Flavonoids are a class of low molecular weight phenolic compounds that is widely distributed in the plant kingdom. They exhibit a diverse spectrum of biological functions and play an important role in the interaction between plants and their environment. Flavonoids not only protect the plant from the harmful effects of UV irradiation but also play a crucial role in the sexual reproduction process. A special class of flavonoid polymers, the tannins, plays a structural role in the plant. Yet other classes (...) of flavonoids, flavonols and anthocyanins, have been implicated in the attraction of pollinators. Certain flavonoids participate in the interaction between plants and other organisms such as symbiotic bacteria and parasites. This raises the intriguing question as to how these different compounds arose and evolved. Based on taxonomy and molecular analysis of gene expression patterns it is possible to deduce a putative sequence of acquisition of the different branches of the biosynthetic pathway and their regulators. (shrink)

In Hellenistic Astronomy: The Science in Its Contexts, renowned scholars address questions about what the ancient science of the heavens was and the numerous contexts in which it was pursued.

The progression of research and scholarly inquiry does not occur in isolation and is wholly dependent on accurate reporting of methods and results, and successful replication of prior work. Without mechanisms to correct the literature, much time and money is wasted on research based on a crumbling foundation. These guidelines serve to outline the respective responsibilities of researchers, institutions, agencies, and publishers or editors in maintaining the integrity of the research record. Delineating these complementary roles and proposing solutions for common (...) barriers provide a foundation for best practices. (shrink)

Background: The rapid pace of progress in medical research, the consequent need for the timely transfer of new knowledge into practice, and the increasing need for ethics support, is making the work of Ethics Committees (ECs) ever more complex and demanding. As a response, ECs in many countries exhibit large variation in number, mandate, organization and member competences. This cross-sectional study aims to give an overview of the different types of activities of Italian ECs and favour discussion at a European (...) level.Methods: A questionnaire was emailed to all Italian Ethics Committees contained in the national Registry of the Ministry of Health, enquiring whether the EC was conducting, or planning to conduct, 4 specific activities. A telephone interview was conducted to determine reasons for failure to respond.Results: Response rate was 53% (101 respondents out of 191). 20% of ECs restrict their responsibilities to research protocol review, 25% also offer ethical consultation to institutions, support on individual health care decisions and promotes educational initiatives, while the remaining 50% conduct a few of the examined activities to varying degrees. Large variation was observed across different types of hosting institutions and geographical locations.Conclusions: A common European model should be developed, defining EC functions, member selection modalities, necessary member competences, decision-making criteria and measures for work verification. In the absence of sound empirical evidence, it would be interesting to study the effectiveness and efficiency of the different existing models. (shrink)

In this paper, I put forward some remarks supporting a reading of Spinoza's metaphysics in terms of process ontology, that is, the notion that processes or activities, rather than things, are the most basic entities. I suggest that this reading, while not the only possible one, offers advantages over the traditional substance-properties interpretation. While this claim may sound implausible vis-à-vis Spinoza's language of ‘substance’ and ‘attributes’, I show that process ontology illuminates important features of Spinoza's thought and can facilitate solutions (...) to some interpretive problems. (shrink)

[Esotericism. One-day Workshop about the Annale n. 25 of the Storia d'Italia Einaudi]. This section contains the proceedings of the one-day workshop on the book Esoterismo, published as the Annale n. 25 in the collection "History of Italy" by Einaudi. The workshop was organized by ISPF on the October 26, 2011 to promote the discussion on the significance of Western esotericist traditions in Italian history. S. Caianiello’s introduction highlights some major concepts and goals of the recent field of studies about (...) Western Esotericism, and some open problems about its definition. M. Cambi comments on the substantial transformation of esotericist themes in Giordano Bruno’s natural philosophy, whereby the sources of the magician’s power are completely enclosed in the realm of nature, thus rejecting any transcendent foundation. M. Conforti focuses on "the function and opportunities" offered by the Western Esotericism approach "to the genesis and development of early modern science" and comments from this perspective on different contributions in the volume, emphasizing however the importance of largely pre-existing traditions in the history of science and medicine which have long challenged the wiggish separation between science and magic, rational and irrational thought. L. Simonutti provides new material to the general theme, with a historical-philosophical analysis of the esotericist elements in Picart’s iconography of the 18th Century edition of "Cymbalum mundi". F. Sofia discusses the effective role of esotericist traditions in the attempts to establish a "civil religion" in Italy from Risorgimento to Fascism, a history in which, she argues, it is difficult to establish "how much esotericism was an intentional choice or the product of an unavoidable nicodemism". C. Castellano reviews the contributions dedicated to the "political teology" of Italian Risorgimento, dealing in depth with the complex relationship between Freemasonry and Carbonari in Italy – in her view, more of a cultural than of a strictly political connection – and highlights the relevance of the anticurial component in their esotericist inspiration. G.M. Cazzaniga, author and editor of the Annale, beyond reacting to the different stimuli offered by the discussion, provides a brief history of Western Esotericism studies in Europe and of the reasons of their difficult reception in Italy. (shrink)

Over the course of more than two millennia the philosophical school of Mīmāṃsā has thoroughly analyzed normative statements. In this paper we approach a formalization of the deontic system which is applied but never explicitly discussed in Mīmāṃsā to resolve conflicts between deontic statements by giving preference to the more specific ones. We first extend with prohibitions and recommendations the non-normal deontic logic extracted in Ciabattoni et al. from Mīmāṃsā texts, obtaining a multimodal dyadic version of the deontic logic \. (...) Sequent calculus is then used to close a set of prima-facie injunctions under a restricted form of monotonicity, using specificity to avoid conflicts. We establish decidability and complexity results, and investigate the potential use of the resulting system for Mīmāṃsā philosophy and, more generally, for the formal interpretation of normative statements. (shrink)

L'uomo è un animale razionale, oltreché politico, socievole, come dice Aristotele. Ma quello del pensiero occidentale è un cammino, non sempre lineare, lungo momenti di apertura e ripiegamento della ragione. Quando la ragione è strumento del conoscere è in una fase di apertura, in cui fioriscono le scoperte scientifiche, l'arte, il pensiero politico ed economico; quando invece la stessa ragione perde il suo carattere strumentale divenendo pensiero assoluto, ripiegato su di sé, cede il passo alla follia, fino agli orrori del (...) Nazismo. La follia è il capitolo oscuro di un logos assolutizzato, che non lascia spazio alla molteplicità dei punti di vista, è la deriva di una ragione non 'addomesticata', privata del contraddittorio con il reale. Con un linguaggio preciso ma accessibile, Campana Comparini, al dualismo ragione 'aperta' e feconda/ragione 'chiusa' e assolutizzata, oppone una diversa categoria filosofica di lettura del reale: la follia della croce; ovvero una prospettiva in cui la fede nel Cristo-uomo diventa la base da cui partire per rifondare la principale caratteristica dell'uomo, cioè il pensiero. La 'follia della croce' non è tanto un'alternativa, quanto il terreno su cui reimpiantare la logica della razionalità umana, poiché viene prima di essa. Una lettura per guardare da un'altra prospettiva le origini del pensiero occidentale."--Page 4 of cover. (shrink)

While caregiving in northern, rural and remote communities takes place in the context of conditions unique to smaller communities, caregivers live with social policies that are shaped by urban norms rather than rural realities. In times of economic decline and government cuts rural issues of limited services and infrastructure as well as dependency on a single industry can lead to unemployment, community and family instability, and a decline in health and well-being. During these times caregivers face increased pressure to voluntarily (...) fill the gaps left by service cuts. Research with women caregivers in four communities in northern British Columbia (BC), Canada explores the experiences of caring and the social, geographic, economic and political contexts within which the caregiving occurs. The discourse of economic efficiencies that speaks solely to the monetary value of care is contrasted with the human condition of connectedness and relationships. These two contradictory perspectives are uncovered during interviews with women caregivers and analyzed in the framework of Olena Hankivsky's discussion of an ethic of care. (shrink)

Recent works in Explainable AI mostly address the transparency issue of black-box models or create explanations for any kind of models (i.e., they are model-agnostic), while leaving explanations of interpretable models largely underexplored. In this paper, we fill this gap by focusing on explanations for a specific interpretable model, namely pattern-based logistic regression (PLR) for binary text classification. We do so because, albeit interpretable, PLR is challenging when it comes to explanations. In particular, we found that a standard way to (...) extract explanations from this model does not consider relations among the features, making the explanations hardly plausible to humans. Hence, we propose AXPLR, a novel explanation method using (forms of) computational argumentation to generate explanations (for outputs computed by PLR) which unearth model agreements and disagreements among the features. Specifically, we use computational argumentation as follows: we see features (patterns) in PLR as arguments in a form of quantified bipolar argumentation frameworks (QBAFs) and extract attacks and supports between arguments based on specificity of the arguments; we understand logistic regression as a gradual semantics for these QBAFs, used to determine the arguments’ dialectic strength; and we study standard properties of gradual semantics for QBAFs in the context of our argumentative re-interpretation of PLR, sanctioning its suitability for explanatory purposes. We then show how to extract intuitive explanations (for outputs computed by PLR) from the constructed QBAFs. Finally, we conduct an empirical evaluation and two experiments in the context of human-AI collaboration to demonstrate the advantages of our resulting AXPLR method. (shrink)

In A Treatise on Virtues and Rewards, Dragonetti advances a theory of action based on rewards for virtues. The idea of rewards, especially of awards, relies on the hypothesis that intrinsic motivations drive the actions of good or virtuous citizens. We apply this theory to virtuous entrepreneurs who voluntarily adopt ethical principles as promoted by a recent Italian law. These firms receive an ethical rating by the Italian Competition Authority and can access a set of economic and non-economic benefits. We (...) survey a sample of 152 private companies with an ER and examine their views on the economic and social motivations and benefits as well as the perceived usefulness of the ER for improving ethical behaviour. An exploratory factor analysis detects four categories of motivation and two categories of benefits, which we use in regression models to test Dragonetti’s theory. Overall, respondents see the ER as an effective tool, except in terms of improving economic performance. We also find that entrepreneurs with lower economic and higher responsiveness motivations attain higher ERs. However, in the respondents’ opinions, the ER is not producing any concrete benefits since we find no relationship between the ER and economic or competitive rewards. These findings have implications for the ICA as well as for private companies. (shrink)

However, as in other disciplines, academic recognition can in turn entrench static and powerful meta-theories and narratives about professional ethos and ...

A cavallo tra i due concili di Costanza e Basilea, che hanno fortemente influito sul giudizio della Chiesa in relazione alle donne visionarie, si staglia la figura di Francesca Bussa dei Ponziani. Le visioni politiche di Francesca rappresentano un fulgido esempio di come i modelli brigidini e cateriniani siano stati ripresi e rimodellati su un nuovo, mutato contesto storico. La sua consolidata autorità le consentì di ammonire a più riprese papa Eugenio IV riguardo alla sua partecipazione al concilio (...) di Basilea, intervenendo attivamente nello scenario religioso e politico romano. (shrink)

At Columbia University in 1906, William James gave a highly confrontational speech to the American Philosophical Association (APA). He ignored the technical philosophical questions the audience had gathered to discuss and instead addressed the topic of human energy. Tramping on the rules of academic decorum, James invoked the work of amateurs, read testimonials on the benefits of yoga and alcohol, and concluded by urging his listeners to take up this psychological and physiological problem. What was the goal of this unusual (...) speech? Rather than an oddity, Francesca Bordogna asserts that the APA address was emblematic—it was just one of many gestures that James employed as he plowed through the barriers between academic, popular, and pseudoscience, as well as the newly emergent borders between the study of philosophy, psychology, and the “science of man.” Bordogna reveals that James’s trespassing of boundaries was an essential element of a broader intellectual and social project. By crisscrossing divides, she argues, James imagined a new social configuration of knowledge, a better society, and a new vision of the human self. As the academy moves toward an increasingly interdisciplinary future, William James at the Boundaries reintroduces readers to a seminal influence on the way knowledge is pursued. (shrink)

In the recent literature on proof theory, there seems to be a new raising topic which consists in identifying those properties that characterise a good sequent calculus. The property that has received by far the most attention is the analyticity property. In this paper we propose a new argument in support of the analyticity property. We will do it by means of the example of the logic of proofs, a logic recently introduced by Artemov [1]. Indeed a detailed proof analysis (...) of this logic sheds new light on the logic itself and perfectly exemplifies our argument in favour of the analiticity. (shrink)

This paper aims to investigate the intersections between Hegel’s aesthetics lec- tures and translation theory and praxis, with reference to the French-Italian translation project Hegel Art Net. Against the background of the historical recon- struction that sees Hegel repeatedly confronted with the fruition and production of translations, we intend to examine the hermeneutic, philological and political challenges that a translator of the aesthetics Nachschriften encounters today, following the “philological turn” of the 1990s and the publication of new sources documenting Hegel’s (...) Berlin lectures on the philosophy of art. (shrink)