The mechanism of chromosome condensation is one of the classic mysteries of mitosis. A number of years ago, it was suggested that nonhistone proteins of the chromosome scaffold fraction might help chromosomes to condense, possibly by constructing a framework for the condensed structure. Recent results have shown that topoisomerase II and the SMC proteins, two abundant members of the scaffold fraction, are required for chromosome condensation and segregation during mitosis. Topoisomerase II is a well‐characterized enzyme. In contrast, nothing is yet (...) known about the function of the SMC proteins. We summarize evidence suggesting that these proteins may be enzymes whose activity is somehow involved in the establishment and maintenance of mitotic chromosome morphology. (shrink)

Most explorations of the epistemic implications of Semantic Anti- Individualism (SAI) focus on issues of self-knowledge (first-person au- thority) and/or external-world skepticism. Less explored has been SAIs implications forthe epistemology of reasoning. In this paperI argue that SAI has some nontrivial implications on this score. I bring these out by reflecting on a problem first raised by Boghossian (1992). Whereas Boghos- sians main interest was in establishing the incompatibility of SAI and the a priority of logical abilities (Boghossian 1992: 22), (...) I argue that Boghossians argument is better interpreted as pointing to SAIs implications for the na- ture of discursive justification. (shrink)

Sanford Goldberg investigates the role that others play in our attempts to acquire knowledge of the world.

In this paper I argue that Rik Peels’s account of doxastic responsibility is too subjectivist, as it fails to deliver the correct verdicts in some cases in which one’s responsibilities derive from a social role and where one has misleading higher-order evidence about the first-order evidence. The take-home point is that the notion of responsibility in doxastic responsibility is something that is owed to others.

In Relying on others [Goldberg, S. 2010a. Relying on others: An essay in epistemology. Oxford: Oxford University Press], I argued that, from the perspective of an interest in epistemic assessment, the testimonial belief-forming process should be regarded as interpersonally extended. At the same time, I explicitly rejected the extendedness model for beliefs formed through reliance on a mere mechanism, such as a clock. In this paper, I try to bolster my defense of this asymmetric treatment. I argue that a (...) crucial assumption lying behind the argument I used to establish interpersonal extendedness in testimony cases does not apply to beliefs formed through reliance on instruments. In this respect, at least, there appears to be something epistemically distinctive about relying on another epistemic agent. (shrink)

Reflection on testimony provides novel arguments for anti-individualism. What is anti-individualism? Sanford Goldberg's book defends three main claims under this heading: first, facts about the contents of beliefs do not supervene on individualistic facts about the believers ; second, an individual's epistemic entitlement to accept a piece of testimony depends on facts about her peers ; third, processes by which some humans acquire knowledge from testimony includes activities performed for them by others. Each of these three claims is argued (...) for separately from premises about the ways in which humans, adult and child, succeed in gaining knowledge by testimony. The three arguments provide the structure for Anti-Individualism.Goldberg's argument for the first claim – that the contents of beliefs do not supervene on individualistic facts about the believers – begins from uncontroversial facts about testimony. Gaining knowledge by testimony depends on knowing the meanings of some utterances, and it is possible to know the meaning of a person's utterance while knowing little that would distinguish this person from anyone else. The best explanation of how this is possible involves postulating linguistic norms which entail facts about the linguistic meanings of utterances. Now in some cases of testimony, a hearer acquires a belief whose content is the linguistic meaning of a speaker's utterance, where the linguistic meaning of this utterance is determined by linguistic norms. But linguistic norms might have been different from what they are even while the person's and her audience's non-relational properties remained unaltered. And in such a case, the hearer would have acquired a belief with a different content. Therefore, ‘Psychological facts such as believing that p do not supervene on the individualistic facts regarding the subject’ …. (shrink)

This article argues that positioning disclosure as a primary remedy in addressing the ethical problems posed by conflicts of interest in medicine and health is an error. Instead, bioethical resources should be devoted to the problems associated with sequestration, defined as the elimination of relationships between commercial industries and health professionals in all cases where it is remotely feasible. The argument begins by arguing that adopting Andrew Stark’s conceptual framework for COIs leads to advantages in understanding COIs and in ordering (...) priorities for intervention. The article then draws on prior work establishing that COIs are, under ordinary epidemiologic standards, properly regarded as population health hazards. This justifies attention to possible remedies, of which disclosure generates by far the most analysis. Such primacy is unwarranted given the extensive evidence suggesting that disclosure as a remedy for COIs is at best ineffective. ‘At best’ is justified because the evidence also shows that disclosure may have a perverse effect, intensifying biased behaviors. Expending significant attention on an ineffective or even deleterious intervention is unjustified and also crowds out devotion of resources to the real problems that attend sequestration. Therefore, disclosure ought to be regarded as a lower priority among possible COI interventions. (shrink)

The following three propositions appear to be individually defensible but jointly inconsistent: (1) reliability is a necessary condition on epistemic justification; (2) on contested matters in philosophy, my beliefs are not reliably formed; (3) some of these beliefs are epistemically justified. I explore the nature and scope of the problem, examine and reject some candidate solutions, compare the issue with ones arising in discussions about disagreement, and offer a brief assessment of our predicament.

(2000). Commentary: A well regulated militia, or a volatile militancy? Criminal Justice Ethics: Vol. 19, No. 1, pp. 2-55. doi: 10.1080/0731129X.2000.9992079.

In this paper I will be arguing that there are cases in which a subject, S, should have known that p, even though, given her state of evidence at the time, she was in no position to know it. My argument for this result will involve making two claims. The uncontroversial claim is this: S should have known that p when another person has, or would have, legitimate expectations regarding S’s epistemic condition, the satisfaction of these expectations would require that (...) S knows that p, and S fails to know that p. The controversial claim is that these three conditions are sometimes jointly satisfied. I will spend the majority of my time defending the controversial claim. I will argue that there are two main sources of legitimate expectations regarding another’s epistemic condition: participation in a legitimate social practice ; and moral and epistemic expectations more generally . In developing my position on this score, I will have an opportunity to defend the doctrine that there are “practice-generated entitlements” to expect certain things, where it can happen that the satisfaction of these expectations requires another’s having certain pieces of knowledge; to contrast practice-generated entitlements to expect with epistemic reasons to believe; to defend the idea that moral and epistemic standards themselves can be taken to reflect legitimate expectations we have of each other; to compare the “should have known” phenomenon with a widely-discussed phenomenon in the ethics literature—that of culpable ignorance; and finally to suggest the bearing of the “should have known” phenomenon to epistemology itself. (shrink)

Philosophy & Public Affairs, Volume 50, Issue 3, Page 375-407, Summer 2022.

Many epistemologists agree that even very young children sometimes acquire knowledge through testimony. In this paper I address two challenges facing this view. The first (building on a point made in Lackey (2005)) is the defeater challenge, which is to square the hypothesis that very young children acquire testimonial knowledge with the fact that children (whose cognitive immaturity prevents them from having or appreciating reasons) cannot be said to satisfy the No-Defeaters condition on knowledge. The second is the extension challenge, (...) which is to give a motivated, extensionally-adequate account of the conditions on testimonial knowledge in early childhood. Neither challenge can be met merely by endorsing externalism about knowledge; but we can meet both by reconceiving the process that eventuates in the child’s consumption of testimony. My central thesis is that this process should be seen as implicating features of the child's social environment. The result is a novel anti-individualistic externalism about knowledge. (shrink)

This article adopts a population-level bioethics approach to analyzing the ethical implications of novel deep-brain stimulation (DBS) technologies. I claim that a microlevel focus on costs and benefits is necessary but insufficient to address the concerns of social justice and health equity that attend the potential utilization of DBS technologies. A macrosocial, population-based analysis notes two ethically significant trends regarding novel health technologies: (1) that they are the prime mover of hyperinflationary health cost trajectories, and (2) that even where they (...) improve overall population health such technologies may expand health inequalities. Such an expansion could exacerbate what Powers and Faden have identified as “densely-woven patterns of disadvantage,” and therein could contravene mandates of social justice. Such concerns of justice and equity are sharpened by the fact that those populations that bear the highest risk of suffering the injuries and illnesses for which DBS technologies might be warranted are among the most disadvantaged groups in American society. Accordingly, ethical analysis of DBS technologies must include an assessment of the evidence suggesting that in their capacity to improve health and compress health inequalities, whole-population approaches that address the upstream factors that shape distributions of neuropsychiatric injuries and illness may be preferable to acute health interventions. However, the article warns against the false-choice fallacy, and notes that whole-population policies and acute care interventions can be simultaneously endorsed. The article concludes by suggesting that the ethical issue of relative priority between these approaches is best framed via a population-level analysis. (shrink)

In this paper I argue that the tendency to defer in matters semantic is rationalized by our reliance on the say-so of others for much of what we know about the world. The result, I contend, is a new and distinctly epistemic source of support for the doctrine of attitude anti-individualism.

A new theoretical approach to language has emerged in the past 10–15 years that allows linguistic observations about form–meaning pairings, known as ‘construc- tions’, to be stated directly. Constructionist approaches aim to account for the full range of facts about language, without assuming that a particular subset of the data is part of a privileged ‘core’. Researchers in this field argue that unusual constructions shed light on more general issues, and can illuminate what is required for a complete account of (...) language. (shrink)

In this paper I formulate the thesis of the Division of Epistemic Labor as a thesis of epistemic dependence, illustrate several ways in which individual subjects are epistemically dependent on one or more of the members of their community in the process of knowledge acquisition, and draw conclusions about the cognitively distributed nature of some knowledge acquisition.

It has been alleged that the demands of friendship conflict with the norms of epistemology—in particular, that there are cases in which the moral demands of friendship would require one to give a friend the benefit of the doubt, and thereby come to believe something in violation of ordinary epistemic standards on justified or responsible belief :329–351, 2004; Stroud in Ethics 116:498–524, 2006; Hazlett in A luxury of the understanding: on the value of true belief, Oxford University Press, Oxford, 2013). (...) The burden of this paper is to explain these appearances away. I contend that the impression of epistemic partiality in friendship dissipates once we acknowledge the sorts of practical and epistemic reasons that are generated by our values: value-reflecting reasons. The present proposal has several virtues: it requires fewer substantial commitments than other proposals seeking to resist the case for epistemic partiality ; it is independently motivated, as it cites a phenomenon—value-reflecting reasons—we have independent reasons to accept; it provides a single, unified account of how various features of friendship bear on belief-formation; and makes clear how it is the very value we place on friendship itself that ensures against epistemic partiality. (shrink)

Pacific Philosophical Quarterly, 80:2, 136-56 (June 1999).

One of the central points of contention in the epistemology of testimony concerns the uniqueness (or not) of the justification of beliefs formed through testimony--whether such justification can be accounted for in terms of, or 'reduced to,' other familiar sort of justification, e.g. without relying on any epistemic principles unique to testimony. One influential argument for the reductionist position, found in the work of Elizabeth Fricker, argues by appeal to the need for the hearer to monitor the testimony for credibility. (...) Fricker (1994) argues, first, that some monitoring for trustworthiness is required if the hearer is to avoid being gullible, and second, that reductionism but not anti-reductionism is compatible with ascribing an important role to the process of monitoring in the course of justifiably accepting observed testimony. In this paper we argue that such an argument fails. (shrink)

This article asserts that traditionally dominant models of health promotion in the US are fairly characterized by methodological individualism. This schema produces a focus on the individual as the node of intervention. Such emphasis results in a number of scientific and ethical problems. I identify three principal ethical deficiencies: first, the health promotions used are generally ineffective, which violates canons of distributive justice because scarce health resources are expended on interventions that are unlikely to produce health benefits. Second, the health (...) promotions used tend to expand health inequalities between the affluent and the least well-off. Third, the health promotions used are likely to intensify stigma against the least well-off, a deficiency that itself may exacerbate the ‘densely-woven patterns of disadvantage’ that characterize life on the tail of the social gradient. Because Powers and Faden’s health sufficiency model of social justice argues that the amelioration of such clusters of disadvantage should be the primary ethical goal of public health policy, methodologically individualist models of health promotion are ethically deficient and should not stand as primary approaches for health promotion in a just social order. (shrink)

Trust is central to the therapeutic relationship, but the epistemic asymmetries between the expert healthcare provider and the patient make the patient, the trustor, vulnerable to the provider, the trustee. The narratives of pain sufferers provide helpful insights into the experience of pain at the juncture of trust, expert knowledge, and the therapeutic relationship. While stories of pain sufferers having their testimonies dismissed are well documented, pain sufferers continue to experience their testimonies as being epistemically downgraded. This kind of epistemic (...) injustice has received limited treatment in bioethics. In this paper, we examine how a climate of distrust in pain management may facilitate what Fricker calls epistemic injustice. We critically interrogate the processes through which pain sufferers are vulnerable to specific kinds of epistemic injustice, such as testimonial injustice. We also examine how healthcare institutions and practices privilege some kinds of evidence and ways of knowing while excluding certain patient testimonies from epistemic consideration. We argue that providers ought to avoid epistemic injustice in pain management by striving toward epistemic humility. Epistemic humility, as a form of epistemic justice, may be the kind disposition required to correct the harmful prejudices that may arise through testimonial exchange in chronic pain management. (shrink)

I believe that the sort of disagreements we encounter in philosophy—disagreements that often take the form that I have elsewhere called system- atic peer disagreements—make it unreasonable to think that there is any knowledge, or even justified belief, when the disagreements themselves are systematic. I readily acknowledge that this skeptical view is quite controversial; I suspect many are unconvinced. However, I will not be defending it here. Rather, I will be exploring a worry, or set of worries, that arise on (...) the assumption that this view is correct. For if it is unreasonable to think that there is justified belief in contexts of systematic philosophical disagreements, by what right do we continue to advance philosophical claims in such contexts? Indeed, by what right do we believe the philosophical claims we advance? And if we don’t believe them, why do we advance them in the first place? An inability to respond to these worries would leave us with the dis- tinct impression that the practice or activity of philosophy is quite suspect: what sort of practice or activity would have us believe unreasonably, assert unwarrantedly, and perhaps exhibit insincerity to boot? (shrink)

To what extent are meaning, on the one hand, and knowledge, on the other, determined by aspects of the 'outside world'? Internalism and Externalism in Semantics and Epistemology presents twelve specially written essays exploring these debates in metaphysics and epistemology and the connections between them. In so doing, it examines how issues connected with the nature of mind and language bear on issues about the nature of knowledge and justification. Topics discussed include the compatibility of semantic externalism and epistemic internalism, (...) the variety of internalist and externalist positions, semantic externalism's implications for the epistemology of reasoning and reflection, and the possibility of arguments from the theory of mental content to the theory of epistemic justification. (shrink)

The idea that correspondences relating grammatical relations and semantics (argument structure constructions) are needed to account for simple sentence types is reviewed, clarified, updated and compared with two lexicalist alternatives. Traditional lexical rules take one verb as ‘input’ and create (or relate) a different verb as ‘output’. More recently, invisible derivational verb templates have been proposed, which treat argument structure patterns as zero derivational affixes that combine with a root verb to yield a new verb. While the derivational template perspective (...) can address several problems that arise for traditional lexical rules, it still faces problems in accounting for idioms, which often contain specifications that are not appropriately assigned to individual verbs or derivational affixes (regarding adjuncts, modification, and inflection). At the same time, it is clear that verbs play a central role in determining their distribution. The balance between verbs and phrasal argument structure constructions is addressed via the Principles of Semantic Coherence and Correspondence together with a usage-based hierarchy of constructions that contains entries which can include particular verbs and other lexical material. (shrink)

The process of education, and in particular that involving very young children, often involves students' taking their teachers' word on a good many things. At the same time, good education at every level ought to inculcate, develop, and support students' ability to think for themselves. While these two features of education need not be regarded as contradictory, it is not clear how they relate to one another, nor is it clear how (when taken together) these features ought to bear on (...) educational practice itself. This article, which is largely programmatic, aims to provide tentative answers to these questions. (shrink)

There are all sorts of normative expectations in epistemology—expectations about the epistemic condition of other subjects—that would appear to be relevant to epistemic assessment in ways that do not conform to epistemic standards as traditionally understood. The expectations in question include expectations of inquiries pursued or completed, expectations of certain competences, professional expectations, expectations of having consulted with experts, institutional expectations, moral expectations, expectations of friends, and so forth. My goals in this paper are two. First, I aim to highlight (...) the prevalence of such expectations, and the range of distinct types of circumstance in which they arise. Second, I assess several responses to the allegation that normative epistemic expectations are relevant to epistemic assessment. These range from “explaining away” the appearances to trying to offer one or another positive account of their significance. The former sort of reaction comes at a greater cost than many appear to appreciate, given the prevalence of these expectations and the range of circumstances in which they arise. The latter sort of reaction comes at the cost of having to revise our account of epistemic assessment itself. My own favored view does so in terms of the doctrine of normative defeat; I present my reasons for preferring this view, though I cannot claim in this paper to vindicate it. (shrink)

Sanford C. Goldberg presents a novel account of the speech act of assertion. He argues that this type of speech act is answerable to an epistemic, context-sensitive norm. On this basis he shows the philosophical importance of assertion for key debates in philosophy of language and mind, epistemology, and ethics.

In other work I have defended the claim that, when we rely on other speakers by accepting what they tell us, our reliance on them differs in epistemically relevant ways from our reliance on instruments, when we rely on them by accepting what they “tell” us. However, where I have explored the former sort of reliance at great length, I have not done so with the latter. In this paper my aim is to do so. My key notions will be (...) those of our social practices, the normative expectations that are sanctioned by those practices, and the epistemically engineered environments constituted by some of these practices. With these notions in mind, I will argue that one’s reliance on instruments, while relevantly different from one’s reliance on other speakers, can nevertheless manifest a kind of epistemic dependence which epistemological theory can and should acknowledge. (shrink)

Reason is precariously positioned in the Critique of Pure Reason. The Transcendental Analytic leaves no entry for reason in the cognitive process, and the Transcendental Dialectic restricts reason to noncognitive roles. Yet, in the Appendix to the Transcendental Dialectic, Kant contends that the ideas of reason can be used in empirical investigation and eventually knowledge acquisition. Given what Kant has said, how is this possible? Kant attempts to answer this in A663–A666/B691–B694 in the Appendix, where he argues that principles of (...) reason “have objective but indeterminate validity.” In Part I of this paper, I explain the full motivation behind this section. In Part II, I provide an exegesis of it. In particular, to reach his conclusion that principles of reason have objective but indeterminate validity, I interpret Kant as making three arguments from analogy. Finally, in Part III, I show that the first and third arguments fail—and what this means for Kant’s project. (shrink)

Elsewhere I and others have argued that evidence one should have had can bear on the justification of one's belief, in the form of defeating one's justification. In this paper, I am interested in knowing how evidence one should have had (on the one hand) and one's higher-order evidence (on the other) interact in determinations of the justification of belief. In doing so I aim to address two types of scenario that previous discussions have left open. In one type of (...) scenario, there is a clash between a subject's higher-order evidence and the evidence she should have had: S's higher-order evidence is misleading as to the existence or likely epistemic bearing of further evidence she should have. In the other, while there is further evidence S should have had, this evidence would only have offered additional support for S's belief that p. The picture I offer derives from two “epistemic ceiling” principles linking evidence to justification: one's justification for the belief that p can be no higher than it is on one's total evidence, nor can it be higher than what it would have been had one had all of the evidence one should have had. Together, these two principles entail what I call the doctrine of Epistemic Strict Liability: insofar as one fails to have evidence one should have had, one is epistemically answerable to that evidence whatever reasons one happened to have regarding the likely epistemic bearing of that evidence. I suggest that such a position can account for the battery of intuitions elicited in the full range of cases I will be considering. (shrink)

In this paper I explore the epistemic significance of practical reasons to inquire. I have in mind the range of practical reasons one might have to do such things as collect (additional) evidence, consult with various sources, employ certain methods or techniques, double-check one’s answer to a question, etc. After expanding the diet of examples in which subjects have such reasons, I appeal to features of these sorts of reason in order to question the motivation for pragmatic encroachment in epistemology. (...) Once we reject pragmatic encroachment, it can seem that we are forced to treat practical reasons to inquire as having no distinctly epistemic significance. This is not so; I conclude by sketching an alternative account of what the epistemic significance of such reasons might be. (shrink)

In this paper I argue that the nature of our epistemic entitlement to rely on certain belief-forming processes—perception, memory, reasoning, and perhaps others—is not restricted to one's own belief-forming processes. I argue as well that we can have access to the outputs of others’ processes, in the form of their assertions. These two points support the conclusion that epistemic entitlements are “interpersonal.” I then proceed to argue that this opens the way for a non-standard version of anti-reductionism in the epistemology (...) of testimony, and a more “extended” epistemology—one that calls into question the epistemic significance that has traditionally been ascribed to the boundaries separating individual subjects. (shrink)

Among epistemologists, it is common to assume that insofar as coherence bears on the justification of belief, the only relevant coherence relations are those _within_ an individual subject’s web of beliefs. After clarifying this view and exploring some plausible motivations for it, we argue that this individualistic account of the epistemic relevance of coherence fails to account for central facets of scientific practice. In its place we propose a social account of coherence. According to the view we propose, a scientist (...) _S_’s belief that _p_ is _prima facie_ unjustified if this belief negatively coheres with justified scientific claims in her scientific community. This account of coherence yields an epistemology for scientific belief which, we argue, has all of the benefits and none of the liabilities of its more individualistic predecessor. (shrink)

The idea that there are conceptual schemes, relative to which we conceptualize experience, and empirical content, the “raw” data of experience that get conceptualized through our conceptual schemes into beliefs or sentences, is not new. The idea that there are neither conceptual schemes nor empirical content, however, is. Moreover, it is so new, that only four arguments have so far been given against this dualism, with Donald Davidson himself presenting versions of all four. In this paper, I show that in (...) both the general and Davidson’s specific form the first three arguments against scheme-content dualism rely on the fourth. From many there is just one. Then I show that the fate of the first three arguments against scheme-content dualism hangs on that of the fourth. Finally I present four reasons why the fourth argument fails. For the sake of the dualism’s detractors, therefore, one can only hope that forthcoming arguments against scheme-content dualism fare better than those given so far. (shrink)

This paper follows a paper by Mitcham and considers whether engineering is among a group of occupations he calls philosophically weak, in the sense that engineering does not aspire to good-in-themselves ideals as do medicine and law. The paper agrees that engineering is philosophically weak, but in the different sense that engineering is not as reflective upon its nature and place in the world as some other professions. The paper recovers Mitcham's distinction by consider the institutional complexity of a given (...) occupation, suggesting that engineering's practice in the context of complex institutional arrangements precludes the relative ethical simplicity of such occupations as medicine and law. (shrink)

In their chapter “Knowledge, Practical Adequacy, and Stakes,” Charity Anderson and John Hawthorne present several challenges to the doctrine of pragmatic encroachment. In this brief reply to their chapter two things are aimed at. First, the chapter argues that there is a sense in which their case against pragmatic encroachment is a bit weaker, and another sense in which that case is much stronger, than Anderson and Hawthorne’s own argument would suggest. Second, the chapter highlights and then builds upon their (...) extremely interesting reflections on one sort of practical matter that has not received proper attention in the literature: the epistemic significance of double-checking. This is done with an eye towards pointing in the direction of further work. (shrink)

In _The Prisonhouse of Psychoanalysis_, Arnold Goldberg trains a searching, critical eye on his own profession. His subject matter is the system of interlocking constraints - theoretical, institutional, educational - that imprisons psychoanalysis and the psychoanalyst. His agenda is to sketch the shape analysis might take in the absence of these constraints. What emerges from these twin endeavors is a penetrating critique of psychoanalysis from the inside - from the vantage point of a senior analyst who has labored for (...) many years within the prisonhouse that he now criticizes. In proffering an alternative vision of psychoanalysis, Goldberg ventures into recent literature in epistemology, philosophy of science, cognitive psychology, and the neurosciences, so that one valuable byproduct of his work is a brilliant application of insights culled from these fields to the question of what analysis is, and what it may yet become. His examination of "psychoanalysis without foundations" challenges the ability of infancy research data and neurological findings, respectively, to provide an empirical rock bottom from which psychoanalytic theory-building can proceed. His chapter on "psychoanalysis without representations" reviews the analytic literature on the latter concept, only to show how recent theories of brain processing, including connectionism, provides a basis for understanding mental phenomena without any intermediary representations. Finally, his vision of "psychoanalysis without a subject" assesses recent findings about the nature of memory, insights of contemporary philosophy, and Kohut's notion of the selfobject as converging tributaries that make possible an analysis that dispenses with the conventional dichotomy of subject and object. (shrink)