Cytokines are polypeptides released by activated vertebrate blood cells which have profound effects on other blood cells and which have hormone‐like properties affecting other organ systems as well. In recent years a wide variety of these mediators has been isolated and characterized. Many of these molecules have subsequently been cloned and expressed in E. coli. The tremendous importance of these proteins to host immune and non‐specific defense systems along with the striking similarities of their properties among different species suggested to (...) us that cytokines may have been proteins that have been conserved through evolution. Investigations of the evolution of cytokines will help us decipher the complex cellular, humoral and molecular interactions that regulate host defenses. Studies of the invertebrates will shed light on the phylogenetic emergence of these molecules as well. (shrink)

How likely is it that traumatic childhood events are misremembered or forgotten? Research on children′s recollections of painful or frightening medical procedures may help answer this question by identifying predictors of accurate versus inaccurate memory. In the present study, 46 3- to 10-year-old children were interviewed after undergoing a stressful medical procedure involving urethral catheterization. Age differences in memory emerged, especially when comparing 3- to 4-year-olds with older children. Children′s understanding of the event, parental communication and emotional support, and children′s (...) own emotional reactions also predicted accuracy. Memory did not reliably vary for children who endured the medical procedure once versus multiple times. Results are discussed in relation to possible precursors of accurate and false memories, and forgetting, of traumatic events experienced in childhood. (shrink)

The technology for the digitized text creates fluid meaning, representing its culture in transition from the dominance of the single-authored text with its hierarchically ordered system. This new architecture for the digitized word has been making explicit the shift from human consciousness reflecting the interiority of the self to a human consciousness reflecting self in relation to others. Educators using the technology of networked writing environments need to understand how the technology functions and intervenes for pedagogical processes during models of (...) asynchronous and synchronous collaborative writing. Both models support a constructivist view of learning; however, for each, educators need to consider the ethos of the writer as inhabiting a negotiated, shared space with readers during text production. As a consequence, cocognition may occur when writers share ideas and engage in the process of collaboration. (shrink)

Self-reported lost memory of child sexual abuse (CSA) can be mistaken for “repressed memory.” Based on our longitudinal studies of memory and disclosure in child maltreatment victims who are now adults, we discuss findings relevant to “repressed memory cases.” We examined relations between self-report of temporarily lost memory of CSA (subjective forgetting) and memory accuracy for maltreatment-related experiences (objective memory). Across two studies involving separate samples, we find evidence for memory suppression rather than repression: (1) Most adults who claimed temporary (...) lost memory of CSA reported memory suppression and clarified that they could have remembered the event if asked; (2) subjective forgetting was positively associated with accurate objective memory for maltreatment-related experiences. Subjective forgetting was also related to increased adult trauma symptoms and related to childhood non-disclosure of CSA. Moreover, trauma-related psychopathology mediated the relation between non-disclosure and subjective forgetting. Implications for psychological theory and repressed memory cases are discussed. (shrink)

Large-scale sequencing tests, including whole-exome and whole-genome sequencing, are rapidly moving into clinical use. Sequencing is already being used clinically to identify therapeutic opportunities for cancer patients who have run out of conventional treatment options, to help diagnose children with puzzling neurodevelopmental conditions, and to clarify appropriate drug choices and dosing in individuals. To evaluate and support clinical applications of these technologies, the National Human Genome Research Institute and National Cancer Institute have funded studies on clinical and research sequencing under (...) the Clinical Sequencing Exploratory Research program as well as studies on return of results. Most of these studies use sequencing in real-world clinical settings and collect data on both the application of sequencing and the impact of receiving genomic findings on study participants. They are occurring in the context of controversy over how to obtain consent for exome and genome sequencing. (shrink)

Meno's Paradox from Socrates to Sextus Gail Fine. sense that they consider the issues it raises; and they argue, against its conclusion, that inquiry is possible. Like Plato and Aristotle, they also explain what makes inquiry possible; and they do ...

Confidentiality is a cornerstone of the physician-patient relationship. Breaches of confidentiality in the context of genetic testing are of particular concern for a number of reasons. First, genetic testing reveals information not only about a particular patient, but also about his or her family members. Second,genetic testing can label healthy people as “at risk,” subjecting them to possible stigmatization or discrimination by third parties. Third, as genetic testing becomes more widespread and is incorporated into primary care, breaches of confidentiality might (...) inadvertently occur more frequently because primary care providers may not be trained to understand the uniqueness of genetic information. Until now, genetic services have been provided primarily by medical geneticists and genetic counselors. However, with the proliferation of new genetic presymptomatic and carrier tests, primary care physicians are going to become increasingly involved in genetic testing. Currently, little is known about physicians’ attitudes toward disclosure of confidential genetic information to third parties. (shrink)

We examine two different descriptions of the behavioral functions of the hippocampal system. One emphasizes spatially organized behaviors, especially those using cognitive maps. The other emphasizes memory, particularly working memory, a short-term memory that requires iexible stimulus-response associations and is highly susceptible to interference. The predictive value of the spatial and memory descriptions were evaluated by testing rats with damage to the hippocampal system in a series of experiments, independently manipulating the spatial and memory characteristics of a behavioral task. No (...) dissociations were found when the spatial characteristics of the stimuli to be remembered were changed; lesions produced a similar deficit in both spatial and nonspatial test procedures, indicating that the hippocampus was similarly involved regardless of the spatial nature of the task. In contrast, a marked dissociation was found when the memory requirements were altered. Rats with lesions were able to perform accurately in tasks that could be solved exclusively on the basis of reference memory. They performed at chance levels and showed no signs of recovery even with extensive postoperative training in tasks that required working memory. In one experiment all the characteristics of the reference memory and working memory procedures were identical except the type of memory required. Consequently, the behavioral dissociation cannot be explained by differences in attention, motivation, response inhibition, or the type of stimuli to be remembered. As a result of these experiments we propose that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material that is to be processed by that memory. (shrink)

Since Kenya gained independence from Britain in 1963, women’s rights in the country have made slow gains and suffered some setbacks. However, the rights of women and their guaranteed participation in politics was outlined in Kenya’s 2010 Constitution. This paper will survey some of those gains as well as describe the social backlash experienced by women leaders who have been trailblazers in post-colonial Kenyan politics.

Prenatal ultrasound use is skyrocketing despite limited evidence of improved outcomes. One factor driving this trend is the widely recognized psychological appeal of real-time fetal imaging. Meanwhile, considering imperfect safety evidence, U.S. professional guidelines dictate that prenatal ultrasound—a screening test—should be governed by expected clinical benefits—an opportunity for intervention. However, when women’s healthcare professionals themselves are pregnant, their access to ultrasound technology permits informal, personal use that may deviate from standard-of-care, e.g., for reassurance. Highlighting a poignant case wherein a pregnant (...) obstetrician’s personal ultrasound use had unforeseen negative consequences, we explore this issue within context of professional ethics and informal medical care. We discuss how women’s health professionals’ self-care may influence and inform prenatal care at large. We advocate curtailing informal prenatal ultrasound use, but also potentially broadening accepted indications for or relaxing proscriptions against ultrasounds for patients. Further research and updated, evidence-based, ethically-sound guidelines are needed. (shrink)

Reasoning about ulterior motives was investigated among children ages 6–10 years (total N = 119). In each of two studies, participants were told about children who offered gifts to peers who needed help. Each giver chose to present a gift in either a public setting, which is consistent with having an ulterior motive to enhance one's reputation, or in a private setting, which is not consistent with having an ulterior motive. In each study, the 6- to 7-year olds showed no (...) evidence of understanding that the public givers might have ulterior motives, but the 8- to 10-year olds rated the private givers more favorably. In , the older children were more likely than the younger children to refer to impression management when explaining their judgments of the givers. The younger children who mentioned impression management did so to justify a preference for public givers (e.g., by explaining that public givers are nicer because more of their peers will know that they are nice). Results from suggest that developmental change in children's reasoning about intentions and social outcomes contributes to their understanding of ulterior motives. (shrink)

The Peri ide^on is the only work in which Aristotle systematically sets out and criticizes arguments for the existence of Platonic forms. Gail Fine presents the first full-length treatment in English of this important but neglected work. She asks how, and how well, Aristotle understands Plato's theory of forms, and why and with what justification he favors an alternative metaphysical scheme. She examines the significance of the Peri ide^on for some central questions about Plato's theory of forms--whether, for example, (...) there are forms corresponding to every property or only to some, and if only to some, then to which ones; whether forms are universals, particulars or both; and whether they are meanings, properties or both. Fine also provides a general discussion of Plato's theory of forms, and of our evidence about the Peri ide^on and its date, scope, and aims. While she pays careful attention to the details of the text, she also relates it to contemporary philosophical concerns. The book will be valuable for anyone interested in metaphysics ancient or modern. (shrink)

Selections seeks to provide an accurate and readable translation that will allow the reader to follow Aristotle's use of crucial technical terms and to grasp the details of his argument. Unlike anthologies that combine translations by many hands, this volume includes a fully integrated set of translations by a two-person team. The glossary--the most detailed in any edition--explains Aristotle's vocabulary and indicates the correspondences between Greek and English words. Brief notes supply alternative translations and elucidate difficult passages.

The idea that teachers love children is often taken for granted in education. Rarely is the idea of love itself examined. Bringing together the work of educators, curriculum theorists and clinical psychoanalysts, and drawing upon autobiographical and narrative case studies, this groundbreaking collection examines the collision of love and learning, including the ways in which such intersections are provoked, repressed and denied. Contributors turn to psychoanalysis to explore questions of love in all of its varying permutations - ambivalence, sexuality, hatred, (...) desire, projection, and loss - in order to demonstrate how the social ramifications of such work is critical to the ways teachers are currently being prepared for life in the classroom. (shrink)

This article considers some of the ways in which ‘the black woman’ as both representation and embodied, sentient being is rendered visible and invisible, and to link these to the multiple and competing ways in which she is ‘present’. The issues are engaged through three distinct but overlapping conceptualisations of ‘presence’. ‘Presence’ as conceived (and highly contested) in performance studies; ‘presence’ as conceived and worked with in psychoanalysis; and ‘presence’ as decolonising political praxis among Indigenous communities. I use these conceptualisations (...) of presence to consider the various ways in which the black woman as figure and as embodied/sentient subject has been made present/absent in different discursive registers. I also explore what is foreclosed and how this is itself linked to legacies of colonial ‘worlding’. I end with consideration of alternative modes of black women's presence and how this offers a resource for new modes of sociality. (shrink)

Most accounts of the influences on Gandhi's philosophy and tactics of nonviolent action do not give enough credit to the role that women in the British suffrage movement played in inspiring and guiding him. The article explains how, despite his specifically mentioning on occasion that he is NOT copying their tactics, he actually does repeat many of them in his 1913 satyagraha campaign in South Africa. And on many occasions he does credit them with inspiring him and his movement. In (...) the early years (1906-1912) Gandhi repeatedly suggested to men in his movement that they copy the brave determination of the British suffragettes, but he did not counsel Indian women to follow their example. Women in his own movement longed to court arrest since 1908, but were only allowed by Gandhi to participate in 1913. It's important to recognize the many ways in which women's leadership were crucial to the success of campaigns that Gandhi is given credit for, including the women's speech making, raising funds, suggesting tactics, as well as their bravery and willingness to endure suffering and even death in prison. (shrink)

The U.S.-led military incursion in Iraq and the subsequent occupation has been filled with myriad examples of the Bush Administration using misleading statements in an effort to win the support of American citizens, and in a secondary sense, the international community and the Iraqis. This situation provides many opportunities to analyze the use of sophistry and linguistic sleight of hand. In this paper, I draw upon the insights offered by Hannah Arendt in the earlier context of her critiques of totalitarianism (...) during the 1930s and 1940s, and her later critique of the United States upon the publication of the Pentagon Papers in the midst of the U.S. war in Vietnam. Her insights regarding truth and lying in politics shed light on what is wrong with U.S. approaches today. Similar methods continue to be used today since people have continued to be gullible to these methods. (shrink)

This chapter offers a brief historical overview of the gendered mind/body dualism associated with the rationalist tradition, according to which women’s bodies have been viewed as a threat to reason and to ethics. Taking up critiques of this model offered by Beauvoir and Fanon, I maintain that the body of the Other makes an ethical claim upon us in the form of “bodily imperatives.” I conclude with a critical analysis of contemporary feminist ethics that seeks to move beyond the false (...) dichotomies of mind/body, reason/emotions, transcendence/immanence, and male/female dualisms. Assuming as their starting point the universality of human dependency and the debilitating reality of embodied oppression, contemporary feminist ethicists seek to overturn the sexist, racist, and ableist effects of a philosophical tradition that has always privileged some minds and bodies over others. (shrink)

No detailed description available for "Spinoza's Philosophy of Law".

Philosophy and the Disdain for History: Reflections on Husserl's Ergiinzungsband to the Crisis GAIL SOFFER HUSSERL'S RECENTLY PUBLISHED Erganzungsband to the Cr/s/s' is a highly inti- mate statement, almost a confession, of hope and despair at the end of a philosophical life, a compendium of urgent, world-historical tasks not yet laid to rest. Above all, it abounds in reflections on history. In these, two things are poignantly clear: the late Husserl is completely convinced that history is of the utmost (...) importance to philosophy; he is not certain why. On a superfi- cial interpretation, the reason may seem obvious: Husserl's philosophical proj- ect is founded on the ideal of presuppositionless rational insight, and hence is Cartesian and ahistorical in its essence. The turn to history is to something external, and an implicit admission of the limitations of phenomenology itself, its inability to address the most pressing and meaningful problems of human existence: the crisis in European society and values, the ultimate significance of a man's life, work, and death. For those who would seek external motives for Husserl's turn to history, material is not lacking in this volume. There are moving philosophical discussions -- set in the atemporal phenomenological present tense -- of nationalism, of territoriality and the search for Lebensraum, of racism and xenophobia, of the forced emigration of families to a "no man's land. '' There is an attack on.. (shrink)

At the end of Republic 5, Plato distinguishes epistêmê from doxa, knowledge from belief. In Posterior Analytics 1.33, Aristotle provides his own distinction between epistêmê and doxa. I explore his way of distinguishing them and compare it with Plato's.

The paper surveys the lifetime achievements of Claude Sumner, S.J., a Canadian Jesuit who lived for 45 years in Ethiopia and devoted his life's work to collecting, documenting and evaluating Ethiopian philosophical texts and oral literature.

According to David Charles, in the Meno Socrates fleetingly distinguishes the signification from the essence question, but, in the end, he conflates them. Doing so, Charles thinks, both leads to Meno's paradox and prevents Socrates from answering it satisfactorily. I argue that Socrates doesn't conflate the two questions, and that his reply to Meno's paradox is more satisfactory than Charles allows.

This paper will highlight Maathai’s insights regarding empowerment, tracing several important themes in her approach, namely, empowerment’s relationship to self esteem, teamwork, and political action, its ambivalent relationship to formal education, and the role of cultural traditions in providing alternatives to colonial-era cultural impositions and current exploitative effects of neo-liberal capitalism. After reviewing Maathai’s thoughts on each of these topics, I will briefly draw upon other East African thinkers and Africanists’ studies of East African communities to present corroborating evidence for (...) Maathai’s views or for challenges to her position. Listening to the perspectives of Maathai and other East Africans provides several important correctives to current popular uses of the term “empowerment.”. (shrink)

Hannah Arendt insisted that citizens should approach politics from a position of disinterest. By this she meant that people should not distort politics by entering it only to benefit their own private good. She refused to condone a politics of competition of interest groups. This approach would seem to be a helpful antidote to many political situations in African countries which have become notorious for blatant use of the political realm to amass private fortunes or to shower gifts on one's (...) own ethnic group to the detriment of others. However, Arendt's approach has also been charged with elitism, since she rejects the poor classes' demand for bread as unallowable manipulation of the public realm for private advancement. In addition some feminists have argued that neutral "disinterest" is an unachievable and in fact wrongheaded goal. The article takes the criticisms into consideration and outlines what aspects of Arendt's insights can still be helpful in the African political context. (shrink)

Arendt is realistic: Our century has witnessed terrible atrocities, such as the rise of totalitarianism and the slaughter of millions for purely racist reasons. At the same time her position is one of profound hope, based on the human capacity to act politically, to begin, in concert with others, something new. My dissertation fills a gap in Arendt scholarship. My work attempts to appropriate Arendt from a left political perspective, gleaning all of her insights that will be of benefit to (...) political activists and revolutionaries. At the same time I must criticize her for what I consider her most blatant mistakes, such as her disregard for human suffering and economic injustice, points on which Arendt could learn much from the left. The major conceptual movement of the dissertation is from theory to practice, from abstract to concrete. Arendt's theoretical framework in which she classifies all of human activity is the starting point. Political action is seen in the broad context of contemplation, thought, work and labor. The focus proceeds to a narrower contrast between political action in the public realm and the various economic and personal relationships in the private realm. The theories unfold to express themselves in a certain kind of political practice. The two most basic characteristics are that action is free, not determined, and based on speech, not violence. Furthermore, correct political action is motivated by a concern for the whole and fueled by that power which arises from the consent and support of the people. Finally the concrete structures and practices of politics is discussed. Arendt criticizes contemporary politics, both the two-party systems of liberal democracies and one-party revolutionary governments. She then proposes an alternative, modeled on the council system of direct participation and federation, and describes both how to found and how to structure such an alternative political realm. (shrink)

The ability of 3- and 4-year-old children to disregard advice from an overtly misleading informant was investigated across five studies (total n = 212). Previous studies have documented limitations in young children's ability to reject misleading advice. This study was designed to test the hypothesis that these limitations are primarily due to an inability to reject specific directions that are provided by others, rather than an inability to respond in a way that is opposite to what has been indicated by (...) a cue. In Studies 1 through 4, a puppet identified as The Big Bad Wolf offered advice to participants about which of two boxes contained a hidden sticker. Regardless of the form the advice took, 3-year olds performed poorly by failing to systematically reject it. However, when participants in Study 5 believed they were responding to a mechanical cue rather than the advice of the Wolf, they were better able to reject misleading advice, and individual differences in performance on the primary task were systematically correlated with measures of executive function. Results are interpreted as providing support for the communicative intent hypothesis, which posits that children find it especially difficult to reject deceptive information that they perceive as being intentionally communicated by others. (shrink)

I distinguish between two senses in which feminists have argued that the knower is social: 1. situated or socially positioned and 2. interdependent. I argue that these two aspects of the knower work in cooperation with each other in a way that can produce willful hermeneutical ignorance, a type of epistemic injustice absent from Miranda Fricker's Epistemic Injustice. Analyzing the limitations of Fricker's analysis of the trial of Tom Robinson in Harper Lee's To Kill a Mockingbird with attention to the (...) way in which situatedness and interdependence work in tandem, I develop an understanding of willful hermeneutical ignorance, which occurs when dominantly situated knowers refuse to acknowledge epistemic tools developed from the experienced world of those situated marginally. Such refusals allow dominantly situated knowers to misunderstand, misinterpret, and/or ignore whole parts of the world. (shrink)

: This response seeks to pick up on the key questions and concerns raised by Nancy C. M. Hartsock and Karen Houle in their critiques of The Spectacle of Violence. I mold my response around two emotions that are never far from the question of violence: fear and hope. Is it fear of ambiguity that stops us from delicately blending the experiential with the discursive, the nodal with the circular, the corporeal with the epistemic, or the oppressive with the constitutive? (...) If so, we can only hope that the power of such ambivalence lies in its ability to unsettle these treasured lines of force. (shrink)

(1995). A Feminist Sociologist Responds to Daniel's 'Exclusion and Emphasis Reframed as a Matter of Ethics' Ethics & Behavior: Vol. 5, No. 4, pp. 369-371.

There has been much discussion concerning whether or not some of Sartre's views on morality may be understood as endorsing Kant's views. Perhaps the most controversial issue has been whether in various places in his corpus Sartre invokes Kant's “universalizability principle.” Indeed, Sartre's frequent use of Kantian language, including the idea of universalizability and “kingdom of ends,” strongly suggests that there is some appreciable convergence between his views and those of Kant. While it is true that Sartre borrows Kant's language (...) and expressions, he does not, I argue, use them in the same sense as Kant does. (shrink)

This paper focuses on evaluating Odera Oruka’s role as an expert witness in customary law for the Luo community during the Nairobi, Kenya-based trial in 1987 to decide on the place of the burial of S.M. Otieno. During that trial, an understanding of Luo burial and widow guardianship (ter) practices was essential. Odera Oruka described the practices carefully and defended them against misunderstanding and stereotype. He revisited related topics in several delivered papers, published articles, and even interviews and columns in (...) the Kenyan newspapers. The paper will raise the questions: How does Odera Oruka’s role as expert on Luo customs fit in with his sage philosophy project? In his testimony at the trial and subsequent public addresses and published work, does he accomplish two important goals, the first being defending African traditions against prejudice and anti-African bias, and secondly, does he champion reform of traditions when reform is needed? And, can Odera Oruka’s participation in the famous trial avoid seeming ethnic chauvinism and marginalization of women? My conclusion is that he achieves the first goal, but some problems remain in the achievement of the other goals. While he often asserted the need to evaluate traditions and to jettison those that have become unhelpful, in this context he evaluated traditions so strongly that the need for evaluation and possible change was muted. (shrink)

The paper explores the insights of Mahmood Mamdani regarding recent U.S. military actions in Iraq and the U.S. role in setting up a new government there. The majority of the paper does not, however, rely on sources of Mamdani addressing this topic directly. Rather the author consults Mamdani's work on colonialism and imperialism to find clues as to what is at heart wrong with the colonial approach to ruling. Four key attributes of colonialism that also play a role in recent (...) U.S. actions in Iraq are the use of indirect rule, the politicization of indigeneity, economic domination, and the »civilizing mission.« While some advocates of imperialism such as Niall Ferguson think that there can be a good imperial power, Mamdani's analysis leads to a different conclusion. In Mamdani's early works we find that colonialism always sows the seeds of its own destruction; this insight is applied to the current Iraq situation as a cautionary tale. (shrink)