Nucleotide diversity of the human Y chromosome is much lower than that in the rest of the genome. A new hypothesis postulates that this invariance may result from mutations in maternally inherited mitochondrial DNA (mtDNA), leading to impaired reproduction among males and lowered male effective population size. If correct, we should expect to see low levels of polymorphism in the male‐specific Y chromosome of many organisms but not necessarily in the female‐specific W chromosome in organisms with female heterogamety. However, recent (...) observations from birds suggest that the avian W chromosome is very low in nucleotide diversity. This indicates that mtDNA mutations cannot broadly explain the evolution of the sex‐limited chromosome. Other work has suggested that sexual selection at loci involved in sex determination or secondary sexual characteristics might reduce levels of genetic variability on Y through hitch‐hiking effects. Although the W chromosome does not seen to play a dominant role for sex determination in birds, it cannot be excluded that selective sweeps arising from natural or sexual selection contribute to the low levels of genetic variability seen on this chromosome. BioEssays 25:163–167, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

The origin and evolutionary dynamics of the spatial heterogeneity in genomic base composition have been debated since its discovery in the 1970s. With the recent availability of numerous genome sequences from a wide range of species it has been possible to address this question from a comparative perspective, and similarities and differences in base composition between groups of organisms are becoming evident. Ample evidence suggests that the contrasting dynamics of base composition are driven by GC‐biased gene conversion (gBGC), a process (...) that is associated with meiotic recombination. In line with this hypothesis, base composition is associated with the rate of recombination and the evolutionary dynamics of the recombination landscape, therefore, governs base composition. In addition, and at first sight perhaps surprisingly, the relationship between demography and genomic base composition is in agreement with the gBGC hypothesis: organisms with larger populations have higher GC content than those with smaller populations. (shrink)

This paper examines and compares the ways in which intentions of the singular kind and the plural kind are subjective. Are intentions of the plural kind ours in the same way intentions of the singular kind are mine? Starting with the singular case, it is argued that “I intend” is subjective in virtue of self-knowledge. Self-knowledge is special in that it is self-identifying, self-validating, self-committing, and self-authorizing. Moving to the plural form, it is argued that in spite of apparent differences, (...) attitudes of the form “we intend” are subjective in the same way. The self-knowledge at work here is plural rather than singular. This supports a plural subject account of collective intentionality. It is argued that the worries sometimes raised in the literature against the metaphysical “spookiness” of plural subjects are due to a fundamental misconception of the way in which attitudes of either kind –singular and plural – are subjective. (shrink)

In this analysis we discuss the change in criteria for triage of patients during three different phases of a pandemic like COVID-19, seen from the critical care point of view. Availability of critical care beds has become a hot topic, and in many countries, we have seen a huge increase in the provision of temporary intensive care bed capacity. However, there is a limit where the hospitals may run out of resources to provide critical care, which is heavily dependent on (...) trained staff, just-in-time supply chains for clinical consumables and drugs and advanced equipment. In the first phase, we can still do clinical prioritisation and decision-making as usual, based on the need for intensive care and prognostication: what are the odds for a good result with regard to survival and quality of life. In the next, the resources are mostly available, but the system is stressed by many patients arriving over a short time period and auxiliary beds in different places in the hospital being used. We may have to abandon admittance of patients with doubtful prognosis. In the last phase, usual medical triage and priority setting may not be sufficient to decrease inflow and there may not be enough intensive care unit beds available. In this phase different criteria must be applied using a utilitarian approach for triage. We argue that this is an important transition where society, and not physicians, must provide guidance to support triage that is no longer based on medical priorities alone. (shrink)

Production of Presence is a comprehensive version of the thinking of Hans Ulrich Gumbrecht, one of the most consistently original literary scholars writing today. It offers a personalized account of some of the central theoretical movements in literary studies and in the humanities over the past thirty years, together with an equally personal view of a possible future. Based on this assessment of the past and the future of literary studies and the humanities, the book develops the provocative thesis (...) that, through their exclusive dedication to interpretation, i.e. to the reconstruction and attribution of meaning, the humanities have become incapable of addressing a dimension in all cultural phenomena that is as important as the dimension of meaning. Interpretation alone cannot do justice to the dimension of "presence," a dimension in which cultural phenomena and cultural events become tangible and have an impact on our senses and our bodies. Production of Presence is a passionate plea for a rethinking and a reshaping of the intellectual practice within the humanities. (shrink)

What role do metaphors play in philosophical language? Are they impediments to clear thinking that should be eradicated in the interests of terminological exactness? Or can they be used by philosophers to indicate the attitudes that regulate an epoch?

This two-part article is a sequel to a two-part paper published in Logos in 2008–2009. It provides a round-up of the current situation of the book industry in Africa today, together with a brief review of the activities of the various organizations that have supported African publishing over the years. Part 1 examines the persistent failure of African governments to support their book industries and public libraries in a tangible and positive fashion. It reviews the current status of book development (...) councils in Africa, the unsatisfactory progress in establishing national book policies, the challenges of generating book industry data, and the opportunities presented to African publishers by the new digital environment. An Appendix provides a list of conferences, meetings, and seminars on publishing and book development held in Africa between 1968 and 2019. Part 2 of this article will appear in Logos, 30. (shrink)

Religions around the world show support, ambivalence and antagonism towards the right to freedom of religion. Legal and political debates are affected by these profound differences. In this book an international group of scholars offer theoretical and empirical analyses.

Felix Kaufmanns Wissenschaftstheorie Hans-Georg Zilian. X KAUFMANN, DIE ÖKONOMEN UND DAS A PRIORI Bei den österreichischen Grenznutzentheoretikern, mit deren Arbeiten sich Kaufmann vor allem auseinandersetzte, ist von ...

A selection from the correspondence of the logician Wilhelm Ackermann (1896?1962) is presented in this article. The most significant letters were exchanged with Bernays, Scholz and Lorenzen, from which extensive passages are transcribed. Some remarks from other letters, with quotations, are also included.

In his choice of texts, the Editor has been faced with the difficult task of selecting, from among the author's more than 600 publications, those of the greatest philosophical interest. It is chiefly the topics of value-rela tivism and the logic of norms that have been kept in view. The selection has also been guided by the endeavour to reprint, so far as possible, texts which have not hitherto appeared in English. At times, however, this aim has had to be (...) discarded, in order to include works of key im portance and also the latest expressions of Kelsen's view. In addition to the two topics already mentioned, the Editor has con sidered Kelsen's discussions of the causal principle to be so far worthy of philosophical attention, that some writings on causality and account ability have been included in this collection of philosophical studies. OTA WEINBERGER Hans Kelsen died on April 19th, 1973. Only his work now lives, for the inspiration of future generations of jurists and philosophers. Graz, 25th April, 1973 OT A WEINBERGER TRANSLATOR'S NOTE I am obliged to the Editor for his careful scrutiny of the translation, which has led to a number of corrections and improvements in the text. (shrink)

It has been claimed, out of admiration for the great thinker, that his political errors have nothing to do with his philosophy. If only we could be content with that! Wholly unnoticed was how damaging such a “defense” of so important a thinker really is. And how could it be made consistent with the fact that the same man, in the fifties, saw and said things about the industrial revolution and technology that today are still truly astonishing for their foresight?In (...) any case: no surprise should be expected from those of us who, for fifty years, have reflected on what dismayed us in those days and separated us from Heidegger for many years: no surprise when we hear that in 1933—and for years previous, and for how long after?—he “believed” in Hitler. But Heidegger was also no mere opportunist. If we wish to dignify his political engagement by calling it a “standpoint,” it would be far better to call it a political “illusion,” which had notably little to do with political reality. If Heidegger later, in the face of all realities, would again dream his dream from those days, the dream of a “people’s religion” [Volksreligion], the later version would embrace his deep disappointment over the actual course of affairs. But he continued guarding that dream—and kept silent about it. Earlier, in 1933 and 1934, he thought he was following his dream, and fulfilling his deepest philosophical mission, when he tried to revolutionize the university from the ground up. It was for that that he did everything that horrified us at that time. For him the sole issue was to break the political influence of the church and the tenacity of academic bossdom. Even Ernst Jünger’s vision of “the worker” [der Arbeiter] was given a place beside his own ideas about overcoming the metaphysical tradition via the reawakening of Being. Later, as is known, Heidegger wandered all the way to his radical talk of the end of philosophy. That was his “revolution.” Hans-Georg Gadamer is professor emeritus of philosophy at the University of Heidelberg. His books include Truth and Method, Philosophical Hermeneutics, The Idea of the Good in Platonic-Aristotelian Philosophy, and The Relevance of the Beautiful and Other Essays. John McCumber, associate professor of philosophy at Northwestern University, is the author of Poetic Interaction: Language, Freedom, Reason. (shrink)

In this study, the impacts of two different “methods” for teaching ethics as part of the religious education in the Swedish upper secondary school were compared by means of a non-randomized controlled trial in two parts, involving 542 students. The question was which “method” had the greatest capacity to generate long-term ethical awareness in the students. The intervention condition consisted of students whose teachers were instructed to teach according to the Three Step Model, a teaching method influenced by research concerning (...) how moral autonomy and ethical awareness could be increased by means of instruction and training. The control condition consisted of students whose teachers were instructed to teach basically as usual but with some added guidelines. During the trial, all students were given a pre-test before the ethics section had started and a post-test 10–12 weeks after it was finished. When quantified and summarized, the results showed an advantage of the intervention condition in measure B but an advantage of the control condition in measure A ; however, the advantage of the intervention condition was clearer and stronger. Even though the intervention students did not experience a stronger development, they appeared to have learned significantly more, not least in terms of procedural knowledge in ethical problem solving. The tentative conclusion is therefore that the Three Step Model is a more effective method for increasing ethical awareness, at least if one defines ethical awareness and measures it the way it was done in this study. (shrink)

Leibniz wrote more than 60 proposals, concepts, and outlines for academies for Holland, Germany, Austria and Russia. Unlike the academies in Paris, London or Rome he intended a narrow connection of theoria and praxis. This should be achieved by his Scientia generalis as a theoretical unification, whereas the aim consisted in a universal Harmony.

Der Tod ist seit jeher und über alle Grenzen hinweg ein Grundthema der Philosophien gewesen - und nicht nur der Philosophien, sondern natürlich ebenso der Religionen, der Literaturen, der Künste. Die Sorgen, die der Tod bereitet, sind nicht allein mehr oder weniger universal oder existentiell, sie sind auch unauflösbar: Mit dem Tod wird man nicht fertig, bis er kommt. Und auch dann wird der Tod bekanntlich eher fertig mit uns als wir mit ihm. Keiner Philosophie oder Religion oder Kunst ist (...) es "endgültig " gelungen ,,durch die Auseinandersetzung mit dem Tod die Besorgnis ihm gegenüber auszulöschen. Dementsprechend versucht der vorliegende Band keinesfalls Antworten - und schon gar nicht "die" Antwort - auf die Fragen des Todes zu geben. Er führt vielmehr eine Reihe von Standpunkten, Einstellungen oder Vorstellungen zum bzw. vom Tode vor und wird für keine(n) Leser(in) das Todesproblem lösen können. Er kann nur an einem eindrucksvollen und tatsächlich jedem(r) nahegehenden Beispiel zeigen, wie man sinnvoll über etwas sprechen, schreiben und denken kann, ohne dabei darüber wirklich schlauer werden zu können. Ein solches Ergebnis ist nun keinesfalls entmutigend, es ist vielmehr eine Einsicht, bei der sich ansonsten so unterschiedliche Denkweisen wie der altchinesische Daoismus und Konfuzianismus einerseits und eine nachkantianische Philosophie des Zeichens andererseits treffen. (shrink)

"All men by nature desire to know"-this is the famous first sentence of Aristotle's Metaphysics. It is interesting to note how knowledge, at least since Aristotle, could be understood as a desire, as a mental craving, so to speak. When understood as a desire, knowledge necessarily goes along with a certain absence, a lack. Those who crave for knowledge are not yet fully in its possession, they are still on the search.