Neuroscience is a multidisciplinary effort to understand the structures and functions of the brain and brain-mind relations. This effort results in an increasing amount of data, generated by sophisticated technologies. However, these data enhance our descriptive knowledge, rather than improve our understanding of brain functions. This is caused by methodological gaps both within and between subdisciplines constituting neuroscience, and the atomistic approach that limits the study of macro- and mesoscopic issues. Whole-brain measurement technologies do not resolve these issues, but rather (...) aggravate them by the complexity problem. The present article is devoted to methodological and epistemic problems that obstruct the development of human neuroscience. We neither discuss ontological questions nor review data, except when it is necessary to demonstrate a methodological issue. As regards intradisciplinary methodological problems, we concentrate on those within neurobiology and psychology. As regards interdisciplinary problems, we suggest that core disciplines of neuroscience can be integrated using systemic concepts that also entail human-environment relations. We emphasize the necessity of a meta-discussion that should entail a closer cooperation with philosophy as a discipline of systematic reflection. The atomistic reduction should be complemented by the explicit consideration of the embodiedness of the brain and the embeddedness of humans. The discussion is aimed at the development of an explicit methodology of integrative human neuroscience, which will not only link different fields and levels, but also help in understanding clinical phenomena. (shrink)

Kaum ein Thema scheint im privaten wie gesellschaftlichen Leben so umstritten zu sein wie die gesunde Lebensfuhrung - Pravention ist ein Kampfplatz von politischen Steuerungsinteressen, okonomischem Kalkul und weltanschaulichen Positionen. Durch die Aufarbeitung der soziohistorischen Entwicklung verschiedener Praventionsverstandnisse tragt dieser interdisziplinare Sammelband zu einem umfassenden Verstandnis von Gesundheitsfursorge und -vorsorge bei und lasst die politischen, soziologischen, rechtlichen und philosophischen Aspekte klar hervortreten.

Variability is pervasive in spoken language, in particular if one is exposed to two varieties of the same language. Unlike in bilingual settings, standard and dialectal forms are often phonologically related, increasing the variability in word forms. We investigate whether dialectal variability in children’s input affects their ability to recognize words in Standard German, testing non-dialectal vs. dialectal children. Non-dialectal children, who typically grow up in urban areas, mostly hear Standard German forms, and hence encounter little segmental variability in (...) their input. Dialectal children in turn, who typically grow up in rural areas, hear both Standard German and dialectal forms, and are hence exposed to a large amount of variability in their input. We employ the familiar word paradigm for German children aged 12–18 months. Since dialectal children from rural areas are hard to recruit for laboratory studies, we programmed an App that allows all parents to test their children at home. Looking times to familiar vs. non-familiar words were analyzed using a semi-automatic procedure based on neural networks. Our results replicate the familiarity preference for non-dialectal German 12–18-month-old children. Non-dialectal children in the same age range, on the other hand, showed a novelty preference. One explanation for the novelty preference in dialectal children may be more mature linguistic processing, caused by more variability of word forms in the input. This linguistic maturation hypothesis is addressed in Experiment 2, in which we tested older children. These children, who are not exposed to dialectal forms, also showed a novelty preference. Taken together, our findings show that both dialectal and non-dialectal German children recognized the familiar Standard German word forms, but their looking pattern differed as a function of the variability in the input. Frequent exposure to both dialectal and Standard German word forms may hence have affected the nature of lexical representations, leading to more mature processing capacities. (shrink)

This issue ofScience in Contextis dedicated to the question of whether there was a “cinematographic turn” in the sciences around the beginning of the twentieth century. In 1895, the Lumière brothers presented their projection apparatus to the Parisian public for the first time. In 1897, the Scottish medical doctor John McIntyre filmed the movement of a frog's leg; in Vienna, in 1898, Ludwig Braun made film recordings of the contractions of a living dog's heart (cf. Cartwright 1992); in 1904, (...) Lucien Bull filmed in slow motion a bullet entering a soap bubble. In 1907 and 1908, respectively, Max Seddig and Victor Henri recorded Brownian motion with the help of a cinematograph (Curtis 2005). In 1909, the Swiss Julius Ries was one of the first to film fertilization and cell division in sea urchins (Ries 1909). In that same year in Paris, Louise Chevroton and Frédéric Vlès used a film camera to observe cell division in the same object (Chevroton and Vlès 1909). As early as 1898, the Parisian surgeon Eugène-Louis Doyen began filming several of his operations, among them the spectacular separation of the Siamese twins Doodica and Radica (Bonah and Laukötter 2009). And in England, the scientist and zoologist Francis Martin Duncan produced an array of popular-scientific films for Charles Urban: “The unseen world: A series of microscopic studies” was presented to the public in the Alhambra Theatre in London for the first time in 1903 (see Gaycken in this issue). (shrink)

Trust is one of the big buzzwords in debates about the shaping of society, democracy, and emerging technologies. For example, one prominent idea put forward by the High‐Level Expert Group on Artificial Intelligence appointed by the European Commission is that artificial intelligence should be trustworthy. In this essay, we explore the notion of trust and argue that both proponents and critics of trustworthy AI have flawed pictures of the nature of trust. We develop an approach to understanding trust in AI (...) that does not conceive of trust merely as an accelerator for societal acceptance of AI technologies. Instead, we argue, trust is granted through leaps of faith. For this reason, trust remains precarious, fragile, and resistant to promotion through formulaic approaches. We also highlight the significance of distrust in societal deliberation, as it is relevant to trust in various and intricate ways. Among the fruitful aspects of distrust is that it enables individuals to forgo technology if desired, to constrain its power, and to exercise meaningful human control. (shrink)

Indexicals are linguistic expressions whose reference shifts from context to context: some paradigm examples are ‘I’, ‘here’, ‘now’, ‘today’,‘he’, ‘she’, and ‘that’. Two speakers who utter a single sentence that contains an indexical may say different things. For instance, Fred and Wilma say different things when they utter the sentence ‘I am female’. Many philosophers (following David Kaplan 1989a) hold that indexicals have two sorts of meaning. The first sort of meaning is often called ‘character’ or ‘linguistic meaning’; the second (...) sort is often called ‘content’. Using this terminology, we can say that the word ‘I’ has a single character (or linguistic meaning), but has different contents in different contexts. (shrink)

Simulations are used in very different contexts and for very different purposes. An emerging development is the possibility of using simulations to obtain a more or less representative reproduction of organs or even entire persons. Such simulations are framed and discussed using the term ‘digital twin’. This paper unpacks and scrutinises the current use of such digital twins in medicine and the ideas embedded in this practice. First, the paper maps the different types of digital twins. A special focus is (...) put on the concrete challenges inherent in the interactions between persons and their digital twin. Second, the paper addresses the questions of how far a digital twin can represent a person and what the consequences of this may be. Against the background of these two analytical steps, the paper defines first conditions for digital twins to take on an ethically justifiable form of representation. (shrink)

Stephen Schiffer says that Nathan Salmon and I are committed to the special-case consequence. He also says that it is possible for - to be true.

A structured character is a semantic value of a certain sort. Like the more familiar Kaplanian characters, structured characters determine the contents of expressions in contexts. But unlike Kaplanian characters, structured characters also have constituent structures. The semantic theories with which most of us are acquainted do not mention structured characters. But I argue in this paper that these familiar semantic theories fail to make obvious distinctions in meaning---distinctions that can be made by a theory that uses structured characters. Thus (...) I conclude that we should reject these familiar semantic theories, and accept a semantic theory that includes structured characters among its semantic values. (shrink)

Hong Oak Yun is a person who is over three inches tall. And now you know who Hong Oak Yun is. For if someone were to ask you ‘Who is Hong Oak Yun?’, you could answer that Hong Oak Yun is a person who is over three inches tall, and you would know what you were saying. So you know an answer to the question ‘Who is Hong Oak Yun?’, and that is sufficient for knowing who Hong Oak Yun is. (...) Getting to know who a person is may be easier than you think. (shrink)

A complete, illustrated survey of Etienne-Jules Marey's work that investigates the far reaching effects of her inventions on stream-of-consciousness literature, psychoanalysis, Bergsonian philosophy, and the art of cubists and futurists.

(1) Harry believes that Twain is a writer. (2) Harry believes that Clemens is a writer. I say that this is Russellianism's most notorious consequence because it is so often used to argue against the view: many philosophers think that it is obvious that (1) and (2) can differ in truth value, and so they conclude that Russellianism is false. Let's call this the Substitution Objection to Russellianism.

Building on the emotion-centered model of voluntary work behavior, this research tests the relations between leader narcissism, followers’ malicious and benign envy, and supervisor-targeted counterproductive work behavior. Results across five studies, two experimental studies, and two field surveys indicate that leader narcissism relates positively to followers’ negative emotions, which in turn mediates the positive relation between leader narcissism and supervisor-targeted CWB. Proposed negative relations between leader narcissism and positive emotions were only partly supported. Our findings advance the understanding of envy (...) and the detrimental impact of leader narcissism on organizational functioning. (shrink)

In the article ‘Represent Me: Please! Towards an Ethics of Digital Twins in Medicine’, I analysed and tried to better understand the main ethical challenges associated with Digital Twins. For those who are just entering the debate with this article: DT is a metaphor for a bundle of artificial intelligence driven simulation technologies that constantly, in real time and ad personam simulate single or multiple parts of the body and make predictions about future health states based on these simulations. My (...) argument addresses the need to look at the breadth of challenges through a perspective of representation. From such a take, key consequences can be drawn for the further development of such technologies, the required means of control and not least the way to think about the interaction between humans and ‘their’ simulations. I am very grateful for the subsequent suggestions, criticisms and further arguments, which have helped me to elaborate my arguments more clearly and have led to a substantial advancement of the debate and the discussion about ethical questions in dealing with DT. Jenny Blumenthal-Barby,1 Deborah Lupton,2 Jenny Krutzinna,3 Janina Loh,4 Brent Mittelstadt,5 Sven Nyholm,6 Daniel Tigard7 and Max Tretter8 have made excellent points, which, in the following, I will not be able to reply to individually and in detail. In this response, I will try to bundle the open points and questions along the comments and considerations mentioned above and attempt to outline their significance for an ethics of DT. Four challenges seem to be central. A first point addresses anthropological issues. It is concerned …. (shrink)

Many philosophers think that the Substitution Objection decisively refutes Russellianism. This objection claims that sentences (1) and (2) can differ in truth value. Therefore, it says, the sentences express different propositions, and so Russellianism is false.

Mitochondrial replacement techniques (MRTs) usually aim to prevent the genetic transmission of maternally inherited mitochondrial diseases. Until now, only the UK and Australia have implemented specific legal regulations of MRTs. In both countries, clinical trials on these techniques are only permissible for cases with a high risk of severe mitochondrial disease in the offspring. However, these techniques can also be applied to treat infertility, especially for older women with impaired oocyte quality. In some countries without legal regulation of these techniques, (...) MRTs are already offered for this purpose. Yet, this application of MRTs has received insufficient attention in the bioethical literature so far.In this paper, I examine whether there are ethical reasons to prohibit trials on MRTs in the context of infertility when they are permitted for preventing mitochondrial disease. Allowing MRTs in one context but not the other might be justified either because their application in the context of mitochondrial disease (1) is supported by a more convincing evidence base, (2) has a higher potential benefit or (3) has a lower risk. I compare both applications of MRTs with respect to these three factors. I conclude that there is no convincing reason to prohibit clinical trials on MRTs for infertility when they are permitted in the context of mitochondrial disease. (shrink)

This article examines some of the story conventions of network television news to explain the ways in which healthcare interest groups develop and maintain their presence in this medium—a process that has significant implications for public understanding of healthcare issues, and therefore to bioethics. The article is divided into three sections. The first section focuses on three major normative conventions of television news: adherence to a simple narrative structure, the balance ethic, and avoidance of the “think-piece” and outlines the basic (...) strategies available to interest groups for exploiting these normative conventions. Section two introduces three case studies of organizations and individuals who have run high-profile media campaigns. Section three explores the implications for bioethics of the observations made in this article. (shrink)

Contextualism about ‘might’ says that the property that ‘might’ expresses varies from context to context. I argue against contextualism. I focus on problems that contextualism apparently has with attitude ascriptions in which ‘might’ appears in an embedded ‘that’-clause. I argue that contextualists can deal rather easily with many of these problems, but I also argue that serious difficulties remain with collective and quantified says-that ascriptions. Herman Cappelen and John Hawthorne atempt to deal with these remaining problems, but I argue that (...) their attempt fails. (shrink)

Genome Editing Techniques are seen to be at the frontier of current research in the field of emerging biotechnologies. The latest revolutionary development, the so-called CRISPR technology, represents a paradigmatic example of the ambiguity of such techniques and has resulted in an international interdisciplinary debate on whether or not it is necessary to ban the application of this technique by means of a moratorium on its use for human germline modifications, particularly in human embryos in the reproduction process. However, given (...) that other germline engineering techniques like mitochondrial DNA transfer techniques are already permitted and applied, the question arises what lies at the root of the apparent social unease about the modification of the human germline by Genome Editing Techniques like CRISPR. Against this background, the book seeks to make a substantial contribution to the current debate about a responsible and participatory framework for research on emerging biotechnologies by analysing underlying perceptions, attitudes, arguments and the reasoning on Genome Editing Techniques. (shrink)

This paper presents a number of objections to Jeffrey King's quantificational theory of complex demonstratives. Some of these objections have to do with modality, whereas others concern attitude ascriptions. Various possible replies are considered. The debate between quantificational theorists and direct reference theorists over complex demonstratives is compared with recent debates concerning definite descriptions.

In der Reihe Beihefte zur Zeitschrift f r die alttestamentliche Wissenschaft (BZAW) erscheinen Arbeiten zu s mtlichen Gebieten der alttestamentlichen Wissenschaft. Im Zentrum steht die Hebr ische Bibel, ihr Vor- und Nachleben im antiken Judentum sowie ihre vielfache Verzweigung in die benachbarten Kulturen der altorientalischen und hellenistisch-r mischen Welt.

Marketers use autobiographical advertising as a means to create nostalgia for their products. This research explores whether such referencing can cause people to believe that they had experiences as children that are mentioned in the ads. In Experiment 1, participants viewed an ad for Disney that suggested that they shook hands with Mickey Mouse as a child. Relative to controls, the ad increased their confidence that they personally had shaken hands with Mickey as a child at a Disney resort. The (...) increased confidence could be due to a revival of a true memory or the creation of a new, false one. In Experiment 2, participants viewed an ad for Disney that suggested that they shook hands with an impossible character (e.g., Bugs Bunny). Again, relative to controls, the ad increased confidence that they personally had shaken hands with the impossible character as a child at a Disney resort. The increased confidence is consistent with the notion that autobiographical referencing can lead to the creation of false or distorted memory. ᭧ 2002 John Wiley & Sons, Inc. (shrink)

Now in its third year, the Russian war of aggression against Ukraine remains at the very top of the international security agenda. This conflict has largely refocused the West's attention away from the counterterrorism and counterinsurgency campaigns that followed the terrorist attacks of September 11, 2001. In February 2022, German chancellor Olaf Scholz went so far as to declare that the invasion signaled a zeitenwende, or “dawn of a new era.”1 Russia's aggression and the threat of having to fight a (...) peer or near-peer competitor raises difficult questions, many of which are ethical in nature. The essays gathered in this roundtable seek to provide answers to some of those questions. They are the result of a workshop I organized for the King's College London Centre for Military Ethics in October 2023. One of my ambitions for this workshop was to put leading academics working on the ethics of war into discussion with military practitioners, making sure to include Ukrainian voices. I was very fortunate to succeed in these objectives, and I am convinced that the published essays have benefited enormously from our conversations. (shrink)

Die großen Seuchen Europas begleiteten oft antisemitische Bilder. Der Aufsatz stellt die Parallelen zwischen dem Wandel der christlichen Heilsbotschaft (von der Glaubensgemeinschaft zur Transsubstantiationslehre) und der Verlagerung vom Antijudaismus zum rassistischen Antisemitismus dar: Aus dem Juden mit der „falschen Religion“ wird der Jude mit dem „falschen Körper“. Die Fantasien vom Juden als „Infektionsträger“ bauen auf alten christlichen Vorurteilen auf, doch im Prozess der Moderne mit ihrer Hinwendung zur Weltlichkeit verwandeln sie sich in körperliche „Realität“. Im frühen 21. Jahrhundert kommt es (...) zur Intensivierung dieses Effekts durch die sozialen Medien: Diese treten die Nachfolge des alten Gerüchts an, das schon immer Brandbeschleuniger antisemitischer Vorurteile war. Fake news und Covid 19 sind die beiden Seiten ein und derselben Epidemie. (shrink)

Successful trust-relations exist if the trustee reciprocates in accordance with his/her promises to the trustor’s unilateral cooperation. Using a parametric rational choice approach, Coleman shows that an egoist without a moral conscience may place trust in another unmoral egoist. Consequently, successful trust-relations between those actors are possible if strategic considerations play no role for individual decision-making. This paper focusses on such considerations for the emergence of those relations, given complete information (in the sense of common knowledge) of the players. Generally, (...) trust-relations are hard to establish if unmoral egoists take into account their strategic interdependence. It is shown that two different motivations of the trustee, viz., altruism and morality, may suffice to overcome the characteristic conflict between individual rationality and social efficiency in situations with strategically deciding actors. (shrink)

In this essay, I reflect on the divergent arguments about limited force made by Daniel R. Brunstetter and Samuel Moyn in their respective monographs. Arguing that their positions can be reconciled, I agree with Brunstetter that limited force has a role to play in establishing and maintaining a just world order. At the same time, however, I am mindful of Moyn's warning that limited force may lead to perpetual war. The way to ensure that limited force both works toward justice (...) and does not result in perpetual war, I argue, is to focus more on considerations of jus ante bellum (right before war) and jus post bellum (right after war), the so-called “growing edges of just war theory.” I hold that the responsible use of statecraft, which just war thinking seeks to inform, accepts that limited force constitutes a legitimate tool to facilitate order, justice, and peace. However, any justifiable use of force must be restrained and limited and aim for a just peace. The embrace of limited force should thus be complemented with an effort by state leaders to bolster the edges of just war in order to facilitate a security environment that requires the use of limited force less frequently. (shrink)

This paper critiques Rothbard’s concept of gross investment. Rothbard introduced the concept in order to demonstrate his point that it is not consumer spending that primarily drives the economy, like the mainstream Keynesian view maintains, but the capitalists’ spending. In this paper, it is argued that, contrary to Rothbard’s opinion, the amount of gross investment as he defines it does not contain significant information concerning the question as to whether the capital structure of a society can be upheld or not. (...) Instead, it is an arbitrary figure that depends on the length of the different stages of production. This problem has not been recognized by Rothbard because his exposition rests upon the assumption of an equal time length for all stages. Apparently, he has been led astray by his intention to find arguments against the importance of consumer spending in the determination of output. (shrink)

Der orientalische Gott Eros ist in seinen Ursprungen ein Zerreisser dieser Welt. Er wirft sie aus dem Takt und zerstort ihre Harmonie. Das jedoch war den fruhen griechischen Baumeistern des Abendlandes gar nicht recht. In einem aufregenden Akt wurde der Zerreisser zum Versohner umgedeutet. Besonders anschaulich wird diese Geschichte beim grossen Philosophen Platon. Dort liegen die Wurzeln fur eine erregende Spiritualitat auf der einen und fur die technisch-wissenschaftliche Welteroberung auf der anderen Seite. Mit didaktischem Geschick entfaltet der Autor mit zahlreichen (...) Ausblicken auf kulturgeschichtliche Hintergrunde die faszinierende Denkwelt Platons. Dies erschliesst ein tieferes Verstandnis fur die feurige Leidenschaft des Fortschritts, den wir hassen und lieben, der uns befreit und knechtet, der uns Hoffnung ist und Angst auslost und von dem wir - so scheint es - doch nicht loskommen.". (shrink)