The CRISPR-Cas systems of bacterial and archaeal adaptive immunity have become a household name among biologists and even the general public thanks to the unprecedented success of the new generation of genome editing tools utilizing Cas proteins. However, the fundamental biological features of CRISPR-Cas are of no lesser interest and have major impacts on our understanding of the evolution of antivirus defense, host-parasite coevolution, self versus non-self discrimination and mechanisms of adaptation. CRISPR-Cas systems present the best known case in point (...) for Lamarckian evolution, i.e. generation of heritable, adaptive genomic changes in response to encounters with external factors, in this case, foreign nucleic acids. CRISPR-Cas systems employ multiple mechanisms of self versus non-self discrimination but, as is the case with immune systems in general, are nevertheless costly because autoimmunity cannot be eliminated completely. In addition to the autoimmunity, the fitness cost of CRISPR-Cas systems appears to be determined by their inhibitory effect on horizontal gene transfer, curtailing evolutionary innovation. Hence the dynamic evolution of CRISPR-Cas loci that are frequently lost and acquired by archaea and bacteria. Another fundamental biological feature of CRISPR-Cas is its intimate connection with programmed cell death and dormancy induction in microbes. In this and, possibly, other immune systems, active immune response appears to be coupled to a different form of defense, namely, “altruistic” shutdown of cellular functions resulting in protection of neighboring cells. Finally, analysis of the evolutionary connections of Cas proteins reveals multiple contributions of mobile genetic elements to the origin of various components of CRISPR-Cas systems, furthermore, different biological systems that function by genome manipulation appear to have evolved convergently from unrelated MGE. The shared features of adaptive defense systems and MGE, namely the ability to recognize and cleave unique sites in genomes, make them ideal candidates for genome editing and engineering tools. (shrink)

In this major contribution to philosophy and rhetoric, Eugene Garver shows how Aristotle integrates logic and virtue in his great treatise, the _Rhetoric._ He raises and answers a central question: can there be a civic art of rhetoric, an art that forms the character of citizens? By demonstrating the importance of the _Rhetoric_ for understanding current philosophical problems of practical reason, virtue, and character, Garver has written the first work to treat the _Rhetoric_ as philosophy and to connect its (...) themes with parallel problems in Aristotle's _Ethics_ and _Politics._ Garver's study will help put rhetoric at the center of investigations of practice and practical reason. (shrink)

What role should it play? And are claims to rationality liberating or oppressive? For the Sake of Argument addresses questions such as these to consider the relationship between thought and character.

The most compelling arguments for ethical veganism hinge on premise-pairs linking the serious wrongness of factory farming to that of buying its products: one premise claiming that buying those products stands in a certain relation to factory farming itself, and one claiming that entering into that relation with a seriously wrong practice is itself wrong. I argue that all such “linkage arguments” on offer fail, granting the serious wrongness of factory farming. Each relevant relation is such that if it holds (...) between factory farming and buying its products, then it holds between some seriously wrong practice and economic transactions of an absurd number and breadth. Hence, all these premise-pairs would, if true, generate unacceptable moral overreach; each premise-pair contains at least one unacceptable member, and the linkage arguments for ethical veganism fail. (shrink)

In the writings of both C. S. Peirce and Sir Karl Popper, we can find “objectivity” defined in the pragmatic sense as being in essence “intersubjective agreement.” The present paper is focused on the general relationship between the conception of objectivity in the above pragmatic sense, and the conception of objectivity in the classical realistic sense of “nonsubjectivity,” or brute otherness, as expressed by Peirce in its purest form in his category of secondness.

: Two common ways of explaining akrasia will be presented, one which focuses on strength of desire and the other which focuses on action issuing from practical judgment. Though each is intuitive in a certain way, they both fail as explanations of the most interesting cases of akrasia. Spinoza 's own thoughts on bondage and the affects follow, from which a Spinozist explanation of akrasia is constructed. This account is based in Spinoza 's mechanistic psychology of cognitive affects. Because Spinoza (...) 's account explains action asissuing from modes of mind that are both cognitive and affective, it captures the intuitions that motivate the two traditional views while avoiding the pitfalls that result from their one‐sided approaches. This project will allow us a fuller understanding of Spinozist moral psychology. In addition to this historical value, the Spinozist theory may offer a satisfactory explanation of certain hard cases of akrasia while avoiding the problems be set by other theories. For this reason, the Spinozist account could also be seen as a useful contribution to our philosophical understanding of the phenomenon of akrasia. (shrink)

Schlossberger contends that we are to be judged morally on the basis of what we are, our "world-view," rather than what we do.In Moral Responsibility and ...

Psychologist Eugene C. Goldfield offers an exciting new theoretical framework--based, in part, on the concept of self-organization--that promises to aid researchers in their quest to discover the underlying origins and process of behavioral development.

The radical empiricism of William James was first formally presented in his seminal papers of 1904, 'Does Consciousness Exist?' and 'A World of Pure Experience'. In James's view, pure experience was to serve as the source for psychology's primary data and radical empiricism was to launch an effective critique of experimentalism in psychology, a critique from which the problem of experimentalism within science could be addressed more broadly. This collection of papers presents James's formal statements on radical empiricism and a (...) representative sample of contemporary responses from psychologists and philosophers. With only a few exceptions, these responses indicate just how badly James was misread - psychologists ignoring the heart of James's message and philosophers transforming James's metaphysics into something quite unintelligible to the emerging generation of experimental psychologists. (shrink)

The conditions of hunting and gathering through which one line of primates evolved into humans form the basis of what I term the wild self, a self marked by developmental needs of prolonged human neoteny and by deep attunement to the profusion of communicative signs of instinctive intelligence in which relatively “unmatured” hominids found themselves immersed. The passionate attunement to, and inquiry into, earth-drama, in tracking, hunting, foraging, rhythming, singing, and other arts/sciences, provided the trail to becoming human, and provide (...) external grammatical structures that became the basis of human language and animate mind. I outline my new philosophy of history as a progress in precision, counteracted by a regressive contraction of mind. The progress associated with history since the beginning of agriculturally-based civilizations can be considered as a regressive contraction from animate mind of our hunter-gatherer evolutionary past, to anthropocentric mind, and finally to the ghost in the machine world-view of mechanico-centric mind. Contemporary consumption culture represents an inversion of the original conditions of the human self, and indeed, targets aspects of developmental neoteny to condition conformity to its rational-mechanical system imperatives. (shrink)

A general introduction by John Dillon, a Russian translation, annotations and indices by Eugene Afonasin. The first annotated Russian translation of the fragments by Neopythagorean philosopher Moderatus of Gades.

This article draws on Principles of Stakeholder Managementrecently published by the Clarkson Centre for Business Ethics. The article discusses the most important principles and the reasoning behind them. First, though, it lays a foundation for the application of these principles by interpreting a massive empirical study that demonstrates strong parallels between stakeholder valuation of firms (measured as overall reputation) and shareholder valuation (stock market returns). This evidence is coupled with conceptual analysis that shows that the most famous pronouncements of Adam (...) Smith and Milton Friedman actually argue for, not against, the stakeholder approach. (shrink)

Spinoza is the great philosopher of the imagination and the first great philosopher of democracy. Rather than seeing democracy as a form of government that has overcome the need for imagination and symbols, he shows in the Tractatus Theologico-Politicus that an enlightened state depends on three myths: the myth of the sovereignty of the people so as to reconcile democracy as rule by the people with each individual living as he or she wants to live; the myth that we are (...) a people, emotionally and morally tied to some people more than to others; and, finally, the myth that the people comprises individuals who are responsible for their own destinies. The democratic imagination differs from earlier forms of politics in that the people construct the social imaginary for themselves and are guided by it without deception. It is the social imaginary thus created, or these three myths, that make room for freedom of thought and therefore for democracy. (shrink)

Throughout his career, William James defended personal consciousness. In his Principles of Psychology (1890), he declared that psychology is the scientific study of states of consciousness as such and that he intended to presume from the outset that the thinker was the thought. But while writing it, he had been investigating a dynamic psychology of the subconscious, which found a major place in his Gifford Lectures, published as The Varieties of Religious Experience in 1902. This was the clearest statement James (...) was able to make before he died with regard to his developing tripartite metaphysics of pragmatism, pluralism and radical empiricism, which essentially asked ‘Is a science of consciousness actually possible?’ James’s lineage in this regard, was inherited from an intuitive psychology of character formation that had been cast within a context of spiritual self-realization by the Swedenborgians and Transcendentalists of New England. Chief among these was his father, Henry James, Sr, and his godfather, Ralph Waldo Emerson. However, James was forced to square these ideas with the more rigorous scientific dictates of his day, which have endured to the present. As such, his ideas remain alive and vibrant, particularly among those arguing for the fusion of phenomenology, embodiment and cognitive neuroscience in the renewed search for a science of consciousness. (shrink)

It is often said that one cannot be held responsible for something one cannot help. Indeed, Ted Honderich, Paul Edwards, and C. A. Campbell have suggested that it is obtuse, barbaric, or a solecism to think otherwise 1. Thus, if (contra Sartre and others) one cannot help feeling one's emotions, one is not responsible for one's emotions. In this paper I will argue otherwise; one is responsible for one's emotions, even if one cannot help feeling them. 2 In particular, I (...) will define a rather special sense of the word 'responsible', one that is closely tied to our ordinary notion of moral worth. We are, in that special sense of the word, 'responsible' for our emotions. I will then argue that my limited sense of 'responsibility' is sufficient to warrant morale valuation of individuals, and can be used as the basis for a theory of punishment. (shrink)

This paper addresses the social, cultural, and ethical dynamics of research in regenerative medicine. The author turns to both science fiction and recent developments in regenerative medicine for clues about the future of the body and medical practice, suggesting that regenerative medicine uses the body as its own resource for the purposes of preserving life, and that by attempting to remove the body from the limitations of both mortality and contingency, regenerative medicine fundamentally alters the meaning of human.

This paper clarifies the notion of "contact with reality" by investigating one way in which lack of such contact can be expressed: the interrogative attitude. The case of a socially withdrawn, seventeen-year-old schoolboy is examined. Paul C. had long been overly logical and precise in his style of thinking. An acute disturbance began with mental fatigue along with apparent obsessive symptoms (e.g., extreme monitoring of his own actions) to the point that simple, everyday actions became very time-consuming; he also developed (...) a tendency to ask endless questions even about trivial phenomena. However, unlike those of the true obsessive, Paul's monitoring, doubting, and querying seemed to lack any emotional or personal element; he was not anxious but, rather, apathetic. Also, Paul lacked real curiosity: To him, everything had the same level of importance, and his attention was not directed by any precise or personal goal. This paper argues that Paul's interrogative attitude was actually a form of autistic-schizophrenic thinking characterized by "pragmatic weakening" and a loss of vital contact with reality, which are consequences of a weakening of the "élan vital" with its "vital propulsion toward the future." Such patients retain their intellectual powers but do not use these powers in accord with the requirements of reality. The interrogative attitude can be seen as a compensation mechanism—a way to maintain some minimal contact with the world. The paper ends with psychotherapeutic recommendations. (Abstract written by special issue editor: L.A.S.). (shrink)

During tumor evolution, cancer cells use the tumor‐stroma crosstalk to reorganize the microenvironment for maximum robustness of the tumor. The success of immune checkpoint therapy foretells a new cancer therapy paradigm: an effective cancer treatment should not aim to influence the individual components of super complex intracellular interactomes (molecular targeting), but try to disrupt the intercellular interactions between cancer and stromal cells, thus breaking the tumor as a whole. Arguments are provided in favor of a hypothesis that such interactions include (...) formation of synapse‐like structures (interfaces) where the interacting cells are located at a distance of ∼10–15 nm. Within these interfaces, molecules initiating and strengthening the interaction are organized, and allow optimum cross‐signaling; a very confined intercellular space facilitates the concentration of secreted cytokines, enhancing the paracrine cross‐communication. These features of tumors form a druggable cancer hallmark the tumor‐stroma symbiotic crosstalk—which represents a new target for efficient cancer drug discovery. (shrink)

This book compares and contrasts the ideas of some of the leading twentieth-century critics of rationalism: Gadamer, Hayek, Kolnai, MacIntyre, Oakeshott, Polanyi, Ryle, Voegelin, and Wittgenstein. This book provides important insights into this major intellectual trend of the past century.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

David Chalmers calls the problem of explaining why physical processes give rise to conscious phenomenal experience the ‘hard problem’ of consciousness. He argues convincingly that no reductive account of consciousness can solve it and offers instead a non-reductive account which takes consciousness as fundamental. This paper argues that a theory of the sort Chalmers proposes cannot hope to solve the hard problem of consciousness precisely because it takes the relation between physical processes and consciousness as fundamental rather than explicable. The (...) hard problem of consciousness is, for reasons Chalmers himself gives, insoluble. Its insolubility does not, however, impugn the naturalistic respectability of consciousness. (shrink)

The materialist interpretation of history dogmatically resolves all histories into one. Marx and Engels themselves thought philosophy progresses toward the ultimate truth of Marxism, and implicitly held all historical positions interesting since their development reveals contradictions generated by inadequacies. Bolshevik Marxism's official ideology does not include philosophy's dissolution. Marxist definitions of philosophy emphasizing correct conclusions neglect distinctively philosophical argument and method. The recent Soviet view of philosophy's history has changed from the history of superstructure to the history of conflicting materialist (...) and idealist theories, thereby conceding the centrality of philosophical ideas rather than trying to reduce them to class or economic interests. (shrink)

This article examines some of Scheler's short writings, written near the end of and shortly after the First World War. Scheler applied his phenomenology of social forms, developed in “Formalism in Ethics,” especially that of the “life community,” which has its model in the true and ancient Christian idea of community, to the problem of the spiritual and intellectual reconstruction of Europe, Germany, and the Christian churches after the end of the First World War in the hope that this would (...) ease the tensions between them. However, the changed social, political and economic conditions after the war made Scheler's analyses and suggestions irrelevant, and Scheler looked for new ways to achieve the social engagement of philosophy. (shrink)

Each of the major engineering societies has its own code of ethics. Seven “common core” clauses and several code-specific clauses can be identified. The paper articulates objections to and rationales for two clauses that raise controversy: do engineers have a duty to provide pro bono services and/or speak out on major issues, and to associate only with reputable individuals and organizations? This latter “association clause” can be justified by the “proclamative principle,” an alternative to Kant’s universalizability requirement. At the heart (...) of engineering codes of ethics, and implicit in what it is to be a moral agent, the “proclamative principle” asserts that one’s life should proclaim one’s moral stances. More specifically, it directs engineers to strive to insure that their actions, thoughts, and relationships be fit to offer to their communities as part of the body of moral precedents for how to be an engineer. Understanding codes of ethics as reflections of this principle casts light both on how to apply the codes and on the distinction between private and professional morality. (shrink)