Scholars have long noticed a similarity of motifs between Catullus’ Carmen 63 and the fifth book of the Odyssey, where the story of Odysseus’ captivity on Ogygia is narrated. A detailed analysis of the poems shows that Catullus wanted the reader to see in this Homeric episode a kind of matrix for the interpretation of Attis’ sojourn at Cybele. The discovery of this dependence casts a light on some of the hitherto proposed interpretations of Carmen 63.

Perhaps in last few centuries not any big theory has resulted in so much opposition as Darwinian theory of evolution. Within this theory, claim that _Homo sapiens _evolved from animal ancestors, namely apes, is undoubtedly the most controversial issue. Long tradition of teaching by Church that a pair of first people was created in short time in Eden Garden is in contradiction to discoveries of biology, including paleontology. If God exists, which is not the research subject of science, he created (...) human beings by a long process of biological Darwinian evolution followed by shorter process of non-Darwinian cultural evolution. Biologist must treat _Homo sapiens _as just one more species with long phylogeny, albeit special species characterized by brains of enormous size, with well-developed neocortex and very special mental traits being the consequence of such brain. The paper considers selection forces toward increase of this extremely expensive organ, draining at least 20% of energy. The main idea is that a series of positive feedbacks were responsible for the development of brain, correlated increase of intelligence and development of culture. Although no great breakthrough is required for such mode of evolution, energetic constrain limiting brain size was present through large part of our evolution, which was first broken by using primitive tools for cutting meat and grinding down seeds, then by thermal processing of food. The new constrain on skull size, and correlated brain size, that is the danger of death of both mother and child during childbirth, has been partly relieved by shifting large part of brain development to postnatal period. Resulting very long childhood was a prerequisite to cultural development of our species. (shrink)

Students of Thomas Aquinas have so far lacked a comprehensive study of his doctrine of the transcendentals. This volume fills this lacuna, showing the fundamental character of the notions of being, one, true and good for his thought. The book inquires into the beginnings of the doctrine in the thirteenth century and explains the relation of the transcendental way of thought to Aquinas's conception of metaphysics. It analyzes 'Being', 'One', 'True', 'Good' and 'Beautiful' individually and discusses their importance for the (...) philosophical knowledge of God. Medieval Philosophy and the Transcendentals: The Case of Thomas Aquinas is intended as a contribution to the question 'What is philosophy in the Middle Ages?' It argues that the doctrine of the transcendentals is essential for understanding medieval philosophy. (shrink)

Cancers often express hundreds of genes otherwise specific to germ cells, the germline/cancer (GC) genes. Here, we present and discuss the hypothesis that activation of a “germline program” promotes cancer cell malignancy. We do so by proposing four hallmark processes of the germline: meiosis, epigenetic plasticity, migration, and metabolic plasticity. Together, these hallmarks enable replicative immortality of germ cells as well as cancer cells. Especially meiotic genes are frequently expressed in cancer, implying that genes unique to meiosis may play a (...) role in oncogenesis. Because GC genes are not expressed in healthy somatic tissues, they form an appealing source of specific treatment targets with limited side effects besides infertility. Although it is still unclear why germ cell specific genes are so abundantly expressed in cancer, from our hypothesis it follows that the germline's reproductive program is intrinsic to cancer development. (shrink)

Mathematical models are an important tool in the development ofsoftware technology, including programming languages and algorithms.During the last few years, a new class of such models has beendeveloped based on the notion of a mathematical game that isespecially well-suited to address the interactions between thecomponents of a system. This paper gives an introduction to thesegame-semantical models of programming languages, concentrating onmotivating the basic intuitions and putting them into context.

After 1945, Czech philosophy and culture were first introduced to existentialism. First it was the original works of French existentialists (Sartre, Camus, Marcel), later by means of the journal Letters (1947) and Václav Černý (The first book on existentialism, 1948). The acceptance of existentialism in Czech context was not univocal. Besides factual analyses (J. Patočka, V. Navrátil, V. T. Miškovská), existentialism met with criticism and rejection mainly from Marxists and Catholic scholars for its rational weakness, pessimism, helplessness and intellectual decline.

The focus of this article is on an ambivalent conception in medieval thought, namely the term ‘transcendens’, which on the one hand signifies a reality beyond created beings, i.e. God, and on the other hand signifies something common to all beings. Armandus de Bellovisu, in his Declaratio difficilium terminorum, has thematized exactly this difference between transcendence that follows from ‘nobility of being’ and that which follows from ‘commonness of predication’ . The medieval term ‘transcendens’, because of its ambiguity, thus includes (...) two fundamental concepts, which represent divergent philosophical tendencies concerning the specification of First Philosophy: the one understands it as «Philosophy of Transcendence», the other as «Transcendental Philosophy». The history of metaphysics is characterized by the tension between these two tendencies, but as we shall see, it also shows that they are intimately connected. (shrink)

We prove the NTP1 property of a geometric theory T is inherited by theories of lovely pairs and H‐structures associated to T. We also provide a class of examples of nonsimple geometric NTP1 theories.

The main thesis of this monograph, and its novelty, is the attempt to read Newman's work not only as a defence of the author's life, but as a defence of individual life in general. This reading is done against the background of his profound personalism based on two foundations: truth and responsibility.

Tato práce se zabývá možnými přístupy k etice sexuality, jejich klady i zápory. Etikou sexuality zde není míněno moralizování, stejně tak sexualitou není míněn pouze koitus, pohlavní chování je zde míněno v širším významu tedy včetně rozlehlé oblasti lidského svádění, okolků či otálení. Popsány jsou čtyři klasické přístupy k etice sexuality: tradicionalistický, romantický, marxisticko-feministický a liberální, avšak uvážen je i přístup antinatalistický, který vyplývá z asymetrického argumentu Davida Benatara uveřejněného v jeho práci Nebýt či být. Benatarův antinatalizmus totiž vytváří etiku (...) pohlavního chování, v níž pouze sex, který nevede k rozmnožení, může být morální. I když je tento pátý, antinatalistický přístup značně kontroverzní a zdaleka ne intuitivní, extrémnost jeho pozic se příliš neliší od tradicionalistického pohledu, v němž je morální pouze sex k rozmnožení vedoucí, tyto dva přístupy tak lze postavit do přímé opozice jako dvě krajní možnosti uvažování o etice pohlavního chování. Roli střední cesty v takovém řazení potom zaujme liberální přístup, který jako jediný etiku sexuality nevidí jako etiku odlišnou od jiných lidských činností. (shrink)