Background: Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy (...) also rely more on discriminative brain regions predefined by prior knowledge. Methods: We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection. Results: Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC ≥ 0.91) and moderate accuracy for amnestic MCI versus controls (AUC ≈ 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson’s r ≈ −0.86, p < 0.001). Conclusion: The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relevance scores as well as the high performance achieved in independent samples support the validity of the CNN models in the detection of AD-related MRI abnormalities. The presented data-driven and hypothesis-free CNN modeling approach might provide a useful tool to automatically derive discriminative features for complex diagnostic tasks where clear clinical criteria are still missing, for instance for the differential diagnosis between various types of dementia. (shrink)

In recent years inclusion has become one of the most dominant values and objectives in education. However, there is still considerable disagreement concerning the theoretical concept of inclusion and its normative implications. This article suggests an understanding of inclusion that first differentiates analytically between societal and communal forms of inclusion, and second, situates the value of inclusion in the debate around recognition and freedom. Furthermore, it connects the discussion to some dilemmas and difficulties we might face in education. The overall (...) approach and goal of the article is to contribute to the on-going debate on the nature and value of inclusion and inclusive education. (shrink)

The spread of unethical behavior in organizations has mainly been studied in terms of processes occurring in a general social context, rather than in terms of actors’ reactions in the context of their specific social relationships. This paper introduces a dynamic social network analysis framework in which this spread is conceptualized as the result of the reactions of perpetrators, victims, and observers to an initial act of unethical behavior. This theoretical framework shows that the social relationships of the actors involved (...) in an initial act impact in multiple ways the likelihood that unethical behavior spreads. It reveals furthermore that social relationships may change in the wake of unethical behavior, such that indirect negative consequences can arise for organizations. The proposed framework provides a basis for the development of a formal stochastic actor-oriented model of network dynamics which would enable simulations of the spread of unethical behavior. (shrink)

Visions of and narratives about the future energy system influence the actual creation of innovations and are thus accompanying the current energy transition. Particularly in times of change and uncertainty, visions gain crucial relevance: imagining possible futures impacts the current social reality by both creating certain spaces of action and shaping technical artifacts. However, different actors may express divergent visions of the future energy system and its implementation. Looking at a particular innovation site involving multiple stakeholders over an 8-year period, (...) we empirically analyze the collective negotiation process of vision making, its shifting over time, and how visions eventually unfold performativity. Adopting a process perspective, we identify four different phases and the respective functions of visions and visioneering related to the site’s development by exploring the question: Why do certain visions gain importance and eventually lead to substantial changes of the project in process? Qualitative data from documents and interviews analyzed with reference to science and technology studies show the interweaving conditions that influence the visioneering and the linkage to the actual development of material artifacts. Against the backdrop of innovation projects, this paper explores visioneering as an ongoing, transformative and collective process and reveals its moments of stabilization. (shrink)

With the rise and public accessibility of AI-enabled decision-support systems, individuals outsource increasingly more of their decisions, even those that carry ethical dimensions. Considering this trend, scholars have highlighted that uncritical deference to these systems would be problematic and consequently called for investigations of the impact of pertinent technology on humans’ ethical decision-making. To this end, this article conducts a systematic review of existing scholarship and derives an integrated framework that demonstrates how intelligent decision-support systems (IDSSs) shape humans’ ethical decision-making. (...) In particular, we identify resulting consequences on an individual level (i.e., deliberation enhancement, motivation enhancement, autonomy enhancement and action enhancement) and on a societal level (i.e., moral deskilling, restricted moral progress and moral responsibility gaps). We carve out two distinct methods/operation types (i.e., processoriented and outcome-oriented navigation) that decision-support systems can deploy and postulate that these determine to what extent the previously stated consequences materialize. Overall, this study holds important theoretical and practical implications by establishing clarity in the conceptions, underlying mechanisms and (directions of) influences that can be expected when using particular IDSSs for ethical decisions. (shrink)

The main ideas in this paper can be summarized in the following three points. (1) Openness, indeterminacy, and exemplarity are elements of both Kant's aesthetics and Wittgenstein's notion of language games. (2) These elements are essential to what makes a person. They are necessary in processes of decision-making and in the development of a person. (3) Such aspects were in the center of discussion during the eighteenth and nineteenth centuries in Europe, especially in the tradition of the so-called Bildungsroman. Unfortunately, (...) they tend to be forgotten nowadays. (shrink)

Der Aufsatz enthält einen Unterrichtsentwurf zur Kontrastierung des Selbstbildes des Kaisers Augustus, wie er es in den Res gestae entwirft, mit den Urteilen moderner Historiker über ihn.

This essay will inform the reader about Kant’s views on mathematics and aesthetics. It will also critically discuss these views and offer further suggestions and personal opinions from the author’s side. Kant (1724-1804) was not a mathematician, nor was he an artist. One must even admit that he had little understanding of higher mathematics and that he did not have much of a theory that could be called a “philosophy of mathematics” either. But he formulated a very influential aesthetic theory (...) that is contained in his “Critique of the Power of Aesthetic Judgment” (1790), and his views on mathematics, especially those that compare it with philosophy, are distinctive and worthy of our attention. Hence, combining mathematics and aesthetics, asking whether mathematics can be beautiful and why and how it can or cannot be so called, according to Kant’s theory, will be particularly interesting. This essay has three parts: it discusses mathematics, aesthetics, and the aesthetics of mathematics, primarily in Kantian perspectives but also in ways that critically evaluate those perspectives. (shrink)

The recent debate about justice and responsibility increasingly tries to accommodate a new type of agentive situation in which local short-term actions have global long-term consequences due to the action’s embedding in complex interactional networks. Currently the debate is shifting focus from the spatial to the temporal dimension of such wide-scope results of individual actions. This shift from “global ethics” to “intergenerational ethics” and, in particular, “climate ethics” requires some new analytical concepts, however. A definition of wide-scope responsibility aimed at (...) articulating our moral concerns about emergent effects in complex systems, such as climate change, is needed. Working from Iris Marion Young’s “social connection model of responsibility,” a notion of shared ecological responsibility with global and intergenerational scope can be developed. This account is not affected by the so-called non-identity objection to intergenerational ethics. From an action-theoretic rather than normative perspective, the account is “ethically parametrized” in the sense that it can be combined with different conceptions of structural and intergenerational justice. The account can be used to support a concrete climate policy proposal: the “Greenhouse Development Rights Framework.”. (shrink)

This essay introduces ideas from Confucius, Xunzi, the Six Dynasties, and Kant about beauty, music, morality, and what we might today call “aesthetic education.” It asks how beauty and morality are related and how they ideally should be related to each other. We know that beauty and morality can drift apart, and we may wonder how aesthetic education might work best. Should the arts be a means for developing morality? Or should it be the other way around? These questions are (...) still relevant today. But our world has changed, not only since Confucius, but also since Kant. We may ask what to make of their ideas in our present time. I argue that there are good reasons for keeping morality and aesthetics apart, somewhat in the spirit of Kant, and in opposition to the idea of “fusing” the two. (shrink)

In a behavioral study we analyzed the influence of visual action primes on abstract action sentence processing. We thereby aimed at investigating mental motor involvement during processes of meaning constitution of action verbs in abstract contexts. In the first experiment, participants executed either congruous or incongruous movements parallel to a video prime. In the second experiment, we added a no-movement condition. After the execution of the movement, participants rendered a sensibility judgment on action sentence targets. It was expected that congruous (...) movements would facilitate both concrete and abstract action sentence comprehension in comparison to the incongruous and the no-movement condition. Results in Experiment 1 showed a concreteness effect but no effect of motor priming. Experiment 2 revealed a concreteness effect as well as an interaction effect of the sentence and the movement condition. The findings indicate an involvement of motor processes in abstract action language processing on a behavioral level. (shrink)

Paulin J. Hountondji is one of the most important and controversial figures in contemporary African philosophy. His critique of ethnophilosophy as a colonial, exoticising and racialized undertaking provoked contentious debates among African intellectuals on the proper methods and scope of philosophy and science in an African and global context since the 1970s. His radical pledge for scientific autonomy from the global system of knowledge production made him turn to endogenous forms of practising science in academia. The horizon of his philosophy (...) is the quest for critical universality from a historical, and situated perspective. Finally, his call for a notion of culture that is antithetical to political movements focused on a single identitarian doctrine or exclusionary norms shows how timely his political thought remains to this day. This book gives a comprehensive overview of Hountondji’s philosophical arguments and provides detailed information on the historical and political background of his intellectual oeuvre. It situates Hountondji in the dialogue with his African colleagues and explores links to current debates in philosophy, cultural studies, postcolonialism and the social sciences. (shrink)

In der Reihe werden herausragende monographische Untersuchungen und Sammelbände zu allen Aspekten der Philosophie Kants veröffentlicht, ebenso zum systematischen Verhältnis seiner Philosophie zu anderen philosophischen Ansätzen in Geschichte und Gegenwart. Veröffentlicht werden Studien, die einen innovativen Charakter haben und ausdrückliche Desiderate der Forschung erfüllen. Die Publikationen repräsentieren damit den aktuellsten Stand der Forschung.

Wittgenstein wrote: “No supposition seems to me more natural than that there is no process in the brain correlated with associating or with thinking; so that it would be impossible to read off thought-processes from brain processes.” In general, he rejects what he calls “psycho-physical parallelism.” In Sect. 1, I explain Wittgenstein’s position on this topic and how his followers defend it. In Sect. 2, I argue against Wittgenstein, contending that there is “thought” in a wider sense and that it (...) can be “manifested” without expression. Thought does not need to be ordinarily expressed or even expressible, and it can be read off from the brain, provided one has sufficient technology, data, and understanding of the subject’s interaction with the environment. In Sect. 3, I offer results from brain-science in support of my claims. (shrink)

Research by academics, professional organizations, and businesses on ethics in the workplace often relies on surveys that ask employees to report how frequently they have observed others engaging in unethical behavior. But what do these frequencies in observer-reports say about the frequencies of committed unethical behavior? This paper is the first to address this question by empirically exploring the relationship between observer- and self-reports. Our survey research among the Swiss working population shows that for all 37 different forms of unethical (...) behavior investigated, observer-reports show higher frequencies than self-reports. Ratios of observer- to self-reports vary substantially among these forms, ranging from 1.46 for improperly gathering competitor’s confidential information to 6.4 for engaging in (sexual) harassment or creating a hostile work environment. The results indicate that researchers should not assume that the frequency in self-reports can generally be approximated by the frequency in observer-reports. Four possible explanations are presented for the differences in ratios, with recommendations for future research. (shrink)

Ob die Kategorien schon bei der Wahrnehmung eine Rolle spielen, wird von Kant-Interpreten unterschiedlich gesehen. Peter Rohs etwa argumentiert für eine Unabhängigkeit und Selbständigkeit der Wahrnehmung gegenüber dem Verstand. Die intuitive Synthesis der Einbildungskraft müsse auf eigenen Füßen stehen können und Bilder und „singuläre Sinne“ der Anwendung der Begriffe vorausgehen. McDowell hingegen spricht sich gegen eine solche Selbständigkeit der Wahrnehmung aus. Setzte man sie voraus, käme der Verstand immer zu spät . Die Argumente beider Seiten sollen am Text Kants untersucht (...) werden . Es liegt hier ein echtes Sachproblem vor. Die gegenwärtige, hauptsächlich amerikanische Diskussion um eine etwaige Notwendigkeit kognitiver Funktionen bei der Wahrnehmung stößt auf ganz ähnliche Probleme wie wir sie schon bei Kant finden, nur daß man sich dieser Ähnlichkeit außerhalb von Kantkreisen oft nicht bewußt zu sein scheint. (shrink)

Two decades ago, the introduction of the Implicit Association Test (IAT) sparked enthusiastic reactions. With implicit measures like the IAT, researchers hoped to finally be able to bridge the gap between self-reported attitudes on one hand and behavior on the other. Twenty years of research and several meta-analyses later, however, we have to conclude that neither the IAT nor its derivatives have fulfilled these expectations. Their predictive value for behavioral criteria is weak and their incremental validity over and above self-report (...) measures is negligible. In our review, we present an overview of explanations for these unsatisfactory findings and delineate promising ways forward. Over the years, several reasons for the IAT’s weak predictive validity have been proposed. They point to four potentially problematic features: First, the IAT is by no means a pure measure of individual differences in associations but suffers from extraneous influences like recoding. Hence, the predictive validity of IAT-scores should not be confused with the predictive validity of associations. Second, with the IAT, we usually aim to measure evaluation (“liking”) instead of motivation (“wanting”). Yet, behavior might be determined much more often by the latter than the former. Third, the IAT focuses on measuring associations instead of propositional beliefs and thus taps into a construct that might be too unspecific to account for behavior. Finally, studies on predictive validity are often characterized by a mismatch between predictor and criterion (e.g., while behavior is highly context-specific, the IAT usually takes into account neither situation nor domain). Recent research, however, also revealed advances addressing each of these problems, namely (1) procedural and analytical advances to control for recoding in the IAT, (2) measurement procedures to assess implicit wanting, (3) measurement procedures to assess implicit beliefs, and (4) approaches to increase the fit between implicit measures and behavioral criteria (e.g., by incorporating contextual information). Implicit measures like the IAT hold an enormous potential. In order to allow them to fulfill this potential, however, we have to refine our understanding of these measures, and we should incorporate recent conceptual and methodological advancements. This review provides specific recommendations on how to do so. (shrink)

Philosophers of science have variously tried to characterize how-possibly explanations (HPEs) and distinguish them from how-actually explanations (HAEs). I argue that existing contributions to this debate have failed to pay attention to the different, but complementary, functions possibilities play in scientific explanations. To bring these functions to the fore, I introduce a distinction between what I call elucidating and embedding HPEs. While elucidating HPEs specify and demonstrate possible processes for a given research target, embedding HPEs demonstrate how the research target (...) fits into a space of suitably constrained possibilities. I specify both functions of HPE with reference to two case studies from origins-of-life research. I contrast my distinction with an alternative proposal by Wirling and Grüne-Yanoff (2024) to highlight that focusing on the functions, rather than types, of possibilities in explanation is better suited to account for key scientific practices. (shrink)

Kant sometimes compares human beings with animals and angels and grants human beings a middle position. But contrary to what one might expect, his transcendental philosophy does not apply well to animals or angels. The question of whether we share perception with animals has no good answer in his system that has to be taken as a single piece and does not allow for introducing steps of empirical, real developments. Differently from Kant, McDowell does compare human beings with animals, but (...) he is not a transcendental philosopher and his attempts to find support in Kant are problematic. Although McDowell says that concepts go "all the way out" and Kant says the categories go "all the way down," which sounds similar, Kant talks of a priori categories, not empirical concepts. Burge is definitely not a transcendental philosopher like Kant. Up front he strongly relies on empirical studies, especially animal perception. Nevertheless, his quest into mental content introduces first-person perspectives that have a metaphysical flavor, and this makes - at least to me - comparisons with Kant tempting again. (shrink)

Care is among the most important concepts in healthcare. It is not only a descriptive concept, but it also conveys a normative orientation. Approaches to the ethics of care have shown that care can indeed be understood as an overarching normative concept that integrates different normative orientations. Nonetheless, determining what constitutes good care is usually a matter of finding reasonable compromises. In healthcare settings, a typical compromise involves finding a balance between optimal care for individuals on the one hand and (...) the institutional demands of providing care to many care receivers over long periods of time as well as the limits of what can legitimately be asked of individual care providers on the other. (shrink)

With the introduction of diagnosis-related groups, German hospitals were obliged to develop quality assurance schemes. This article analyses (1) commonly used definitions for quality in health care and (2) their implementation in terms of interventions for improving quality in hospitals. -/- Consequences of current quality assurance practices include advances in objective quality, but also a shift within the culture of medicine towards dividing the treatment of patients into measurable and standardized steps. In contrast to this objective meaning of quality, there (...) is a demand for more patient orientation and for more attention to the subjective quality of treatment which refers to a therapeutic interaction-based notion of quality standards. Besides technical quality standards, there are important quality standards that are being defined in and through interpersonal therapeutic interaction. Good hospital management should, therefore, protect the cultivation of therapeutic interaction in its essentially interpersonal qualities. (shrink)

The interdisciplinary series "Law & Literature" takes a systematic look at the correlation between literature and the law. The studies presented in this series analyze the complex interrelation between two cultural spheres which are not only at the basis of Western Culture and Society, but share in a common focus on texts. Bringing together contributions by jurists, historians of law, legal philosophers, and specialists in literary and cultural studies, this series reflects a trend in current inter- and transdisciplinary research which (...) has recently shown rapid growth both in Europe and the United States. (shrink)

In this essay I focus on Wittgenstein's discussion of how we understand and feel about people that come from cultures very different from our own. Wittgenstein writes about "guessing thoughts", "regularities", and "common human behaviour" (gemeinsame menschliche Handlungsweise) in this context. I argue that his idea about given forms of life that we should "accept", will be problematic if we want to find a meaningful way of relating to such people with whom we "cannot find our feet" (in die man (...) sich nicht finden kann). (shrink)