Receptor‐mediated stimulation induces massive actin polymerization and cyto‐skeletal reorganization. The activity of a potent actin‐modulating protein, gelsolin, is regulated both by Ca2+ and polyphos‐phoinositides, and it may have a pivotal role in restructuring the actin cytoskeleton in response to agonist stimulation. Structure‐function analysis of gelsolin has (1) indicated that its NH2‐terminal half is primarily responsible for modulating actin filament length and polymerization; and (2) elucidated mechanisms by which Ca2+ and phospholipids may regulate such functions. Gelsolin is functionally and structurally similar (...) to villin, another Ca2+‐activated actin‐severing protein found in microvilli, suggesting that gelsolin may be a prototype of this family of actin‐modulating proteins. A molecular variant of gelsolin is secreted and may be involved in the clearance of actin filaments released during tissue damage. The two forms of gelsolin are encoded by a single gene, and distinct messages are derived by alternative message splicing. (shrink)

The de minimis principle states that some risks are so trivial that they can be ignored or treated categorically differently from non-trivial risks. Lundgren and Stefánsson criticize the de minimis principle, arguing that it either has to be applied locally or globally and that problems arise whichever application is chosen. Aven and Seif respond to Lundgren and Stefánsson’s argument and defend the de minimis principle as a “meaningful and useful perspective for handling risk in practice.” The response highlights some aspects (...) of the argument in Lundgren and Stefánsson that needs clarification, which is what we do in this note. (shrink)

I defend the permissibility of paid surrogacy arrangements against the arguments Sara Ketchum advances in " Selling Babies and Selling Bodies." I argue that the arrangements cannot be prohibited out of hand on the grounds that they treat persons as objects of sale, because it is possible to view the payments made in these arrangements as compensation for the woman ' s services. I also argue that the arguments based on exploitation and parental custodial rights fail to provide adequate grounds (...) for prohibiting the arrangements. (shrink)

Este artículo muestra el probable origen de las concepciones del desarrollo linear ascendente, cuyos representantes más conocidos en la era moderna fueron Hegel y Marx. En contraposición al concepto circular de la evolución histórica, que fue el predominante en muchas culturas, las doctrinas del des..

RESUMENUn intento por comprender la realidad sociopolítica podría consistir en situarse entre posiciones que marcan polos opuestos en el espectro de las ideas. Desde la filosofía griega se conocen las bondades y desventajas de colocarse en puntos intermedios que se hallan entre actitudes extremas en lo concerniente a asuntos morales y sociales. Una de las respuestas plausibles es una forma de eclecticismo, que tendría la función de una síntesis fructífera. Este teorema del sentido común guiado críticamente se asienta en concepciones (...) filosóficas clásicas, incluyendo la Escuela de Frankfurt. El ensayo pone como ejemplo principal el tratamiento de las utopías políticas.PLABARAS CLAVEARISTÓTELES, HABERMAS, HEGEL, SENTIDO COMÚN, TEORÍA CRÍTICA, UTOPÍAABSTRACTAn effort to understand the social-political reality could consist in taking a position between opposite poles in the spectrum of ideas. The advantages and disadvantages of placing oneself midway between extreme attitudes concerning moral and social problems have been aknowledged since Greek philosophy. A plausible answer is a form of eclecticism, which could have the function of a fertile synthesis. This theorem of a critically guided common sense is based on classic philosophic conceptions, including the Frankfurt School. This essay sets the analysis of political utopias as a main example.KEY WORDSARISTOTLE, COMMON SENSE, CRITICAL THEORY, UTOPY. (shrink)

Study of Islamic philosophy of Yaḥyá ibn Ḥabash Suhrawardī, 1152 or 1153-1191.

Criminal jurisdiction; international criminal courts.

In this note we prove that the abstract property "weakly subdirectly indecomposable" does not characterize the class IWs α of weak cylindric set algebras. However, we give another (similar) abstract property characterizing IWs α . The original property does characterize the directed unions of members of $\mathrm{IWs}_alpha \operatorname{iff} \alpha$ is countable. Free algebras will be shown to satisfy the original property.