Evidence-based medicine frequently uses statistical hypothesis testing. In this paradigm, data can only disconfirm a research hypothesis’ competitors: One tests the negation of a statistical hypothesis that is supposed to correspond to the research hypothesis. In practice, these hypotheses are often misaligned. For instance, directional research hypotheses are often paired with non-directional statistical hypotheses. Prima facie, one cannot gain proper evidence for one’s research hypothesis employing a misaligned statistical hypothesis. This paper sheds lights on the nature of and the reasons (...) for such misalignments and it provides a thorough analysis of whether they pose a threat to evidence-based medicine. The upshots are that the misalignments are often hidden for clinicians and that although some cases of misalignments can be partially counterbalanced, the overall threat is non-negligible. The counterbalances either lead to methodological inadequacy, loss of statistical power, or involve a lack of information that could be crucial for decision making. This result casts doubt on various findings of medical studies in addition to issues associated with under-powered studies or the replication crisis. (shrink)

Expecting the imminent triumph of religious and political absolutism Locke tries, in »A Letter concerning Toleration«, to define the true Christian and the true church. He invites his readers to differentiale between civil goverment and religious communities. A church is a voluntary association, the members of which are hold together by the common hope of salvation. In this association there is no need for power and force, which are necessary in civil government. Pursuing this theme in a subtile way Locke (...) develops the reformatorical doctrine of the two kingdoms. (shrink)

Name der Zeitschrift: Neue Zeitschrift für Systematische Theologie und Religionsphilosophie Jahrgang: 56 Heft: 2 Seiten: 234-252.