In this post‐sequencing era, geneticists can focus on functional genomics on a much larger scale than ever before. One goal is the discovery and elucidation of the intricate genetic networks that co‐ordinate transcriptional activation in different regulatory circuitries. High‐throughput gene expression measurement using DNA arrays has thus become routine strategy. This approach, however, does not directly identify gene loci that belong to the same regulatory group; e.g., those that are bound by a common (set of) transcription factor(s). Working in yeast, (...) two groups have recently published an elegant method that could circumvent this problem, by combining chromatin immunoprecipitation and DNA microarrays.(1,2) The method is likely to provide a powerful tool for the dissection of global regulatory networks in eukaryotic cells. BioEssays 23:473–476, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Originally published in 1963. Can one discern certain regularities in the manoeuvrings and techniques employed by scientists and can these be formulated into the methodological principles of science? What is the origin and basis of such principles? Are they imposed by objective realities, do they derive from conceptual necessities or are they rooted in our own deep seated predilections? This volume investigates these questions and sheds light on the growth mechanism of the evolving structure of science itself.

This book was first published in 1991. The study of ancient science and its relations with Greek philosophy has made a significant and growing contribution to our understanding of ancient thought and civilisation. This collection of articles on Greek science contains fifteen of the most important papers published by G. E. R. Lloyd in this area since 1961, together with three newer articles. The topics range over all areas and periods of Greek science, from the earliest Presocratic philosophers to Ptolemy (...) and Galen. In each case the article is preceded by an introduction that assesses scholarly debate on the topic since the original publication. Professor Lloyd also suggests modifications and developments to his own position in the light of those debates and his own further research. (shrink)

Modern thinkers long have been troubled by everyday talk. For example, one nineteenth-century Tory critic observes, “General small-talk” is any exchange “in mixed society, where men and women, young and old, wise and foolish, are all mingled together.” However available the occasion or obvious the topics, chatting is easy for the talented but awkward for the ungifted. On the other hand, “special, or professional small talk” is an exchange of words between persons of “the same mode of life, as between (...) two apothecaries, two dissenters, two lawyers, two beggars, two reviewers, two butlers, two statements, two thieves, &c.&c.&c.; in short all conversations which are tinctured with the art, craft, mystery, occupation... (shrink)

Open peer commentary on the article “Info-computational Constructivism and Cognition” by Gordana Dodig-Crnkovic. Upshot: Dodig-Crnkovic’s “info-computational constructivism” (IC), as an essential part of a constructivist approach, needs integration with the logical, mathematical and physical evidence coming from quantum field theory (QFT) as the fundamental physics of the emergence of “complex systems” in all realms of natural sciences.