The universality of gravity (1g) in our daily lives makes it difficult to appreciate its importance in morphology and physiology. Bone and muscle support systems were created, cellular pumps developed, neurons organised and receptors and transducers of gravitational force to biologically relevant signals evolved under 1g gravity. Spaceflight provides the only microgravity environment where systematic experimentation can expand our basic understanding of gravitational physiology and perhaps provide new insights into normal physiology and disease processes. These include the surprising extent of (...) our body's dependence on perceptual information, and understanding the effect and importance of forces generated within the body's weightbearing structures such as muscle and bones. Beyond this exciting prospect is the importance of this work towards opening the solar system for human exploration. Although both appear promising, we are only just beginning to taste what lies ahead. (shrink)

In this paper I show how what came to be known as “the double law of habit,” first formulated by Joseph Butler in a discussion of moral psychology in 1736, was taken up and developed by medical physiologists William Porterfield, Robert Whytt, and William Cullen as they disputed fundamental questions regarding the influence of the mind on the body, the possibility of unconscious mental processes, and the nature and extent of voluntary action. The paper shows, on a particular topic, the (...) overlap between eighteenth-century philosophical writings on the science of human nature on the one hand,and medical writings and lectures in physiology on the other. Other early modern writers discussed in the paper include René Descartes, Herman Boerhaave and David Hume. (shrink)

While gender and race often are considered socially constructed, this book argues that they are physiologically constituted through the biopsychosocial effects of sexism and racism. This means that to be fully successful, critical philosophy of race and feminist philosophy need to examine not only the financial, legal, political and other forms of racist and sexism oppression, but also their physiological operations. Examining a complex tangle of affects, emotions, knowledge, and privilege, The Physiology of Sexist and Racist Oppression develops an understanding (...) of the human body whose unconscious habits are biological. On this account, affect and emotion are thoroughly somatic, not something "mental" or extra-biological layered on top of the body. They also are interpersonal, social, and can be transactionally transmitted between people.Ranging from the stomach and the gut to the hips and the heart, from autoimmune diseases to epigenetic markers, Sullivan demonstrates the gastrointestinal effects of sexual abuse that disproportionately affect women, often manifesting as IBS, Crohn's disease, or similar functional disorders. She also explores the transgenerational effects of racism via epigenetic changes in African American women, who experience much higher pre-term birth rates than white women do, and she reveals the unjust benefits for heart health experienced by white people as a result of their racial privilege. Finally, developing the notion of a physiological therapy that doesn't prioritize bringing unconscious habits to conscious awareness, Sullivan closes with a double-barreled approach for both working for institutional change and transforming biologically unconscious habits. The Physiology of Sexist and Racist Oppression skillfully combines feminist and critical philosophy of race with the biological and health sciences. The result is a critical physiology of race and gender that offers new strategies for fighting male and white privilege. (shrink)

Neuroendocrine regulation plays a pivotal role in orchestrating various physiological processes in organisms. The neuroendocrine system is a complex, multifaceted process that acts as a resource distributor in the body, monitoring and regulating a variety of physiological functions like metabolism, reproduction, stress response, and immunity by using complicated signaling pathways and sophisticated feedback mechanisms that use hormones, neurotransmitters, and neural circuits. This study aims to investigate the intricate mechanisms by which neuroendocrine signals modulate physiological functions. Adjuvant neuroendocrine strategies such as (...) the use of neurotransmitters, hormones, pharmacotherapy, surgical intervention, and emerging technologies play an invaluable role in alleviating symptoms and improving outlooks for people suffering from these conditions. Through a comprehensive review of current literature, we explore the role of neuroendocrine pathways in regulating processes such as metabolism, reproduction, stress response, and immune function. We highlight the involvement of key neuroendocrine factors such as hormones, neuropeptides, and neurotransmitters in modulating these physiological processes. Additionally, authors discuss emerging research avenues and potential clinical implications of understanding neuroendocrine regulation in health and disease. (shrink)

In 1929 the newly-reorganized Rockefeller Foundation funded the work of a cross-disciplinary group at Harvard University called the Committee on Industrial Physiology. The committee’s research and pedagogical work was oriented towards different things for different members of the alliance. The CIP program included a research component in the Harvard Fatigue Laboratory and Elton May’s interpretation of the Hawthorne Studies; a pedagogical aspect as part of Wallace Donham’s curriculum for Harvard Business School; and Lawrence Henderson’s work with the Harvard Pareto Circle, (...) his course Sociology 23, and the Harvard Society of Fellows. The key actors within the CIP alliance shared a concern with training men for elite careers in government service, business leadership, and academic prominence. But the first communications between the CIP and the Rockefeller Foundation did not emphasize training in human biology. Instead, the CIP presented itself as a coordinating body that would be able to organize all the varied work going on at Harvard that did not fit easily into one department, and it was on this basis that the CIP became legible to the President of Harvard, A. Lawrence Lowell, and to Rockefeller’s Division of Social Sciences. The members of the CIP alliance used the term human biology for this project of research, training and institutional coordination. (shrink)

The issue of power has been addressed as part of human actions, which form the basis of the discussions of destiny in Islamic theology. Various schools of kalām have extensively discussed the issue of power throughout history. The locus of power is also one of the critical concerns that have been emphasized within these discussions. The schools of the Mu'tazila, al-Ashʿarī and al-Māturīdī have put forward different perspectives on whether the locus of power exists or not and where it (...) exists if it does so. Mutazilites are known to be in agreement with the view that te human body is the substrate of power. On the other hand, However, they hold different views, not only on the exact locus of power in the body but also on its type. While some argue that the locus of power in the body is the organs, others claim that it is not the organs. The schools of al-Ashʿarī and al-Māturīdī accept that there is no locus for power and emphasize that power is created by Allah the moment it would initiate action. When these views of the kalām schools are considered within the framework of the data from the modern science of anatomy, it is seen that what modern science has to say on this issue concurs well with the Mu'tazilite view that the locus of power is the body and that it creates the action by managing the organs from a single center. This is because, when considered from the lens of anatomy, what is meant by the schools of kalām with “power” is electrical activity (stimulus) that activates the muscles. Therefore, scientifically considered, for any movement to occur, an electrical activity must first begin in the brain and be transmitted to the muscles via motor nerves. If there were no electrical activity in the brain, the muscles and energy that make up the human movement system would not be active, so movement would hardly take locus. Therefore, the claim made some of the Mu'tazili scholars that the power is in the organs is scientifically not valid. As for the debates on whether the power in different organs is the same or different in terms of its type, the views of the scholars who argue that they are the same genus are apparently correct. This is because the electrical activity, which we accept as power, spreads to the organs after it is formed in the brain. This implies that the power which activates the organs is of the same type. However, it can be said that Mu'tazila’s idea of the constant presence of power in its locus conflicts with modern scientific data. The views of al-Ash'arite and al-Maturidite schools that power is free from being in a constant location are compatible with the findings of recent experiments on brain activities. That is, some experimental studies have indicated that the electrical activity that creates an act occurs in the brain before the act itself and outside the will of the human. In brief, the view of Ash'arite and Maturidite scholars that power is not constantly present in the body and that it is created by Allah each time it is needed is compatible with the creation of power, which we define as electrical activity. (shrink)

Extrapolation from a well-understood base population to a less-understood target population can fail if the base and target populations are not sufficiently similar. Differences between laboratory mice and humans, for example, can hinder extrapolation in medical research. Mice that carry a partial or complete human physiological system, known as humanized mice, are supposed to make extrapolation more reliable by simulating a variety of human diseases. But what justifies our belief that these mice are similar enough to their (...) class='Hi'>human counterparts to simulate human disease? I argue that, unless three requirements are met in the process of humanizing mice, very little does. My requirements are not meant to provide necessary and sufficient conditions that guarantee a particular outcome. Instead, they serve as a heuristic for guiding scientific judgments involving extrapolation. In developing each requirement, I engage with philosophical issues concerning the nature of model-based science and the mechanistic approach (and its limits) to making generalizations in the life sciences. (shrink)

Descartes understood the subject matter of physics (or natural philosophy) to encompass the whole of nature, including living things. It therefore comprised not only nonvital phenomena, including those we would now denominate as physical, chemical, minerological, magnetic, and atmospheric; it also extended to the world of plants and animals, including the human animal (with the exception of those aspects of the human mind that Descartes assigned to solely to thinking substance: pure intellect and will). Descartes wrote extensively on (...) physiology and on the physiology and psychology of the senses. This chapter examines the notions of *physiology* and *psychology* in medical and natural philosophical works of Descartes' day; follows his efforts to bring physiology into his mechanistic idiom; considers the relation between physiology of the animal machine and psychological functions that yield functionally appropriate behavior; goes into his physiology and psychology of vision; and elaborates the tension in Descartes' works between his metaphysically supported micro-corpuscularism and his discussion of the animal machine as an organic unity comprising various functionally and teleologically characterized systems. The chapter draws on Descartes' works in both metaphysics and natural philosophy, including his Treatise on Man (originally published as L'Homme, 1664). (shrink)

This article regards the field of neuroscience and indicates on the proper or erroneous functioning of the human brain. Intellectual virtues, especially practical wisdom play a significant role in capturing the truth and implementing it in life. The agile formation of the cognitive function of man encompasses both his reason as well as the sensual judgment of utility with all the bodily backup. The brain possesses great plasticity in the production of neuronal connections. Habit as a permanent wont utilizes (...) the reactions being developed to the construction of often inappropriate mechanisms, that in turn are not easy or completely impossible to eliminate. When practical reason is introduced into a false ethos, the brain responds by forming “ruts” of neuronal connections which seem difficult to consider as something appropriate. The reparation of the existing situation and the removal of the wrong habit require relevant virtues so as to unblock the psychological resistance that is deeply rooted within the physiological neuronal substrate. The learning about the virtues of St. Thomas Aquinas is the best warranty not only for theoretical explanations, but also for the practical application of virtues in dealing with the arised situation. Only well-formed virtues give the opportunity to correct the false instinctive cognition and liberate from erroneous actions. (shrink)

Research with human–animal chimera raises a number of ethical concerns, especially when neural stem cells are transplanted into the brains of non-human primates . Besides animal welfare concerns and ethical issues associated with the use of embryonic stem cells, the research is also regarded as controversial from the standpoint of NHPs developing cognitive or behavioural capabilities that are regarded as “unique” to humans. However, scientists are urging to test new therapeutic approaches for neurological diseases in primate models as (...) they better mimic human physiology than all current animal models. As a response, various countries have issued reports on the topic. Our paper summarizes the ethical issues raised by research with human–animal brain chimeras and compares the relevant regulatory instruments and different recommendations issued in national reports from three important European research nations: Germany, Switzerland and the United Kingdom. We assess and discuss the focus and priorities set by the different reports, review various reasons for and perspectives on the importance of the brain in chimera research, and identify critical points in the reports that warrant further specification and debate. (shrink)

ArgumentNineteenth-century Prussia was deeply entrenched in philhellenism, which affected the ideological framework of its public institutions. At Berlin’s Friedrich Wilhelm University, philhellenism provided the rationale for a persistent elevation of the humanities over the burgeoning experimental life sciences. Despite this outspoken hierarchy, professor of physiology Emil du Bois-Reymond eventually managed to increase the prestige of his discipline considerably. We argue that du Bois-Reymond’s use of philhellenic repertoires in his expositions on physiology for the educated German public contributed to the rise (...) of physiology as a renowned scientific discipline. Du Bois-Reymond’s rhetorical strategies helped to disassociate experimental physiology from clinical medicine, legitimize experimental practices, and associate the emerging discipline with the more esteemed humanities and theoretical sciences. His appropriation of philhellenic rhetoric thus spurred the late nineteenth-century change in disciplinary hierarchies and helped to pave the way for the current hegemonic position of the life sciences. (shrink)

Academic physiology, as it was taught by John Hughes Bennett during the 1870s, involved an understanding of the functions of the human body and the physical laws which governed those functions. This knowledge was perceived to be directly relevant and applicable to clinical practice in terms of maintaining bodily hygiene and human health. The first generation of medical women received their physiological education at Edinburgh University under Bennett, who emphasised the importance of physiology for women due to its (...) relevance for the hygienic needs of the family and of society. With the development of laboratory-based science as a distinct aspect of medical education during the later nineteenth century, however, so the direct application of physiology to clinical practice diminished. The understanding of physiology as hygiene was marginalised by the new orthodoxy of scientific medicine. This shift in the physiological paradigm enabled medical women to stake out a specific field of interest within medicine which was omitted from the new definition of physiology as pure medical science: hygiene and preventive medicine. Women physicians were able to take advantage of the shift towards science as the basis of medical theory and practice to define their own specific role within the profession. (shrink)

The concept of a G‐quartet, a unique structural arrangement intrinsic to guanine‐rich DNA, was first introduced by Gellert and colleagues1 over 40 years ago. For decades, it has been uncertain whether the G‐quartet and the structure that it gives rise to, the G‐quadruplex, are purely in vitro phenomena. Nevertheless, the presence of signature G‐rich motifs in the eukaryotic genome, and the plethora of proteins that bind to, modify or resolve this nucleic acid structure in vitro have provided circumstantial evidence for (...) its physiological relevance. More recently, direct visualisation of G‐quadruplex DNA at native telomeres was achieved, bolstering the evidence for its existence in the cell. Furthermore, G‐quadruplex folded telomeric DNA has been found to perturb telomere function and to impede the action of telomerase, an enzyme overexpressed in >85% of human cancers, hence opening up a novel avenue for cancer therapy in the form of G‐quadruplex stabilising agents. BioEssays 29: 155–165, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Three decades ago, interactions between evolutionary biology and physiology gave rise to evolutionary physiology. This caused comparative physiologists to improve their research methods by incorporating evolutionary thinking. Simultaneously, evolutionary biologists began focusing more on physiological mechanisms that may help to explain constraints on and trade‐offs during microevolutionary processes, as well as macroevolutionary patterns in physiological diversity. Here we argue that evolutionary physiology has yet to reach its full potential, and propose new avenues that may lead to unexpected advances. Viewing physiological (...) adaptations in wild animals as potential solutions to human diseases offers enormous possibilities for biomedicine. New evidence of epigenetic modifications as mechanisms of phenotypic plasticity that regulate physiological traits may also arise in coming years, which may also represent an overlooked enhancer of adaptation via natural selection to explain physiological evolution. Synergistic interactions at these intersections and other areas will lead to a novel understanding of organismal biology. (shrink)

Cybernetics saturates the humanities. Norbert Wiener’s movement gave vocabulary and hardware to developments all across the early digital era, and still does so today to those who seek to interpret it. Even while the Macy Conferences were still taking place in the early 1950s, talk of feedback and information and pattern had spread to popular culture – and to Europe. The new science created a shared language and culture for surpassing political and intellectual ideas that could be relegated to a (...) pre-computing tradition, and it refracted or channelled currents developing in fields from manufacturing to human physiology. It produced conceptions of the political world, as well as new forms of historical consciousness. It offered frameworks for structuralist thought, but also for policies regarding manufacturing and technology, international relations, and governmental decision-making. But the rising sense of the breadth, importance, and even shock of cybernetics long remained understudied, even as its intellectual assemblages continued to, well, relay. In devices and the so-called ‘digital humanities’, a refracted legacy of cybernetics is also visible. From mainframes to category-frameworks, cybernetics is everywhere in our material and intellectual worlds, even as the name and its meaning have faded. To the extent that cybernetics permeates the human sciences and our culture at large, it remains opaque – an only partially visible legacy often deemed too complex to form a simple object of historical narrative. This special issue on cybernetics in the human sciences outlines the history and stakes of cybernetics, as well as the possibilities of returning to it today. (shrink)

The main purpose of this study is the scientific practice of Edgard Roquette-Pinto at the National Museum of Rio de Janeiro during the 1910’s and 1920’s in the XXth Century. The article examines the relationship between laboratory science and nation building. Driven by Physicians-Anthropologists like Edgard Roquette-Pinto among others, the investigations performed at the Anthropology Laboratory there reveal the dynamic of the borders between Laboratory and Field Sciences, and the new biological parameters adopted at that time. The investigative agenda involved (...) plants, animals and human bodies, and it was related to the current Anthropology concept aligned with the debate of Nation construction. The physiological studies amplified the scientific exchange with different institutions, emphasizing cultural exchange between Brazil and Paraguay, and the role played by Edgard Roquette-Pinto there as he inaugurated the Physiological course at Faculty of Medicine at University of Asunción. (shrink)

In this paper I challenge the widely held view which associates Hume’s philosophy with mechanical philosophies of nature and particularly with Newton. This view presents Hume’s account of the human mind as passive receiver of impressions which bring into motion, from the outside, a mental machinery whose functioning is described in terms of mechanical causal principles. Instead, I propose an interpretation which suggests that for Hume the human mind is composed of faculties that can be characterized by their (...) active contribution which frequently results in qualitative change. This anatomy of the mind is explored from a physiological perspective focused on the normal functioning and interaction of the mind’s various organs. While pursuing this enterprise, I suggest that Hume’s outlook is closer to eighteenth-century “philosophical chemistry” and vitalistic physiology than to the heritage of mechanical philosophies. (shrink)

What determines if the first interaction between strangers will be a pleasant experience? We conducted an experiment to investigate the extent to which the perceived quality of an interaction is influenced by conversation content and context, and we document the physiological changes that are likely to play a role in establishing rapport. Females who did not know each other met in pairs and conducted a gossip- or creativity task, either face-to-face or online. The conversation content had no effect on the (...) quality of online interactions. However in the face-to-face condition gossip was associated with better interaction quality. Tonic electrodermal activity steadily declined throughout the interaction, while phasic electrodermal activity first peaked and then returned to baseline. Neither were related to perceived interaction quality. Heart rate variability dropped at first but then remained stable. A smaller drop in HRV drop corresponded to higher ratings of rapport and liking. Together these results suggest that gossip can improve the quality of a face-to-face interaction between strangers, and support the conjecture that parasympathetic activity is a marker of human openness to social engagement. (shrink)

As human–machine teams are being considered for a variety of mixed-initiative tasks, detecting and being responsive to human cognitive states, in particular systematic cognitive states, is among the most critical capabilities for artificial systems to ensure smooth interactions with humans and high overall team performance. Various human physiological parameters, such as heart rate, respiration rate, blood pressure, and skin conductance, as well as brain activity inferred from functional near-infrared spectroscopy or electroencephalogram, have been linked to different systemic (...) cognitive states, such as workload, distraction, or mind–wandering among others. Whether these multimodal signals are indeed sufficient to isolate such cognitive states across individuals performing tasks or whether additional contextual information (e.g., about the task state or the task environment) is required for making appropriate inferences remains an important open problem.In this paper, we introduce an experimental and machine learning framework for investigating these questions and focus specifically on using physiological and neurophysiological measurements to learn classifiers associated with systemic cognitive states like cognitive load, distraction, sense of urgency, mind wandering, and interference. Specifically, we describe a multitasking interactive experimental setting used to obtain a comprehensive multimodal data set which provided the foundation for a first evaluation of various standard state-of-the-art machine learning techniques with respect to their effectiveness in inferring systemic cognitive states. While the classification success of these standard methods based on just the physiological and neurophysiological signals across subjects was modest, which is to be expected given the complexity of the classification problem and the possibility that higher accuracy rates might not in general be achievable, the results nevertheless can serve as a baseline for evaluating future efforts to improve classification, especially methods that take contextual aspects such as task and environmental states into account. (shrink)

The period 1873–1947 was productive in fostering ideas about observing, measuring, and quantifying repetitive human movements, prior to the rise of occupational health and ergonomics within industrial psychology. Starting with physiological experimentation in the lab, instruments of graphic inscription were then applied in the industrial workplace, initially as a benevolent measurement for monitoring worker health, but elsewhere as a more invasive measurement for the surveillance of worker efficiency. Herman Helmholtz’s invention of the myograph, and an adaptation called the ergograph, (...) would help form what Kronecker (1873) and later Mosso (1891) termed the ‘curve of fatigue’, and were used in extensive research on factory workers for Jules Amar’s Le Moteur humain in 1914. Meanwhile, in Britain in 1915 the physiologist Sherrington was observing workers in munitions factories, feeding into the formation of the Industrial Fatigue Research Board in 1919, which produced official reports. In the United States, similar but more high-profile research was conducted by Frederick Winslow Taylor and Lillian and Frank Gilbreth, who studied movement efficiency to maximize industrial productivity by innovating upon photographic and chronophotographic techniques. Further physiological research was taken up in Lawrence J. Henderson’s Harvard Fatigue Laboratory between 1927 and 1947 on subjects situated in environmental extremes. (shrink)

Human brain organoids (HBOs) are three-dimensional biological entities grown in the laboratory in order to recapitulate the structure and functions of the adult human brain. They can be taken to be novel living entities for their specific features and uses. As a contribution to the ongoing discussion on the use of HBOs, the authors identify three sets of reasons for moral concern. The first set of reasons regards the potential emergence of sentience/consciousness in HBOs that would endow them (...) with a moral status whose perimeter should be established. The second set of moral concerns has to do with an analogy with artificial womb technology. The technical realization of processes that are typically connected to the physiology of the human body can create a manipulatory and instrumental attitude that can undermine the protection of what is human. The third set concerns the new frontiers of biocomputing and the creation of chimeras. As far as the new frontier of organoid intelligence is concerned, it is the close relationship of humans with new interfaces having biological components capable of mimicking memory and cognition that raises ethical issues. As far as chimeras are concerned, it is the humanization of nonhuman animals that is worthy of close moral scrutiny. A detailed description of these ethical issues is provided to contribute to the construction of a regulative framework that can guide decisions when considering research in the field of HBOs. (shrink)

The story of the body. Fay Bound Alberti takes the human body apart in order to put it back anew, telling the cultural history of our key organs and systems from the inside out, from blood to guts, brains to sex organs.

This paper focuses on an understudied aspect of Hobbes's natural philosophy: his approach to the domain of life. I concentrate on the role assigned by Hobbes to the heart, which occupies a central role in both his account of human physiology and of the origin of animal locomotion. With this, I have three goals in mind. First, I aim to offer a cross-section of Hobbes's effort to provide a mechanistic picture of human life. Second, I aim to contextualize (...) Hobbes's views in the seventeenth-century debates on human physiology and animal locomotion. In particular, I will compare Hobbes's views with the theories put forth by Harvey, Descartes, the Galenic, and Peripatetic traditions. Also, I will show that Hobbes was receptive to advances within contemporary English physiology and chemistry. Third, by means of a comparison with Descartes, I advance some hypothesis to explain why Hobbes indentified the heart, and not the brain (as was increasingly com... (shrink)

A physiological model for short-term memory (STM) based on dual theta (5–10 Hz) and gamma (20–60 Hz) oscillation was proposed by Lisman and Idiart (1995). In this model a memory is represented by groups of neurons that fire in the same gamma cycle. According to this model, capacity is determined by the number of gamma cycles that occur within the slower theta cycle. We will discuss here the implications of recent reports on theta oscillations recorded in humans performing the Sternberg (...) task. Assuming that the oscillatory memory models are correct, these findings can help determine STM capacity. (shrink)

Involuntary eye movement during gaze fixation, referred to as fixational eye movement, consists of two types of components: a Brownian motion like component called drifts-tremor and a ballistic component called microsaccade with a mean saccadic amplitude of about 0.3° and a mean inter-MS interval of about 0.5 s. During GZ fixation in healthy people in an eccentric position, typically with an eccentricity more than 30°, eyes exhibit oscillatory movements alternating between centripetal drift and centrifugal saccade with a mean saccadic amplitude (...) of about 1° and a period in the range of 0.5–1.0 s, which has been known as the physiological gaze-evoked nystagmus. Here, we designed a simple experimental paradigm of GZ fixation on a target shifted horizontally from the front-facing position with fewer eccentricities. We found a clear tendency of centripetal DRT and centrifugal MS as in GEN, but with more stochasticity and with slower drift velocity compared to GEN, even during FEM at GZ positions with small eccentricities. Our results showed that the target shift-dependent balance between DRT and MS achieves the GZ bounded around each of the given targets. In other words, GZ relaxes slowly with the centripetal DRT toward the front-facing position during inter-MS intervals, as if there always exists a quasi-stable equilibrium posture in the front-facing position, and MS actions pull GZ intermittently back to the target position in the opposite direction to DRT. (shrink)

A key emergent property of group social dynamic is synchrony–the coordination of actions, emotions, or physiological processes between group members. Despite this fact and the inherent nested structure of groups, little research has assessed physiological synchronization between group members from a multi-level perspective, thus limiting a full understanding of the dynamics between members. To address this gap of knowledge we re-analyzed a large dataset comprising physiological and psychological data that were collected in two laboratory studies that involved two different social (...) group tasks. In both studies, following the group task, members reported their experience of group cohesion via questionnaires. We utilized a non-linear analysis method-multidimensional recurrence quantification analysis that allowed us to represent physiological synchronization in cardiological interbeat intervals between group members at the individual-level and at the group-level. We found that across studies and their conditions, the change in physiological synchrony from baseline to group interaction predicted a psychological sense of group cohesion. This result was evident both at the individual and the group levels and was not modified by the context of the interaction. The individual- and group-level effects were highly correlated. These results indicate that the relationship between synchrony and cohesion is a multilayered construct. We re-affirm the role of physiological synchrony for cohesion in groups. Future studies are needed to crystallize our understanding of the differences and similarities between synchrony at the individual-level and synchrony at the group level to illuminate under which conditions one of these levels has primacy, or how they interact. (shrink)

Research FocusThe promotion of domain-specific knowledge is a central goal of higher education and, in the field of medicine, it is particularly essential to promote global health. Domain-specific knowledge on its own is not exhaustive; confidence regarding the factual truth of this knowledge content is also required. An increase in both knowledge and confidence is considered a necessary prerequisite for making professional decisions in the clinical context. Especially the knowledge of human physiology is fundamental and simultaneously critical to medical (...) decision-making. However, numerous studies have shown difficulties in understanding and misconceptions in this area of knowledge. Therefore, we investigate how preclinical medical students acquire knowledge in physiology over the course of their studies and simultaneously gain confidence in the correctness of this knowledge as well as the interrelations between these variables, and how they affect the development of domain-specific knowledge.MethodIn a pre–post study, 169 medical students’ development of physiology knowledge and their confidence related to this knowledge were assessed via paper-pencil questionnaires before and after attending physiology seminars for one semester. Data from a longitudinal sample of n = 97 students were analyzed using mean comparisons, regression analyses, and latent class analyses. In addition, four types of item responses were formed based on confidence and correctness in the knowledge test.ResultsWe found a significant and large increase in the students’ physiology knowledge, with task-related confidence being the strongest predictor. Moreover, a significantly higher level of confidence at t2 was confirmed, with the level of prior confidence being a strong predictor. Furthermore, based on the students’ development of knowledge and confidence levels between measurement points, three empirically distinct groups were distinguished: knowledge gainers, confidence gainers, and overall gainers. The students whose confidence in incorrect knowledge increased constituted one particularly striking group. Therefore, the training of both knowledge and the ability to critically reflect on one’s knowledge and skills as well as an assessment of their development in education is required, especially in professions such as medicine, where knowledge-based decisions made with confidence are of vital importance. (shrink)

Steroid‐hormone‐activated receptor proteins are among the best‐understood class of factors for altering gene transcription in cells. Steroid receptors are of major importance in maintaining normal human physiology by responding to circulating concentrations of steroid in the nM range. Nonetheless, most studies of steroid receptor action have been conducted using the supra‐physiological conditions of saturating concentrations (≥100 nM) of potent synthetic steroid agonists. Here we summarize the recent developments arising from experiments using two clinically relevant conditions: subsaturating concentrations of agonist (...) (to mimic the circulating concentrations in mammals) and saturating concentrations of antagonists (which are employed in endocrine therapies to block the actions of endogenous steroids). These studies have revealed new facets of steroid hormone action that could not be uncovered by conventional experiments with saturating concentrations of agonist steroids, such as a plethora of factors/conditions for the differential control of gene expression by physiological levels of steroid, a rational approach for examining the gene‐specific variations in partial agonist activity of antisteroids, and a dissociation of steroid potency and efficacy that implies the existence of separate, and possibly novel, mechanistic steps and cofactors. BioEssays 30:744–756, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

The gastrointestinal tract is normally investigated using reductionism methods in human studies, where the focus is on each segment of the gastrointestinal system and the specific links between various parts of it. This helps researchers and clinicians to produce a simple relationship between the elements of the gastrointestinal tract based on clinical diagnosis and treatment. However, there is evidence indicating that the gastrointestinal tract has properties that are beyond function of the simple systems, such as, multiplicity of elements, network (...) communication, emergence, self-organization, sudden transition, nonlinearity, and adaptation, all of which are attributes of complex systems. It seems that the gastrointestinal tract is an appropriate candidate for complexity research. If the gastrointestinal tract is assumed as a complex system, then it would be more fitting to study the tract using holistic methods through interdisciplinary perspective. In the present paper, the features of the gastrointestinal that correlate to complex systems have been explained using physiological examples from studies done on human subjects. (shrink)

Humans accumulate porphyrins in the body mostly during the course of porphyrias, diseases caused by defects in the enzymes of the heme biosynthesis pathway and that produce acute attacks, skin lesions and liver cancer. In contrast, some wild mammals and birds are adapted to accumulate porphyrins without injurious consequences. Here we propose viewing such physiological adaptations as potential solutions to human porphyrias, and suggest certain wild animals as models. Given the enzymatic activity and/or the patterns of porphyrin excretion and (...) accumulation, the fox squirrel, the great bustard and the Eurasian eagle owl may constitute overlooked models for different porphyrias. The Harderian gland of rodents, where large amounts of porphyrins are synthesized, presents an underexplored potential for understanding the carcinogenic/toxic effect of porphyrin accumulation. Investigating how these animals avoid porphyrin pathogenicity may complement the use of laboratory models for porphyrias and provide new insights into the treatment of these disorders. (shrink)

This article concerns the notion of living bodies that Spinoza develops in the Ethics (published posthumously in 1677). While commentators have emphasized the relevance of Spinoza’s works for contemporary physiology, they have neglected to study Spinoza’s own views on this topic. My aim is to draw attention to the specific parti pris that underlies Spinoza’s passages on anatomy. To do so, I first compare Spinoza’s claims on human body with the conceptions developed in his immediate historical environment. Then, I (...) propose to draw a parallel between Lakatos’s notion of “negative heuristics” and the high level of generalization Spinoza demonstrates in his propositions on the human body. This parallel allows me to show how Spinoza’s critical remarks on our knowledge of human body have heuristic value. (shrink)

THAT a human action is in some sense identical with its physiological basis is true. The sense in which that identity is properly to be understood is a very subtle one, and although I shall make some suggestions about it here, this paper is designed chiefly to make the negative point that the identity is, at any rate, not properly to be understood in the sense that a physicalist would maintain. The physicalist theory of the identity of A and (...) PB is analogous to the theory of mind-body identity maintained by central state materialists, but I shall not deal directly with the latter theory, for reasons that will soon become clear. All the same, if the present refutation of a physicalist identity of A and PB is successful, it will be seen to be a fortiori effective against the analogous mind-body identity. (shrink)

Human skin is the one authentic criterion of the universe which philosophers recognize when they appraise knowledge under their professional rubric, epistemology. By and large—except for a few of the great Critics and Sceptics—they view knowledge as a capacity, attribute, possession, or other mysterious inner quality of a “knower”; they view this knower as residing in or at a “body”; they view the body as cut off from the rest of the universe by a “skin”; all of which holds (...) for philosophizing physicists and physiologists even as for the professionals of the arcanum itself. If this assertion seems crude, one may recall that there are times when a bit of crudity is a fair physic for an inflamed subtlety. In the case before us the factual crudity lies in the use of “skin” for a criterion, not in our calling attention to the fact. The “skin” that is so used is, indeed, that of ancient anatomical schematism, unaffected by the transformation of understanding which modern physiological research has brought about. Yet if philosophers cease thus crudely to employ it, all their issues of epistemology will vanish, and the very type of attack they make on cognition will be discredited; whereupon the task of determining the status of knowledge itself will pass from their hands to those of the scientists who have taken over so many regions of philosophical arrogation in the past. This is what I propose here to show. (shrink)

Generalized Quantum Theory seeks to explain and predict quantum-like phenomena in areas usually outside the scope of quantum physics, such as biology and psychology. It draws on fundamental theories and uses the algebraic formalism of quantum theory that is used in the study of observable physical matter such as photons, electrons, etc. In contrast to quantum theory proper, GQT is a very generalized form that does not allow for the full application of formalism. For instance neither a commutator, such as (...) Planck’s constant, nor any additive operations are defined, which precludes the usage of a full Hilbert-space formalism. But it is a formalized phenomenological theory that is applicable whenever the core element of a quantum theory needs to be captured, namely in the presence of incompatible or non-commuting operations. As a consequence, it also predicts nonlocal, generalized entanglement correlations in systems other than proper quantum systems. In this paper we summarize the specific scientific evidence relating to the quantum-like mental, behavioral and physiological nonlocal correlations. Such non-local, generalized entanglement correlations are expected, both in space and time, between subsystems of a larger system, whenever observables pertaining to the global system are incompatible or complementary to observables pertaining to subsystems, as predicted by GQT. The result is a coherent explanation of a significant amount of controversial and seemingly weird occurrences that cannot be explained by classical physical laws. This review also offers a new perspective of the human mind’s potential. (shrink)

In his concept of an anthropological physiology, F.J.J. Buytendijk has tried to lay down the theoretical and scientific foundations for an anthropologically-oriented medicine. The aim of anthropological physiology is to demonstrate, empirically, what being specifically human is in the most elementary physiological functions. This article contains a sketch of Buytendijk''s life and work, an overview of his philosophical-anthropological presuppositions, an outline of his idea of an anthropological physiology and medicine, and a discussion of some episternological and methodological problems. It (...) is demonstrated that Buytendijk''s design of an anthropological physiology is fragmentary and programmatic and that his methodology offers few points of contact for specific anthropological experimental research.Notwithstanding, it is argued that Buytendijk''s description of the subjective, animated body forms a pre-eminent point of reference for all research in physiology and psychology in which the specific human aspect is not ignored beforehand. (shrink)

The discovery of participation of astrocytes as active elements in glutamatergic tripartite synapses (composed by functional units of two neurons and one astrocyte) has led to the construction of models of cognitive functioning in the human brain, focusing on associative learning, sensory integration, conscious processing and memory formation/retrieval. We have modelled human cognitive functions by means of an ensemble of functional units (tripartite synapses) connected by gap junctions that link distributed astrocytes, allowing the formation of intra- and intercellular (...) calcium waves that putatively mediate large-scale cognitive information processing. The model contains a diagram of molecular mechanisms present in tripartite synapses and contributes to explain the physiological bases of cognitive functions. It can be potentially expanded to explain emotional functions and psychiatric phenomena. (shrink)