Driven by technological innovations, newborn screening (NBS) panels have been expanded and the development of genomic NBS pilot programs is rapidly progressing. Decisions on disease selection for NBS are still based on the Wilson and Jungner (WJ) criteria published in 1968. Despite this uniform reference, interpretation of the WJ criteria and actual disease selection for NBS programs are highly variable. A systematic literature search [PubMED search “Wilson” AND “Jungner”; last search 16.07.22] was performed to evaluate the applicability of the WJ (...) criteria for current and future NBS programs and the need for adaptation. By at least two reviewers, 105 publications (systematic literature search, N = 77; manual search, N = 28) were screened for relevant content and, finally, 38 publications were evaluated. Limited by the study design of qualitative text analysis, no statistical evaluation was performed, but a structured collection of reported aspects of criticism and proposed improvements was instead collated. This revealed a set of general limitations of the WJ criteria, such as imprecise terminology, lack of measurability and objectivity, missing pediatric focus, and absent guidance on program management. Furthermore, it unraveled specific aspects of criticism on clinical, diagnostic, therapeutic, and economical aspects. A major obstacle was found to be the incompletely understood natural history and phenotypic diversity of rare diseases prior to NBS implementation, resulting in uncertainty about case definition, risk stratification, and indications for treatment. This gap could be closed through the systematic collection and evaluation of real-world evidence on the quality, safety, and (cost-)effectiveness of NBS, as well as the long-term benefits experienced by screened individuals. An integrated NBS public health program that is designed to continuously learn would fulfil these requirements, and a multi-dimensional framework for future NBS programs integrating medical, ethical, legal, and societal perspectives is overdue. (shrink)

Purpose This systematic review aims to identify factors that influence parents’ decisions regarding pediatric diagnostic and predictive genetic testing (DT/PT). Factors are integrated into a conceptual model of decision-making. Implications for genetic counseling, research, and ethics are derived. Methods PubMed, PsychInfo, WebofScience and references of related reviews were searched for original publications between 2000 and 2023. Extracted factors were categorized into an existing model. Results Of 5843 publications, 56 met inclusion criteria. The included studies differentiate between DT, traditional, and expanded (...) PT and describe factors impacting parental decisions on both to have the child genetically tested and to be informed about additional findings. Factors included: 1. benefits/hopes, 2. worries/concerns, 3. values and beliefs, 4. individual circumstances, and 5. emotional states. Conclusion Our work extends an existing empirical decision model of family decisions about genome sequencing to genetic testing in pediatrics in general, adding the categories “individual circumstances” and “emotional states”. The factors can be further integrated into the Health Belief Model; the importance of emotional states is reflected in dual-process theories, such as Fuzzy Trace Theory. Research is required on emotional states, differences between DT and PT, parents’ decisions about result disclosure, and dyadic variables as decision-making predictors. (shrink)

Menschen schreiben sich ein Selbst zu. Die Wissenschaften haben Mühe zu sagen, was das ist und wie es zustande kommt. Sie sind sich aber sicher, dass wir es haben und brauchen. Für Forscher ist es jedoch kaum greifbar und deshalb ein verflixtes Problem. Daran wird die Entwicklung einer starken KI scheitern, Menschen bleiben etwas anderes. Der Inhalt Die Stunde Null; Vorteile der Sterblichkeit Die Erfindung des Selbst; ohne Selbsttäuschung geht es nicht Nagelprobe Moral; warum der Liberalismus einen Neustart braucht Über (...) den Autor Dr. Heiko Reisch ist Philosoph und arbeitet als Kommunikationsberater und Journalist. Er ist Autor der,,Kleinen Geschichte der Philosophie" bei Springer VS. (shrink)

Immanuel Kant is, famously, not only the major philosopher of European enlightenment, but also one of the first philosophers to develop a philosophical theory of “human races”. How do these two sides of Kant relate to each other? What is the significance of race in Kant’s philosophy? In this article, we aim to discuss these questions by taking a close look into the conceptual and philosophical presuppositions underlying Kant’s understanding of race; relating them to the concept of teleology as developed (...) by Kant in the Critique of Judgement and to the idea of natural history that can be derived from there. In the last two chapters, we intertwine both perspectives in such a way that, on the one hand, we can determine the philosophical significance of race for Kant, and, on the other hand, show how a race-sensible perspective gives new and critical insight into Kant’s concept of reason. (shrink)

The present study evaluates the cognitive representation of a kicking movement performed by a human and a humanoid robot, and how they are represented in experts and novices of soccer and robotics, respectively. To learn about the expertise-dependent development of memory structures, we compared the representation structures of soccer experts and robot experts concerning a human and humanoid robot kicking movement. We found different cognitive representation structures for both expertise groups under two different motor performance conditions . In general, the (...) expertise relies on the perceptual-motor knowledge of the human motor system. Thus, the soccer experts’ cognitive representation of the humanoid robot movement is dominated by their representation of the corresponding human movement. Additionally, our results suggest that robot experts, in contrast to soccer experts, access functional features of the technical system of the humanoid robot in addition to their perceptual-motor knowledge about the human motor system. Thus, their perceptual-motor and neuro-functional machine representation are integrated into a cognitive representation of the humanoid robot movement. (shrink)

This is the first of the two volumes the second volume being Thomas Ballmer s Biological Foundations of Linguistic Communication (P&B III:7) treating ...

Empirical research on the perception of physical events is rarely designed to test a particular theory. The research often fails to be embedded in a larger theoretical context or it is carried out with the implicit goal to support a particular theoretical approach. I argue that this is not very productive. While three theories are relevant for our understanding of events, their limits have rarely been addressed. I expose these limits. The three theories or approaches are direct or ecological perception, (...) inference theory, and the concept of internalization. I demonstrate that all three fail empirically and/or theoretically with respect to explaining the perception of events. They fail because they adhere to simplistic stationary views or because they remain too vague. An adequate theory of event perception has to include three factors at the level of the explanans, namely the stimulus, the purpose of the action to which the percept belongs, and the appraisal of this action's success. Examples from the domains of arrival-time judgment and perception of events involving classical mechanics are used to support the claims. I suggest that a new pragmatic theory of event perception ought to modify and to incorporate the three concepts of affordances, thought-like processes, and evolutionary principles. (shrink)

Implicit and explicit filling-in phenomena should be distinguished. Blind spot phenomena and mechanisms of boundary completion can be accounted for by implicit filling-in. Surface regions are “painted” with perceptual quantities, such as brightness, by explicit filling-in. “Filling-in” and “finding-out” relate to different computational tasks. Mechanisms of purposive computation (e.g., for navigation) evaluate local measurements, thus “finding out”; whereas mechanisms for grasping might require passive reconstruction, thus “filling in.”.

This conceptual paper analyses the arguments which have been made in favour of a transition towards humanistic management. In order to reconcile economic as well as moral arguments an integrative model of humanistic management is presented. This model outlines prospective lines of empirical research especially in the area where business conduct is profitable but not humanistic.

While organizational learning literature has generated significant insight into the effective and efficient achievement of organizational goals as well as to the modus of learning, it is currently unable to describe moral learning processes in organizations consistently. Corporations need to learn morally if they want to deal effectively with stakeholders criticizing their conduct. Nongovernmental organizations do not ask corporations to be more effective or efficient in what they do, but to become more responsible or to learn morally. Current research on (...) the moral aspect of organizational learning has been primarily of a theoretical nature and is in need of empirical verification. Results of a longitudinal case study as Citigroup’s conflict with the Rainforest Action Network show that current organizational moral learning theories do not fit the moral learning path observed at Citigroup. More empirical research is needed to describe organizational moral learning. (shrink)

Interdisciplinary explorations of the implications of recent developments in vision theory for our understanding of the nature of pictorial representation and ...

Name der Zeitschrift: Kierkegaard Studies Yearbook Jahrgang: 20 Heft: 1 Seiten: 101-136.

Cancer is a complex disease, necessitating research on many different levels; at the subcellular level to identify genes, proteins and signaling pathways associated with the disease; at the cellular level to identify, for example, cell-cell adhesion and communication mechanisms; at the tissue level to investigate disruption of homeostasis and interaction with the tissue of origin or settlement of metastasis; and finally at the systems level to explore its global impact, e.g. through the mechanism of cachexia. Mathematical models have been proposed (...) to identify key mechanisms that underlie dynamics and events at every scale of interest, and increasing effort is now being paid to multi-scale models that bridge the different scales. With more biological data becoming available and with increased interdisciplinary efforts, theoretical models are rendering suitable tools to predict the origin and course of the disease. The ultimate aims of cancer models, however, are to enlighten our concept of the carcinogenesis process and to assist in the designing of treatment protocols that can reduce mortality and improve patient quality of life. Conventional treatment of cancer is surgery combined with radiotherapy or chemotherapy for localized tumors or systemic treatment of advanced cancers, respectively. Although radiation is widely used as treatment, most scheduling is based on empirical knowledge and less on the predictions of sophisticated growth dynamical models of treatment response. Part of the failure to translate modeling research to the clinic may stem from language barriers, exacerbated by often esoteric model renderings with inaccessible parameterization. Here we discuss some ideas for combining tractable dynamical tumor growth models with radiation response models using biologically accessible parameters to provide a more intuitive and exploitable framework for understanding the complexity of radiotherapy treatment and failure. (shrink)

Using an explicit task cuing paradigm, we tested whether masked cues can trigger task-set activation, which would suggest that unconsciously presented stimuli can impact cognitive control processes. Based on a critical assessment of previous findings on the priming of task-set activation, we present two experiments with a new method to approach this subject. Instead of using a prime, we varied the visibility of the cue. These cues either directly signaled particular tasks in Experiment 1, or certain task transitions in Experiment (...) 2. While both masked task and transition cues affected task choice, only task cues affected the speed of task performance. This observation suggests that task-specific stimulus–response rules can be activated only by masked cues that are uniquely associated with a particular task. Taken together, these results demonstrate that unconsciously presented stimuli have the power to activate corresponding task sets. (shrink)

chapter Introduction Poststructuralist perspectives on language, gender and sexual identity Since the inception of the field of language and gender in the, ...

The article critically engages Menachem Fisch’s account of normative frameworks, in particular of (rational) transitions between them. I argue, first, that exposure to the normative criticism leveled at us by other human beings is indeed “capable of destabilizing normative commitment” to one’s own underlying framework beliefs and standards, as Fisch holds; however, closer scrutiny reveals that such exposure is neither sufficient nor necessary but rather accidental in this respect. Second, I will try to show that Søren Kierkegaard’s account of how (...) people fundamentally change their mind provides resources for both a substantial critique of Fisch and a more adequate understanding of the transitions in question. The article argues, third, that Fisch’s framework model – though meaningful, in fact heuristically indispensable in and as of itself – has robust transcendental implications which as such are being ignored, if not directly denied by Fisch and, precisely by being ignored or denied, unnecessarily weaken the overall plausibility of his account. Finally, and ex post, I will address an important objection raised by some commentators. (shrink)

This study presents a contrastive corpus linguistic analysis of language use before and after Stonewall. It uses theoretical insights on normativity from the field of language and sexuality to investigate how the shifting normativities associated with the Stonewall Riots – widely considered the central event of gay liberation in the Western world – have shaped our conceptualization of sexuality as it surfaces in language use. Drawing on two corpora of gay men’s pre-Stonewall narratives dating from two time periods, the analysis (...) combines quantitative and qualitative corpus linguistic methods to examine discursive shifts as evident from narrators’ language use. The study identifies the terms homosexual and normal as central contrastive labels in PRE, and gay and straight as corresponding terms in POST. Other discursive shifts detected are from sexual desire/practices to identity, from an individualistic to a community-based conceptualization of sexuality, and from unquestioned heteronormativity and gender binarism to a weakening of such dominant discourses. The findings are discussed in relation to the desire-identity shift, which is traditionally assumed to have taken place at the end of the 19th century, and shed new light on Stonewall as a central event for the development of an identity-based conceptualization of sexuality as we know it today. (shrink)

The present paper is the third and final piece of an ongoing and as of yet unfinished dialog on normative issues about rationality and the self. After specifying the differences, yet also the actual – and to some extent: unexpected – agreements between myself and Menachem Fisch, I argue that the latter are more substantial and far-reaching. This is an assumption I seek to justify by unpacking the implications of Fisch’s core idea, according to which being rational in the fullest (...) human sense goes hand in hand with and in fact depends on being (able to be) a self. However, I also argue that some remaining shortcomings in Fisch’s account are mainly due to the latter’s all too liberal notion of rationality (“acting for a reason”) – shortcomings, which in my view can easily be remedied by a more restricted account, according to which acting for a reason only counts as rational, if and to the extent that the agent is “responsive to reasons,” i. e. willing to call his claim to being and acting rationally into question, whenever that claim is (expected to be) challenged by his peers. This notwithstanding, the entire conversation between Fisch and myself is arguably itself an instance of what it is about: a dialog concerning issues of rationality in the environment and spirit of a rationality conceived of as irreducibly dialogical. (shrink)