Fluorescence microscopy has provided a route to qualitatively analyze features of nuclear structures and chromatin domains with increasing resolution. However, it is becoming increasingly important to develop tools for quantitative analysis. Here, we present an automated method to quantitatively determine the enrichment of several endogenous factors, immunostained in pericentric heterochromatin domains in mouse cells. We show that this method permits an unbiased characterization of changes in the enrichment of several factors with statistical significance from a large number of nuclei. Furthermore, (...) the nuclei can be sorted according to the enrichment value of these factors. This method should prove useful to monitor events related to changes in the amount, rather than the presence or absence, of any factor. By adapting a few parameters, it could be extended to other nuclear structures and the benefit of using available software will permit its use in many biological labs. (shrink)

This new edition of Genevieve Lloyd's classic study of the maleness of reason in philosophy contains a new introduction and bibliographical essay assessing the book's place in the explosion of writing and gender since 1984.

Genevieve Lloyd illuminates and challenges some perplexing aspects of contemporary attitudes to wonder. She draws especially on Flaubert, who influenced the thought of Jean-Paul Sartre, Gilles Deleuze and Jacques Derrida. She also reaches into contemporary debates on refugees, secularisation and climate change.

Over 50,000 youth, mostly between the ages of 13 and 17 years, migrated to the United States without familial accompaniment in the fiscal year 2018. The tripartite process of pre-flight, flight, and resettlement exposes these unaccompanied immigrant children to multiple, and often ongoing, traumatic events that can significantly and adversely impact their mental health into adulthood. However, the ethical considerations for psychologists working with this growing population, with limited exceptions, remain largely unaddressed. As more and more UIC flee their home (...) countries due to violence, abuse, and economic instability only to experience further stressors during the processes of detainment, custodial placement, and acculturative adjustment in the US, there is an increasing need for psychological services; thus, the importance of preparation of mental health providers is increasingly significant. Psychologists must have the requisite skills and knowledge of the complex experiences of UIC, and of how these intersect with salient cultural, developmental, and systemic factors, as a means of providing competent and ethical mental health treatment. The present article highlights several ethical issues that arise when providing psychological services to UIC, with particular consideration paid to the embeddedness of UIC in various organizational entities with which psychologists will likely need to interface when working with this population. Implications and recommendations for practicing psychologists and training programs are discussed. (shrink)

The paper's aim is to tackle some significant challenges faced by democratic theory in plurinational societies. Claims to recognition challenge the assumption of a ‘people speaking in one voice’ and therefore, some basic tenets of liberal democracy. In a context where one cannot assume anymore a homogeneous demos, it is tempting to believe that there may be an independent, yet democratic, principle that may help us to solve the problem of the ‘constitution of the demos.’ Goodin argues that the all-affected (...) interests principle is in fact the best principle of inclusion in democratic decision-making. Yet I argue that the all-affected interests principle is not really useful, at least as a starting point. But if this is so, and if the picture underlying modern democratic theory is seriously undermined by claims to recognition, how are the communities to which self-rule necessarily relates to be bounded? (shrink)

Parler d’« exception culturelle » française est parfois pleinement justifié. Ainsi, dès lors que sont étudiés de près les rapports pour le moins conflictuels entre genre et cinéma en France, certaines tendances spécifiques se dessinent. Il n’est pas nouveau de dire que l’équivalent français du terme anglais gender a quelques difficultés à s’intégrer dans le monde universitaire hexagonal et les réticences à envisager la société au sens large en fonction des sexes biologiques et des rapports en...

Genevieve Lloyd presents a new study of the place of Enlightenment thought in intellectual history and of its continued relevance. She offers original readings of a range of key texts, which highlight the ways in which Enlightenment thinkers enacted in their writing--and reflected on--the interplay of intellect, imagination, and emotion.

“Modern slavery,” a term used to describe severe forms of labor exploitation, is beginning to spark growing interest within business and society research. As a novel phenomenon, it offers potential for innovative theoretical and empirical pathways to a range of business and management research questions. And yet, development into what we might call a “field” of modern slavery research in business and management remains significantly, and disappointingly, underdeveloped. To explore this, we elaborate on the developments to date, the potential drawbacks, (...) and the possible future deviations that might evolve within six subdisciplinary areas of business and management. We also examine the value that nonmanagement disciplines can bring to research on modern slavery and business, examining the connections, critiques, and catalysts evident in research from political science, law, and history. These, we suggest, offer significant potential for building toward a more substantial subfield of research. (shrink)

Being in Time examines philosophical treatments of time and self-consciousness in relation to concepts of narrative, focusing on the literary aspects of philosophical writing. Lloyd shows how philosophy bears on the human and emotional aspects of the experience of time which are often neglected by the history of philosophy. Starting with Augustine's treatment of the ways in which time makes him a 'problem to himself', the book traces the themes of unity and the experience of fragmentation and loss as expressed (...) by Descartes, Hume and Kant. The idea of the past as 'lost' is explored through Bergson's philosophy of time and Nietzsche's doctrine of eternal return. The book concludes with a discussion of philosophical aspects of themes of self-consciousness, memory and writing in Proust's Remembrance of Things Past and the novels of Virginia Woolf. (shrink)

An increasing number of studies about teacher’s induction issues mention that it is essential to take into account the types of support needs of beginning teachers to offer them adequate support. Few researchers have accurately portrayed the types of support needs felt by novice teachers and focused on the degree of agreement between the type of support needs felt and the perceived support received. This research used data drawn from a French-language survey (n = 156) and semi-directed interviews (n = (...) 10) conducted in Quebec with novice teachers. Quantitative analyzes using association measures on types of support needs and perception of support received indicate that the support perceived by teachers is largely inconsistent with the types of support needs felt. The interviews provide a better understanding of the quantitative results and suggest some possible solutions. (shrink)

Oscillations in cytosolic Ca2+ occur in a wide variety of cells, either spontaneously or as a result of external stimulation. This process is often accompanied by intracellular Ca2+ waves. A number of theoretical models have been proposed to account for the periodic generation and spatial propagation of Ca2+ signals. These models are reviewed and their predictions compared with experimental observations. Models for Ca2+ oscillations can be distinguished according to whether or not they rely on the concomitant, periodic variation in inositol (...) 1,4,5‐trisphosphate. Such a variation, however, is not required in models based on Ca2+‐induced Ca2+ release. When Ca2+diffusion is incorporated into these models, propagating waves of cytosolic Ca2+ arise, with profiles and rates comparable to those seen in the experiments. (shrink)

The starting point of this study is the observation of a new importance of philosophy « in the post-metaphysical era » (according to the expression of J.-L. Schlegel) in the analysis of the religious fact and the significance of the Bible in Western culture, including the most contemporary. The recent Chilean film El Cristo ciego/Blind Christ by director Christopher Murray (2016) offers an emblematic example of the problems posed by the interpretation of a work that questions the mystery of transcendence (...) in a context marked both by the radical immanence of the characters’ experience and by the explicit and massive reference to the New Testament. The short narratives of the main character will be analyzed as parables (exegetic approach) and will be interpreted in the light of the Christology of liberation (cf. Jon Sobrino) and the philosophy of deconstruction (cf. J.-L. Nancy), which will lead to the question of the epistemological coherence of the proposed analysis. (shrink)

Comment supporter d’apprendre ta mort sur une page de journal? À cette place là, tu es tout à coup morte et vivante à la fois. Tu ne nous as pas laissé approcher ta mort ; et la mort t’a si vite attrapée. Mais cela te va bien de t’absenter sans prévenir. Tu nous avais suffisamment confié, il y a très longtemps, que ta santé n’était pas bonne. C’était à nous de te croire. Je t’ai cru alors ; mais je n’ai (...) pas été assez vigilante. Au temps du féminisme allié au gauchisme, nous te rencontrions à... (shrink)

The anonymous Armenian commentary was transmitted together with the Armenian translation of Aristotle's Peri Hermeneias. It was composed in the Hellenizing style and commonly associated with the figure of David the Invincible, a philosopher of the Neoplatonic School of Alexandria. This article presents a general structural analysis of the commentary followed by a comparative study and translation of its first chapter. It argues that the commentary was indeed written in the tradition of late antique Greek commentaries but was probably not (...) associated with late Neoplatonism. The Armenian commentary shares many common features with Ammonius’ commentary, but also departs from it on many crucial aspects. From a philosophical standpoint, it has much more in common with Boethius’ and Alexander of Aphrodisias’ commentaries than with those of the Neoplatonic School of Alexandria, thus suggesting an early writing date. (shrink)

At first sight, Isocrates’ use of the term “sophist” may appear contradictory as it is associated with both a positive and a pejorative meaning. The article contends that Isocrates was not being unintentionally vague or imprecise as he deliberately used the term to refer to two disparaging groups of professional teachers or writers who, in his opinion, had nothing in common. Isocrates tended to privilege the positive meaning of the term over the negative one, considering the latter as a contemporary (...) deviation of the former. (shrink)

The idea that liberal democratic legitimacy presupposes the final authority of the state in solving the juridictional boundary question depends upon the argument according to which Westphalian sovereignty has evolved in a liberal democratic direction. From this point of view, sovereignty is internally limited by liberal democratic principles. However, I argue that it is rather public politics, more than Westphalian sovereignty, that has been transformed, in liberal states, and that hence, there is an enduring tension between democratic legitimacy and state (...) sovereignty. (shrink)

Le présent ouvrage offre un aperçu des connaissances actuelles dans le domaine de la parentalité et des problèmes de santé mentale.

En 2017, des spécialistes de différentes disciplines (santé, éducation et travail social) issus de cinq pays européens (France, Géorgie, Italie, Norvège et Suisse) ont créé un réseau afin de poursuivre leurs recherches sur le handicap et la migration. Le présent article expose les principaux résultats d’un premier workshop qu’ils ont réalisé et les pistes qui en découlent pour de futures recherches. D’une part, les enfants migrants en situation de handicap restent invisibles sur le plan statistique dans plusieurs pays. Leurs besoins (...) en tant que migrants et personnes en situation de handicap sont pris en compte par des politiques et des dispositifs distincts. D’autre part, dans les cinq pays, un écart important entre les normes légales et la situation des familles migrantes ayant un enfant en situation de handicap est constaté. Il en est de même en ce qui concerne la collaboration entre les différents services publics, ou entre ces services et les associations soutenant les personnes en situation de handicap, les personnes migrantes et/ou les minorités. Les futures recherches seront centrées sur les moyens d’augmenter la participation sociale des enfants migrants en situation de handicap et de leurs familles dans des contextes d’interventions interculturelles et interdisciplinaires. (shrink)

This article examines a neglected dimension of Bazin's work, namely his writings for the daily newspaper Le Parisien libéré. Four key points emerge from this corpus. First, Bazin goes beyond the film-reviewing norms of the day to analyse the intentions and achievements of the film-makers. Second, Bazin foregrounds the capacity of cinema to address the concerns of contemporary society. Third, as a result, he ascribes a particular value to films that actively engage with the new social realities of post-war France. (...) Four, Bazin remains blind to the misogynistic dimension of post-war French cinema, with its tendency to culpabilize women for the national disgrace of the Occupation. Ultimately, Bazin's newspaper reviewing represents a more socially aware vision of cinema than that promoted by more specialized cinema journals, yet his criticism remains caught within the gender ideology of his time. (shrink)

ABSTRACT Spinoza has often been cited as a classic example of the philosophical category of ‘rationalism’; and there is indeed much about his philosophy that can seem to warrant that classification. This essay will argue that it is nonetheless a simplification, which can cloud some of the most important and interesting insights that can be gained from reading Spinoza now. Although it is true that his treatment of human knowledge emphasized the exercise of reason, his crucial—and frequently misunderstood—concept of ratio (...) was much richer and more nuanced than the common understanding of ‘rationalism’ can capture. The essay seeks to clarify Spinoza’s version of human reason, elaborating its interconnections with imagination and emotion; and its positioning within the totality of Nature. It draws on comparisons with Pascal—and on consideration of Flaubert’s responses to Spinoza’s works—to illuminate what is distinctive in Spinoza’s account of human reason. What emerges, it is argued, is important—not only for contemporary philosophy, but more broadly for the understanding of conceptual aspects of current issues associated with the status of human beings within the natural world. (shrink)

Based on archival and ethnographic data, this article analyzes the iconic-making, iconoclastic unmaking, and iconographic remaking of national identifications. The window into these processes is the career of Saint John the Baptist, patron saint of French Canadians and national icon from the mid-nineteenth century until 1969, when his statue was destroyed by protesters during the annual parade in his honor in Montréal. Relying on literatures on visuality and materiality, I analyze how the saint and his attending symbols were deployed in (...) processions, parades, and protests. From this analysis, I develop the sociological concept of aesthetic revolt, a process whereby social actors rework iconic symbols, redefining national identity in the process. The article offers a theoretical articulation and an empirical demonstration of how the context, content, and the form of specific cultural objects and symbols—national icons—are intertwined in public performance to produce eventful change, and shows why and how the internal material logic and the social life of these icons shape the articulation of new national identities. (shrink)

As a constructive alternative to the exclusionary binaries of Cartesian philosophy, Genevieve Lloyd and Moira Gatens turn to Spinoza. Spinoza's understanding of the body as "in relation" takes the focus of philosophical thought from the homogeneous subject to the heterogeneity of the social, and the focus of politics from individual rights to collective responsibility. The implications for feminism are radical; Spinoza enables a reconceptualization of the imaginary and the possibility of a sociability of inclusion.

La asociación entre educación y democracia es insepar a b le del pensamiento democrá tico. La escuela es una institución fundamental que resultan tener a su c a r go, en la m a y oría de los Estados mode r nos, los poderes pú b licos. Esta b lecida sobre el principio de iguald a d , la instrucción pú b lica pr e vé el aprendizaje y la profundización en la ciudadanía política y social. P er mite tanto (...) disf r utar de los derechos del hombre y ejercer las libe r tades fundamentales, como comprender los deberes y las restricciones inherentes a la prese r v ación de la "cosa pú b lica". Sin emba r go, en F rancia ha sufrido remodelaciones: la "inst r ucción cívica" se ha co n v er tido en la "educación para la ciudadanía". Se ha operado un deslizamiento desde la fo r mación en el espíritu crítico hacia la obediencia a la autoridad. El "c i vismo", con una función política esencial en la democracia, se ha ocultado bajo la "c i vilidad", que tiene una connotación inn e g a b lemente moral. Ahora bien, la c i vilidad e x clu y e la aprehensión de las solidaridades inherentes al n e xo social y no i n v estiga las vías de la socialización política de los (futuros) ciudadanos. (shrink)

La colonisation n’est faite que de commencements. Ces commencements font les passages de temps vers la décolonisation. Mais l’histoire de la colonisation et des décolonisations se raconte dans les balancements qui évoluent, selon les points de vue adoptés, pour les uns, les « colonisés », entre conquête et établissement, exploration et exploitation,..

Spinoza is a key figure in modern philosophy. _Ethics_ is his most studied and well known work. Being both up-to-date and clear, this Guidebook is designed to lead the reader through this complex seminal text. _Spinoza's Ethics_ introduces and assess: * Spinoza'a life, and its connection with his thought * The text of the _Ethics_ * Spinoza's continuing relevence to contemporary philosophy.