IntroductionPreoperative neurocognitive disorder is a common condition affecting 14–51. 7% of the elderly population. General anesthesia has already been associated with the one-year post-operative neurocognitive disorder, specifically, a deficit in executive function, measured by the Trail Making Test B, but its long-term effects on cognitive function have not been investigated. We aimed to detect preO-NCD prevalence in patients scheduled for cardiac surgery and further investigate the possible role of previous general anesthesia in general preoperative cognitive status [measured via the Montreal (...) Cognitive Assessment ] and/or in executive functioning.MethodsIn this observational, prospective study, 151 adult patients scheduled for elective cardiac surgery underwent MoCA and TMT-B. Data on age, education, pGA, comorbidities, and laboratory results were collected.ResultsWe discovered a general cognitive function impairment of 79.5% and an executive function impairment of 22%. Aging is associated with an increased likelihood and education with a decreased likelihood of general cognitive impairment, but only education was significantly associated with a decreased likelihood of executive function impairment. While pGA did not significantly affect preO-NCD, a noteworthy interaction between aging and pGA was found, resulting in a synergistic effect, increasing the likelihood of executive function impairment.ConclusionWe found a high prevalence of preO-NCD in patients scheduled for cardiac surgery. General cognitive function impairment is highly associated with advancing age. However, older patients with at least one pGA appeared to be at an increased risk of preO-NCD, especially executive function impairment, suggesting that TMT-B should be associated with MoCA in the preoperative cognitive evaluation in this population. (shrink)

This article defends the centrality of practical wisdom in medical practice by building on a monistic view of moral virtue, termed the “Aretai model,” according to which possession of practical wisdom is necessary and sufficient for virtuousness, grounding both moral growth and effective moral behavior. From this perspective, we argue that practical wisdom should be conceived as a cross-situational ethical expertise consisting of four skills:moral perception, moral deliberation, emotion regulation, and moral motivation. Conceiving of practical wisdom as both overall virtuousness (...) and ethical expertise makes it possible to deal adequately with the uniqueness of concrete ethically relevant situations. We contend that this becomes particularly evident in the context of medical practice, both in terms of decision-making and action-taking, especially in the most challenging or contentious clinical cases. We conclude the article by suggesting the potential implications of the Aretai model for continuing education in medical and healthcare professions. (shrink)

RESUMEN El artículo reconstruye la concepción metodológica de Leibniz de finales del periodo parisino, que subyace al tratado Sobre la cuadratura aritmética del círculo, la elipse y la hipérbola (1676). Se muestra que Leibniz concibió un procedimiento en el cual el hallazgo de nuevos conocimientos de alguna manera coincide con su demostración, y en el que los procesos de análisis y síntesis se emplean de diversas maneras. ABSTRACT The article reconstructs Leibniz's methodological conception of the late Parisian period underlying the (...) treatise On the Arithmetical Squaring of the Circle, the Ellipse, and the Hyperbola (1676). It is shown that Leibniz conceived of a procedure where the finding of new knowledge somehow coincided with its demonstration and in which the processes of analysis and synthesis were employed in various ways. (shrink)

Resumen: En este trabajo examinaremos la evolución del tratamiento de la noción de “espacio” en los escritos de juventud de Leibniz. Distinguiremos tres momentos del desarrollo de esta noción. En un primer momento, consideraremos la concepción del espacio como un “lugar universal” que el filósofo de Leipzig presentó entre 1669 y 1671. En segundo lugar, abordaremos algunos escritos físicos de 1672 en los que introdujo el movimiento en la definición de cuerpo. Esto lo llevó a rechazar su concepción anterior del (...) espacio como “lugar universal”. En tercer lugar, consideraremos algunos textos redactados entre 1675 y 1676 en los que elaboró un examen de la noción de “espacio universal” que difiere de la concepción desarrollada en el periodo preparisino y que se vincula con el surgimiento de la noción de extensión como atributo de Dios.: In this paper we will examine the evolution of the treatment of the notion of “space” in the young Leibniz’s writings. We will distinguish three moments of the development of this notion. First, we will consider the conception of space as a “universal place” which the philosopher of Leipzig presented between 1669 and 1671. Then, we will examine some physical writings of 1672 in which he introduced motion in the definition of body. This led him to reject his previous conception of space as “universal place”. Third, we will consider some texts written between 1675 and 1676 in which he developed an exam of the notion of “universal space” which differs from the conception he held in the pre-Parisian period and which is related with the emergence of the notion of extension as an attribute of God. (shrink)

La teoría del derecho de Robert Alexy. Análisis y crítica es un libro escrito por el profesor Jan-R. Sieckmann, de la Universidad Friedrich-Alexander de Erlangen-Nürnberg, y publicado en la prestigiosa serie de teoría jurídica y filosofía del derecho de la editorial Universidad Externado de Colombia. El libro sistematiza un conjunto de trabajos que tratan sobre la conocida teoría del derecho...

Este trabajo busca responder al siguiente interrogante: ¿es posible resolver confl ictos entre normas constitucionales que disponen derechos fundamentales sin necesidad de ponderar? Para ello expondremos la teoría que, para los casos de confl ictos constitucionales de derechos, propone reconstruir sistemas normativos. Esta teoría está representada en los trabajos de Moreso, Mendonca y Martínez Zorrilla y se presenta como una alternativa a la ponderación. Concluiremos que, si bien esta teoría puede resultar un buen complemento a la hora de formalizar las (...) decisiones judiciales sobre asuntos constitucionales, no puede reemplazar de plano a la ponderación, pues ésta siempre subyacería latente. Ello puede vislumbrarse con claridad en los casos donde derechos sociales fundamentales pretenden validez, en cuyo contexto la ponderación se presenta como algo conceptualmente necesario. (shrink)

El tema de este trabajo es el benchmarking en el sector público. Esta investigación, parte del interés por analizar la importancia que ha cobrado el benchmarking en el sector como herramienta de mejora e innovación de la gestión pública donde los Estados comprometen esfuerzos para conseguir calidad, eficiencia y eficacia en los servicios que presta. En esta lógica se inscribe el principal objetivo, que consiste en realizar aportes y propuestas, para la implementación de herramientas de benchmarking en las dimensiones transversales (...) y regionales del Estado de la Provincia de Buenos Aires. El estudio es exploratorio y descriptivo, emplea una metodología cualitativa que combina un análisis bibliográfico para la elaboración del marco teórico y la definición de los tipos y dimensiones del benchmarking, con la identificación y descripción de experiencias a partir de la evidencia empírica relevada. El punto de partida teórico, se estructura en base a los modelos y enfoques desarrollados por Robert Camp, Michael Spendolini, Rolf Pfeiffer y Fernando Marchitto. Este marco conceptual, permite examinar distintas prácticas institucionales de los niveles subnacional, nacional e internacional. (shrink)

¿De qué hablamos cuando decimos Diseño Sustentable? El diseño sustentable podría definirse como el diseño que tiene en cuenta los aspectos ambientales en todos los niveles de producción. Así mismo, persigue el objetivo de fabricar productos que aporten el menor impacto posible en el ecosistema a lo largo de todo el ciclo de vida. Es muy difícil encontrar productos de consumo que cumplan puntualmente con los Preceptos del eco diseño y que sean exitosos en el mercado. Ante esta situación es (...) necesario revisar los aspectos involucrados en la concepción de un nuevo producto: ¿El rol del diseñador es el adecuado?, ¿Existe una seria y responsable conciencia por parte de los empresarios para llevar adelante un proyecto de eco diseño?, ¿Son los productos eco lo suficientemente atractivos para captar la atención de los consumidores? (shrink)

This book gathers experiences, reflections and new pedagogical proposals that are being incorporated to the teaching practices, in different levels of the technical education in our countries. The authors' interventions, which cover different perspectives and depth, allow us to understand and evaluate: the trajectories that technical education has had since its origins with the advances and setbacks it has experienced with political, economic and productive changes; the methodologies to incorporate the new models of industrial production; the experiences of education for (...) entrepreneurship; and, technical-professional education in development processes. (shrink)

A Second level Master in “Clinical Bioethics Consultation” has been organized in Italy to offer an opportunity to offer an adequate training to carry out an ethics consultation in different health fields. The master has been promoted and realized by different institutions: Catholic University of Sacred Hearth in Rome, Insubria University in Varese, “Federico II” University in Naples, Lanza Foundation in Padua and the Local Health and Social Care Unit n.7 in Veneto Region. The aim of the master is (...) train ethics consultants to offer help regarding a correct decision, which will take by others. The choice must be as much as possible shared between patient, family and health care team. Ethics consultation can be primarily request by the physicians, nurses and health care staff such as support about a choice that wants to be the most appropriate and to clarify a dilemma between different options. Secondly an ethics consultation can be demand by the patient and the family members to find a clarification about their dilemmas and future choices. Also the administrative staff could ask the consultation, when it need to better explain ad example about a specific clinical case or a question concerned the health policy. (shrink)

We present a generalization of the problem of pattern recognition to arbitrary probabilistic models. This version deals with the problem of recognizing an individual pattern among a family of different species or classes of objects which obey probabilistic laws which do not comply with Kolmogorov’s axioms. We show that such a scenario accommodates many important examples, and in particular, we provide a rigorous definition of the classical and the quantum pattern recognition problems, respectively. Our framework allows for the introduction of (...) non-trivial correlations between the different species involved, opening the door to a new way of harnessing these physical resources for solving pattern recognition problems. Finally, we present some examples and discuss the computational complexity of the quantum pattern recognition problem, showing that the most important quantum computation algorithms can be described as non-Kolmogorovian pattern recognition problems. (shrink)

According to the received view in epistemology, inferential knowledge from non-knowledge is impossible – that is, in order for a subject to know the conclusion of their inference, they must know the essential premises from which that conclusion is drawn. In this book, Federico Luzzi critically examines this view, arguing that it is less plausible than intuition suggests and that it can be abandoned without substantial cost. In a discussion that ranges across inference, testimony and memory he analyses the (...) full range of challenges to the view, connecting them to epistemological cases that support those challenges. He then proposes a defeater-based framework which allows the phenomenon of knowledge from non-knowledge across these three epistemic areas to be better understood. His book will be of interest to a wide range of readers in epistemology. (shrink)

The aim of this paper is to analyze an Intensive Care Unit case that required ethics consultation at a University Hospital in Northern Italy. After the case was resolved, a retrospective ethical analysis was performed by four clinical ethicists who work in different healthcare contexts. Each ethicist used a different method to analyze the case; the four general approaches provide insight into how these ethicists conduct ethics consultations at their respective hospitals. Concluding remarks examine the similarities and differences among the (...) various approaches and offer a reflection concerning the possibility of a shared resolution to the case. The authors’ efforts to come to a tentative consensus may serve as an example for professionals working in medical contexts that reflect an increasing pluralism of values. This article aims to respond to some of these concerns by illustrating how different methods in clinical ethics would be used when considering a real case. The goal is not to establish the best model on a theoretical level, but to learn from actual practice in order to see if there are common elements in the different methods, and to validate their pertinence to clinical ethics consultation. (shrink)

Human cerebral organoids are three-dimensional biological cultures grown in the laboratory to mimic as closely as possible the cellular composition, structure, and function of the corresponding organ, the brain. For now, cerebral organoids lack blood vessels and other characteristics of the human brain, but are also capable of having coordinated electrical activity. They have been usefully employed for the study of several diseases and the development of the nervous system in unprecedented ways. Research on human cerebral organoids is proceeding at (...) a very fast pace and their complexity is bound to improve. This raises the question of whether cerebral organoids will also be able to develop the unique feature of the human brain, consciousness. If this is the case, some ethical issues would arise. In this article, we discuss the necessary neural correlates and constraints for the emergence of consciousness according to some of the most debated neuroscientific theories. Based on this, we consider what the moral status of a potentially conscious brain organoid might be, in light of ethical and ontological arguments. We conclude by proposing a precautionary principle and some leads for further investigation. In particular, we consider the outcomes of some very recent experiments as entities of a potential new kind. (shrink)

The Rovelli relational interpretation of quantum mechanics is based on the assumption that the notion of observer-independent state of a physical system is to be rejected. In RQM the primary target of the theory is the analysis of the whole network of relations that may be established among quantum subsystems, and the shift to a relational perspective is supposed to address in a satisfactory way the general problem of the interpretation of quantum mechanics. Here I discuss two basic issues, that (...) I take to be serious open problems of the interpretation. First, I wish to show—mainly through an analysis of the so-called third person problem—that it is far from clear what a relativization of states to observers exactly achieves and in what sense such an approach really advances our understanding of the peculiar features of quantum phenomena. Second, I argue that the claim, according to which RQM is able to preserve locality, is at best dubious. I conclude that further work needs to be done before RQM may aspire to become a satisfactory interpretational framework for the main foundational issues in quantum mechanics. (shrink)

We will present a three-valued consequence relation for metainferences, called CM, defined through ST and TS, two well known substructural consequence relations for inferences. While ST recovers every classically valid inference, it invalidates some classically valid metainferences. While CM works as ST at the inferential level, it also recovers every classically valid metainference. Moreover, CM can be safely expanded with a transparent truth predicate. Nevertheless, CM cannot recapture every classically valid meta-metainference. We will afterwards develop a hierarchy of consequence relations (...) CMn for metainferences of level n. Each CMn recovers every metainference of level n or less, and can be nontrivially expanded with a transparent truth predicate, but cannot recapture every classically valid metainferences of higher levels. Finally, we will present a logic CMω, based on the hierarchy of logics CMn, that is fully classical, in the sense that every classically valid metainference of any level is valid in it. Moreover, CMω can be nontrivially expanded with a transparent truth predicate. (shrink)

This paper addresses the problem of pluralism in democratic societies, by exploiting some insights from the debate about the epistemology of disagreement. First, by focusing on the permissibility of experiments on nonhuman animals for research purposes, we provide an epistemic analysis of deep normative disagreements. We understand that to mean disagreements in which epistemic peers disagree about both the substantive content of an ethical issue and the correct justificatory reasons for their contrary claims. Second, we argue for a compromise solution (...) in which the reasons for reaching it are not prudential but grounded on the recognition of epistemic peerhood. (shrink)

In previous works, an ontology of properties for quantum mechanics has been proposed, according to which quantum systems are bundles of properties with no principle of individuality. The aim of the present article is to show that, since quasi-set theory is particularly suited for dealing with aggregates of items that do not belong to the traditional category of individual, it supplies an adequate meta-language to speak of the proposed ontology of properties and its structure.

This book is the first to present a comprehensive investigation of the technical features of the metainferential logics developed in the last years, with their most relevant results and applications. It provides some new paths to define and investigate metainferential logics and offers a thorough study of the semantics and the proof-theories of this new and exciting variety of families of logics. This volume examines the hierarchies of metainferential logics and gives a general and systematic theory of them, and of (...) the truth theories based on these logics. This book puts forward the prospects for truth-theories based on the metainferential logics of the TS/ST hierarchy and argues for its promise noting that each of these logics can be safely expanded with a transparent truth predicate. It also goes onto to explore new developments in three fields related to logics – namely metainferential logics built by means of the Weak Kleene schema and combining them with logics defined through the Strong Kleene schema, proof-theoretic presentations, and those with a with a global or an absolutely global validity standard, instead of a local one. This book is of interest to scholars in formal logic. (shrink)

ABSTRACTWe will present 12 different mixed metainferential consequence relations. Each one of them is specified using two different inferential Tarskian or non-Tarskian consequence relations: or. We will show that it is possible to obtain a Tarskian logic with non-Tarskian inferential logics, but also a non-Tarskian logic with Tarskian inferential logics. Moreover, we will show how some of these metainferential logics work better than the corresponding inferential rivals. Finally, we will show how these logics prove that it is not enough to (...) work with inferences as pairs of sets of formulas to obtain a contractive logic. (shrink)

The terrorist attacks that struck France in 2015 had reverberations throughout the country’s intellectual fields. Among the most significant was a widespread polemic that turned around whether sociological explanations of the attacks amounted to excuses and justifications for terrorists. When prominent politicians and pundits made allegations of this nature, sociologists reacted in three main ways: most denied the allegations, others reappropriated the derogatory label of excuse, while others still accepted criticism and called for a reformation of sociology. These epistemological stances (...) can be properly understood only by studying the long history of debates around ‘sociological excuses’ in France and by analysing French sociology as a field of forces and struggles. (shrink)

The social sciences are predominantly seen by their practitioners as critical endeavours, which should inform criticism of harmful institutions, beliefs and practices. Accordingly, political attacks on the social sciences are often interpreted as revealing an unwillingness to accept criticism and an acquiescence with the status quo. But this dominant view of the political implications of social scientific knowledge misses the fact that people can also be outraged by what they see as its apologetic potential, namely that it provides excuses or (...) justifications for people doing bad things, preventing them from being rightfully blamed and punished. This introduction to the special issue sketches the long history of debates about the exculpatory and justificatory consequences of social science and lays the foundations for a theory of social scientific apologia by examining three main aspects: what social and cognitive processes motivate this type of accusation, how social theorists respond to it and whether different contexts of circulation of ideas affect how these controversies unfold. (shrink)

En este artículo, analizamos el significado de las matrices densidad en el formalismo de la mecánica cuántica. Discutimos el problema de los "sistemas cuánticos compuestos" en la lógica cuántica así como también la interpretación de las mezclas impropias. Tomando en cuenta el desarrollo de la lógica cuántica convexa, presentamos un análisis de la estructura formal de la teoría que, argumentaremos, debe ser considerado a la hora de desarrollar un nuevo esquema conceptual para la interpretación de las mezclas cuánticas. In this (...) article, we analyze the meaning of density matrices within the formalism of quantum mechanics. We discuss the problem of compound systems in the context of quantum logic as well as the interpretation of improper mixtures. Taking into account the development of convex quantum logic, we present an analysis of the formal structure of the theory which we will argue, must be taken into account when developing a new conceptual scheme for the interpretation of quantum mixtures. (shrink)

According to a shared functionalist view in philosophy of mind, a cognitive system, and cognitive function thereof, is based on the components of the organism it is realized by which, indeed, play a causal role in regulating our cognitive processes. This led philosophers to suggest also that, thus, cognition could be seen as an extended process, whose vehicle can extend not only outside the brain but also beyond bodily boundaries, on different kinds of devices. This is what we call the (...) ‘Externally Extended Cognition Thesis.’ This notion has generated a lively debate. Here, we offer a novel notion of extended cognition, according to which cognition can be seen as being realized outside the brain, but still inside the body. This is what we call the ‘Internally Extended Cognition Thesis’. Not only our thesis but also our approach while defending it is innovative. The argument we offer is supported by recent empirical findings in the life sciences and biomedicine, which suggest that the gut microbiota’s activity has a functional role in regulating our cognitive processes and behaviors. In doing so, we embrace the holobiont-perspective, according to which it is possible to claim that what we call biological individuals are not autonomous entities with clear boundaries, but should rather be seen as networks of multiple interactions among species. Thus, by analyzing different sets of evidence in light of the holobiont-perspective, we argue that the gut microbiota could be seen as a component of our organism. On the basis of the philosophical interpretation of this evidence, however, we also suggest that there are no impediments standing the way of considering the gut microbiota also as a functional extension of our cognitive system. If so, this amounts to extending cognition out of ‘our skull’, though still confining it within ‘our body’: to ‘our gut’. This is an instance of the ‘Internally Extended Cognition Thesis,’ whose benefits for an original theory of extended cognition are discussed. (shrink)

In this work we discuss issues of ontological commitment towards one of the most important examples of contemporary fundamental science: the standard model of particle physics. We present a new form of selective structural realism, which uses as its basis the distinction between what have been called framework and interaction theories. This allows us to advance the ongoing debate about the ontological status of (quasi-)particles and quantum fields, by emphasising the distinction between quantum field theory serving as a framework, and (...) the standard model itself, which we argue is an interaction theory embedded within this framework. Following a discussion of what ontological commitments corresponds to each of these two classes, we argue that some of the previous proposals in the literature might have been misguided by the blending of quantum field theory and the standard model into an undifferentiated unity, and defend a moderate form of object realism with respect to particle-like entities. (shrink)

Observables have a dual nature in both classical and quantum kinematics: they are at the same time quantities, allowing to separate states by means of their numerical values, and generators of transformations, establishing relations between different states. In this work, we show how this twofold role of observables constitutes a key feature in the conceptual analysis of classical and quantum kinematics, shedding a new light on the distinguishing feature of the quantum at the kinematical level. We first take a look (...) at the algebraic description of both classical and quantum observables in terms of Jordan–Lie algebras and show how the two algebraic structures are the precise mathematical manifestation of the twofold role of observables. Then, we turn to the geometric reformulation of quantum kinematics in terms of Kähler manifolds. A key achievement of this reformulation is to show that the twofold role of observables is the constitutive ingredient defining what an observable is. Moreover, it points to the fact that, from the restricted point of view of the transformational role of observables, classical and quantum kinematics behave in exactly the same way. Finally, we present Landsman’s general framework of Poisson spaces with transition probability, which highlights with unmatched clarity that the crucial difference between the two kinematics lies in the way the two roles of observables are related to each other. (shrink)

Although the idea of dignity has always been applied to human beings and although its role is far from being uncontroversial, some recent works in animal ethics have tried to apply the idea of dignity to animals. The aim of this paper is to discuss critically whether these attempts are convincing and sensible. In order to assess these proposals, I put forward two formal conditions that any conception of dignity must meet and outline three main approaches which might justify the (...) application of dignity to animals: the species-based approach, moral individualism and the relational approach. Discussing in particular works by Martha Nussbaum and Michael Meyer I argue that no approach can convincingly justify the extension of dignity to animals because all fail to meet the formal conditions and do not provide an appropriate basis for animal dignity. I conclude by arguing that the recognition of the moral importance of animals and their defense should appeal to other normative concepts which are more appropriate than dignity. (shrink)