If we live on the weak brane with zero effective cosmological constant in a warped 5D bulk spacetime, gravitational waves and brane fluctuations can be generated by a part of the 5D Weyl tensor and carries information of the gravitational field outside the brane. We consider on a cylindrical symmetric warped FLRW background a U self-gravitating scalar field coupled to a gauge field without bulk matter. It turns out that brane fluctuations can be formed dynamically, due to the modified energy–momentum (...) tensor components of the scalar-gauge field. As a result, we find that the late-time behavior could significantly deviate from the standard evolution of the universe. The effect is triggered by the time-dependent warpfactor with two branches of the form \}\) constants) and the modified brane equations comparable with a dark energy effect. This is a brane-world mechanism, not present in standard 4D FLRW, where the large disturbances are rapidly damped as the expansion proceed. Because gravity can propagate in the bulk, the cosmic string can build up a huge angle deficit by the warpfactor and can induce massive KK-modes felt on the brane. Disturbances in the spatial components of the stress-energy tensor cause cylindrical symmetric waves, amplified due to the presence of the bulk space and warpfactor. They could survive the natural damping due to the expansion of the universe. It turns out that one of the metric components becomes singular at the moment the warp factor develops an extremum. This behavior could have influence on the possibility of a transition from acceleration to deceleration or vice versa. (shrink)

d. 1. Secularisering -- d. 2. Humanisering en emancipatie.

Cancers often express hundreds of genes otherwise specific to germ cells, the germline/cancer (GC) genes. Here, we present and discuss the hypothesis that activation of a “germline program” promotes cancer cell malignancy. We do so by proposing four hallmark processes of the germline: meiosis, epigenetic plasticity, migration, and metabolic plasticity. Together, these hallmarks enable replicative immortality of germ cells as well as cancer cells. Especially meiotic genes are frequently expressed in cancer, implying that genes unique to meiosis may play a (...) role in oncogenesis. Because GC genes are not expressed in healthy somatic tissues, they form an appealing source of specific treatment targets with limited side effects besides infertility. Although it is still unclear why germ cell specific genes are so abundantly expressed in cancer, from our hypothesis it follows that the germline's reproductive program is intrinsic to cancer development. (shrink)

Mathematical models are an important tool in the development ofsoftware technology, including programming languages and algorithms.During the last few years, a new class of such models has beendeveloped based on the notion of a mathematical game that isespecially well-suited to address the interactions between thecomponents of a system. This paper gives an introduction to thesegame-semantical models of programming languages, concentrating onmotivating the basic intuitions and putting them into context.

After 1945, Czech philosophy and culture were first introduced to existentialism. First it was the original works of French existentialists (Sartre, Camus, Marcel), later by means of the journal Letters (1947) and Václav Černý (The first book on existentialism, 1948). The acceptance of existentialism in Czech context was not univocal. Besides factual analyses (J. Patočka, V. Navrátil, V. T. Miškovská), existentialism met with criticism and rejection mainly from Marxists and Catholic scholars for its rational weakness, pessimism, helplessness and intellectual decline.

Since rules - legal, ethical or otherwise - cannot determine their own application, they require persons of flesh and blood to interpret and apply them in concrete cases. Presidents and prime ministers, judges, prosecutors, mediators, leaders of international organizations, and even religious leaders and public intellectuals make decisions on how best to understand rules and how best to apply them. It stands to reason that their character traits influence the sort of decisions they take. This book provides the first systematic (...) framework for discussing global governance in terms of the virtues, and illustrates it with a number of detailed examples of concrete decision-making in specific situations. Virtue in Global Governance combines insights from law, ethics, and global governance studies in developing a unique approach to global governance and international law. (shrink)

The main thesis of this monograph, and its novelty, is the attempt to read Newman's work not only as a defence of the author's life, but as a defence of individual life in general. This reading is done against the background of his profound personalism based on two foundations: truth and responsibility.

Tato práce se zabývá možnými přístupy k etice sexuality, jejich klady i zápory. Etikou sexuality zde není míněno moralizování, stejně tak sexualitou není míněn pouze koitus, pohlavní chování je zde míněno v širším významu tedy včetně rozlehlé oblasti lidského svádění, okolků či otálení. Popsány jsou čtyři klasické přístupy k etice sexuality: tradicionalistický, romantický, marxisticko-feministický a liberální, avšak uvážen je i přístup antinatalistický, který vyplývá z asymetrického argumentu Davida Benatara uveřejněného v jeho práci Nebýt či být. Benatarův antinatalizmus totiž vytváří etiku (...) pohlavního chování, v níž pouze sex, který nevede k rozmnožení, může být morální. I když je tento pátý, antinatalistický přístup značně kontroverzní a zdaleka ne intuitivní, extrémnost jeho pozic se příliš neliší od tradicionalistického pohledu, v němž je morální pouze sex k rozmnožení vedoucí, tyto dva přístupy tak lze postavit do přímé opozice jako dvě krajní možnosti uvažování o etice pohlavního chování. Roli střední cesty v takovém řazení potom zaujme liberální přístup, který jako jediný etiku sexuality nevidí jako etiku odlišnou od jiných lidských činností. (shrink)