The Mesillas Yesharim / Path of the Just was the masterpiece of Rabbi Moshe Chaim Luzzatto, the great mystic, philosopher, sage, and saint. For centuries, this classic text for better living has been every man's primer for ideal life. Wherever there were Jews there was a well-thumbed Mesillas Yesharim. In this book, Rabbi Twerski applies the text and themes of Mesillas Yesharim to the everyday challenges of the 90s. He shows us how we can succeed in the quest for (...) a better life and in bettering ourselves. (shrink)

Studying Mesilat Yesharim with Hadar Goldin.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Mesillat Yesharim Dialogue Version Mesillat Yesharim Thematic Version Mesillat Yesharim, the basic ethical work, is presented here in twin versions, both written by RaMHaL. Mesillat Yesharim Dialogue Version is published for the first time from an autograph manuscript, Moscow Guenzburg 1206. Mesillat Yesharim Thematic Version is based on the first edition published in Amsterdam, 1740, during the author's lifetime, and corrected from parallel passages in the newly found manuscript. Mesillat Yesharim Dialogue Version is an independent work, adding chapters and new (...) material, which sheds brilliant light on the known thematic version. With source notes, references and comments, introduction and indices. (shrink)

Clonal disease is often regarded as almost synonymous with cancer. However, it is becoming increasingly clear that our bodies harbor numerous mutant clones that are not tumors, and mostly give rise to no disease at all. Here we discuss three somatic mutations arising within the hematopoietic system: BCR‐ABL, characteristic of chronic myeloid leukemia; mutations of the PIG‐A gene, characteristic of paroxysmal nocturnal hemoglobinuria; the V617F mutation in the JAK2 gene, characteristic of myeloproliferative diseases. The population frequencies of these three blood (...) disorders fit well with a hierarchical model of hematopoiesis. The fate of any mutant clone will depend on the target cell and on the fitness advantage, if any, that the mutation confers on the cell. In general, we can expect that only a mutation in a hematopoietic stem cell will give long‐term disease; the same mutation taking place in a cell located more downstream may produce just a ripple in the hematopoietic ocean. (shrink)

Rabbi Simone Luzzatto was the first thinker of the early modern period to put forth new political and philosophical ideas under the banner of scepticism, helping to make the Jews an integral part of society.