This is one of the first books in a new series that will publish the very best work in the philosophy of biology. The series will be non-sectarian in character, will extend across the broadest range of topics, and will be genuinely interdisciplinary. The Immune Self is a critical study of immunology from its origins at the end of the nineteenth century to its contemporary formulation. The book offers the first extended philosophical critique of immunology, in which the (...) function of the term 'self' that underlies the structure of current immune theory is analysed. However, this analysis is carefully integrated into a broad survey of the major scientific developments in immunology, a discussion of their historical context, and a review of the conceptual arguments that have moulded this sophisticated modern science. (shrink)

Author comments on the changes in the philosophy of immunology that have occurred since the publication of his book The Immune Self: Theory or Metaphor?, as well as on the dangers, misunderstandings and expectations in this area. Finally, he presents his account of moral agency in the context of his own works discussing this question.

The idea that the immune system distinguishes between self and non-self was one of the central assumptions of immunology in the second half of 20 th century. This idea influenced experimental design and data interpretation. However, in the face of new evidence there is a need for a new conceptual framework in immunology.

It is accepted that first-person thoughts are immune to error through misidentification. I argue that there is also immunity to error through misascription, failure to recognise which has resulted in mistaken claims that first-person thoughts involving the self-ascription of bodily states are, at best, circumstantially immune to error through misidentification relative to ‘I’ and, at worst, subject to error. Central to my thesis is that, first, ‘I’ is immune to error through misidentification absolutely, and that if (...) there is any problem with first-person thoughts this cannot be with the self-identification component, but only with the self-ascriptive component. Secondly, the ‘know who’, or ‘know what’, or ‘know which’ requirement is appropriately relevant to considerations of different self-ascriptive properties, and thus its inapproriateness in self-identification does not entail that ‘I’ may fail to refer and identify. (shrink)

The thesis addresses the issues of error through misidentification and immunity to error through misidentification in relation to the problem of the first person. First, it provides an explanation of error through misidentification. Secondly, it shows that there are two possible ways of understanding immunity to error through misidentification. It is then argued that the first understanding of immunity to error through misidentification leads to what is labelled "the trilemma about the self". That is to say, either we provide (...) an explanation of immunity to error through misidentification, but we subscribe to two contentious metaphysical views about the self-the Cartesian and the Idealist; or else we hold the view that the self is identical with a human being, but we have no explanation of immunity to error through misidentification. It is then shown that in order to solve the trilemma, a different understanding of immunity to error through misidentification must be offered. After discussing various possible understandings of immunity to error through misidentification, a sound account of it is finally provided. Moreover, it is shown how non-inferential, introspection-based mental self-ascriptions can comply with it, in such a way that they turn out to be logically immune to error through misidentification. Finally, by drawing on Evans' and Peacocke's accounts of the possession conditions of the first person concept-in which IEM I-judgements play a central role-, it is shown that it is a concept of a human being who thinks of herself as such. Hence, our first person concept is firmly anti-Cartesian and anti-Idealist. As a consequence, it is maintained that not only is there no need to hold the Cartesian and the Idealist metaphysics of the self in order to explain why some I-judgements can be immune to error through misidentification, but it is also argued that one can no longer be either Cartesian or Idealist. For that would expose one to conceptual incoherence. (shrink)

The reductivist view of war holds that the moral rules of killing in war can be reduced to the moral rules that govern killing between individuals. Noam Zohar objects to reductivism on the grounds that the account of individual self-defence that best supports the rules of war will inadvertently sanction terrorist killings of non-combatants. I argue that even an extended account of self-defence—that is, an account that permits killing at least some innocent people to save one's own life—can (...) support a prohibition on terrorism, provided that it distinguishes between direct and indirect threats. What such an account cannot support is the blanket immunity of non-combatants to defensive killing. If a non-combatant is morally responsible for indirectly threatening in an unjust war, she can be liable to defensive killing. However, this gives us reason to revise our account of permissible killing in war, rather than to reject the reductivist account. (shrink)

It is accepted that first-person thoughts are immune to error through misidentification. I argue that there is also immunity to error through misascription, failure to recognise which has resulted in mistaken claims that first-person thoughts involving the self-ascription of bodily states are, at best, circumstantially immune to error through misidentification relative to.

Recanati’s (2007, 2009) argues for a Lewisian subjectless view of the content of “implicit” de se thought, on the basis that we can thus better explain the phenomenon of immunity to error through misidentification. The paper argues that this is not the case, and suggests that such a view is in tension with Recanati’s mental files approach to de re thought in general and the SELF concept in particular.

Three pathologies of alienation have been claimed to refute the philosophical thesis that introspection-based self-ascriptions of mental states are immune to error through misidentification. In this paper, I show that this critique of the Immunity Thesis is misguided; the cases of alienation either are not self-ascriptions or do not involve misidentification. Rather, these cases undermine a widely assumed explanation of immunity, which is based on the idea that self-ascriptions of mental states are identification-free. I argue that, (...) given a certain understanding of the Immunity Thesis, identification-freedom does not explain immunity anyhow, and I offer an alternative explanation, one which posits a tight link between first-personal awareness and ownership of a mental state. (shrink)

Sydney Shoemaker, developing an idea of Wittgenstein’s, argues that we are immune to error through misidentification relative to the first-person pronoun. Although we might be liable to error when “I” (or its cognates) is used as an object, we are immune to error when “I” is used as a subject (as when one says, “I have a toothache”). Shoemaker claims that the relationship between “I” as-subject and the mental states of which it is introspectively aware is tautological: when, (...) say, we judge that “I feel pain,” we are tautologically aware that feels pain is instantiated and that it is instantiated in oneself. Moreover, he contends that this relationship holds not just for bodily sensations, but also for the sense of agency and for visual perception. But we deny that this relationship is tautological; instead, we treat Shoemaker’s principle (IEM) as a hypothesis. We then proceed to show that certain pathological states and experimentally-induced illusions can be adduced to show that IEM describes not a necessary relationship but a contingent relationship, one that sometimes fails to obtain. That we are not immune to error in the way Shoemaker describes has grave consequences for many aspects of his ideas concerning the first-person perspective. In the course of arguing that these empirical phenomena count against IEM, we also show that not only can the content of conscious experience be misrepresented, so too can the subject: that is, not only can the what of conscious experience be misrepresented, so too can the who. (shrink)

Fernández offers an account of the nature of episodic memory that marries two core ideas: role-functionalism about episodic memory, and self-reflexive mnemonic content. One payoff of this view is that episodic memory judgments are immune to error through misidentification. Fernández takes this to reveal something important about the nature of one’s self-awareness in memory and our first-person conception of ourselves. However, once one sees why such judgments are immune in this way, according to the proposed account, (...) the fact that they are immune becomes moot. While technically immune to error through misidentification, episodic memory judgments are not grounded in a way such that they have any interesting epistemological import for the subject, and any insights about our self-awareness and self-conception are directly derivable from the metaphysics of memory content alone. (shrink)

There is a consensus among philosophers that some “I”-thoughts are immune to error through misidentification. In some recent papers, this property has been formulated in the following deflationist way: an “I”-thought is immune to error through misidentification when it can misrepresent the mental or bodily property self-ascribed but cannot misrepresent the subject possessing that property. However, it has been put forward that the range of mental and bodily states that are immune in that limited sense cannot (...) include nonconceptual forms of self-representation. In this paper, I claim the opposite. I argue in favor of a theoretical framework inspired by semantic relativism that solves the problem of immune nonconceptual self-representations. In order to do so, I refute an argument against the relativist account which is based on the existence of shared representations. This argument, I contend, rests on a confusion between two conditions to which a relativist may appeal when considering whether a certain mental content is relative to the self: a strong invariance condition and a weak invariance condition. I then argue that even if we acknowledge the existence of shared representations, the weak invariance condition is still satisfied, and consequently the relativist framework can make sense of INSRs. I argue that this weak invariance condition is satisfied by a representational function that self-relativizes certain representations. I then provide an empirical instance of such a function by discussing some of the recent literature on motor representations and the sense of agency. In the last part of the paper, I answer several potential objections. These potential objections lead me to distinguish two fundamental kinds of error relative to the self: error through misidentification and error through misapplication. This distinction allows me to answer a fundamental question raised by the very idea of de facto immunity to error through misidentification. (shrink)

In The Blue Book, Wittgenstein defined a category of uses of “I” which he termed “I”-as-subject, contrasting them with “I”-as-object uses. The hallmark of this category is immunity to error through misidentification (IEM). This article extends Wittgenstein’s characterisation to the case of memory-judgments, discusses the significance of IEM for self-consciousness—developing the idea that having a first-person thought involves thinking about oneself in a distinctive way in which one cannot think of anyone or anything else—and refutes a common objection to (...) the claim that memory-judgments exhibit IEM. (shrink)

Both concepts of the holobiont and the immune system are at the heart of an ongoing scientific and philosophical examination concerning questions of the organism’s individuality and identity as well as the relations between organisms and their environment. Examining the holobiont, the question of boundaries and individuality is challenging because it is both an assemblage of organisms with physiological cohesive aspects. I discuss the concept of immunity and the immune system function from the holobiont perspective. Because of the (...) host-microbial close relations of codependence and interdependence, the holobiont is more often than not confused with the host, as the host is the domain in which this entity exists. I discuss the holobiont unique ecological characteristics of microbial assemblages connected to a host in a network of interactions in which the host is one of the organisms in the community but also its landscape. Therefore, I suggest viewing the holobiont as a host-ecosystem and discuss the implication of such a view on the concept of immunity and the meaning of protection. Furthermore, I show that viewing the holobiont as a host ecosystem opens the possibility of using the same ecological definition of boundaries and immunity dealing with an ecological system. Thus, the holobiont’s boundaries and immunity are defined by the persistence of its complex system of interactions integrating existing and new interactions. This way of thinking presents a notion of immunity that materializes as the result of the complex interdependence relations between the different organisms composing the holobiont similar to that of an ecosystem. Taking this view further, I discuss the notion of immunogenicity that is ontologically heterogeneous with various causal explanations of the processes of tolerance and targeted immune response. Finally, I discuss the possible conceptualization of already existing and new biomedical practices. (shrink)

In Immunity, Alfred Tauber sets forth a new theory of immunology that rejects the common principle of self and non-self, and the immune system's role as a protector of the self from external threats. Rather than serving to defend an independent entity, he argues, immunity participates in a large, complex eco-system of porous and flexible boundaries. Tauber's new approach to immunology necessitates a new biology in which symbiosis is the rule, not the exception.

Judgments based on episodic memory are often thought to be immune to errors of misidentification (IEM). Yet there is a certain category of episodic memories, viz. observer memories, that seems to threaten IEM. In the resulting debate, some say that observer memories are a threat to the IEM enjoyed by episodic memory (Michaelian, 2021); others say that they pose no such threat (Fernández, 2021; Lin, 2020). In this paper, we argue for a middle way. First, we frame the debate, (...) claiming that the existing literature lacks a satisfying definition both of observer memories and of the precise issue of errors of identification in such memories. Then, we contribute to the debate by challenging an anti-separatist view about the relation between phenomenal and intentional features of observer memories that looms behind this debate. On this view, if the rememberer's self is a phenomenal feature of the memory, by implication it is also built into the intentional content. We reject this view and offer a moderate separatist account. Distinguishing between empirically-grounded species of observer memories, we say that the phenomenal self sometimes is, and sometimes is not built into the intentional content of the memory, and this results in different implications for IEM. (shrink)

Despite the development of a vast body of literature pertaining to feminism and science, examples of how feminist phifosophies might be applied to scientific theories and practice have been limited. Moreover, most scientists remain unfamiliar with how feminism pertains to their work. Using the example of the immune system, this paper applies three feminist epistemologies feminist empiricism, feminist standpoint theory, and feminist postmodernismtoassess competingchims of immune function within a feminist context.

Wittgenstein distinguished between two uses of “I”, one “as object” and the other “as subject”, a distinction that Shoemaker elucidated in terms of a notion of immunity to error through misidentification (“IEM”); first-personal claims are IEM in the use “as subject”, but not in the other use. Shoemaker argued that memory judgments based on “personal”, episodic memory are not strictly speaking IEM; Gareth Evans disputed this. Similar issues have been debated regarding self-ascriptions of conscious thoughts based on first-personal awareness, (...) in the light of claims of “thought insertion” in schizophrenic patients. The paper aims to defend a Shoemaker-like line by critically engaging with some compelling recent contributions. Methodologically, the paper argues that to properly address these issues the all-inclusive term “thought” should be avoided, and specific types of thoughts countenanced. (shrink)

The current model of adult neurogenesis in mammals suggests that adult‐born neurons are generated by stem cells that undergo long‐term self‐renewal, and that a lifetime supply of stem cells resides in the brain. In contrast, it has recently been demonstrated that adult‐born neurons in crayfish are generated by precursors originating in the immune system. This is particularly interesting because studies done many years ago suggest that a similar mechanism might exist in rodents and humans, with bone marrow providing (...) stem cells that can generate neurons. However, the relevance of these findings for natural mechanisms underlying adult neurogenesis in mammals is not clear, because of uncertainties at many levels. We argue here that the recent findings in crayfish send a strong signal to re‐examine existing data from rodents and humans, and to design new experiments that will directly test the contributions of the immune system to adult neurogenesis in mammals. (shrink)

Cancer cells seem to exploit mechanisms that evolve as part of physiological tolerance, which is a complementary and often beneficial form of defense. The study of physiological systems of tolerance can therefore provide insights into the development of a state of host tolerance of cancer, and how to break it. Analysis of these models has the potential to improve our understanding of existing immunological therapeutic targets, and help to identify future targets and rational therapeutic combinations. The treatment of cancer with (...) immune checkpoint inhibitors aims to reverse the progression to tolerance of cancer, and achieve an immunogenic, rather than tolerogenic, homeostasis. Broadening the efficacy and durability of checkpoint inhibitors focuses on reversing tolerance and stimulating immunogenicity in the cancer, host, and environment. Two examples of important physiological states of tolerance that may inform tolerance of cancer are microbial infection and placental reproduction. These states of tolerance result from bilateral shaping of host and non‐self, akin to immunoediting in cancer, and offer reliable models to study the immune tolerance paradigm. (shrink)

According to immunology’s prevailing paradigm, immunity is based on self/nonself discrimination and thus requires a construction of identity. Two orientations vie for dominance: The original conception, conceived in the context of infectious diseases, regards the organism as insular and autonomous, an entity that requires defense of its borders. An alternate view places the organism firmly in its environment in which both benign and onerous encounters occur. On this latter relational account, active tolerance allows for cooperative relationships with other organisms (...) in the larger ecological economy. These contending orientations —one derived from biomedicine and the other from the ecological sciences— have drawn the attention of social scientists and culture critics. On the one hand, feminists have portrayed immune theory as based upon borrowed social notions of identity that reflect male aggressive values and thus distort more balanced accounts of immunity; and, on the other hand, other commentary projects immune theory as a framework in which analysis of Western societies putatively reveals analogous patterns of ‘self’ and ‘other’ interactions, where autoimmunity and immunization are understood as expressions of the insular understanding of identity. Here, a meta-interpretation is presented that shows how these critiques place the immune self on a spectrum stretching from its formulation as an autonomous agent, a modernist conception of the independent individual, to a postmodern portrayal in which this conception of selfhood has been deconstructed. Accordingly, immunology is drawn into a wide-ranging debate about agency, where differing interpretations of immunity serves as a template in which competing understandings of human social intercourse is modeled.Según el paradigma dominante en inmunología, la inmunidad está basada en la discriminación entre yo/noyo y requiere, por tanto, una construcción de la identidad. Dos orientaciones compiten por dominar: la concepción original, concebida en el contexto de las enfermedades infecciosas contempla al organismo como aislado y autónomo, como una entidad que necesita defender sus fronteras. Una visión alternativa sitúa firmemente al organismo en su entorno, en el cual suceden tanto encuentros beneficiosos como costosos. En este enfoque relacional, la tolerancia activa permite relaciones cooperativas con otros organismos en una economía ecológica más amplia. Estas orientaciones en liza —una derivada de la biomedicina y otra de las ciencias ecológicas— han llamado la atención de los científicos sociales y de los críticos de la cultura. Por una parte, el feminismo ha descrito la teoría inmunológica como basada en nociones sociales prestadas de identidad que reflejan los valores agresivos del macho y que, de este modo, impiden una explicación más equilibrada de la inmunidad. Por otra parte, otro comentario proyecta la teoría inmunológica como un marco en el que el análisis de las sociedades occidentales revela aparentemente patrones análogos de interacciones ‘yo’ y ‘otros’, en las que la autoinmunidad y la inmunización son entendidas como expresiones de la comprensión insular de la identidad. Se ofrece aquí una meta-representación que muestra cómo estas críticas sitúan al yo inmune en un espectro que va desde su formulación cómo un agente autónomo, una concepción modernista del individuo independiente, a una visión postmoderna en la que esta concepción de la identidad ha sido deconstruida. De acuerdo con esto, la inmunología recoge un amplio debate sobre la agencia en el que diferentes interpretaciones de la inmunidad sirven como molde en el que se modelan comprensiones competidoras de la comprensión de las relaciones sociales humanas. (shrink)

In this paper I aim to illuminate the significance of thought insertion for debates about the first-person concept. My starting point is the often-voiced contention that thought insertion might challenge the thesis that introspection-based self-ascriptions of psychological properties are immune to error through misidentification relative to the first-person concept. In the first part of the paper I explain what a thought insertion-based counterexample to this immunity thesis should be like. I then argue that various thought insertion-involving scenarios do (...) not give rise to successful counterexamples to the immunity of the target class of self-ascriptions. In the second part of the paper I turn to defend a Metasemantic Explanation of why the immunity thesis holds. The Metasemantic Explanation rests on a reference-fixing story about the mental ‘I’ whose key contention is that introspective impressions play an essential role in fixing its reference. It is part of my argument in favour of the proposed reference-fixing story, as well as of the Metasemantic Explanation, that they respect the paradigmatic features of self-ascriptions of inserted thoughts. (shrink)

Studies of the activation of the behavioral immune system triggered by the coronavirus disease-2019 pandemic have demonstrated that evolutionary explanations of individual differences in self-protection should not be based only on parental investment and sexual selection theory. An evolutionary model must also incorporate individual differences that arise within each sex as a result of life history strategies and attachment patterns.

Artificial Immune Systems (AIS) are intelligent algorithms derived on the principles inspired by human immune system. In this research work, electroencephalography (EEG) signals for four distinct motor movement of human limbs are detected and classified using Negative Selection Classification Algorithm (NSCA). For this study, a widely studied open source EEG signal database (BCI IV - Graz dataset 2a, comprising 9 subjects) has been used. Mel Frequency Cepstral Coefficients (MFCCs) are extracted as selected feature from recorded EEG signals. Dimensionality (...) reduction of data is carried out by applying two hidden layered stacked auto-encoder. Genetic Algorithm (GA) optimized detectors (Artificial Lymphocytes) are trained using Negative Selection Algorithm (NSA) for detection and classification of four motor movements. The trained detectors consist of four sets of detectors, each set is trained for detection and classification of one of the four movements from the other three movements. The optimized radius of detector is small enough not to mis-detect the sample. Euclidean distance of each detector with every training dataset sample is taken and compared with optimized radius of detector as a non-self detector. Our proposed approach achieved a mean classification accuracy of 86.39% for limb movements over 9 subjects with a maximum individual subject classification accuracy of 97.5 % for subject number eight. (shrink)

It has long been taken for granted that the immune system’s capacity to protect an individual from infection and disease depends on the power of the system to distinguish between self and nonself. However, accumulating data have undermined this fundamental concept. Evidence against the self/nonself discrimination model left researchers in need of a new overarching framework able to capture the immune system’s reactivity. Here, I highlight that along with the self/nonself model, another powerful representation of (...) the immune system’s reactivity has been developed in the twentieth century immunology. According to this alternative view, the immune system is not a killer of nonself strangers but a peace-maker helping to establish harmony with the environment. The balance view of the system has never become part of the dominant paradigm. However, it is gaining more and more currency as new research develops. Advances in mucosal immunology confirm that instead of distinguishing between self and foreign the immune system reacts to microbial, chemical and self-induced alterations to produce responses that counterbalance effects of these changes. (shrink)

This paper presents a view on bodily IEM by describing, first, the structure that grounds need to have in order to yield IEM judgments, and then arguing that somatosensation has this structure. I make my case by presenting an analysis of the sense of bodily ownership. According to this analysis, there is a substantive explanatory relationship between bodily self-consciousness and psychological self-consciousness. I argue that one central virtue of this approach to bodily self-consciousness is that, not only (...) does it help explain bodily IEM, but it also sheds some light on the fact that both psychological and bodily self-ascriptions are subject to analysis in IEM terms, despite their differences. (shrink)

What is the relation of risk to negativity? Is it possible to think a notion of the negative that doesn't exclude the other via inclusion? These two questions are at the heart of Massimo Donà's discussion of immunity. Drawing on Roberto Esposito's genealogy of immunity in community, Donà shows how immunity depends upon a paradox of separation that brings the common and the immune closer together. After sketching the relation of immunity to the notion of polemos, Donà argues that (...) the immune subject, by including the other, negates itself so that the other becomes the true self. The essay closes with a series of reflections on how to think negation and immunity together through pregnancy; a negation that affirms a nonsubstitutive or alternative way of being. (shrink)

Adaptive immunity provides the unique ability to respond to a nearly infinite range of antigenic determinants. Given the inherent plasticity of the adaptive immune system, a series of tolerance mechanisms exist to reduce reactivity toward self. While this reduces the probability of autoimmunity, it also creates an important gap in adaptive immunity: the ability to recognize microbes that look like self. As a variety of microbes decorate themselves in self‐like carbohydrate antigens and tolerance reduces the ability (...) of adaptive immunity to react with self‐like structures, protection against molecular mimicry likely resides within the innate arm of immunity. In this review, we will explore the potential consequences of microbial molecular mimicry, including factors within innate immunity that appear to specifically target microbes expressing self‐like antigens, and therefore provide protection against molecular mimicry. (shrink)

Are bodily self-ascriptions immune to error through misidentification? According to the Inside mode view, one cannot be mistaken about whose body part it is when experiencing them from the inside. Here I shall consider two possible objections to bodily immunity. On the one hand, I shall briefly envisage two cases of misidentification: somatoparaphrenia and the Rubber Hand illusion. I shall show that none of them challenges the immunity principle. On the other hand, I shall highlight a more serious (...) issue for bodily immunity, namely, the multimodal nature of bodily self-knowledge. Very few bodily self-ascriptions are based on grounds that are purely or exclusively from the inside. I shall evaluate the consequences of multimodality for bodily immunity. (shrink)

Self‐consciousness is a topic located at the intersection of a range of different philosophical concerns. One set of concerns is metaphysical. Another is epistemological. When discussing the phenomenon of consciousness in general, philosophers generally think it possible to give an account of consciousness that is independent of how one understands the objects, properties, and events of which one is conscious. Self‐consciousness is important because of the role it plays in the cognitive economy. Self‐consciousness can be understood either (...) in terms of direct awareness of the self or in terms of propositional awareness. Self‐conscious thoughts can be based on a range of different sources of information. Some of these sources can provide information either about the self or about other people. Some influential accounts of self‐consciousness, such as those of Shoemaker (1963, 1968) and Evans (1982), have attributed a fundamental role to the phenomenon of immunity to error through misidentification. (shrink)

I argue that immunity to error through misidentification primarily characterizes thoughts that are 'implicitly' de se, as opposed to thoughts that involve an explicit self-identification. Thoughts that are implicitly de se involve no reference to the self at the level of content: what makes them de se is simply the fact that the content of the thought is evaluated with respect to the thinking subject. Or, to put it in familiar terms : the content of the thought is (...) a property which the thinking subject self-ascribes (as in the Loar/Lewis/Chisholm analysis). After answering an objection (to the effect that immunity can affect explicit de se thoughts), I extend the analysis to demonstrative thoughts, which also exhibit the property of immunity to error through misidentification. (shrink)

A self-ascription is a thought or sentence in which a predicate is self-consciously ascribed to oneself. Self-ascriptions are best expressed using the first-person pronoun. Mental self-ascriptions are ascriptions to oneself of mental predicates (predicates that designate mental properties), non-mental self-ascriptions are ascriptions to oneself of non-mental predicates (predicates that designate non-mental properties). It is often claimed that there is a range of self-ascriptions that are immune to error through misidentification relative to the first-person (...) pronoun (IEM for short). What this means, and exactly which self-ascriptions are properly classed as IEM, is a topic hotly disputed. Some claim that only mental self-ascriptions are IEM, others claim that some non-mental self-ascriptions are IEM. Before this question can be decided, it needs to be judged exactly what it means to say that a self-ascription is IEM. And here we stumble across the fact that there are, at least, two non-equivalent ways of defining the phenomenon1. I will be claiming that one of these definitions should be rejected. (shrink)

Immunity was an institution of Roman and Frankish public law that conferred exemption from various kinds of state obligations. In Roman law, immunity might be granted to an individual, group, or community by the public authority, whether the Roman state itself or one of its constituent self-regulating bodies. It was not an institution with a fixed content; terms varied according to the discretion and powers of the grantor and the system of obligations from which relief was sought. Exemption might (...) be for a limited duration and was always liable to be revoked, especially by imperial authorities, a circumstance that makes it difficult to evaluate the role and extent of immunities in the late empire. Immunities conferred by the emperors are mentioned quite frequently in the legal sources of the fourth and fifth centuries in reference to exemptions from taxation and other public burdens. These imperial grants are generally regarded as the forerunners of Merovingian concessions. (shrink)

Recent studies suggest that insects use pattern recognition molecules to distinguish prokaryotic pathogens and fungi from “self” structures. Less understood is how the innate immune system of insects recognizes endoparasitic Hymenoptera and other eukaryotic invaders as foreign. Here we discuss candidate recognition factors and the strategies used by parasitoids to overcome host defense responses. We suggest that host–parasitoid systems are important experimental models for studying how the innate immune system of insects recognizes foreign invaders that are phylogenetically (...) more closely related to their hosts. The strategies used by parasitoids suggest that insects may employ “hidden-self” recognition molecules for attacking foreign objects intruding the open circulatory system. BioEssays 23:344–351, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

I argue that immunity to error through misidentification primarily characterizes thoughts that are 'implicitly' de se, as opposed to thoughts that involve an explicit self-identification. Thoughts that are implicitly de se involve no reference to the self at the level of content: what makes them de se is simply the fact that the content of the thought is evaluated with respect to the thinking subject. Or, to put it in familiar terms : the content of the thought is (...) a property which the thinking subject self-ascribes (as in the Loar/Lewis/Chisholm analysis). After answering an objection (to the effect that immunity can affect explicit de se thoughts), I extend the analysis to demonstrative thoughts, which also exhibit the property of immunity to error through misidentification. (shrink)

It has been observed that, unlike other kinds of singular judgments, mental self-ascriptions are immune to error through misidentification: they may go wrong, but not as a result of mistaking someone else’s mental states for one’s own. Although recent years have witnessed increasing interest in this phenomenon, three basic questions about it remain without a satisfactory answer: what is exactly an error through misidentification? What does immunity to such errors consist in? And what does it take to explain (...) the fact that mental self-ascriptions exhibit this sort of immunity? The aim of this paper is to bring these questions into focus, propose some tentative answers and use them to show that one prominent attempt to explain the immunity to error through misidentification of mental self-ascriptions is unsuccessful. (shrink)

The vertebrate adaptive immune system has well defined functions in maintaining tolerance to self‐tissues. Suppression of autoreactive T cells is dependent on the regulatory cytokine transforming growth factor‐β (TGF‐β) and regulatory T (Treg) cells, a distinct T cell lineage specified by the transcription factor Foxp3. Although TGF‐β promotes thymic Treg (tTreg) cell development by repressing T cell clonal deletion and peripheral Treg cell differentiation by inducing Foxp3 expression, a recent study shows that TGF‐β suppresses autoreactive T cells independent (...) of Foxp3+ Treg cells. These findings imply that as an ancestral growth factor family member, TGF‐β may have been co‐opted as a T cell‐intrinsic mechanism of self‐tolerance control to assist the evolutionary transition of vertebrate adaptive immunity. Later, perhaps in placental mammals upon their acquisition of a TGF‐β regulatory element in the Foxp3 locus, the TGF‐β pathway is further engaged to induce peripheral Treg cell differentiation and expand the scope of T cell tolerance control to innocuous foreign antigens. (shrink)

Many male traits are well explained by sexual selection theory as adaptations to mating competition and mate choice, whereas no unifying theory explains traits expressed more in females. Anne Campbell's “staying alive” theory proposed that human females produce stronger self-protective reactions than males to aggressive threats because self-protection tends to have higher fitness value for females than males. We examined whether Campbell's theory has more general applicability by considering whether human females respond with greater self-protectiveness than males (...) to other threats beyond aggression. We searched the literature for physiological, behavioral, and emotional responses to major physical and social threats, and found consistent support for females' responding with greater self-protectiveness than males. Females mount stronger immune responses to many pathogens; experience a lower threshold to detect, and lesser tolerance of, pain; awaken more frequently at night; express greater concern about physically dangerous stimuli; exert more effort to avoid social conflicts; exhibit a personality style more focused on life's dangers; react to threats with greater fear, disgust, and sadness; and develop more threat-based clinical conditions than males. Our findings suggest that in relation to threat, human females have relatively heightened protective reactions compared to males. The pervasiveness of this result across multiple domains suggests that general mechanisms might exist underlying females' unique adaptations. An understanding of such processes would enhance knowledge of female health and well-being. (shrink)

Abstract: What grounds the experience of our body as our own? Can we rationally doubt that this is our own body when we feel sensations in it? This article shows how recent empirical evidence can shed light on issues on the body and the self, such as the grounds of the sense of body ownership and the immunity to error through misidentification of bodily self-ascriptions. In particular, it discusses how bodily illusions (e.g., the Rubber Hand Illusion), bodily disruptions (...) (e.g., somatoparaphrenia), and the multimodal nature of bodily self-knowledge challenge a classic view of ownership and immunity that puts bodily sensations at its core. (shrink)

I discuss an aspect of the relation between accounts of de se thought and the phenomenon of immunity to error through misidentification. I will argue that a deflationary account of the latter—the Simple Account, due to Evans —will not do; a more robust one based on an account of de se thoughts is required. I will then sketch such an alternative account, based on a more general view on singular thoughts, and show how it can deal with the problems I (...) raise for the Simple Account. (shrink)

The immune system does not just fight pathogens but also engages in interactions with beneficial microbes and non-immune cells of the body to harmonize their behavior by means of cytokines, antibodies and effector cells (Dinarello, 2007; Moticka, 2015, pp. 217e226, 261e267). However, the importance of these “housekeeping” functions has not been fully appreciated (Cohen, 2000). In his new book Immunity: The Evolution of an Idea Alfred I. Tauber traces the history of fundamental ideas in immunology and refers to (...) recent advances in the field to overturn the notion that immunity is the ability of an autonomous organism to protect itself against pathogens. Indeed, as suggested by the author, the autonomy of the organism is illusive because individuals develop as holobionts: functionally integrated multispecies consortia (p. 98). Similarly, he suggests that pathogenicity also emerges from the lack of subordination of a microbe to social welfare of the holobiont rather than from context-independent properties of this organism (pp. 165, 181). Emphasizing the contextual character of the parasite and the host, Tauber redefines immunity as an active process of coordination of a cellular ecosystem, which allows this collective to navigate through challenges of the environment and to face demands of the communal living (pp. 10e16). From this point of view, the failure to modulate intercellular interactions by the immune system entails mitigating immunity and impairing resistance to infection and disease (pp. 103e104). Immunity is a groundbreaking work establishing a new framework for understanding the function and activity of the immune system. Its value also lies in the fact that it serves as an important stepping-stone towards an integrated philosophical, ecological and immunological study of our embedment in the microbial world. (shrink)