermines the conception of semantical presupposition, removes a support for the existence of truth-value gaps for presuppositional sentences (the remaining arguments for which are viciously circular), and lifts (...) the Russell-Strawson dispute of 1950–1964 from stalemate to a formulation in which a resolution is possible for the first time. Suggestions of Davidson, Montague, Stalnaker, Kaplan and H. P. Grice are shown to be inadequate semantic descriptions of negative, presuppositional sentences. I briefly discuss the radical Pragmatics view of my 1975 publications and suggest that it too fails to do justice to the linguistic data. I speculate that Semantic Representations should be given the form (more or less) of computer programs, describable in Dana Scott's mathematical semantics for programming languages. (shrink)

The participation of adolescents in genetic research engenders unusual problems concerning the nature of their informed consent. In this study we analyze 70 consent documents collected from genetics investigators in the United States who conduct research with children and adolescents. We find that many consent documents do not reflect either the current or the developing ethical and legal standards for research with adolescents and that in many cases the documents are simply confusing or unclear. We make recommendations for change to (...) reflect more adequately the changing perspective concerning the autonomous decision-making capacity of adolescents. (shrink)

In recent years, there has much attention given by philosophers to the ubiquitous role of models and modeling in the biological sciences. Philosophical debates has focused on several areas of discussion. First, what are models in the biological sciences? The term ‘model’ is applied to mathematical structures, graphical displays, computer simulations, and even concrete organisms. Is there an account which unifies these disparate structures? Second, scientists routinely distinguish between theories and models; however, this distinction is more difficult to draw in (...) the biological sciences since biologists often only have a variety of models and rarely have something like a fundamental theory. What then is a theory in biology? Third, how are models related to empirical or “target” systems? (shrink)

four ancestry, is that there are . A proposition may be true (and true only), false (and false only), both true and false, neither true nor false , ,.

Some ecologists have argued that theoretical model building in population and community ecology has gone evidentially unconstrained. In the essay, I argue that "bottle experiments" offer ecological model building evidential constraints and illustrate this by considering work on chaotic models tested by the dynamics of flour beetles. Critics reply that these experiments are importantly unlike nonmanipulated natural systems and thus do not constitute genuine tests of the models. I conclude by considering two responses to this worry and a suggestion on (...) how to move forward on this debate. (shrink)

Recently, there has been a rise in pessimism concerning what theoretical ecology can offer conservation biologists in the formation of reasonable environmental policies. In this paper, I look at one of the pessimistic arguments offered by Kristin Shrader-Frechette and E. D. McCoy (1993, 1994)--the argument from conceptual imprecision. I suggest that their argument rests on an inadequate account of the concepts of ecological stability and that there has been conceptual progress with respect to complexity-stability hypotheses. Such progress, I maintain, can (...) supply important resources for conservation biologists in determining environmental policies. (shrink)

Journal of Applied Philosophy, EarlyView.

In this commentary on Torbjörn Tännsjö’s Setting Health-Care Priorities, I argue that sufficientarianism provides a valuable perspective in considering how to set health care priorities. I claim that pace Tännsjö, sufficientarianism does offer a distinct alternative to prioritarianism. To demonstrate this, I introduce sufficientarianism and distinguish two forms: Tännsjö’s “weak sufficientarianism” and an alternative strong form of sufficientarianism that I call “revised lexical sufficientarianism.” I raise a problem for Tännsjö’s sufficientarianism, and advocate for the revised view on this basis. I (...) then demonstrate that in the area of population ethics, the revised view outperforms the other views Tännsjö considers. As such, I aim to demonstrate that sufficientarianism — understood as its own theory and not just as a form of prioritarianism — offers unique advantages in population ethics, and would have been a valuable complement to the other theories Tännsjö considers. (shrink)

The Covid-19 pandemic resulted in school closures around the world, leaving lasting negative impacts on many children. Given that such closures are justified public health measures, this raises the question of compensating children for school closures. In this article I address the question of compensation from the perspective of a popular theory of justice: luck egalitarianism. In doing so, I examine a problem with applying luck egalitarianism to children, called the agency assumption. I then argue this assumption results in a (...) dilemma for luck egalitarianism and suggest how this dilemma can be overcome. I argue that the resulting form of luck egalitarianism reveals something interesting about compensating children for school closures: luck egalitarianism requires us to address all bases of justice-relevant inequality among children—Covid-19-related and beyond. Although much of the current discussion of compensating children for such closures has focused narrowly on the need to make up for lost instruction time or to prevent reductions in educational achievement, I argue that a luck egalitarian conception of justice requires us to go beyond merely compensating children for educational losses and instead aim for radical equality in education. (shrink)

Nāgārjuna argues for the fundamental importance of causality, and dependence more generally, to our understanding of reality and of human life: his account of these matters is generally correct. First, his account of interdependence shows how we can clearly understand the nature of scientific explanation, the relationship between distinct levels of theoretical analysis in the sciences (with particular attention to cognitive science), and how we can sidestep difficulties in understanding the relations between apparently competing ontologies induced by levels of description (...) or explanation supervening on one another. Then rGyal tshab's exposition of Dharmakīrti's account, in the pramānasiddhi chapter of the "Pramāṇavarttika", of the necessity of a belief in rebirth for the cultivation of bodhicitta is examined. This account is accepted in the dGe lugs tradition both as an accurate representation of Dharmakīrti's views and as authoritative regarding bodhicitta and the mahākarunā that is its necessary condition. But Dharmakīrti, rGyal tshab, and their followers, by virtue of accepting this argument, neglect Nāgārjuna's account of dependent arising and in consequence are implicated in what might be seen from a proper Prāsaṅgika-Madhyamaka point of view as the very subtlest form of self-grasping. (shrink)

Events in the history of thought have often moved as elements of drama—now tense, now tragic, now triumphant. And, it would appear, sometimes ludicrous. This latter is the thrust of a parody which Molière visited upon the savants of his day; he pictures a candidate for a medical degree being solemnly asked why opium puts people to sleep. Just as solemnly and sagaciously, the candidate replies..

Greg Cooper’s The Science of the Struggle for Existence is a must read for those interested in the history and philosophy of ecology and in topics like laws of nature, scientific explanation, and mathematical modeling. If you want to explore some of the metaphysical and methodological challenges that face ecology, there is no better place to go. Thus, this book marks an important moment in the philosophy of ecology. Folks like myself will be responding to it for quite a while. (...) What I find most appealing about the book is just how much there is to argue with. On every page there are interesting ideas presented but which are excitingly controversial. Some will argue with Cooper’s interpretation of the history of ecology. There are parts of the book that empiricists will balk at. You will not be left unstirred. Having said this, Cooper can be longwinded and while you read you should remember patience is a virtue. (shrink)

Sellars’s views on the Myth of the Given and the ontological status of secondary qualities, one would have thought, are well-known, even if not always well-understood. One would not have expected his Carus Lectures, then, to offer anything radically new and exciting. The ground that they cover is, after all, familiar—from “Empiricism and the Philosophy of Mind”, from “Philosophy and the Scientific Image of Man”, from “The Identity Approach to the Mind-Body Problem”, and from the ensuing debates with Cornman and (...) with Firth. One would not really have anticipated many surprises. But one would have been wrong. (shrink)

Instead of another federal advisory panel to identify ethical principles governing human subjects research, it is time we had a national board with authority to regulate and review such research.

Biographical sketches show how six writers and public figures prepared for their deaths.

As a critic, I am in the unenviable position of agreeing with nearly all of what Mark does in this lucid, erudite and creative book. My comments will hence not be aimed at showing what he got wrong, as much as an attempt from a Madhyamaka point of view to suggest another way of seeing things, in particular another way of seeing how one might think of how Madhyamaka philosophers, such as Någårjuna and Candrak¥rti, see conventional truth, our engagement with (...) conventional truth, and the status of persons. I suspect that this alternative is also in the minds of earlier Buddhist philosophers, and that Madhyamaka may be more an explicit working out of ideas implicit in the tradition than a radical break. If this suspicion—for which I will not argue here—is correct, this alternative is also available to those to whom Mark refers as “reductionists.” I think that this way of seeing things may put certain ideas in Buddhist philosophy into better focus, and may indeed make them more attractive as well. (shrink)

Origin of Species was published; he approached the end of his life just before Albert Einstein presented us with General Relativity. His lifetime saw the emergence of psychology as a discipline separate from philosophy, a birth attended by philosopher-psychologists such as his good friend William James. The work of Peirce, like that of the other American Pragmatists, reflects the ferment of the times. His thought bears the imprint of science, not the science of that Nineteenth Century which as Loren Eiseley (...) has remarked, "regarded the 'laws' of nature as imbued with a kind of structural finality, an integral determinism, which it was the scientists’ duty to describe," (Eisele, 1971) but rather, of science as open, as intrinsically revisable, as radically empirical. Working from the model of science in this latter sense, Peirce held that philosophy, and indeed logic.. (shrink)

The roughly two and a half millennia over which we can trace the development of mathematics as a discipline have seen ups and downs in its study; the "ups" have involved varying emphases and interests depending on the problems and the temper of the time. The 19th Century may be characterized as a period of development of rigor and attention to the axiomatic method in mathematics. This focus on the deductive process in mathematics was accompanied by the application of mathematics (...) in the study of the deductive process itself. It is safe, I think, to say that the best-known and most influential of the lines of.. (shrink)

Science and Engineering Ethics, to appear.

Assertive community treatment (ACT) is a widely propagated team approach to community mental health care that ‘assertively’ engages a subgroup of individuals with severe mental illness who continuously disengage from mental health services. It involves a number of interested parties – including clients, carers, clinicians and managers. Each operates according to perceived ethical principles related to their values, mores and principles. ACT condenses a dilemma that is common in psychiatry. ACT proffers social control whilst simultaneously holding therapeutic aspiration. The clients’ (...) perspective of this dilemma was studied in interviews with 12 clients using the ‘grounded theory’ approach. Results suggest that clients’ disengagement is as much a historical and cultural phenomenon as a result of lack of insight. Many clients had experienced rejection of early help–seeking behaviour and all had been subject to coercive interventions. These coercive interventions were experienced as an attack on identity. All felt that their voice had not been listened to in previous interactions with psychiatric services. Consequentially the clients had an increased level of arousal around issues of power, which needs to be incorporated when examining the ethics of community psychiatry. Traditional notions of the difference between persuasion and coercion – for example – may need to be adapted for this client group. Results are compared with the provider perspective. We conclude that the perspectives differ on two key dimensions. Such an empirical approach to examining psychiatric ethics may ensure that we incorporate the subjectivities of various interested parties in the clinical decision–making process. (shrink)

Philosophers of the life sciences have devoted considerably more attention to evolutionary theory and genetics than to the various sub-disciplines of ecology, but recent work in the philosophy of ecology suggests reflects a growing interest in this area (Cooper 2003; Ginzburg and Colyvan 2004). However, philosophers of biology and ecology have focused almost entirely on conceptual and methodological issues in population and community ecology; conspicuously absent are foundational investigations in ecosystem ecology. This situation is regrettable. Ecosystem concepts play a central (...) role in many branches of theoretical and applied ecology, and in environmental literature generally. Indeed, for some historians, the division of ecological theory into population-community and ecosystem research traditions, and the methodological and conceptual debates that have arisen between workers in these respective camps, is the distinguishing feature of 20th century ecological science (Hagen 1992). These include debates over, among others: reductionistic vs. holistic research methodologies; the existence and metaphysics of ecological “kinds”; the relationship between evolutionary mechanisms and ecosystem phenomena; and the nature and scope of ecological science and its relationship to other branches of natural and social science. Philosophers of ecology have written on all these topics, but almost exclusively from the theoretical perspective of population, community or evolutionary ecology. Philosophical attention to these issues from the perspective of ecosystem ecology is long overdue. It would be misleading to assert that philosophers in general have ignored ecosystem ecology. Environmental philosophers, including environmental ethicists so-called “radical” environmental philosophers (deep ecologists, social ecologists, ecofeminists, etc.), and policy theorists, have had a long-standing interest in ecosystem ecology (e.g. Callicott 1986; Cahen 1988; Warren and Cheney 1993; Westra 1994; Sagoff 1997; Fitzsimmons 1999).. (shrink)

According to Hume, the idea of a persisting, self-identical object, distinct from our impressions of it, and the idea of a duration of time, the mere passage of time without change, are mutually supporting "fictions". Each rests upon a "mistake", the commingling of "qualities of the imagination" or "impressions of reflection" with "external" impressions (perceptions), and, strictly speaking, we are conceptually and epistemically entitled to neither. Among Kant's aims in the First Critique is the securing of precisely these entitlements. Like (...) Hume, he acknowledges the correlativity of the notions of temporal duration and persisting self-identical objects (i.e., continuant substances). Unlike Hume, however, he undertakes to establish the legitimacy or objective validity of the schematized category of substance and, correspondingly, of the representation of time as a formal unity with duration as one of its modes. (shrink)

One proposal to significantly reduce cardiovascular disease is the idea of administering a ‘polypill’—a combination of drugs that reduce the risk of heart disease and carry few side effects—to everyone over the age of 55. Despite their promise, population strategies like the polypill have not been well-accepted. In this article, I defend the polypill by appealing to fairness. The argument focuses on the need to fairly distribute the costs to individuals. While the fact that population strategies like the polypill impose (...) minor costs on everyone has primarily been used to criticize such strategies, I argue that it gives us a reason to support them. I argue that implementing a population strategy with the polypill contributes to the public good of ‘health system capacity’. I then explain that public goods have widely accepted obligations: they carry an obligation to fairly distribute the costs of the goods and prevent free-riding. Thus, we have at least one pro tanto moral reason to implement the polypill. As such, this article challenges the current literature on the topic, which has largely held adopting population strategies like the polypill to be unjustifiable. (shrink)

Most analytic epistemologists, foundationalists and coherentists alike, have rejected the possibility of an infinitely long, non-recurring regress of justified beliefs. it is instructive to inquire why this notion has received nearly universal condemnation. in a review of recent work six sorts of arguments against infinite justificatory chains are examined. it is concluded firstly that, while regresses in which each belief is justified solely via relations to further beliefs cannot exist, the impossiblity of other sorts of infinite justificatory chains has not (...) been shown, and secondly that there may nevertheless be sound methodological reasons for provisionally rejecting the infinite regress possibility while more satisfactory alternatives are explored. (shrink)

Written by researchers in their field, this book is about the skills beyond basic word recognition that are necessary for the processing and comprehension of spoken and written language. It offers topics such as: language and text analysis; cognitive processing and comprehension; development of literacy; literacy and schooling; and more.

Sahotra Sarkar’s Biodiversity and Environmental Philosophy is a welcome addition to the fields of environmental philosophy and the philosophy of science. First, his book has a rigorous and careful discussion of why we should preserve biodiversity. This is all the more important since much of environmental ethics has rested on normative claims which are unclear in meaning, appear unjustified at best and unjustifiable at worst, and are politically ineffective. Second, Sarkar is at home in the science of conservation biology and (...) offers important analyses of methodological issues in both ecology and conservation biology. Third, his book does not sustain what might be thought of as a “North American bias” but takes seriously environmental issues and perspectives from many different places like Australia and India. In this commentary, I raise worries and open questions that can be divided into four sections: (a) those concerning moral philosophy, (b) those concerning ecology and in particular whether we are in an extinction crisis, (c) how biodiversity is defined as a concept, and (d) what the aim and structure of conservation biology is. Ultimately, though my analysis is critical at some junctures, its purpose is to repay and hopefully improve on Sarkar’s rewarding analysis. Let me now turn from praise to criticism. (shrink)