Given that natural selection is so powerful at optimizing complex adaptations, why does it seem unable to eliminate genes (susceptibility alleles) that predispose to common, harmful, heritable mental disorders, such as schizophrenia or bipolar disorder? We assess three leading explanations for this apparent paradox from evolutionary genetic theory: (1) ancestral neutrality (susceptibility alleles were not harmful among ancestors), (2) balancing selection (susceptibility alleles sometimes increased fitness), and (3) polygenic mutation-selection balance (mental disorders reflect the inevitable mutational load on the thousands (...) of genes underlying human behavior). The first two explanations are commonly assumed in psychiatric genetics and Darwinian psychiatry, while mutation-selection has often been discounted. All three models can explain persistent genetic variance in some traits under some conditions, but the first two have serious problems in explaining human mental disorders. Ancestral neutrality fails to explain low mental disorder frequencies and requires implausibly small selection coefficients against mental disorders given the data on the reproductive costs and impairment of mental disorders. Balancing selection (including spatio-temporal variation in selection, heterozygote advantage, antagonistic pleiotropy, and frequency-dependent selection) tends to favor environmentally contingent adaptations (which would show no heritability) or high-frequency alleles (which psychiatric genetics would have already found). Only polygenic mutation-selection balance seems consistent with the data on mental disorder prevalence rates, fitness costs, the likely rarity of susceptibility alleles, and the increased risks of mental disorders with brain trauma, inbreeding, and paternal age. This evolutionary genetic framework for mental disorders has wide-ranging implications for psychology, psychiatry, behavior genetics, molecular genetics, and evolutionary approaches to studying human behavior. (Published Online November 9 2006) Key Words: adaptation; behavior genetics; Darwinian psychiatry; evolution; evolutionary genetics; evolutionary psychology; mental disorders; mutation-selection balance; psychiatric genetics; quantitative trait loci (QTL). (shrink)

Moral patients deserve moral consideration and concern – they have moral standing. What factors drive attributions of moral standing? Understanding these factors is important because it indicates how broadly individuals conceptualize the moral world, and suggests how they will treat various entities, both human and non-human. This understanding has recently been advanced by a series of studies conducted by both psychologists and philosophers, which have revealed three main drivers of moral standing: the capacity to suffer, intelligence or autonomy, and the (...) nature of an entity's disposition. These studies have also revealed causal links between moral standing and other variables of interest, namely, mental state attributions and moral behavior. In this review, I consider this recent research, aiming to clarify what the balance of evidence indicates about how moral standing is judged and about its links to mind perception and behavior. I conclude by suggesting open questions for future research on this exciting topic. (shrink)

This paper examines how communities of naturalists in mid-nineteenth-century Britain were formed and solidified around the shared practices of public meetings, the publication and reading of periodicals, and the making and printing of images. By focusing on communities of naturalists and the sites of their communication, this article undermines the distinction between amateur and professional scientific practice. Building on the notion of imagined communities, this paper also shows that in some cases the editors and illustrators utilized imagery to construct a (...) specifically British naturalist community. Following three ‘amateur’ natural-history periodicals (Science Gossip,Midland Naturalistand theJournal of the Quekett Microscopical Club) the article demonstrates how the production and reproduction of natural history in the nineteenth century was contingent on community debate – and that this debate both was highly visual and moved across printed and geographical boundaries. This paper investigates images both for their purported success and for their ascribed value to natural history. Additionally, it considers the debates over their limitations and alleged failures of printing. Altogether, the article argues that investigating the communal practices of observation, writing, drawing and engraving allows for a better understanding of the shared practices of nineteenth-century natural history. (shrink)

It is critically important for emerging professionals in education to be sensitised to the ethical and moral responsibilities of their practice throughout their training and beyond. There is a wide disparity in contemporary practice in this regard, which points to a need for greater clarity and consistency in our thinking about ethics within education. Ethics in Education attempts to meet this need, and will be a valuable resource for students, teachers and researchers in education, health and social sciences. Most significantly, (...) the increasing awareness of the importance of ethics, diversity and social pedagogy in the teacher education curriculum will ensure that this book becomes essential reading or recommended reading for initial teacher education and CPD courses in education. The Editors have gathered together an exciting and dynamic group of contributors across many fields of English education, and asked them to help rethink the role of ethics in education in the 21st century. The types of questions that we address include: Do we have a shared view of ethical practice? What are the values that underpin ethical practice? What are our ethical responsibilities as pedagogues? (shrink)

: Descartes provides an original and puzzling argument for the traditional theological doctrine that the world is continuously created by God. His key premise is that the parts of the duration of anything are "completely independent" of one another. I argue that Descartes derives this temporal independence thesis simply from the principle that causes are necessarily simultaneous with their effects. I argue further that it follows from Descartes's version of the continuous creation doctrine that God is the instantaneous and total (...) cause of everything that happens, and that this is just what his physics demands. But although God is the total cause of everything, he is not the only cause, since Descartes considers it obvious that finite minds have the power to move bodies. In the face of this apparent paradox, several recent commentators have suggested that Descartes accepted the late scholastic view that God and finite causes somehow collaborate or concur in the production of numerically identical effects. But close examination reveals that the case for Cartesian concurrentism is weak. Fortunately, there is a simpler and more fruitful solution to the problem of reconciling divine and human action. I argue that that in Descartes's world certain motions, such as voluntary movements of our bodies, are causally overdetermined This account allows Descartes to avoid occasionalism without embracing an elaborate metaphysics of secondary causality. Finally, I argue that the overdeterminist interpretation sheds new light on two longstanding problems of Cartesian metaphysics. First, it resolves a serious difficulty with a standard reading of Descartes's conception of human freedom. Second, it offers a novel approach to the old problem of reconciling genuine human action with the principle of the conservation of total quantity of motion. (shrink)

God and time play crucial, intricately related roles in Descartes' project of grounding mathematical physics on metaphysical first principles. This naturally raises the perennial theological question of God's precise relation to time. I argue, against the strong current of recent commentary, that Descartes' God is fully temporal. This means that God's duration is successive, with parts ordered 'before and after', rather than permanent or 'all at once'. My argument will underscore the seamless connection between Descartes' theology and his physics, and (...) the degree to which he was prepared to depart from orthodoxy in the former in order to secure an a priori foundation for the latter. As Newton would later do, Descartes freed time from its traditional dependence on bodily motion and so removed an important barrier to making God temporal. Acting in time, God makes the physical world intelligible in a way He could not were He timeless. (shrink)

Descartes and William Harvey engaged in a polite dispute about the cause of the heart's motion. Descartes saw the heart's motion of passive; Harvey saw it as active. I criticize three prominent explanations for Descartes' opposition to Harvey's theory. I argue that Descartes found Harvey's model to be inconsistent with mind-body dualism and this was the reason he opposed it.

Introduction Someone comes and says something. Without really needing to think, I understand what is said, refer it without difficulty to familiar codes, ...

In his recent survey of the “dialectic of creation” in seventeenth-century philosophy, Thomas Lennon has suggested that Descartes’s assumptions about causality encourage a kind of “pantheistic emanationism”. Lennon notes that Descartes regularly invokes the principle that there is nothing in the effect which was not previously present, either formally or eminently, in the cause. Descartes also believes that God is the continuous, total, and efficient cause of everything. From these assumptions it should follow that everything that exists in the created (...) world is previously present in God. Indeed, Descartes embraces the emanationist doctrine explicitly when, at the end of his replies to the Second Set of Objections, he arranges the arguments of the Meditations in “geometrical fashion.” The demonstration of Proposition III includes a sub-proof of the proposition that “he who preserves me has within himself, either formally or eminently, whatever is in me”. Since God preserves the entire universe, it follows that everything is in him, either formally or eminently. While far from the radical Spinozistic view that God and the world are identical, the notion that everything in creation is also in God would seem to have its own unwelcome theological consequences, at least from a Cartesian point of view. In particular, it implies that extension, and hence divisibility, are in God. But, as Descartes himself cautions, “being divisible is an imperfection” and so completely foreign to God. (shrink)

Seventeenth-century authors frequently infer the attributes of time by analogy from already established features of space. The rationale for this can be traced back to Aristotle's analysis of time as ?the number of movement?, where movement requires a prior understanding of spatial magnitude. Although these authors are anti-Aristotelian, they were concerned, contra Aristotle, to establish the existence of ?empty space?, and a notion of absolute space which fit this idea. Although they had no independent rationale for the existence of absolute (...) time, it seemed to go with absolute space, and they drew on a long tradition of space-time parallelism in securing this. (shrink)

At Cratylus 385b–c, Plato appears to argue that names have truth-value. Critics have almost universally condemned the argument as fallacious. Their case has proven so compelling that it has driven editors to recommend moving or removing the argument from its received position in the manuscripts. I argue that a close reading of the argument reveals it commits no fallacy, and its purpose in the dialogue justifies its original position. I wish to vindicate the manuscript tradition, showing that the argument establishes (...) that there is subject matter for investigation, and there is a correctness of names. (shrink)

"The four essays in this volume constitute Derrida's most explicit and sustained reflection on the art work as pictorial artifact, a reflection partly by way of philosophical aesthetics, partly by way of a commentary on art works and art scholarship. The illustrations are excellent, and the translators, who clearly see their work as both a rendering and a transformation, add yet another dimension to this richly layered composition. Indispensable to collections emphasizing art criticism and aesthetics."—Alexander Gelley, _Library Journal_.

We identify three points of intersection between economics and ethics: the ethics of economics, ethics in economics and ethics out of economics. These points of intersection reveal three types of conversation between economists and moral philosophers that have produced, and may continue to produce, fruitful exchange between the disciplines.

The desire for esteem, and the associated desire for good reputation, serve an important role in ordinary social life in disciplining interactions and supporting the operation of social norms. The fact that many Internet relations are conducted under separate dedicated e-identities may encourage the view that Internet relations are not susceptible to these esteem-related incentives. We argue that this view is mistaken. Certainly, pseudonyms allow individuals to moderate the effects of disesteem-either by changing the pseudonym to avoid the negative reputation, (...) or by partitioning various audiences according to different audience values. However, there is every reason to believe that a good e-reputation is an object of desire for real agents. Further, although integrating one’s reputation under a single identity has some esteem-enhancing features, those features are not necessarily decisive. We explore in the paper what some of the countervailing considerations might be, by appeal to various analogies with the Internet case. (shrink)

Our central aim is to explore the ideas involved in the claim that certain institutional structures economize on virtue and, in particular, to explore the widely held idea that reliance on institutions that economize on virtue may undermine virtue itself. We explore these ideas both by discussing alternative conceptions of virtue and economizing, and by constructing a simple model of the relationship between a specific institutional structure that may be said to economize on virtue and the emergence of virtue. "There (...) exists in every human breast an inevitable state of tension between the aggressive and acquisitive instincts and the instincts of benevolence and self-sacrifice. It is for the preacher, lay or clerical, to inculcate the duty of subordinating the former to the latter. It is the humbler, and often invidious, role of the economist to help, so far as he can, in reducing the preacher's task to manageable dimensions. It is his function to emit a warning bark if he sees courses of action being advocated or pursued which will increase unnecessarily the inevitable tension between self-interest and public duty; and to wag his tail in approval of courses of action which will tend to keep the tension low and tolerable.... What does the economist economize? Tis love, tis love... that scarce resource, love—which we know, just as well as anybody else, to be the most precious thing in the world". (shrink)

ArgumentDuring the two decades before the turning point in Copernicus's personal and scientific development in 1510, he had experience of political activity which has been largely ignored by the existing Copernicus literature but part of which is reconstructed in outline in this paper. Given the close linkage between politics and astrology, Copernicus's likely reaction to astrology is re-examined here. This reconstruction also suggests that the turning point in 1510, when Copernicus left his post as secretary to his uncle Lucas Watzenrode (...) the prince-bishop of Warmia, was not only linked to Copernicus's first version of his heliocentric theory in theCommentariolus, but also to major political setbacks being experienced by Watzenrode during these years, and with the publication of Copernicus's translation of theLettersof Theophylactus Simocatta. Some of these considerations contribute to maintaining the view that Copernicus and his work were in several respects exceptional. (shrink)

The contributions in this book address the relation between evil, symbolism and psychoanalysisc by focusing on the two works of Riœur in which these topics play the most prominent role: The Symbolism of Evil and Freud and Philosophy. Furthermore, the bilingual book includes contributions that examine the relation between evil, symbolism and psychoanalysis in Ricœur’s work in a more general fashion, by investigating his philosophy as a whole. It brings together both French and English chapters from leading Ricœur scholars from (...) over the world. The international multilinguistic perspective reflects Ricœur’s spirit who said that when he worked on a book, all of the others were simultaneously open on his writing table. It is a groundbreaking work to those interested in Ricœur, Freud and religion. (shrink)

The Allegory of the Cave (Pl. Resp. 514a1–520e2) is often analyzed in terms of metaphysical, epistemological, political, and psychic hierarchies that are clarified and reinforced by philosophical education. But the Allegory also contains an important historical allusion to the silver mining that took place in classical Attica. Examining the Cave in light of the enslaved miners around Lavrio leads us to reconsider the philosophical ‘liberation’ (λύσιν … τῶν δεσμῶν, 515c4) at the Allegory’s heart in the context of Athenian slavery and (...) Plato’s thoughts on the practice. Elsewhere in his work Plato generally uses servile metaphors in two ways: to depict ‘bad’ internal psychic subjection and ‘good’ submission to logos as manifested in various entities. This historical dimension of the Allegory works to undermine the ostensible naturalness of the slave/citizen distinction and suggest that philosophical education has the potential to ‘free’ the former and ‘subjugate’ the latter. The implication that these juridical categories are, to an extent, arbitrary and mutable reveals important differences between Plato’s views and those of his classical peers, and it adds to the dialogue’s protreptic dimension for its readers then and now. (shrink)

It is argued that Kant’s claimed reconciliation of politics and ethics in the Appendix to ‘Perpetual Peace’ founders on an irreducible element of secrecy that no amount of ‘publicity’ could ever dissipate. This shows up figuratively in images of veiling, and more especially in the paradoxical ‘very transparent veil’ associated with British politics in a footnote to ‘The Contest of Faculties’. This figure suggests that the structure of the ‘public’ itself involves a kind of transcendental secrecy that cannot be ‘publicly’ (...) overcome, and that public space therefore cannot become fully visible to itself. This structural problem, it is claimed, prevents Kant from securing his proposed distinctions between the ‘moral politician’ and the ‘political moralist’, and between ‘political prudence’ or expediency and ‘political wisdom’. A similar problem reappears in the supplementary ‘Secret Article’ that Kant includes in the second edition of ‘Perpetual Peace’, which specifies, ‘secretly’, that heads of state should take secret counsel from the open and public discussions of philosophers. In giving away this secret, even as he declares it to be a secret, Kant essentially repeats the gesture of revealing the violent origin of the state, shown in the ‘ Rechtslehre’ to be illegal, and in so doing condemns the philosopher at best to a kind of exile with respect to political time and space, a marginal place that is here aligned with the place of ‘ ius aequivocum’ addressed in the Appendix to the Introduction to the ‘ Rechtslehre’, where appeals to equity on the one hand and the right of necessity on the other are described as being inaudible in the system of public right. It is suggested that these marginal and equivocal places all show up an internal frontier in the transcendental account of public space, and that this frontier zone, the very place of politics, sets a limit to the prospects of Enlightenment itself. In conclusion, it is proposed that thinking through these problems would require less a turn toward ethics than a rereading of the concept of nature, on the basis of its Heraclitean penchant for hiding or veiling itself. (shrink)

Scepticism has been the driving force in the development of Greco-Roman culture in the past, and the impetus for far-reaching scientific achievements and philosophical investigation. Early Jewish culture, in contrast, avoided creating consistent representations of its philosophical doctrines. Sceptical notions can nevertheless be found in some early Jewish literature such as the Book of Ecclesiastes. One encounters there expressions of doubt with respect to Divine justice or even Divine involvement in earthly affairs. During the first centuries of the common era, (...) however, Jewish thought, as reflected in rabbinic works, was engaged in persistent intellectual activity devoted to the laws, norms, regulations, exegesis and other traditional areas of Jewish religious knowledge. An effort to detect sceptical ideas in ancient Judaism, therefore, requires a closer analysis of this literary heritage and its cultural context. This volume of collected essays seeks to tackle the question of scepticism in an Early Jewish context, including Ecclesiastes and other Jewish Second Temple works, rabbinic midrashic and talmudic literature, and reflections of Jewish thought in early Christian and patristic writings. Contributors are: Tali Artman, Geoffrey Herman, Reuven Kiperwasser, Serge Ruzer, Giuseppe Veltri, Cana Werman, and Casten Wilke. (shrink)

In Morality, Bernard Gert argues that the fundamental demands of morality are well articulated by ten distinct, and relatively simple, rules. These rules, he holds, are such that any person, no matter what her circumstances or interests, would be rational in accepting, and guiding her choices by, them. The rules themselves are comfortably familiar (e.g. “Do not kill,” “Do not deceive,” “Keep your promises”) and sit well as intuitively plausible. Yet the rules are not, Gert argues, to be accepted merely (...) because they are intuitively attractive, nor because they are already widely recognized, but because they stand as the only set of rules that can qualify as appropriately acceptable to all rational beings. (shrink)

_Quod non est in actis, non est in mundo_. Once files are reduced to the status of stylized icons on computer screens, the reign of paper files appears to be over. With the epoch of files coming to an end, we are free to examine its fundamental influence on Western institutions. From a media-theoretical point of view, subject, state, and law reveal themselves to be effects of specific record-keeping and filing practices. Files are not simply administrative tools; they mediate and (...) process legal systems. The genealogy of the law described in Vismann's _Files_ ranges from the work of the Roman magistrates to the concern over one's own file, as expressed in the context of the files kept by the East German State Security. The book concludes with a look at the computer architecture in which all the stacks, files, and registers that had already created order in medieval and early modern administrations make their reappearance. (shrink)

The paper mobilizes Adam Smith’s treatment of the division of labour in relation to the production, consumption and exchange of knowledge. One aspect of this mobilization deals with the epistemic demands that exchange makes on its participants. The other deals with increasing returns in the provision of knowledge itself, treating knowledge creation as just another example of specialization and exchange. These two aspects come together in relation to the epistemic demands associated with assessing knowledge quality. These demands differ according to (...) whether the knowledge is embodied in products or whether the knowledge is an object for its own sake. It is argued that disciplines play a critical role as institutions for meeting the epistemic demands that the division of labour creates in the ‘knowledge’ case. (shrink)

Environmental, Social, and Governance (ESG) investing is increasingly popular (Giese, Lee, Melas, Nagy, & Nishikawa 2019), and is now percolating into sustainability textbooks and pedagogy. This is problematic because many faculty teaching sustainability do not have a background in finance, and thus find teaching ESG challenging. This paper develops pedagogical resources to teach the fundamentals of ESG investing, be that in a Foundations of Sustainable Management course or a Business Ethics course. We do this by developing four learning objectives: (1) (...) Understand the ESG basics, including why ESG investing is important to investors and, for faculty, outlining where it might be appropriately placed in an ethics or introduction to sustainability class, (2) Define ESG Investing and discuss how ESG investing strategies differ from regular investment strategies, (3) Identify the primary methods to choose ESG investments, the related ESG rating systems, and the primary proprietary investment options based on these screening rules, and (4) Identify ESG options available to investors that meet their risk preferences. (shrink)

Winfried bühler's edition of Moschus’ Europa [Hermes, Einzelschrift 12 [1960]) has had the rare accolade of unstinted praise from reviewers in all languages. And deservedly so. Its text is eminently sound, its commentary relevantly erudite and richly instructive particularly about Moschus’ stylistic debts and paternities. Bühler's review of the Europa saga in ancient literature supersedes all that was written previously. And finally, his detailed collation of the nine independent manuscripts of the text establishes for the first time the full evidence (...) for a completely effective stemma which few will challenge and none substantially alter. (shrink)