IntroductionPreoperative neurocognitive disorder is a common condition affecting 14–51. 7% of the elderly population. General anesthesia has already been associated with the one-year post-operative neurocognitive disorder, specifically, a deficit in executive function, measured by the Trail Making Test B, but its long-term effects on cognitive function have not been investigated. We aimed to detect preO-NCD prevalence in patients scheduled for cardiac surgery and further investigate the possible role of previous general anesthesia in general preoperative cognitive status [measured via the Montreal (...) Cognitive Assessment ] and/or in executive functioning.MethodsIn this observational, prospective study, 151 adult patients scheduled for elective cardiac surgery underwent MoCA and TMT-B. Data on age, education, pGA, comorbidities, and laboratory results were collected.ResultsWe discovered a general cognitive function impairment of 79.5% and an executive function impairment of 22%. Aging is associated with an increased likelihood and education with a decreased likelihood of general cognitive impairment, but only education was significantly associated with a decreased likelihood of executive function impairment. While pGA did not significantly affect preO-NCD, a noteworthy interaction between aging and pGA was found, resulting in a synergistic effect, increasing the likelihood of executive function impairment.ConclusionWe found a high prevalence of preO-NCD in patients scheduled for cardiac surgery. General cognitive function impairment is highly associated with advancing age. However, older patients with at least one pGA appeared to be at an increased risk of preO-NCD, especially executive function impairment, suggesting that TMT-B should be associated with MoCA in the preoperative cognitive evaluation in this population. (shrink)

This book presents a comprehensive and detailed exploration of the relationship between the thought of G.W.F. Hegel and that of John McDowell, the latter of whom is widely considered to be one of the most influential living analytic philosophers. It serves as a point of entry in McDowell’s and Hegel’s philosophy, and a substantial contribution to ongoing debates on perceptual experience and perceptual justification, naturalism, human freedom and action. The chapters gathered in this volume, as well as McDowell’s responses, make (...) it clear that McDowell’s work paves the way for an original reading of Hegel’s texts. His conceptual framework allows for new interpretive possibilities in Hegel’s philosophy which, until now, have remained largely unexplored. Moreover, these interpretations shed light on various aspects of continuity and discontinuity between the philosophies of these two authors, thus defining more clearly their positions on specific issues. In addition, they allow us to see Hegel’s thought as containing a number of conceptual tools that might be useful for advancing McDowell’s own philosophy and contemporary philosophy in general. (shrink)

The goal of this article is to show that formal analysis and reconstructions may be useful to discuss and shed light on substantive meta-theoretical issues. We proceed here by exemplification, analysing and reconstructing as a case study a paradigmatic biochemical theory, the Monod-Wyman-Changeux theory of allosterism, and applying the reconstruction to the discussion of some issues raised by prominent representatives of the new mechanist philosophy. We conclude that our study shows that at least in this case mechanicism and more traditional (...) accounts are not rivals but complementary approaches. (shrink)

A Second level Master in “Clinical Bioethics Consultation” has been organized in Italy to offer an opportunity to offer an adequate training to carry out an ethics consultation in different health fields. The master has been promoted and realized by different institutions: Catholic University of Sacred Hearth in Rome, Insubria University in Varese, “Federico II” University in Naples, Lanza Foundation in Padua and the Local Health and Social Care Unit n.7 in Veneto Region. The aim of the master is (...) train ethics consultants to offer help regarding a correct decision, which will take by others. The choice must be as much as possible shared between patient, family and health care team. Ethics consultation can be primarily request by the physicians, nurses and health care staff such as support about a choice that wants to be the most appropriate and to clarify a dilemma between different options. Secondly an ethics consultation can be demand by the patient and the family members to find a clarification about their dilemmas and future choices. Also the administrative staff could ask the consultation, when it need to better explain ad example about a specific clinical case or a question concerned the health policy. (shrink)

We present a generalization of the problem of pattern recognition to arbitrary probabilistic models. This version deals with the problem of recognizing an individual pattern among a family of different species or classes of objects which obey probabilistic laws which do not comply with Kolmogorov’s axioms. We show that such a scenario accommodates many important examples, and in particular, we provide a rigorous definition of the classical and the quantum pattern recognition problems, respectively. Our framework allows for the introduction of (...) non-trivial correlations between the different species involved, opening the door to a new way of harnessing these physical resources for solving pattern recognition problems. Finally, we present some examples and discuss the computational complexity of the quantum pattern recognition problem, showing that the most important quantum computation algorithms can be described as non-Kolmogorovian pattern recognition problems. (shrink)

Although the idea of dignity has always been applied to human beings and although its role is far from being uncontroversial, some recent works in animal ethics have tried to apply the idea of dignity to animals. The aim of this paper is to discuss critically whether these attempts are convincing and sensible. In order to assess these proposals, I put forward two formal conditions that any conception of dignity must meet and outline three main approaches which might justify the (...) application of dignity to animals: the species-based approach, moral individualism and the relational approach. Discussing in particular works by Martha Nussbaum and Michael Meyer I argue that no approach can convincingly justify the extension of dignity to animals because all fail to meet the formal conditions and do not provide an appropriate basis for animal dignity. I conclude by arguing that the recognition of the moral importance of animals and their defense should appeal to other normative concepts which are more appropriate than dignity. (shrink)

According to the received view in epistemology, inferential knowledge from non-knowledge is impossible – that is, in order for a subject to know the conclusion of their inference, they must know the essential premises from which that conclusion is drawn. In this book, Federico Luzzi critically examines this view, arguing that it is less plausible than intuition suggests and that it can be abandoned without substantial cost. In a discussion that ranges across inference, testimony and memory he analyses the (...) full range of challenges to the view, connecting them to epistemological cases that support those challenges. He then proposes a defeater-based framework which allows the phenomenon of knowledge from non-knowledge across these three epistemic areas to be better understood. His book will be of interest to a wide range of readers in epistemology. (shrink)

In the same days in which Albert Einstein was completing his formulation of the theory of general relativity, David Hilbert arrived to the same field equations following a different path and different mathematical procedures. In this article, both ways to get to the same formal result will be analyzed, together with the exchange of letters between the two scientists, underlining the two different, but extremely sharp, creativities.

Human cerebral organoids are three-dimensional biological cultures grown in the laboratory to mimic as closely as possible the cellular composition, structure, and function of the corresponding organ, the brain. For now, cerebral organoids lack blood vessels and other characteristics of the human brain, but are also capable of having coordinated electrical activity. They have been usefully employed for the study of several diseases and the development of the nervous system in unprecedented ways. Research on human cerebral organoids is proceeding at (...) a very fast pace and their complexity is bound to improve. This raises the question of whether cerebral organoids will also be able to develop the unique feature of the human brain, consciousness. If this is the case, some ethical issues would arise. In this article, we discuss the necessary neural correlates and constraints for the emergence of consciousness according to some of the most debated neuroscientific theories. Based on this, we consider what the moral status of a potentially conscious brain organoid might be, in light of ethical and ontological arguments. We conclude by proposing a precautionary principle and some leads for further investigation. In particular, we consider the outcomes of some very recent experiments as entities of a potential new kind. (shrink)

The aim of this paper is to analyze an Intensive Care Unit case that required ethics consultation at a University Hospital in Northern Italy. After the case was resolved, a retrospective ethical analysis was performed by four clinical ethicists who work in different healthcare contexts. Each ethicist used a different method to analyze the case; the four general approaches provide insight into how these ethicists conduct ethics consultations at their respective hospitals. Concluding remarks examine the similarities and differences among the (...) various approaches and offer a reflection concerning the possibility of a shared resolution to the case. The authors’ efforts to come to a tentative consensus may serve as an example for professionals working in medical contexts that reflect an increasing pluralism of values. This article aims to respond to some of these concerns by illustrating how different methods in clinical ethics would be used when considering a real case. The goal is not to establish the best model on a theoretical level, but to learn from actual practice in order to see if there are common elements in the different methods, and to validate their pertinence to clinical ethics consultation. (shrink)

The Rovelli relational interpretation of quantum mechanics is based on the assumption that the notion of observer-independent state of a physical system is to be rejected. In RQM the primary target of the theory is the analysis of the whole network of relations that may be established among quantum subsystems, and the shift to a relational perspective is supposed to address in a satisfactory way the general problem of the interpretation of quantum mechanics. Here I discuss two basic issues, that (...) I take to be serious open problems of the interpretation. First, I wish to show—mainly through an analysis of the so-called third person problem—that it is far from clear what a relativization of states to observers exactly achieves and in what sense such an approach really advances our understanding of the peculiar features of quantum phenomena. Second, I argue that the claim, according to which RQM is able to preserve locality, is at best dubious. I conclude that further work needs to be done before RQM may aspire to become a satisfactory interpretational framework for the main foundational issues in quantum mechanics. (shrink)

In recent years, some scholars have claimed that humans are unique in their capacity and motivation to engage in cooperative communication and extensive, fast-paced social interactions. While research on gestural communication in great apes has offered important findings concerning the gestural repertoires of different species, very little is known about the sequential organization of primates’ communicative behavior during interactions. Drawing on a conversation analytic framework, this paper addresses this gap by investigating the sequential organization of bonobo mother-infant interactions, and more (...) specifically, how individuals solicit carries from one another. It shows how bonobos establish participation frameworks before producing a carry request gesture and how the ensuing communicative actions can be organized in adjacency-pair sequences. Moreover, the timing between the initiation of an action and its response is similar to what has been documented in adult human interaction. Finally, it outlines some of the orderly practices bonobos use to deal with the absence of response from the addressed participants in carry sequences. Keywords: adjacency pair; pan paniscus ; conversation analysis; gestures; interactional time; sequence organization. (shrink)

The principle of equal consideration of interests is a very popular principle in animal ethics. Peter Singer employs it to ground equal treatment and solve the problem of the basis of equality, namely the problem of why we should grant equal treatment despite the variability of people’s features. In this paper, I challenge Singer’s argument because ECOI does not provide plausible grounds to presume that the interests of diverse individuals are actually equal. Analyzing the case of pain and the interest (...) in not suffering in particular, I contend that there are some insurmountable epistemic and axiological problems in accounting for the equality of interests. Besides criticizing ECOI as a basis of equality, I argue that we need to rely on an equality of moral status. I conclude by providing some considerations on the relation between equality and the principle of proportionality. (shrink)

We will present a three-valued consequence relation for metainferences, called CM, defined through ST and TS, two well known substructural consequence relations for inferences. While ST recovers every classically valid inference, it invalidates some classically valid metainferences. While CM works as ST at the inferential level, it also recovers every classically valid metainference. Moreover, CM can be safely expanded with a transparent truth predicate. Nevertheless, CM cannot recapture every classically valid meta-metainference. We will afterwards develop a hierarchy of consequence relations (...) CMn for metainferences of level n. Each CMn recovers every metainference of level n or less, and can be nontrivially expanded with a transparent truth predicate, but cannot recapture every classically valid metainferences of higher levels. Finally, we will present a logic CMω, based on the hierarchy of logics CMn, that is fully classical, in the sense that every classically valid metainference of any level is valid in it. Moreover, CMω can be nontrivially expanded with a transparent truth predicate. (shrink)

In previous works, an ontology of properties for quantum mechanics has been proposed, according to which quantum systems are bundles of properties with no principle of individuality. The aim of the present article is to show that, since quasi-set theory is particularly suited for dealing with aggregates of items that do not belong to the traditional category of individual, it supplies an adequate meta-language to speak of the proposed ontology of properties and its structure.

This paper addresses the problem of pluralism in democratic societies, by exploiting some insights from the debate about the epistemology of disagreement. First, by focusing on the permissibility of experiments on nonhuman animals for research purposes, we provide an epistemic analysis of deep normative disagreements. We understand that to mean disagreements in which epistemic peers disagree about both the substantive content of an ethical issue and the correct justificatory reasons for their contrary claims. Second, we argue for a compromise solution (...) in which the reasons for reaching it are not prudential but grounded on the recognition of epistemic peerhood. (shrink)

Jeff McMahan has recently provided a forceful defense of methodological anti-speciesism against speciesists’ claim that species standard is a meaningful criterion to assess the value of lives and the nature of deprivation. In this paper I discuss McMahan’s favored account (the Intrinsic Potential Account) to assess the value of life and the nature of deprivation and challenge its overall ethical and methodological tenability. I level three charges against the Intrinsic Potential Account. I argue, first, that it cannot be consistent with (...) some widely held egalitarian moral intuitions. Second, it is unconvincing in its justification of the idea of equal respect for persons. Third, it is unclear how it can make sense of the value of individual capacities without referring to some species-based standard. Although I remain neutral with respect to the debate between anti-speciesists and speciesists, I argue that anti-speciesists cannot rely on McMahan’s arguments. (shrink)

This book is the first to present a comprehensive investigation of the technical features of the metainferential logics developed in the last years, with their most relevant results and applications. It provides some new paths to define and investigate metainferential logics and offers a thorough study of the semantics and the proof-theories of this new and exciting variety of families of logics. This volume examines the hierarchies of metainferential logics and gives a general and systematic theory of them, and of (...) the truth theories based on these logics. This book puts forward the prospects for truth-theories based on the metainferential logics of the TS/ST hierarchy and argues for its promise noting that each of these logics can be safely expanded with a transparent truth predicate. It also goes onto to explore new developments in three fields related to logics – namely metainferential logics built by means of the Weak Kleene schema and combining them with logics defined through the Strong Kleene schema, proof-theoretic presentations, and those with a with a global or an absolutely global validity standard, instead of a local one. This book is of interest to scholars in formal logic. (shrink)

En este artículo, analizamos el significado de las matrices densidad en el formalismo de la mecánica cuántica. Discutimos el problema de los "sistemas cuánticos compuestos" en la lógica cuántica así como también la interpretación de las mezclas impropias. Tomando en cuenta el desarrollo de la lógica cuántica convexa, presentamos un análisis de la estructura formal de la teoría que, argumentaremos, debe ser considerado a la hora de desarrollar un nuevo esquema conceptual para la interpretación de las mezclas cuánticas. In this (...) article, we analyze the meaning of density matrices within the formalism of quantum mechanics. We discuss the problem of compound systems in the context of quantum logic as well as the interpretation of improper mixtures. Taking into account the development of convex quantum logic, we present an analysis of the formal structure of the theory which we will argue, must be taken into account when developing a new conceptual scheme for the interpretation of quantum mixtures. (shrink)

Spacetime measurements and gravitational experiments are made by using objects, matter fields or particles and their mutual relationships. As a consequence, any operationally meaningful assertion about spacetime is in fact an assertion about the degrees of freedom of the matter (i.e. non gravitational) fields; those, say for definiteness, of the Standard Model of particle physics. As for any quantum theory, the dynamics of the matter fields can be described in terms of a unitary evolution of a state vector in a (...) Hilbert space. By writing the Hilbert space as a generic tensor product of “subsystems” we analyse the evolution of a state vector on an information theoretical basis and attempt to recover the usual spacetime relations from the information exchanges between these subsystems. We consider generic interacting second quantized models with a finite number of fermionic degrees of freedom and characterize on physical grounds the tensor product structure associated with the class of “localized systems” and therefore with “position”. We find that in the case of free theories no spacetime relation is operationally definable. On the contrary, by applying the same procedure to the simple interacting model of a one-dimensional Heisenberg spin chain we recover the tensor product structure usually associated with “position”. Finally, we discuss the possible role of gravity in this framework. (shrink)