A central debate in philosophy and neuroscience pertains to whether PFC activity plays an essential role in the neural basis of consciousness. Neuroimaging and electrophysiology studies have revealed that the contents of conscious perceptual experience can be successfully decoded from PFC activity, but these findings might be confounded by post- perceptual cognitive processes, such as thinking, reasoning, and decision-making, that are not necessary for con- sciousness. To clarify the involvement of the PFC in consciousness, we present a synthesis of research (...) that has used intracranial electrical stimulation (iES) for the causal modulation of neural activity in the human PFC. This research provides compelling evidence that iES of only certain prefrontal regions (i.e., orbitofrontal cortex and anterior cingu- late cortex) reliably perturbs conscious experience. Conversely, stimulation of anterolateral prefrontal sites, often con- sidered crucial in higher-order and global workspace theories of consciousness, seldom elicits any reportable alterations in consciousness. Furthermore, the wide variety of iES-elicited effects in the PFC (e.g., emotions, thoughts, and olfactory and visual hallucinations) exhibits no clear relation to the immediate environment. Therefore, there is no evidence for the kinds of alterations in ongoing perceptual experience that would be predicted by higher-order or global workspace theories. Nevertheless, effects in the orbitofrontal and anterior cingulate cortices suggest a specific role for these PFC subregions in supporting emotional aspects of conscious experience. Overall, this evidence presents a challenge for higher-order and global workspace theories, which commonly point to the PFC as the basis for con- scious perception based on correlative and possibly confounded information. (shrink)

Despite increasing scientific interest in self-generated thought-mental content largely independent of the immediate environment-there has yet to be any comprehensive synthesis of the subjective experience and neural correlates of affect in these forms of thinking. Here, we aim to develop an integrated affective neuroscience encompassing many forms of self-generated thought-normal and pathological, moderate and excessive, in waking and in sleep. In synthesizing existing literature on this topic, we reveal consistent findings pertaining to the prevalence, valence, and variability of emotion in (...) self-generated thought, and highlight how these factors might interact with self-generated thought to influence general well-being. We integrate these psychological findings with recent neuroimaging research, bringing attention to the neural correlates of affect in self-generated thought. We show that affect in self-generated thought is prevalent, positively biased, highly variable (both within and across individuals), and consistently recruits many brain areas implicated in emotional processing, including the orbitofrontal cortex, amygdala, insula, and medial prefrontal cortex. Many factors modulate these typical psychological and neural patterns, however; the emerging affective neuroscience of self-generated thought must endeavor to link brain function and subjective experience in both everyday self-generated thought as well as its dysfunctions in mental illness. (shrink)

The neural basis of human memory is incredibly complex. We argue that the diversity of neural systems underlying various forms of memory suggests that any discussion of enhancing ‘memory’ per se is too broad, thus obfuscating the biopolitical debate about human enhancement. Memory can be differentiated into at least four major systems with largely dissociable neural substrates. We outline each system, and discuss both the practical and the ethical implications of these diverse neural substrates. In practice, distinct neural bases imply (...) the possibility, and likely the necessity, of specific approaches for the safe and effective enhancement of various memory systems. In the debate over the ethical and social implications of enhancement technologies, this fine-grained perspective clarifies—and may partially mitigate—certain common concerns in enhancement debates, including issues related to safety, fairness, coercion, and authenticity. While many researchers certainly appreciate the neurobiological complexity of memory, the political debate tends to revolve around a monolithic one-size-fits-all conception. The overall project—exploring how human enhancement technologies affect society – stands to benefit from a deeper appreciation of memory’s neurobiological diversity. (shrink)

An often-overlooked characteristic of the human mind is its propensity to wander. Despite growing interest in the science of mind-wandering, most studies operationalize mind-wandering by its task-unrelated contents. But these contents may be orthogonal to the processes that determine how thoughts unfold over time, remaining stable or wandering from one topic to another. In this chapter, we emphasize the importance of incorporating such processes into current definitions of mind-wandering, and propose that mind-wandering and other forms of spontaneous thought (such as (...) dreaming and creativity) are mental states that arise and transition relatively freely due to an absence of constraints on cognition. We review existing psychological, philosophical and neuroscientific research on spontaneous thought through the lens of this framework, and call for additional research into the dynamic properties of the mind and brain. (shrink)

Most research on mind-wandering has characterized it as a mental state with contents that are task unrelated or stimulus independent. However, the dynamics of mind-wandering—how mental states change over time—have remained largely neglected. Here, we introduce a dynamic framework for understanding mind-wandering and its relationship to the recruitment of large-scale brain networks. We propose that mind-wandering is best understood as a member of a family of spontaneous-thought phenomena that also includes creative thought and dreaming. This dynamic framework can shed new (...) light on mental disorders that are marked by alterations in spontaneous thought, including depression, anxiety and attention deficit hyperactivity disorder. (shrink)

Reasons without Rationalism has two related parts, devoted to action theory and ethics, respectively. In the second part, I argue for a close connection between reasons for action and virtues of character. This connection is mediated by the idea of good practical thought and the disposition to engage in it. The argument relies on the following principle, which is intended as common ground: " Reasons: The fact that p is a reason for A to ϕ just in case A has (...) a collection of psychological states, C, such that the disposition to be moved to ϕ by C-and-the-belief-that- p is a good disposition of practical thought, and C contains no false beliefs."In effect, reasons are premises for episodes of sound practical thinking whose other conditions already …. (shrink)

A 1999–2000 national study of U.S. hospitals raised concerns about ethics consultation (EC) practices and catalyzed improvement efforts. To assess how practices have changed since 2000, we administered a 105-item survey to “best informants” in a stratified random sample of 600 U.S. general hospitals. This primary article details the methods for the entire study, then focuses on the 16 items from the prior study. Compared with 2000, the estimated number of case consultations performed annually rose by 94% to 68,000. The (...) median number of consults per hospital was unchanged at 3, but more than doubled for hospitals with 400+ beds. The level of education of EC practitioners was unchanged, while the percentage of hospitals formally evaluating their ECS decreased from 28.0% to 19.1%. The gap between large, teaching hospitals and small, nonteaching hospitals widened since the prior study. We suggest targeting future improvement efforts to hospitals where needs are not being met by current approaches to EC. (shrink)

Context: Although ethics consultation is commonplace in United States (U.S.) hospitals, descriptive data about this health service are lacking. Objective: To describe the prevalence, practitioners, and processes of ethics consultation in U.S. hospitals. Design: A 56-item phone or questionnaire survey of the "best informant" within each hospital. Participants: Random sample of 600 U.S. general hospitals, stratified by bed size. Results: The response rate was 87.4%. Ethics consultation services (ECSs) were found in 81% of all general hospitals in the U.S., and (...) in 100% of hospitals with more than 400 beds. The median number of consults performed by ECSs in the year prior to survey was 3. Most individuals performing ethics consultation were physicians (34%), nurses (31%), social workers (11%), or chaplains (10%). Only 41% had formal supervised training in ethics consultation. Consultation practices varied widely both within and between ECSs. For example, 65% of ECSs always made recommendations, whereas 6% never did. These findings highlight a need to clarify standards for ethics consultation practices. (shrink)

To design effective strategies to improve ethics consultation (EC) practices, it is important to understand the views of ethics practitioners. Previous U.S. studies of ethics practitioners have overrepresented the views of academic bioethicists. To help inform EC improvement efforts, we surveyed a random stratified sample of U.S. hospitals, examining ethics practitioners’ opinions on EC in general, on their own EC service, on strategies to improve EC, and on ASBH practice standards. Respondents across all categories of hospitals had very positive perceptions (...) of their own ethics consultation service (ECS) and few concerns about quality. Our findings suggest that the ethics-related needs of small, rural, non-teaching hospitals may be very different from those of academic medical centers, and therefore, different approaches to addressing ethical issues might be warranted. (shrink)

The annual volume of ethics consultations (ECs) has been a topic of interest in the bioethics literature, in part because of its presumed relationship to quality. To better understand factors associated with EC volume, we used multiple linear regression to model the number of case consultations performed in the last year based on a national survey. We found that hospital bed size, academic affiliation, and urban/rural location were all associated with EC volume, but were not the primary drivers. Instead, these (...) variables affected EC volume through three other variables, all of which relate to ethics staffing: the percentage of case consultations performed by a single individual; whether the survey respondent’s main role at the hospital contained the word “ethics”; and especially, the number of full-time ethics program staff. We conclude that EC is an example of supply-sensitive care, and further research is needed to determine the optimal level of EC activity. (shrink)

Mill defines utilitarianism as the combination of a “theory of life” and a moral claim: only pleasure and freedom from pain are desirable as ends, and the promotion of happiness is the sole goal of moral action. So defined, utilitarianism is open to ad hominem pessimistic objection: a “theory of life” which entails the impossibility of happiness fits poorly with a morality centered on its promotion. The first two challenges Mill confronts in Utilitarianism share this pessimistic structure. Interestingly, however, these (...) challenges paint inverted pictures of the best utilitarian life: one suggests this life is satisfying but ignoble, the other that it is noble but unsatisfying. I explain Mill's treatment of both challenges as genuinely pessimistic interpretations of utilitarianism's “theory of life.” Read through the lens of Mill's engagement with pessimism, these challenges point to distinctive conceptions of dignity and satisfaction that play a significant role in Mill's ethics. (shrink)

This essay evaluates the moral logic of ‘liberal eugenics’: the ideal of genetic control which leaves decisions about what sort of people to produce in the hands of individual parents, absent government intervention. I argue that liberal eugenics cannot be justified on the basis of the underlying liberal theory which inspires it. I introduce an alternative to Rawls's social primary goods that might be called natural primary goods: hereditable mental and physical capacities and dispositions that are valued across a range (...) of projects and pursuits. I suggest that reproductive genetic biotechnologies like embryo selection, cellular surgery, and genetic engineering, which aim to enhance ‘general purpose’ traits in offspring are less like childrearing practices a liberal government leaves to the discretion of parents than like practices the state makes compulsory. I argue that if the liberal commitment to autonomy is important enough for the state to mandate childrearing practices such as health care and basic education, that very same interest is important enough for the state to mandate safe, effective, and functionally integrated genetic practices that act on analogous all‐purpose traits such as resistance to disease and general cognitive functioning. I conclude that the liberal case for compulsory eugenics is a reductio against liberal theory. (shrink)

Much has been written in recent years on environmental ethics relating to the more general 'natural' environment but little specifically written about ethics of the built environment. Ethics and the Built Environment responds to this need and offers a debate on the ethical dimension of building in all its forms from a variety of disciplinary perspectives and approaches. This book should be of interest to architects, students of building and building design, environmentalists, politicians and general readers with an interest in (...) ethics. (shrink)

From late 1684 through mid-1685, Isaac Newton turned to developing and refining the conceptual foundations presupposed by his emerging physics. Analysis of his manuscripts from this period reveals that Newton’s understanding of the relativity of acceleration led him to seek a spatiotemporally invariant quantity of matter. He found two such quantities and then designed an experiment to discover their relationship. Interpreting the experiment, however, required distinguishing a new notion of force. Others have recognized the conceptual distinction between inertial and gravitational (...) mass. I show here that Newton clearly saw this distinction and that he provisionally established their equivalence. (shrink)

: Puritanism and Confucianism have little in common in terms of their substantive teachings, but they do share an emphasis on bounded, authoritative, localized human arrangements, and this profoundly challenges the dominant presumptions of contemporary globalization. It is not enough to say that these worldviews are ‘‘communitarian’’ alternatives to globalism, for that defines away what needs to be explained. This article compares the ontology of certain elements of the Puritan and Confucian worldviews, and, by focusing on the role of both (...) authority and activity in these systems, assesses (with the assistance of Max Weber) the theories of harmony that each invoke. It concludes by identifying the distinct options that these two modes of human existence suggest for those who wish to defend the relevance of boundedness and authority, and thus the very possibility of a human-scaled politics, in today’s world. (shrink)

While there had still been an increasing flow of foreign direct investment (FDI) into China during the 2002 downturn in FDI globally, such investments have historically been only sporadically successful. Much writing has detailed and discussed problems associated with China FDI but several costs remain dangerously overlooked. One such cost is that of micro-monitoring plants for work conditions and employee treatment in violation of local Chinese laws and possible home country ethics. Further, a more personal cost is presented – the (...) personal cost associated with maintaining an investment in a facility that violates standards of ethical employee treatment. Background information related to these issues is presented, along with a general overview of FDI in China. (shrink)

Beyond Health applies post-structuralist and postmodern ideas to issues of health and health care to provide a radical re-think of how health is to be understood. It offers a perspective in which health is seen as an affirmation of potential rather than as a narrow biopsychosocial construct. The author develops his notion of arche-health and in so doing provides a lucid account of a wide range of post-structuralist and postmodern theoretical perspectives and their relevance to the field of health. This (...) text explains complex ideas so even a reader with no previous background in the topic can grasp it. In each chapter the author explains and applies a selection of theoretical perspectives. (shrink)

It is well known that in certain environments the scope of a moved quantifier phrase can be determined at either its pre-movement position (“scope reconstruction”) or its postmovement position (“surface scope”). Thus the familiar ambiguity of (1) results from two choices for the scope of the moved QP. Under scope reconstruction, the scope of the moved existential QP is the sister of the pre-movement position (i.e. the sister of t, [to win the lottery]), while under surface scope it is the (...) sister of the post-movement position (i.e. [is likely t to win the lottery]). The two scope possibilities yield different semantic interpretations, corresponding to the paraphrases in (2). (1) Someone from New York is likely t to win the lottery (2) a. It is likely that there will be someone from New York who wins the lottery.. (shrink)

This book explores the differences and similarities between Sartrean existentialism and French poststructuralism.

Modern philosophy has been vexed by the question "Why should I be moral?" and by doubts about the rational authority of moral virtue. In Reasons without Rationalism, Kieran Setiya shows that these doubts rest on a mistake. The "should" of practical reason cannot be understood apart from the virtues of character, including such moral virtues as justice and benevolence, and the considerations to which the virtues make one sensitive thereby count as reasons to act. Proposing a new framework for (...) debates about practical reason, Setiya argues that the only alternative to this "virtue theory" is a form of ethical rationalism in which reasons derive from the nature of intentional action. Despite its recent popularity, however, ethical rationalism is false. It wrongly assumes that we act "under the guise of the good," or it relies on dubious views about intention and motivation. It follows from the failure of rationalism that the virtue theory is true: we cannot be fully good without the perfection of practical reason, or have that perfection without being good. Addressing such topics as the psychology of virtue and the explanation of action, Reasons without Rationalism is essential reading for philosophers interested in ethics, rationality, or the philosophy of mind. (shrink)

The variety of nature presents a challenge for ecologists. Individual organisms differ from one another in ways both obvious and subtle, even if they’re members of the same species living in the same location. Different populations, species, communities, ecosystems, biomes, habitats, food webs, etc. also differ from another. What, if anything, can be said in general about ecological systems and how they work? If there are generalities in ecology, do they take the form of exceptionless “laws of nature” analogous to (...) the laws of physics? Or do they take some other form? Should ecologists even try to identify ecological generalities? If so, how? The variety of nature is matched by the variety of ecologists’ answers to those questions. I will suggest that all of their answers are right—sometimes. Here I propose a taxonomy of the many different “roads to generality” in ecology: the various different kinds of “generality” that ecologists seek. I argue that each road to generality is valuable in its own way, but that different roads are useful in different contexts and for different purposes. Different roads to generality thus can be complementary to one another, and it would be a mistake for the field of ecology as a whole to focus exclusively on any one of them. (shrink)

It has long been known that the red blood cell contains a membrane skeleton that stabilizes the plasma membrane, determines its shape, and regulates the lateral distribution of the membrane glyco‐proteins to which it is attached. The way in which these functions are regulated in other cells has not been understood. It has now been shown that platelets also contain a membrane skeleton. In contrast to the membrane skeleton of the red blood cell, the platelet membrane skeleton has actin‐binding protein, (...) not spectrin, as a major component. The platelet membrane skeleton regulates the same cellular functions as the red blood cell membrane skeleton. Other cells may contain a membrane skeleton that is critical to their viability and normal functioning. (shrink)

Creating a single national health insurance pool is not likely to destabilize the economy by supplanting the private health insurance industry. This industry insures a relatively small percentage of the population and holds very little of the risk such insurance implies. In effect, insurance companies function as middlemen, bundling risk packages to distribute to other, larger companies and so serve a limited purpose. Were insurers to handle claims for a national pool as they do for the Medicare program, any destabilization (...) to the economy more broadly would be further minimized. (shrink)

This new heuristic model of perceptual analysis raises interesting issues but in the end falls short. Its arguments are more in the Cartesian than Gestalt tradition. Much of the argument is based on setting up theoretical straw men and ignores well known perceptual and brain science. Arguments are reviewed in light of known physiology and traditional Gestalt theory.

Schopenhauer had important things to say about ethics in both normative and meta-ethical senses, but his impact on the evolution of moral theory has been minimized by the unfortunate neglect of his philosophy in general. A contemporary assessment of his ethical views reveals that they are both imaginative and interesting, not least because they challenge assumptions held by more canonical figures in the history of philosophy, both before and after his time. Since the roots of ethics are currently being vigorously (...) re-examined, it is regrettable that Schopenhauer's ideas have been omitted from mainstream discussion in the field. I attempt to remedy this lack by investigating how his ethics of compassion contributes to the following areas: reconciling ethics with strict determinism; naturalizing ethics; developing the philosophy of education; seeking inner peace and world peace; re-visioning our relationship with non-human animals and the environment. As this list indicates, Schopenhauer's moral theory has relevance for a much wider audience, beyond the limited sphere of professional philosophy. And because the world is in dire need of moral rejuvenation, any inspiration provided by a major thinker such as Schopenhauer should be heartily welcomed. While certain internal problems are posed by his metaphysical and epistemological doctrines, we can see past these in order to appropriate the living insights still to be found in Schopenhauer's ethical thought. (shrink)

Words like well, oh, and you know have long been observed and studied in spontaneous speech. With the proliferation of on-line dialogues, such as instant messaging between friends or back-and-forth postings at websites, there are increasing opportunities to observe them in spontaneous writing. In Experiment 1, the interpretation of discourse markers in on-line debates was compared to proposed functions of those markers identified in other settings. In Experiment 2, the use of discourse markers in spontaneous speech was compared to their (...) uses in spontaneous writing. Results support the conclusion that although they vary in frequency in spoken versus written domains, discourse markers are used similarly across domains, but with particular communicative functions that make them non-interchangeable. (shrink)

What I call the minimal notion of truth is just that which the redundancy thesis claims suffices for all legitimate purposes. I argue that the minimal notion is legitimate and useful whatever one's preferred theory of truth. I rebut some arguments against the redundancy thesis which are in effect arguments against the legitimacy of the minimal notion. Finally I compare the minimal notion with a slightly stronger notion I call the semiminimal notion, and argue that this does issue a refutation (...) of the redundancy thesis as I have defined it. (shrink)

Many solar systems in the universe may be expected to contain rocky planets that have accreted organic compounds. These compounds are likely to be universally found. In addition, the chemistry of sulfur, phosphorus, and iron is likely to dominate energy transductions and monomer activation, leading to the eventual emergence of polymers. Proteins and polynucleotides provide living matter with function, structure, and information. The conceptual puzzle regarding their emergence is discussed. The fitness of various elements to serve various roles is analyzed (...) from the viewpoint of electron orbitals. Elements with d orbitals are of central importance. (shrink)

The intellectualist position held by structuralists does not explain the extremes of emotional reaction to the disruption of social categories. An approach from neuroscience based on the functions of the limbic system in the creation of long‐term memory through the role of the hippocampus and REM sleep is proposed to account for the emotive loading of cognitive categories.

This chapter contains sections titled: Simple (or Hard) Decisions Simplicity and Complexity Globalization, Coffee, and Sweden Simple (or Hard) Gifts Notes.

Name der Zeitschrift: Kierkegaard Studies Yearbook Jahrgang: 23 Heft: 1 Seiten: 3-32.