© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

When a group does harm, sometimes there’s no obvious individual who bears moral responsibility, and yet we still intuit that someone is to blame. This apparent ‘deficit’ of moral responsibility has led some scholars to posit that groups themselves can be responsible, and that this responsibility is distributed in some uniform fashion among group members. This solution to the deficit, however, risks providing a scapegoat for individuals who have acted wrongly and shifting blame onto those who have not. Instead, this (...) article argues that, in most deficit cases, moral responsibility is borne not by the group but by specific individual members. When an individual acts within a group, she gains an increased potential for doing harm – and, accordingly, heightened duties of care toward others. These duties can, depending on the individual’s position, require amending the group’s rules, procedures, and norms. In most deficit cases, it is individuals who have failed to fulfill these duties who are responsible. (shrink)

Although medical providers rely on similar tools to “treat” intersex and trans individuals, their enactment of medicalization practices varies. To deconstruct these complexities, we employ a comparative analysis of providers who specialize in intersex and trans medicine. While both sets of providers tend to hold essentialist ideologies about sex, gender, and sexuality, we argue they medicalize intersex and trans embodiments in different ways. Providers for intersex people are inclined to approach intersex as an emergency that necessitates medical attention, whereas providers (...) for trans people attempt to slow down their patients’ urgent requests for transitioning services. Building on conceptualizations of “giving gender,” we contend both sets of providers “give gender” by “giving sex.” In both cases too, providers shift their own responsibility for their medicalization practices onto others: parents in the case of intersex, or adult recipients of care in the case of trans. According to the accounts of most providers, successful medical interventions are achieved when a person adheres to heteronormative gender practices. (shrink)

During the Philippine-American War, the Anti-Imperialist League was the organizational vanguard of an anti-imperialist movement. Research on this period of U.S. imperialism has focused on empire building, ignoring the gendered activity of anti-imperialists in the metropole. The author outlines the constitutive relationship between gendered structures and experience that informed anti-imperialists' “contentious politics,” using archival sources of the Anti-Imperialist League and anti-imperialist debates in newspapers. The author shows how anti-imperialist leaders informally included women's monetary donations, labor, networks, and reputations while formally (...) excluding their full membership. Finally, the author shows how masculinist ambivalence, or the pattern of the gendered inclusions/exclusions of anti-imperialists, explains the incremental transformations and reproductions of gendered structures in anti-imperialists' contentious politics. The author suggests masculinist ambivalence has theoretical utility for explaining gendered inclusions and exclusions in movements that are not explicitly about gender conflict or change. (shrink)

Grief is an emotion that reaches across multiple disciplines in healthcare. In this series we hear from medical students, residents and fellows, physicians, nurses, chaplains and social workers. Writers share their challenges with vulnerability, uncertainty, and emotional exhaustion. Many identify a sense of isolation within the very system they are seeking to support. While not all are confident, they have reached a new grounding after grief, these authors do offer a sense of hope for recovery and rediscovery of the joy (...) in the privilege of the practice of medicine. (shrink)

The Cistercian order, which had its origins in the late eleventh century, transformed the spiritual landscape of western Europe. The order's insistence on a return to the austerity and simplicity that had originally informed Benedictine life reenergized monasticism, spawning hundreds of new abbeys within decades. By the beginning of the thirteenth century, the Cistercians dominated monastic life, surpassing their black-robed predecessors in terms of popularity and replacing them among patrons as favored recipients of donations. Yet, while a sizable body of (...) historiography exists concerning the ability of men's houses to translate this appeal into spiritual and material success, questions remain regarding the order's female members. In particular, some scholars have constructed a narrative of financial difficulties and eventual decline for Cistercian nunneries, one that began in the thirteenth century and accelerated throughout the late Middle Ages. According to this narrative, such difficulties, by-products of the secondary status of religious women, manifested themselves in small monastic complexes and limited patrimonies. In her work on English Cistercians, Sally Thompson argues that religious women were dependent upon men because of their inferior position in medieval society and generally lacked a true religious vocation, characteristics that led to smaller, impoverished houses. Cistercian nunneries are portrayed in monastic histories as constantly struggling and are often “lumped together as being poor, scandalous, passive institutions which were eschewed by medieval patrons.” The majority of their houses are characterized by modern historians as enjoying a perilous existence at best, permanently poised on the brink of extinction and beset by a host of financial and spiritual difficulties. (shrink)

Local food systems can have economic and social benefits by providing income for producers and improving community connections. Ongoing global climate change and the acute COVID-19 pandemic crisis have shown the importance of building equity and resilience in local food systems. We interviewed ten stakeholders from organizations and institutions in a U.S. midwestern city exploring views on past, current, and future conditions to address the following two objectives: 1) Assess how local food system equity and resilience were impacted by the (...) COVID-19 pandemic, and 2) Examine how policy and behavior changes could support greater equity and resilience within urban local food systems. We used the Community Capitals Framework to organize interviewees’ responses for qualitative analyses of equity and resilience. Four types of community capital were emphasized by stakeholders: cultural and social, natural, and political capital. Participants stated that the local food system in this city is small; more weaknesses in food access, land access, and governance were described than were strengths in both pre- and post-pandemic conditions. Stakeholder responses also reflected lack of equity and resilience in the local food system, which was most pronounced for cultural and social, natural and political capitals. However, local producers’ resilience during the pandemic, which we categorized as human capital, was a notable strength. An improved future food system could incorporate changes in infrastructure (e.g., food processing), markets (e.g., values-based markets) and cultural values (e.g., valuing local food through connections between local producers and consumers). These insights could inform policy and enhance community initiatives and behavior changes to build more equitable and resilient local food systems in urban areas throughout the U.S. Midwest. (shrink)

We propose a new approach for tracing value change. Value change may lead to a mismatch between current value priorities in society and the values for which technologies were designed in the past, such as energy technologies based on fossil fuels, which were developed when sustainability was not considered a very important value. Better anticipating value change is essential to avoid a lack of social acceptance and moral acceptability of technologies. While value change can be studied historically and qualitatively, we (...) propose a more quantitative approach that uses large text corpora. It uses probabilistic topic models, which allow us to trace values that are latent. We demonstrate the approach for five types of value change in technology. Our approach is useful for testing hypotheses about value change, such as verifying whether value change has occurred and identifying patterns of value change. The approach can be used to trace value change for various technologies and text corpora, including scientific articles, newspaper articles, and policy documents. (shrink)

Conflict adaptation reflects the increase in cognitive control after previous conflict between task-relevant and task-irrelevant information. Tonic arousal elicited by emotional words e...

Although online education is becoming increasingly commonplace in health professional education, methods to evaluate student progress and knowledge base adequately remain uncertain. This paper describes a project that attempted to assess whether or not an online course was an effective way to teach applied ethics to students preparing for the health professions by qualitatively analyzing responses to a pre-test and post-test administered to students in the course. While previous studies have reported various findings regarding the success of online ethics courses, (...) our study failed to demonstrate that students gained a greater understanding of key concepts in ethics—respect for autonomy, decisional capacity, informed consent, and role of the provider. Our findings demonstrate the need for better subjective methods of evaluation and raise questions regarding the efficacy of current models of online ethics courses for health professional students. (shrink)

Although written consent forms are standard in clinical research, there is little regulatory or empirical guidance regarding how to most effectively review consent forms with potential participants. We developed an algorithm for embedding five questions with corrective feedback while reading consent forms with potential participants, and then applied it in the context of seven clinical research studies. A substantial proportion of participants within each protocol displayed initially inadequate responses to at least one question, but after the protocol elements were explained (...) again, most people demonstrated adequate understanding of them. These data illustrate the need for more attention not just to the content of consent forms, but also to the manner in which the forms are incorporated into the consent process. Embedding explicit inquiries about key protocol elements during consent form review and giving corrective feedback appears to be a simple yet effective way to foster better understanding of disclosed information. (shrink)

Background: This study attempts to understand if medical providers beliefs about the moral permissibility of honoring patient-directed refusals of life-sustaining treatment (LST) are tied to their beliefs about the patient’s decision-making capacity. The study aims to answer: 1) does concern about a patient’s treatment decision-making capacity relate to beliefs about whether it is morally acceptable to honor a refusal of LST, 2) are there differences between provider types in assessments of decision-making capacity and the moral permissibility to refuse LST, and (...) 3) do provider demographics impact beliefs about decision-making capacity and the moral permissibility to refuse LST. Methods: A mixed-methods survey using Likert assessment and vignette-based questions was administered to medical providers within a single health system in the upper Midwest (N = 714) to assess their perspectives on the moral acceptance and decision-making capacity in cases of withholding and withdrawing treatment and suicide. Results: Behavioral health providers report accepting of the moral permissibility of suicide (91.2%) more than either medical providers (77.2%) or surgeons (74.4%) (n = 283). Decision-making capacity was questioned more in the vignettes of the patients refusing life-saving surgery (36%) and voluntarily starvation (40.8%) than in the vignette of the patient requesting to deactivate a pacemaker (13%) (n = 283). Behavioral health providers were more concerned about the capacity to refuse life-saving surgery (55.9%) than medical providers (33.8%) or surgeons (23.1%) (n = 283). Conclusions: Respondents endorse the moral permissibility of persons to withhold or withdraw from treatment regardless of motive. Clinical concerns about a patient’s treatment decision-making capacity do not strongly correlate to views about the moral permissibility of honoring refusals of LST. Different provider types appear to have different thresholds for when to question treatment decision-making capacity. Behavioral health providers tend to question treatment decision-making capacity to refuse LST more than non-behavioral health providers. (shrink)

Leading social innovation is challenging. Creating enduring social innovation requires navigating the tension of simultaneously engaging top-down and shared leadership. We outline the crux of the challenge and provide key takeaways and practical advice for the tandem deployment of top-down and shared leadership for social innovation success.

In lieu of an abstract, here is a brief excerpt of the content:A Plutarchan Hypomnema on Self–LoveLuc Van der StocktHypomnemata and QuellenforschungPlutarch's "hypomnemata statement" in the introduction to De Tranquillitate Animi has elicited much industrious activity from the scholarly world, and rightly so. The sentence (464F) invites one naturally to apply the method of classical hermeneutics (as understood by Babilas 1961, 30, 51–52), consisting in the confrontation of an author's oeuvre (its inventio, dispositio, and elocutio) with all the elements of (...) its generating "context" (historical circumstances, literary antecedents, biography and psychology of the author, immediate reasons for the composition, etc.) that might shed some light on the work in question and help to understand it. In the case of De Tranquillitate Animi Plutarch himself mentions his hypomnemata as one of the elements that contributed to this work, thus provoking his reader to investigate the relationship between these hypomnemata and the text in hand.Under the positivist paradigm generated and promoted by the physical sciences, the interpretation of texts suffered from reduction: its aim became explanation by reducing the thematic, structural, and stylistic data of a text to its antecedents, that is, by simply equating text and context; moreover, this context was frequently reduced to literary antecedents. In the present case, it was the conviction of several scholars that De Tranquillitate Animi could be explained by reducing it to an amalgamation of literary sources (Quellen) and by assuming that the hypomnemata represented these sources without further ado.The consequences of this approach were considerable: in general, Quellenforschung created the image of "Plutarch the eclectic," copying and pasting together literary sources, and De Tranquillitate Animi in particular became a textbook case of his modus operandi—it was but a patchwork of the opinions of Panaetius, or Ariston, or Epicureanism,1 [End Page 575] and one even finds a meritorious scholar who is indignant because Plutarch "mutilates" his source by disturbing its composition!2 From the conflicting scholarly opinions, from their highly hypothetical nature, and from such awkward appreciations as that just mentioned, it is easy to see that the positivist approach failed really to understand Plutarch: his personality and writing activity were so utterly neglected that one wonders why ultimately even the sentence μνημάτων was not regarded as "aliunde petita"!3Nowadays the assumptions of Quellenforschung are rejected: Plutarch's personal contribution in the invention, composition, and style of his works in general is widely recognized. In regard to his writing technique, and especially the role of the hypomnemata in it, it has been observed that the very mention of the hypomnemata in De Tranquillitate Animi does not mean that Plutarch was simply copying, let alone copying only one source;4 moreover, we are not entitled to view hypomnemata as sources5 without any qualification. As to the general tendency of the work, Stoic influences in the presentation of its theme have been seriously questioned.6While fully agreeing with the critique of Quellenforschung and sympathizing with the more positive results of our recent understanding of Plutarch, I cannot but consider the question of Plutarch's hypomnemata a continuing challenge: their importance for his "Compositionsweise"7 cannot be doubted, even if we are somewhat at a loss concerning their size, content, and nature. With the aim of advancing our [End Page 576] knowledge in this matter,8 I here identify a hypomnema, make some observations on Plutarch's treatment of it, and consequently show its relevance for the interpretation of the meaning intended by Plutarch. But before doing so, an analysis of the "hypomnemata statement" and its immediate context seems appropriate: the sentence may trigger our search and condition our expectations.An Analysis of the "Hypomnemata Statement" and its ContextThe composition of De Tranquillitate Animi took place in urgent circumstances:9 Paccius, we are told, has asked for some exegesis of Pla-to's Timaeus and (apparently in dire need)10 for some advice on tranquility of mind. The obvious messenger, Eros, has been called away urgently to Rome by Fundanus, another representative of the genus irascibile.11 Plutarch adopts emergency measures: First, he does not want to disappoint his friend Paccius completely. Thus in this "letter– essay" (Betz 1978, 199) he will deal with the theme... (shrink)

Precision medicine research involving human biological material is becoming an increasingly central component of healthcare, and its potential is quickly growing due to rapid technological progress...

Emotional memories are vivid and lasting but not necessarily accurate. Under some conditions, emotion even increases people’s susceptibility to false memories. This review addresses when and why emotion leaves people vulnerable to misremembering events. Recent research suggests that pregoal emotions—those experienced before goal attainment or failure (e.g., hope, fear)—narrow the scope of people’s attention to information that is central to their goals. This narrow focus can impair memory for peripheral details, leaving people vulnerable to misinformation concerning those details. In contrast, (...) postgoal emotions—those experienced after goal attainment or failure (e.g., happiness, sadness)—broaden the scope of attention leaving people more resistant to misinformation. Implications for legal contexts, such as emotion-related errors in eyewitness testimony, are discussed. (shrink)

Social robots and their interactions with children are becoming increasingly sophisticated, with the emergence of child-robot relationships as a likely result. However, adequate measurement instruments that tap into concepts associated with child-robot relationship formation are scarce. We aimed to develop three measures that can be used to assess children’s closeness to, trust in, and perceived social support from, a social robot. We established the validity and reliability of these measures among 87 Dutch children aged 7 to 11 years old. Because (...) of their shortness, the measures can efficiently be applied by scholars aiming to gain insight into the general process of child-robot relationship formation and its specific sub-processes, that is, the emergence of closeness, trust, and perceived social support. (shrink)

ObjectivesMany older adults with visual impairment also have significant hearing loss. The aim was to investigate the effectiveness of a newly developed Dual Sensory Loss protocol on communication and wellbeing of older persons with DSL and their communication partners in the Netherlands and Belgium.MethodsParticipants and their communication partners were randomized in the “DSL-protocol” intervention group or a waiting-list control group. The intervention took 3 to 5 weeks. Occupational therapists focused on optimal use of hearing aids, home-environment modifications and effective communication (...) strategies. The primary outcome was the Communication Strategies domain of the Communication Profile for the Hearing Impaired. Secondary outcomes measured in participants were the Low Vision Quality Of Life Adjustment subscale, the Center for Epidemiological Studies - Depression Scale, De Jong Gierveld Loneliness Scale and the Fatigue Assessment Scale. The Hearing Handicap and Disability Inventory - Reaction of Others subscale and the Care-related Quality of Life - 7 Dimensions was measured in communication partners. Measurements were taken at baseline and 3-month follow-up. Linear mixed models were used to analyze effects between groups over time for every outcome measure.ResultsIntention-to-treat analyses showed a significant effect of the DSL-protocol on the use of verbal strategies in favor of the control group, however, this effect was non-significant after adjustment for confounding. Effect sizes of other outcomes varied between −0.23 [−0.57, 0.12] and 0.30 [−0.05, 0.64]. The LMM showed a significant effect on the HHDI-Reaction of others scale in favor of communication partners in the treatment group, however, the effect did not remain significant at a 0.01 significance level and the effect size was very small and non-significant 0.12, 95% CI [−0.27 to 0.51]. Adjusted analyses did not reveal treatment effects.ConclusionThe DSL-protocol did not clearly contribute to the enhancement of communication and wellbeing in DSL-patients. Possible reasons for the lack of effects are OTs not being comfortable giving advice on communication and psychosocial issues or the short-term treatment and follow-up period. Further study is warranted to find out how the protocol may be adapted or whether it is necessary to involve mental healthcare professionals.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier NTR2843. (shrink)

An innovative examination of the ways in which dance and philosophy inform each other, Dance and Philosophy brings together authorities from a variety of disciplines to expand our understanding of dance and dance scholarship. Featuring an eclectic mix of materials from exposes to dance therapy sessions to demonstrations, Dance and Philosophy addresses centuries of scholarship, dance practice, the impacts of technological and social change, politics, cultural diversity and performance. Structured thematically to draw out the connection between different perspectives, this books (...) covers: - Philosophy practice and how it corresponds to dance - Movement, embodiment and temporality - Philosophy and dance traditions in everyday life - The intersection between dance and technology - Critical reflections on dance Offering important contributions to our understanding of dance as well as expanding the study of philosophy, this book is key to sparking new conversations concerning the philosophy of dance. (shrink)

The commentaries have both drawn out the implications of, and challenged, our definition and operationalization of innovation. In this response, we reply to these concerns, discuss the differences between our operationalization and the preexisting operationalization if innovation, and make suggestions for the advancement of the challenging and exciting field of animal innovation.

In this article, we provide a detailed discussion of Hasok Chang’s analysis of the Chemical Revolution. Our focus lies on his use of the framework of systems of practice and his claim that the abandonment of the phlogiston theory was irrational. We argue that his framework runs into problems when applied to the chemical revolution because of its static view on the aims of the historical actors and we suggest using Nicholas Jardine’s concept of the reality of questions instead as (...) a more flexible historiographical tool. We show how Chang’s claim regarding the irrational aspects of the chemical revolution follows from his strictly individualistic epistemology, leading him to see institutional and social aspects that impact the determination of aims as external to scientific rationality. We argue that a viable pragmatist and pluralist philosophy of science needs to embrace ‘academic politics’ as an explicit part of its view of rationality. (shrink)

The value of Plutarch’s perception of physical reality and his attitude towards the natural spectacle Plutarch was very interested in the natural world around him, not only in terms of its elementary composition and physical processes, but also with respect to its providential ordering and marvels. His writings teach us a lot about his perception of physical reality and about his attitude to the natural spectacle. He found his greatest inspiration in the ontological and epistemological framework of Plato’s Timaeus, but (...) a wide range of other authors were also of seminal interest to his project. Moreover, the highly literary value of Plutarch’s natural philosophical writings should not be underrated. It is therefore not surprising that recently scholars have started to reassess the ancient scientific value of Plutarch’s natural philosophical writings. Natural Spectaculars aims to give further impetus to this dynamic by treating several aspects of Plutarch’s natural philosophy which have remained unexplored up to now. (shrink)

This article integrates research on gendered organizations and the work-family interface to investigate an innovative workplace initiative, the Results-Only Work Environment, implemented in the corporate headquarters of Best Buy, Inc. While flexible work policies common in other organizations “accommodate” individuals, this initiative attempts a broader and deeper critique of the organizational culture. We address two research questions: How does this initiative attempt to change the masculinized ideal worker norm? And what do women’s and men’s responses reveal about the persistent ways (...) that gender structures work and family life? Data demonstrate the ideal worker norm is pervasive and powerful, even as employees begin critically examining expectations regarding work time that have historically privileged men. Employees’ responses to ROWE are also gendered. Women are more enthusiastic, while men are more cautious. Ambivalence about and resistance to change is expressed in different ways depending on gender and occupational status. (shrink)

The suggestion of seeking specificity in a higher-order array is attractive, but Stoffregen & Bardy fail to provide a compelling empirical basis to their claim that specificity exists solely in the global array. Using the example of relative motion, the alternate hypotheses that must be considered are presented.