The aim of this paper is to argue that lying differs from mere misleading in a way that can be morally relevant: liars commit themselves to something they believe to be false, while misleaders avoid such commitment, and this difference can make a moral difference. Even holding all else fixed, a lie can therefore be morally worse than a corresponding misleading utterance. But, we argue, there are also cases in which the difference in commitment makes lying morally better than misleading, (...) as well as cases in which the difference is not morally relevant. This view conflicts with the two main positions philosophers have defended in the ethics of lying and misleading, which entail either that lying is in virtue of its nature worse than misleading or that there is no morally relevant difference between lying and misleading. (shrink)

Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...) of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

Studies on students' perception of corporate social responsibility (CSR) have been growing in western scholarship. For students in African countries, such as Nigeria, there is little that is known about how and whether gender, level of study, and being enrolled in business education courses impact their perception of and disposition towards CSR. This study explores the significance of gender, academic status or level of study, and exposure to business ethics education (BEE) on Nigerian students' perception of CSR as a veritable (...) business ethic. Specifically, the effects of these factors on students' perception of CSR are examined using analysis of variance. The results show a significant effect of exposure to BEE and gender on CSR‐sensitivity, and a mild, but significant effect of academic status. This implies that male students and female students had different perspectives on CSR issues. Students who took ethics courses and those who did not would run businesses differently. However, age and experience on campus did not influence students' perception or position on CSR. The study recommends that more behavioral models be estimated with the inclusion of more demographic and socioeconomic variables to elicit more robust results. (shrink)

Clinical fields of the “sciences of the mind” (psychotherapy, psychiatry, etc.) lack integrative conceptual frameworks that have explanatory power. Mainly descriptive-classificatory taxonomies like DSM dominate the field. New taxonomies such as Research Domain Criteria (RDoC) aim to collect scientific knowledge regarding “systems” for “processes” of the brain. These terms have a supradisciplinary” meaning if they are considered in context of Systems Science. This field emerges as a platform of theories like general systems theory, catastrophe theory, synergetics, chaos theory, etc. It (...) provides a lot of abstract concepts, constructs, methods and models. We assume that these tools also enable theoretical integration in the diversified field of clinical practice in the sciences of the mind. Additionally, systems thinking in clinical psychology improves conceptual links to currently network-oriented neurobiology. However, clear definitions of systemic terms are necessary to emerge from their mainly metaphorical use. Here we revise mainly terms like “structure”, “process” and “dynamics” as they are used already in psychology, psychoanalysis, psychopathology and psychiatry in an ill-defined way. For instance, affective-cognitive structures like “life space” or “object representations” can be seen as products of mental processing. These structures, in turn, modulate dynamics of mental processes. Additionally, we suggest a coupled network concept of emotions and motivations as the main subsystem that modulates mental dynamics that results in a qualitative systemic model of the mind. Finally, we assume that a revisited systemic approach could improve interdisciplinary understanding of the mental. ystem for mental dynamics. In this context, we assume that a revisited systemic approach could improve interdisciplinary understanding of the mental. (shrink)

Gene therapy has emerged from the idea of inserting a wild‐type copy of a gene in order to restore the proper expression and function of a damaged gene. Initial efforts have focused on finding the proper vector and delivery method to introduce a corrected gene to the affected tissue or cell type. Even though these first attempts are clearly promising, seveal problems remain unsolved. A major problem is the influence of chromatin structure on transgene expression. To overcome chromatin‐dependent repressive transgenic (...) states, researchers have begun to use chromatin regulatory elements to drive transgene expression. Insulators or chromatin boundaries are able to protect a transgene against chromatin position effects at their genomic integration sites, and they are able to maintain transgene expression for long periods of time. Therefore, these elements may be very useful tools in gene therapy applications for ensuring high‐level and stable expression of transgenes. BioEssays 26:796–807, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This article aims to reconstruct the way by which Leibniz presents in some of his texts an a posteriori proof of God’s existence. To this end, we intend to demonstrate the centrality of the Principle of Sufficient Reason applied to the contingency of the passage to the existence of a given world. Once demonstrated the existence of God by these ways, and still taking into account the Principle of Sufficient Reason - now applied to the existence of this world in (...) particular -, we will discuss the theory of possible worlds and Leibniz’s thesis according to which the Actual World is the most perfect possible. (shrink)

Este artigo visa analisar de que modo as questões pertinentes à situação do Paraguai do Pós-Guerra da Tríplice Aliança serviram de instrumento de luta político-partidária entre nacionalistas e autonomistas durante a campanha presidencial argentina de 1873 e 1874. Para isso, foram consultados alguns jornais de Buenos Aires, uma vez que eram os principais canalizadores dos debates públicos e difusores de representações. Da análise das fontes pode-se apontar que a facção autonomista fez daquele conflito, da ocupação do Paraguai e das questões (...) pendentes daquele evento uma das suas principais armas de combate em sua luta eleitoral contra o nacionalismo. (shrink)

En este artículo se estudia un peculiar recurso discursivo de un cronista barroco del virreinato del Perú: un elogio de las mujeres criollas de la ciudad de Arequipa, que se transforma en una vindicación general de los indígenas como una forma de exaltar a la ciudad criolla a través de una serie de analogías históricas con experiencias e ideales de la tradición hispánica asumibles para una audiencia metropolitana.

Für den metaethischen Realismus sind Werteigenschaften wie die Vortrefflichkeit ein irreduzibler Teil der subjektunabhängigen Welt. Obwohl sich diese Position in den letzten Jahren zunehmender Beliebtheit erfreut, bleibt die Frage nach der Ontologie dieser Eigenschaften meist ausgeklammert. Der Magnetismus des Guten diskutiert eine philosophiegeschichtlich höchst einflussreiche, in der zeitgenössischen Metaethik jedoch weitgehend vernachlässigte Antwort auf diese Frage: den metanormativen Platonismus. Ihm zufolge ist das Gutsein im Sinne der Vortrefflichkeit nichts anderes als ein bestimmtes In-Beziehung-Stehen zu einem Ideal. Verschiedene Formen dieser Theorie (...) lassen sich anhand zweier Fragen unterscheiden. Erstens, ist das Ideal selbst normativ irreduzibel? Zweitens, muss es personal oder nicht-personal verstanden werden? Anhand von Studien zu Platon, Plotin, Iris Murdoch und Robert Adams untersucht Der Magnetismus des Guten den Platonismus in seinen verschiedenen Varianten auf seine Erklärungskraft. Das Buch stellt damit zugleich die erste historisch informierte systematische Rekonstruktion der Normativitätstheorie des Platonismus dar.­­. (shrink)

Cet ouvrage est une réédition numérique d’un livre paru au XXe siècle, désormais indisponible dans son format d’origine.

La familia Murcia de la Llana desarrolló a lo largo de casi un siglo una de las tareas más significativas y a su vez más desconocidas dentro del complicado proceso por el que un manuscrito debía transcurrir hasta abandonar la imprenta: la corrección de libros. Por sus manos pasaron la mayor parte de los escritos del siglo XVII, muchos de los cuales alcanzarían posteriormente un éxito sin precedentes, caso del Quijote de Miguel de Cervantes. Este estudio se articula en base (...) a una serie de noticias documentales, muchas inéditas, que intentan esclarecer la compleja relación de parentescos, así como interesantes datos sobre el oficio de corrector general de libros. (shrink)

This essay was written on the basis of a lecture given by its author in 1999, entitled “The status of human subject in the vestiges of Modernity”. Modernity, with capital letters, was the first ideological object reviewed.

El presente trabajo intenta reflexionar sobre la importancia pedagógica del afecto y del cuidado, no sólo en tiempos de pandemia, sino como elemento clave, aunque olvidado, del proceso educativo. Para ello, se expondrán las consecuencias de la pandemia y el confinamiento para la salud de la ciudadanía, en un contexto dominado por el Global Educational Reform Movement. A continuación, señalamos que las preocupaciones de las administraciones y organizaciones internacionales durante el confinamiento han estado centradas en la ‘mantener’ la presión sobre (...) el aprendizaje, mantener la máquina del aprendizaje, intentando mejorar el acceso y la conectividad online, y olvidando otras cuestiones como la situación de las familias y el alumnado. En este sentido, mostramos cómo la preocupación por el otro (familias y alumnado) ha sido una preocupación constante en muchos docentes, por encima incluso del curriculum establecido y del aprendizaje. Por último, y como complemento de las mejores prácticas educativas, analizamos qué supone el cuidado y el afecto para el proceso pedagógico, indicando que no se puede volver a la antigua normalidad, sino recrear una _nueva normalidad _basada en la ética del cuidado y en la justicia afectiva. (shrink)

Contre la metaphysique: questions de methode / par Felix Le Dantec,...Date de l'edition originale: 1912Collection: Bibliotheque de philosophie contemporaineCe livre est la reproduction fidele d'une oeuvre publiee avant 1920 et fait partie d'une collection de livres reimprimes a la demande editee par Hachette Livre, dans le cadre d'un partenariat avec la Bibliotheque nationale de France, offrant l'opportunite d'acceder a des ouvrages anciens et souvent rares issus des fonds patrimoniaux de la BnF.Les oeuvres faisant partie de cette collection ont ete (...) numerisees par la BnF et sont presentes sur Gallica, sa bibliotheque numerique.En entreprenant de redonner vie a ces ouvrages au travers d'une collection de livres reimprimes a la demande, nous leur donnons la possibilite de rencontrer un public elargi et participons a la transmission de connaissances et de savoirs parfois difficilement accessibles.Nous avons cherche a concilier la reproduction fidele d'un livre ancien a partir de sa version numerisee avec le souci d'un confort de lecture optimal. Nous esperons que les ouvrages de cette nouvelle collection vous apporteront entiere satisfaction.Pour plus d'informations, rendez-vous sur www.hachettebnf.frhttp: //gallica.bnf.fr/ark: /12148/bpt6k5477903d. (shrink)

El comentario de texto es una práctica habitual en la enseñanza de la filosofía y de otras disciplinas. En general, los modelos existentes se centran en la comprensión del texto y del contexto del autor y la época, pero menos en la apropiación dialogada por parte del lector de los problemas a los que el texto hace frente. Basados en las aportaciones de algunas de las corrientes hermenéuticas más significativas del siglo XX, los autores fundamentan y exponen un modelo de (...) comentario de texto centrado en el diálogo establecido entre el lector y el texto. (shrink)

The overall concern of this issue is not really to question whether there is such a thing as “African philosophy.” Any question concerning “African philosophy,” i.e. a specifically pan-African discipline with its own methods and forms, is partly different from that of “African thought” in general, for the latter includes not only processes of consciousness that reflect on the natural and human fields, but also practices whose very nature is to create or express specific cultural textures. The choice of “African (...) Thought” – rather than “African Philosophy” – in this series of essays is a way of leaving the door open to thought-practices that would be considered as foreign or simply borderline to what is usually considered as philosophy by the Western establishment, that is, by those who have come to believe and persuade the rest of the world that the love of wisdom is the love of logos. (shrink)

A partir du double constat d’une carence de statut et d’une crise de sens de la topologie lacanienne du nœud borroméen, nous tenterons d’expliciter le sens phénoménologique de ce nœud. Réduit à son essence, le nœud borroméen est composé de points et de trous. Or ces trous sont le résultat de mouvements expérimentables sur un mode affectif et charnel. La pul- sion, le désir, l’amour, constituent en effet la matière phénoménale du nœud borroméen. Avec Husserl, Merleau-Ponty et Patočka, nous montrerons (...) que la Terre originaire et immobile cons- titue l’ancrage de tous ces mouvements. Les mouvements-nœuds de la vie affective reçoivent alors une signification ontologique. Ils sont autant de variantes du mouvement primordial vers l’être. (shrink)

Following Professor Obiora Ike’s view and in particular Obiora 2012, 2013, 2017 (see reference below), the more students are exposed to ethics practice, the greater their propensity and capability to seek for ethical living. This important assumption is worth close statistical scrutiny as the author shows. Through empirical researches and the stratified sampling approach, 435 university students are randomly selected to illustrate this claim. The method used is the “Perceived Role of Ethics and Democracy Outcome Scale” (PREDOS) and a survey (...) questionnaire used to measure exposure to common good ethics among the respondents. Descriptive analysis – tables and analysis and covariance (ANCOVA), are aimed at facilitating the analysis of the data collected in the study. In tandem with the conclusions drawn from extant literature and works of Professor Obiora Ike, the findings, as the author see, show that exposure to common good ethics has a significant positive effect on students’ ethics practice and democracy outcomes. (shrink)

The Spirit and the Screen explores pertinent pneumatological issues that arise in film and asks how Christian convictions and experiences of the Spirit might shape the way one thinks about films and film-making.

El objetivo de este artículo es analizar las aportaciones que los avances en neuroética tienen en la toma de decisiones en las empresas. Empezaremos por cuestionar el paradigma dominante de la toma de decisiones empresariales desde el análisis crítico de los presupuestos epistemológicos de la teoría económica liberal, así como desde las perspectivas de las ciencias cognitivas y sus aportaciones al análisis del comportamiento humano. Continuaremos presentando dos grandes modelos de toma de decisiones éticas que se basan en la creación (...) de sentido intuitivo y que tienen sus fundamentos en los avances de las neurociencias. Concluiremos con breves observaciones críticas. (shrink)

El artículo estudia la heráldica los linajes vinculados al Castillo de Portillo, desde el reinado de Enrique IV de Castilla (1454).