© 2015 Elsevier Inc.Postnatal organogenesis occurs in an immune competent environment and is tightly controlled by interplay between positive and negative regulators. Innate immune cells have beneficial roles in postnatal tissue remodeling, but roles for the adaptive immune system are currently unexplored. Here we show that adaptive immune responses participate in the normal postnatal development of a non-lymphoid epithelial tissue. Since the mammary gland is the only organ developing predominantly after birth, we utilized it as a powerful system to study (...) adaptive immune regulation of organogenesis. We found that antigen-mediated interactions between mammary antigen-presenting cells and interferon-γ -producing CD4+ T helper 1 cells participate in MG postnatal organogenesis as negative regulators, locally orchestrating epithelial rearrangement. IFNγ then affects luminal lineage differentiation. This function of adaptive immune responses, regulating normal development, changes the paradigm for studying players of postnatal organogenesis and provides insights into immune surveillance and cancer transformation. Plaks et al. (shrink)

The article is devoted to the identification of factors influencing the export trade flows of the Russian Federation to the EAEU member states. Gravity modeling (H. Linnemann's model) was used as a research tool. The introduction of dummy variables is justified. A comparative analysis of the identified factors is presented. A forecast of export trade flows of the Russian Federation to the EAEU countries for 2020-2022 has been made.

The purpose of the study is to identify quantitative and qualitative factors affecting the import flows of the Republic of Kyrgyzstan from the EAEU member states using gravity modeling. The article analyzes the identification of quantitative and qualitative factors that affect the value of import trade flows of the Republic of Kyrgyzstan from the EAEU member countries. The research toolkit is H. Linnemann's gravitational model. Gravity models of import trade flows of the Republic of Kyrgyzstan with each EAEU member (...) country have been built. The comparative characteristics of the identified quantitative factors are given. The forecast valuesfor 2021-2023 of the value of import trade flows of the Republic of Kyrgyzstan from the EAEU member countries have been made. (shrink)

Die Frage nach der Seele der Tiere ist so alt wie die Frage nach der Seele des Menschen und die nach der Welt. Die 18 Beitrage des Bandes geben einen Uberblick von der Antike bis in das 20. Jahrhundert, beschreiben den Stand der Forschung zu philosophischen sowie rechtsphilosophischen Fragen nachder Seele der Tiere und werfen zugleich die Frage nach dem Recht der Tiere auf.Aus dem InhaltJ.-C. Wolf, Haben Tiere Rechte?J.-H. Michel, Le droit romain et les animauxH. Schmidt-Glintzer, "Seid freundlich zu (...) den Tieren!". Tier, Mensch und Individualitat in ChinaE. Hornung, Die Vieldeutigkeit der Tiere im alten AgyptenE. Nicolay, Homere et l'ame des betesC. Frenzel, Tier, Mensch und Seele bei den VorsokratikernU. Perez-Paoli, Porphyrios' Gedanken zur Gerechtigkeit gegenuber TierenA. Giese, "Vier Tieren auch verheissen war, ins Paradies zu kommen" - Betrachtungen zur Seele der Tiere im islamischen MittelalterWeitere Beitrage von: D. Arendt, H. Breger, G. Boros, J.-L. Seban, G. Frank, M. Kowalewicz, H.W. Ingensiep, H. Baranzke, M. Linnemann, R. D. Precht. (shrink)

This paper presents four different understandings of the family and their concomitant views of the authority of the family in pediatric medical decision making. These different views are grounded in robustly developed, and conflicting, worldviews supported by disparate basic premises about the nature of morality. The traditional worldviews are often found within religious communities that embrace foundational metaphysical premises at odds with the commitments of the liberal account of the family dominant in the secular culture of the West. These disputes (...) are substantial and ultimately irresolvable by sound rational argument because of the failure to share common foundational premises and rules of evidence. It is in light of these fundamental disagreements that there is a need to evaluate critically the claims and agenda advanced by the Convention on the Rights of the Child. (shrink)

The COVID-19 pandemic has necessitated a rapid escalation in the use of telepsychiatry. Herein we revisit some of the ethical issues regarding its use, including patient benefice, distributive justice, privacy, and autonomy. Based on these considerations we would hold that telepsychiatry is a vital aspect of providing psychiatric care, and ethically should be offered as a format for treatment, likely beyond the pandemic period. Investigative and advocacy efforts will need to continue to determine its exact role within psychiatric care, and (...) expand its availability for those most in need. (shrink)

Guidelines for a model bride in Islam based on Islamic teachings; includes stories of six exemplary Muslim wives during Prophet Muhammad's time.

Die drei Bücher "Vom rechten Handeln" beschäftigen sich mit dem Verhältnis zwischem dem "Sittlichen" und dem "Nützlichen". Cicero vertritt die These, dass beide Begriffe "von Natur aus" identisch sind. Einen Konflikt zwischen dem Sittlichen, d.h. den aus den Tugenden folgenden Pflichten, und dem Nützlichen kann es daher im Grunde nicht geben. Was immer auf den ersten Blick sich als Konfliktfall darstellen mag - und Cicero geht zahlreiche Beispiele durch -, erweist sich bei genauer Betrachtung stets als scheinbarer Konflikt, der Nutzen (...) als scheinbarer Nutzen. Cicero verfasste "De officiis" als Vermächtnis an seinen Sohn in den Monaten nach der Ermordung Caesars. Von allen Werken Ciceros hat es am stärksten auf die Nachwelt gewirkt, von der Antika an, über Mittelalter, Renaissance bis hin zur Neuzeit; es wurde 1465 in Mainz als erstes gedruckt und am häufigsten übersetzt und kommentiert. Voltaire und Friedrich der Große hielten "De officiis" für das beste Buch über Moral. Die Übersetzung Karl Büchners sucht so wörtlich wie möglich die kunstvolle Sprache Ciceros nachzubilden. Der lateinische Text folgt der maßgeblichen Ausgabe von C. Atzert, die zahlreichen Abweichungen werden ausführlich kommentiert. Mit Einführung, Verzeichnis der Eigennamen und Literaturhinweisen. (shrink)

First published in 1962, Freedom and History expresses a deep concern about freedom and the way it is imperilled by misunderstandings. Professor Lewis examines works of T.H. Green and compares Green with Locke and Rousseau.

The paper gives an introduction to the problem whether there is a logic ℒ that captures PTIME in the sense that, via some natural encoding, the classes of finite structures axiomatizable in ℒ correspond to the languages in PTIME. It discusses several notions of capturing, thereby giving a picture of the general theory. The question for the most important version is still open. The paper surveys positive answers for certain classes of graphs that are based on the method of canonization.