Cancer is a complex disease, necessitating research on many different levels; at the subcellular level to identify genes, proteins and signaling pathways associated with the disease; at the cellular level to identify, for example, cell-cell adhesion and communication mechanisms; at the tissue level to investigate disruption of homeostasis and interaction with the tissue of origin or settlement of metastasis; and finally at the systems level to explore its global impact, e.g. through the mechanism of cachexia. Mathematical models have been proposed (...) to identify key mechanisms that underlie dynamics and events at every scale of interest, and increasing effort is now being paid to multi-scale models that bridge the different scales. With more biological data becoming available and with increased interdisciplinary efforts, theoretical models are rendering suitable tools to predict the origin and course of the disease. The ultimate aims of cancer models, however, are to enlighten our concept of the carcinogenesis process and to assist in the designing of treatment protocols that can reduce mortality and improve patient quality of life. Conventional treatment of cancer is surgery combined with radiotherapy or chemotherapy for localized tumors or systemic treatment of advanced cancers, respectively. Although radiation is widely used as treatment, most scheduling is based on empirical knowledge and less on the predictions of sophisticated growth dynamical models of treatment response. Part of the failure to translate modeling research to the clinic may stem from language barriers, exacerbated by often esoteric model renderings with inaccessible parameterization. Here we discuss some ideas for combining tractable dynamical tumor growth models with radiation response models using biologically accessible parameters to provide a more intuitive and exploitable framework for understanding the complexity of radiotherapy treatment and failure. (shrink)

The essay aims to show how business ethics—understood as a three-level approach—can strengthen the social cohesion of a society, which is jeopardized today in many ways. In the first part, the purpose of business and the economy is explained as the creation of wealth defined as a combination of private and public wealth that includes natural, economic, human, and social capital. Special emphasis is placed on the implications of the creation of public wealth which requires institutions other than the market (...) and motivations other than self-regarding ones. In the second part, the question of what holds a society together is discussed through different approaches: enlightened self-interest, a new game-theoretical approach, and the concept of the common good advanced by Catholic Social Teaching, followed by my own proposal. The third part presents several perspectives for business ethics to strengthen social cohesion of a society by focusing on the purpose of business and the economy to create natural, economic, human, and social capital; by advancing public goods that stand the test of ethical scrutiny; and by securing human rights conceptualized as public goods. (shrink)

If managerial leadership means deciding responsibly in a complex situation, the ethical dimension of leadership — besides its analytical and instrumental aspects — has to be clarified. I present and discuss several essential aspects of managerial ethical leadership: (a) some major presuppositions (the concepts of leadership and responsibility), (b) three normative-ethical tasks of the activity of leadership (perceiving, interpreting and creating reality — being responsible for the effect of one's decisions on the human beings concerned — being responsible for the (...) implementation of corporate goals) and (c) some claims on the leader as a subject responsible for his or her own activities. I shall conclude by adding some reflections on the limits of managerial ethical leadership. (shrink)

What is the purpose of our economic system? What would a more life-serving economy look like? There are many books about business and society, yet very few of them question the primacy of GDP growth, profit maximization and individual utility maximization. Even developments with a humanistic touch like stakeholder participation, corporate social responsibility or corporate philanthropy serve the same goal: to foster long-term growth and profitability. Humanism in Business questions these assumptions and investigates the possibility of creating a human-centered, value-oriented (...) society based on humanistic principles. An international team of academics and practitioners present philosophical, spiritual, economic, psychological and organizational arguments that show how humanism can be used to understand, and possibly transform, business at three different levels: the systems level, the organizational level and the individual level. This groundbreaking book will be of interest to academics, practitioners and policymakers concerned with business ethics and the relationship between business and society. (shrink)

In recent years, corporate environmental policies have become urgently needed, demanded by influential environmentalist groups and launched by an increasing number of companies. Those demands and efforts, however, often lack an ethical underpinning. This paper deals with some basic ethical issues and outlines three perspectives for further investigation: (1) How can we take into account ethical pluralism that characterizes most contemporary societies?; (2) What is the content of environmental ethics viewed from a Christian perspective, taken as an example of various (...) existent doctrines in the pluralistic world?; and (3) What relevance may this "Christian environmental stewardship" have for the understanding of corporate environmental responsibility? (shrink)

The author of this major study compares the significantly different approaches to business ethics on both sides of the Atlantic and considers what they have to learn from each other. He has considerable experience of business ethics in both Europe and North America, having taught and researched the subject at the University of St Gallen in his native Switzerland before his appointment as Professor of International Business Ethics in the College of Business Administration, University of Notre Dame, Indiana 46556, USA. (...) Professor Enderle was also the founding Honorary Treasurer of the European Business Ethics Network and is an Associate Editor of this Review. (shrink)

In the last 30 years, China has experienced an astounding economic development that calls for a differentiated understanding of this complex process of wealth creation. In the first section of this article, I present a new concept of wealth creation that goes beyond making money, maximizing profit and adding value and serves as a framework to address the article's main topic.In the second section, I investigate in what ways and to what extent this new concept might apply to China's economic (...) reform and development, particularly in the 1980s and 1990s. In the third section, I attempt to draw a couple of lessons for development ethics in general. (shrink)

Recalling several profound disagreements about business ethics as it is currently discussed in Western societies, I emphasize the need for business ethics as an academic discipline that constitutes the “backbone” for both teaching business ethics and improving business practice (section 1). Then I outline a conceptual framework of business ethics that promotes a “bottom-up” approach (section 2). This “problem-and action-oriented” conception appears to be fruitful in terms of both practical relevance and theoretical understanding. Finally, I argue for (section 3) the (...) relevance of discussing goals at all levels of human action (i.e., individuals, organizations, systems) as well as the indispensability of human rights, and propose Amartya Sen's “goal-rights-system” approach as a normative-ethical framework for business ethics that integrates these two fundamental aspects. (shrink)

Abstract Along with China’s stunning economic growth, marketing has become a multi-billion dollar business, afflicted by a plethora of marketing scandals. However, little attention has been paid, until now, to a more systematic approach to marketing ethics in China. This essay attempts to provide a broad and timely, but far from complete, view on marketing issues in China. It uses four ethical guidelines which capture the fundamental features particularly relevant to marketing activities: practicing honest communication; enhancing human capabilities; fostering creative (...) intercultural diversity; and promoting sustainable growth and eco-efficiency. These guidelines are then elucidated with 12 positive and negative cases of Chinese and non-Chinese companies. By combining guidelines with case studies, it is hoped that ethical challenges for marketing in China will be discerned in a more systematic and comprehensible fashion. The article concludes by indicating several perspectives for further research. Content Type Journal Article Category Original Paper Pages 1-20 DOI 10.1007/s13520-011-0014-0 Authors Georges Enderle, Mendoza College of Business, University of Notre Dame, Notre Dame, IN, USA Qibin Niu, School of Business Administration, China University of Petroleum, Changping, Beijing, People’s Republic of China Journal Asian Journal of Business Ethics Online ISSN 2210-6731 Print ISSN 2210-6723. (shrink)

Using an explicit task cuing paradigm, we tested whether masked cues can trigger task-set activation, which would suggest that unconsciously presented stimuli can impact cognitive control processes. Based on a critical assessment of previous findings on the priming of task-set activation, we present two experiments with a new method to approach this subject. Instead of using a prime, we varied the visibility of the cue. These cues either directly signaled particular tasks in Experiment 1, or certain task transitions in Experiment (...) 2. While both masked task and transition cues affected task choice, only task cues affected the speed of task performance. This observation suggests that task-specific stimulus–response rules can be activated only by masked cues that are uniquely associated with a particular task. Taken together, these results demonstrate that unconsciously presented stimuli have the power to activate corresponding task sets. (shrink)

This paper offers a new concept of the firm that aims at balancing the corporate economic, social, and environmental responsibilities and goes beyond the stakeholder approach. It intends to provide a conceptual and operationalizable basis to fairly assess corporate conduct from both inside and outside the companies. To a large extent these different responsibilities may overlap and reinforce each other. However, if they conflict, they should be clearly evaluated for their own sake and in terms of wealth creation. Only then (...) can a balanced approach be realized. Section 1 briefly discusses some general aspects of the relationship between concepts and measurement. In Section 2, a concept of the firm is developed that is based on the notion of responsibility and balances economic, social and environmental responsibilities. According to these concepts, different ways of measuring corporate planning and performance are examined in Section 3, followed up by a summary and conclusions. (shrink)

This unique collection of reports encompasses a wide range of challenges and activities of business ethics in most parts of the world. In the introduction, after a brief explanation of the sixfold questionnaire and its assumptions, I try to highlight a number of striking features contained in these reports, which may help to delineate the state-of-the-art of business ethics at national and regional levels. As a result of this international comparison, the following features deserve particular attention: the relevance of semantics, (...) corruption, leadership, corporate responsibilities, the need for case studies, business ethics as a social institution, and the question as to how important international issues really are. (shrink)

The notion of internalization put forth by Roger Shepard continues to be appealing and challenging. He suggests that we have internalized, during our evolutionary development, environmental regularities, or constraints. Internalization solves one of the hardest problems of perceptual psychology: the underspecification problem. That is the problem of how well-defined perceptual experience is generated from the often ambiguous and incomplete sensory stimulation. Yet, the notion of internalization creates new problems that may outweigh the solution of the underspecification problem. To support this (...) claim, I first examine the concept of internalization, breaking it down into several distinct interpretations. These range from well-resolved dynamic regularities to ill-resolved statistical regularities. As a function of the interpretation the researcher selects, an empirical test of the internalization hypothesis may be straightforward or it may become virtually impossible. I then attempt to cover the range of interpretations by drawing on examples from different domains of visual event perception. Unfortunately, the experimental tests regarding most candidate regularities, such as gravitational acceleration, fail to support the concept of internalization. This suggests that narrow interpretations of the concept should be given up in favor of more abstract interpretations. However, the latter are not easily amenable to empirical testing. There is nonetheless a way to test these abstract interpretations by contrasting internalization with the opposite concept: externalization of body dynamics. I summarize evidence for such a projection of body constraints onto external objects. Based on the combined evidence of well-resolved and ill- resolved regularities, the value of the notion of internalization has to be reassessed. Key Words: event perception; evolution; internalization. (shrink)

Menschen schreiben sich ein Selbst zu. Die Wissenschaften haben Mühe zu sagen, was das ist und wie es zustande kommt. Sie sind sich aber sicher, dass wir es haben und brauchen. Für Forscher ist es jedoch kaum greifbar und deshalb ein verflixtes Problem. Daran wird die Entwicklung einer starken KI scheitern, Menschen bleiben etwas anderes. Der Inhalt Die Stunde Null; Vorteile der Sterblichkeit Die Erfindung des Selbst; ohne Selbsttäuschung geht es nicht Nagelprobe Moral; warum der Liberalismus einen Neustart braucht Über (...) den Autor Dr. Heiko Reisch ist Philosoph und arbeitet als Kommunikationsberater und Journalist. Er ist Autor der,,Kleinen Geschichte der Philosophie" bei Springer VS. (shrink)

The purpose of this article is to take a fresh look at the concept of wealth creation that is urgently needed, given the huge gap between the global importance of wealth creation and the attention paid to it. It is argued that its notion we encounter is often very simple (as in "making money") or extremely vague (as in "adding value"). In the first section "Need for a fresh look at the creation of wealth", the need for a fresh look (...) is highlighted by pointing to three concerns about globalization and the roles and responsibilities of corporations. In the second section "Conceptual clarifications: what is the creation of wealth?", a rich concept of wealth creation is developed that includes physical, financial, human, and social capital, encompasses private and public wealth, accounts for its production and distribution, recognizes its material and spiritual side, and places wealth in the time horizon of sustainability. Moreover, creating (wealth) as "making something new and better" is distinguished from possessing and acquiring, and different motivations required for wealth creation are explored. The third section "Challenges for business ethics" discusses several challenges of this rich concept for the understanding of business ethics. (shrink)

The article critically engages Menachem Fisch’s account of normative frameworks, in particular of (rational) transitions between them. I argue, first, that exposure to the normative criticism leveled at us by other human beings is indeed “capable of destabilizing normative commitment” to one’s own underlying framework beliefs and standards, as Fisch holds; however, closer scrutiny reveals that such exposure is neither sufficient nor necessary but rather accidental in this respect. Second, I will try to show that Søren Kierkegaard’s account of how (...) people fundamentally change their mind provides resources for both a substantial critique of Fisch and a more adequate understanding of the transitions in question. The article argues, third, that Fisch’s framework model – though meaningful, in fact heuristically indispensable in and as of itself – has robust transcendental implications which as such are being ignored, if not directly denied by Fisch and, precisely by being ignored or denied, unnecessarily weaken the overall plausibility of his account. Finally, and ex post, I will address an important objection raised by some commentators. (shrink)

Given a huge variety of international relations in the age of globalization, business ethics needs to take them seriously in a differentiated way with great sensitivity and sophisticated understanding. This essay proposes to structure the field of business ethics by distinguishing three levels of analysis and four types of international relations. It builds on Richard T. De George’s pioneering work as an early leader in the field of business ethics. It is hoped that such differentiation may help to better identify (...) the ethical responsibilities of all actors in business and the economy. The first part explains the extended three-level conception of business ethics with four types of international relations. The second part shows De George’s contribution to substantiate this conceptual framework. And the third part discusses the significance of this framework for better ways of securing human rights in international relations. (shrink)

In his famous lecture on ‘Politics as a Vocation’, Max Weber coined and elaborated on the antithesis between the ethics of conviction and the ethics of responsibility, which has had a far-reaching impact on the ethics discussions, particularly in German-speaking countries. The article explores what Weber himself meant with this distinction and what implications result from it. As an interesting historical observation, Weber's interpretation of ‘Do not resist an evildoer’ in the (Christian) New Testament is contrasted with Mahatma Gandhi's diametrically (...) opposed interpretation. After criticizing Weber's position, the article outlines how today's business ethics can be based on a new and different foundation that overcomes the ‘profound antithesis’ between the ethics of conviction and the ethics of responsibility without disregarding the tensions between internal attitudes and external action results. (shrink)

Innovation has become a buzzword that promises dramatic changes in almost every field of business. Absent from this attention is a serious discussion of the ethical sides of dramatic change. To address this, editors Georges Enderle and Patrick E. Murphy gather a team of experts to fully examine the ethics of innovation within business and the economy in this standout addition to the Studies in TransAtlantic Business Ethics series. The book opens with an exploration and clarification of several key concepts (...) necessary for a thorough study of innovation such as business ethics, moral innovation, creativity, and wealth creation. The opening chapters also propose a novel theoretical foundation and methodological approach with which to address ethical innovation. Subsequently, the contributors discuss challenges and opportunities of innovation for individuals, organizations, and systems while zoning in on a wide range of specific examples, including but not limited to: managerial responsibilities, morality and imagination of leaders, as well as the ethics of the Maker Movement. This comprehensive book evaluates organizational innovations from diverse parts of the world including Egypt, India, Latin America, the UK, and the US. Ethical Innovation in Business and the Economy concludes with a presentation of methods for improving economic systems, such as tracing Adam Smith in emerging enterprises, developing a justice model of marketing to the poor, and bridging the formal and informal economies in an African context. This in-depth examination of innovation, and its involvement in the business and economic world, is an invaluable reference tool for students, teachers, and researchers in business and economic ethics, as well as executives in business and other organizations who search for new and more responsible ways to address globalization, sustainability, and financialization. (shrink)

Given the enormous changes in the ways we will live together on the planet Earth, business and economic ethics, with its considerable developments since the1980s, is called to ask itself what major challenges lay ahead for it in the next ten years. It seems three major challenges have emerged with increasing clarity, urgency, and importance. They concern all levels of business, from the personal to the organizational and the systemic level and likely will become even more important in the future. (...) In three sections, the paper explicates the following challenges: (a) a rich and comprehensive understanding of wealth creation as the purpose of business and economics; (b) the guarantee of securing all human rights to all people; and (c) the active involvement of the world’s religions in meeting the challenges of creating wealth and securing human rights. (shrink)

Einer weit verbreiteten Lesart zu folge hat Kant mit seiner Kritik der praktischen Vernunft den Ansatz der Grundlegung zur Metaphysik der Sittenverworfen. Während er in der Grundlegung noch an einer Deduktion der Freiheit und Sittengesetzes arbeite, habe er diesen Gedanken in der zweiten Kritik mit seiner Theorie vom Faktum der Vernunft aufgegeben. Dementsprechend wird auch angenommen, dass das Gefühl der Achtung, welches in Kants Faktum-Lehre eine zentrale Rolle spielt, in der Grundlegung keine zentrale Funktion zukomme. Der vorliegende Aufsatz untersucht die (...) Funktion der Achtung in dieser Schrift und kommt zu dem Ergebnis, dass der Achtung schon dieselbe moralepistemische Funktion zukommt, wie in der zweiten Kritik. Kant behandelt im Kontext der Zirkelproblematik der Grundlegung ausgiebig das moralische Interesse. Dieser Ausdruck ist lediglich ein anderer Begriff für die Achtung. Dieser kommt damit für die Auflösung des Zirkelverdachts in GMS III eine bedeutende Funktion zu und ihre Bedeutung für die Grundlegung als ganze muss revidiert werden. (shrink)

chapter Introduction Poststructuralist perspectives on language, gender and sexual identity Since the inception of the field of language and gender in the, ...

Der dritte Abschnitt der Grundlegung zur Metaphysik der Sitten gilt als der am schwierigsten zu interpretierende Text der praktischen Philosophie Kants. Argumentationsziel und Aufbau des Textes sind bis heute umstritten, seine Deutung hängt in hohem Maße von philologischen Fragestellungen ab. Der Kommentar interpretiert den dritten Abschnitt der Grundlegung Satz für Satz entlang dem Fortgang des Textes. Er widmet der gängigen These von der Deduktion des kategorischen Imperativs kritische Aufmerksamkeit und analysiert Überlegungen Kants zum sittlichen Bewusstsein, die bereits auf die Faktum-Lehre (...) der zweiten Kritik vorausweisen. (shrink)

Der Aufsatz fragt am Beispiel von Tucholskys Pyrenäenbuch von 1927 nach den Möglichkeiten disziplinärer Zuständigkeiten und methodisch gesteuerter Interpretationen im Feld der Kulturwissenschaft. Gibt im Falle des Pyrenäenbuchs die aus Sicht der Medienwissenschaft avancierte Kombinatorik von Text und Photographie die Auslegung vor oder lässt sich jenseits dieser etablierten medienwissenschaftlichen Theorie-Topik dem Text selbst noch ein anderer konkurrenzfähiger Auslegungshorizont abgewinnen? Gelesen im Umfeld von Arnold Gehlens Reflexionen über Gewohnheit (1927) und Walter Benjamins Kunstwerk-Aufsatz wird Tucholskys Reisebuch lesbar als aktualisierte Kierkegaard-Lektüre und (...) damit als systematische Abhandlung über mediale Gebrauchsweisen und Praktiken im Zeichen der Wiederholung. Drawing upon the example of Tucholsky's 1927 [Book of the Pyrenees], the paper inquires into the possibilities of disciplinary competences and methodology-driven interpretations in the field of cultural studies. It asks whether in the case of the, the combination strategies of text and photography necessarily predetermine the interpretation, or whether there are other competitive horizons of interpretation beyond this wellestablished theoretical topos of media studies. If it is read in the context of Arnold Gehlen's 1927 [Reflections on habit] and Walter Benjamin's, Tucholsky's [Book/journal of voyages] presents itself as an contemporary reading of Kierkegaard and thus as a systematic discussion of medial usages and practices under the sign of repetition. (shrink)

This chapter contains sections titled: Introduction A Conceptual Framework for Business Ethics Charting the Emerging Field of Business Ethics Theoretical Approaches to Business Ethics Concluding Remarks.

The 24 components of the relativistic spin tensor consist of 3 + 3 basic spin fields and 9 + 9 constitutive fields. Empirically only three basic spin fields and nine constitutive fields are known. This empirem can be expressed by two spin axioms, one of them denying purely relativistic spin fields, and the other one relating the three additional basic fields and the nine additional constitutive fields to the known (and measurable) ones. This identification by the spin axioms is material-independent (...) and does not mix basic spin fields with constitutive properties. The approaches to the Weyssenhoff fluid and the Dirac-electron fluid found in literature are discussed with regard to these spin axioms. The conjecture is formulated, that another reduction from six to three basic spin fields which does not obey the spin axioms introduces special material properties by not allowed mixing of constitutive and basic fields. (shrink)

Implicit and explicit filling-in phenomena should be distinguished. Blind spot phenomena and mechanisms of boundary completion can be accounted for by implicit filling-in. Surface regions are “painted” with perceptual quantities, such as brightness, by explicit filling-in. “Filling-in” and “finding-out” relate to different computational tasks. Mechanisms of purposive computation (e.g., for navigation) evaluate local measurements, thus “finding out”; whereas mechanisms for grasping might require passive reconstruction, thus “filling in.”.

In his applied moral philosophy, Kant formulates the parents’ duty to make their child happy. I argue that, for Kant, this duty is an ad hoc attempt at compensating for the parental guilt of having brought a person into the condition of existence – and hence also having created her need for happiness – on their own initiative. I argue that Kant’s considerations regarding parental duties and human reproduction in general imply arguments for an ethically justified anti-natalism, but that this (...) position is abolished in his teleology for meta-ethical reasons. (shrink)

Hexa-Sabbath. Foreign Matter and Vital Substances, Experts and the Critical Consumer in the FRG during the 1950s and 1960sIn the late Fifties and early Sixties the regulation of food additives represented a remarkable turning point in German consumer politics, establishing a debate about decision making and policy advice, altering the discourse of purity and contamination, and inaugurating a new political actor, the organized critical consumer. The amendment of the Food Law in December 1958 functioned as a negotiation process between representatives (...) of science, industry and the state, which was institutionalized in the Senate Commissions of the German Research Foundation. While these Commissions for preservatives, foreign matter and colorants worked behind closed doors, a public discourse about the “toxic condition” of modern life and the negative role of the pharmaceutical and chemical industry gained strength.The debate about the admission of hexamethylenetetramine (hexa) took part at a crucial moment. Hexa was used as a preservative in the fish industry. But its anti microbial effectiveness was caused by the decomposition of hexa to formaldehyde. Despite the commission’s verdict against hexa, the lobbying activities of the industry granted it a reprieve. In the media, the case of hexa was seen as a touchstone for the capacity of negotiated decision making and the ability of rational scientists to resist the demands of industry. Finally, in 1963 it was the new political actor of the organized critical consumer, heir and successor to the housewife federations as well as to “purists” advocating life reform, who, supported by the media, enforced the prohibition of hexa as a preservative. (shrink)