In describing the flawless regularity of developmental processes and the correlation between changes at certain genetic loci and changes in morphology, biologists frequently employ two metaphors: that genes ‘control’ development, and that genomes embody ‘programs’ for development. Although these metaphors have an admirable sharpness and punch, they lead, when taken literally, to highly distorted pictures of developmental processes. A more balanced, and useful, view of the role of genes in development is that they act as suppliers of the material needs (...) of development and, in some instances, as context‐dependent catalysts of cellular changes, rather than as ‘controllers’ of developmental progress and direction. The consequences of adopting this alternative view of development are discussed. (shrink)

This book is intended for the use of the candid student, devised as a monitory preparation for deeper study of the philosophy of Spinoza. By its means it is hoped that the student may avoid the chief pitfalls of Spinoza-interpretation, and be carried past many of the difficulties encountered by the modern mind in the study of his writings. To this end perhaps the greatest hindrance to be met by the beginner is the ‘popular' exposition that attempts to expound the (...) thought of one age in terms of the favoured categories of another. By providing the necessary safeguards against misinterpretations arising from such causes, the author has sought to awaken interest in the closely knit fabric of Spinoza's doctrine of man and nature and God, and its practical import - and thus to revivify a specimen too long deprived of its native air. (shrink)

Originally published in 1915, this book presents the content of four lectures delivered by the author at the University of Cambridge from 1914 to 1915, as part of the Hulsean Lectures series. The text discusses the abiding value of Pascal and deals with misconceptions regarding the nature of his work and character. Detailed notes and an authorial preface are also provided. This book will be of value to anyone with an interest in Pascal and his influence on early twentieth-century thought.

Open peer commentary on the target article “Arguments Opposing the Radicalism of Radical Constructivism” by Gernot Saalmann. First paragraph: My remarks are basedon the view that mind-and-world structures of subject-inclusive experience are created by individual and collective subjects, and are not derived from pre-existing subject-exclusive structures structuring; see my papers in CF and the Karl Jaspers Forum). I will comment on two points.

Mark, G. La crisis de la física clásica por obra del experimento.--Thirring, J. La transformación del sistema conceptual de la física.--Hahn, J. La crisis de la intuición.--Nöbeling, J. La cuarta dimensión y el espacio curvo.--Menger, C. La nueva lógica.

Cognition or higher brain activity is sometimes seen as a phenomenon greater than the sum of its parts. This viewpoint however is largely dependent on the state of the art of experimental techniques that endeavor to characterize morphology and its association to function. Retinal ganglion cells are readily accessible for this work and we discuss recent advances in computational techniques in identifying novel parameters that describe structural attributes possibly associated with specific function. These parameters are based on calculating wavelet gradients (...) from cell images followed by the extraction of meaningful measures including 2nd wavelet moment, entropy of orientation, and curvature. For the three cell types analyzed, the mean 2nd wavelet moment, which relates to the field of influence of the dendritic-tree segments was significantly different. cells had the highest mean 2nd wavelet moment, followed by the and cells (134 ± 22, 93 ± 19 and 63 ± 12, respectively). There was no significant difference between cells for entropy of orientation, indicating no class with a preferential orientation of their dendritic tree. Curvature provided similar results to the 2nd wavelet moment with cells having the highest curvature followed by and the cells (mean ± SD: 161 ± 15; 134 ± 22; 121 ± 15). Our feature space analysis also indicated a difference between these cell types. No difference was found between the and cell types and their physiological counterparts the Y and X cells based on wavelet analysis. Both the X and Y cells can be divided into two subtypes, the ON- and OFF-center cells based on the stratification level of the dendritic tree within the retina. Using 2nd wavelet moment, a difference in their morphological attributes, not reported previously, was noted for these subtypes. The 2nd wavelet moment and curvature are further discussed with respect to explaining regularity of spacing and coverage associated with retinal ganglion cell mosaics. (shrink)

Burgess, J.P. and Rosen, G. Subject with No ObjectElliott, R.Faking Nature.

A new challenge for Bible translators A few decades ago the development of the dynamic-equivalent method of translation (which later became known as functional equivalence) broke radically away from the formal and traditional method of translation. Since then the functional-equivalent approach has undergone refinement, but the development can no longer be called revolutionary. However, research in the art of translation has now shifted from the method of translation to the format of the printed text (also called the paralinguistic features of (...) the text). In this article practical examples are given of how the employment of paralinguistic features can underscore the meaning of the text of the Bible, especially the Afrikaans Bible since it has become imperative to start working on a new translation. (shrink)