ABSTRACTIn this paper, I explore Margaret Cavendish’s engagement with mid-seventeenth-century debates on spirits and spiritual activity in the world, especially the problems of incorporeal substance and magnetism. I argue that between 1664 and 1668, Cavendish developed an increasingly robust form of materialism in response to the deficiencies which she identified in alternative philosophical systems – principally mechanical philosophy and vitalism. This was an intriguing direction of travel, given the intensification in attacks on the supposedly atheistic materialism of Hobbes. While some (...) scholars claim that Cavendish’s views were not formed out of extensive engagement with contemporary thinkers, I suggest that, on the contrary, Cavendish engaged very closely with the views of More, Hobbes and others – including the vitalist thinker Johannes Baptista van Helmont and the mechanical philosopher Henry Power – on the subject of spirits and... (shrink)

It is often claimed that Margaret Cavendish was an anti-experimentalist who was deeply hostile to the activities of the early Royal Society—particularly in relation to Robert Hooke's experiments with microscopes. Some scholars have argued that her views were odd or even childish, while others have claimed that they were shaped by her gender-based status as a scientific ‘outsider’. In this paper I examine Cavendish's views in contemporary context, arguing that her relationship with the Royal Society was more nuanced than previous (...) accounts have suggested. This contextualized approach reveals two points: first, that Cavendish's views were not isolated or odd when compared with those of her contemporaries, and second, that the early Royal Society was less intellectually homogeneous than is sometimes thought. I also show that, although hostile to some aspects of experimentalism, Cavendish nevertheless shared many of the Royal Society's ambitions for natural philosophy, especially in relation to its usefulness and the importance of plain language as a means to disseminate new ideas. (shrink)

In the seventeenth century the new science was introduced through the works of Bacon, Hooke, Boyle, Power, and others. The advocates of the new science promised to divulge the inner workings of nature and to help man overcome his painful fallen state by means of controlling nature. The new sciences of mechanism and corpuscularism were to be based on objective experiments that would reveal the secret inner natures of minerals, vegetables, animals, the sun, moon, and stars. These experiments were done (...) with new and improved telescopes and microscope with magnifications of up to 100 times. One early critic of the new science was Margaret Cavendish. Cavendish was skeptical of the ambitious claims, methodology, instruments, and institutions of the new science. In her work, Observations Upon Experimental Philosophy, Cavendish argued against “experimental and dioptrical writers,” provided her own account of the natural world, investigated aspects of chemistry, medicine, and the nature of heat and color, as well as many other topics in natural philosophy (OEP 10). While many think Cavendish landed on the wrong side of history with respect to her skepticism regarding microscopes and telescopes, her criticisms of the new science were wide ranging and she was by no means the only one to question the value of such experiments and instruments. While several commentators, like Eve Keller (1997), have argued that Cavendish was against all things experimental, several recent commentators, Emma Wilkins (2014) and Deborah Boyle (2018), have tried to show the much more complicated relationship between Cavendish and the Royal Society and medical studies, respectively. In addition, some commentators, such as Lisa Sarasohn (1984, 2010) and Eve Keller (1997), have argued that Cavendish’s criticisms of the new science are based on her belief that Nature, as a representation of the feminine, was under attack by the experimentalists desire to “penetrate” and “manipulate” her for their own ends. While it is certainly true that Cavendish and many of the experimentalists personified nature as a woman, and that Cavendish does portray the men as trying to make her into something she is not, I agree with Deborah Boyle (2004) that these descriptions are not the focus of her objections to experimentalism. Rather than hold that Cavendish is concerned with, as Sarasohn claims, “the sexual implications for both women and nature of the new philosophy” (2010: 147), it seems that Cavendish’s objections were largely based on her philosophical commitments. However, I believe there is one aspect of the new science that Cavendish does critique from a feminist perspective, and that is what she sees as its institutional nature and its exclusion of women on the basis of sex, and to this I will turn in the last section of the chapter.1 My aim is to address Cavendish’s three major critiques of the new science. The chapter is divided as follows: The first section provides a brief overview of Cavendish’s views on the nature of bodies and perception. The second regards her critique of the methods and aims of the new science as represented by Bacon and Boyle. The third section examines her critique of Hooke and the instruments of experimentalism. The final section lays out her feminist critique of the institution of the new science. (shrink)

The impact of neoliberal reforms of education systems on the work of teachers and school leaders, particularly in relation to high-stakes accountability frameworks, has been extensively studied in recent decades. One significant aspect of neoliberal schooling is the emergence of quasi-autonomous public schools (such as Academies in England, Charter Schools in the USA and Independent Public Schools in Australia), characterised by heterarchical governance models, the promotion of entrepreneurial leadership cultures, and the promotion of a discourse of pursuing educational equity by (...) means of ‘achievement for all’. This paper explores the emergence of a mode of teacher professionalism characteristic of these quasi-autonomous schools, and conceptualises this as being ‘neo-performative’. The neo-performative profession is shaped by the shift in the focus of the regulation and management of schools from ‘governing to governance’, and the consequential rise of the ‘responsibilised profession’, and marked by the emergence of an entrepreneurial model of school leadership. The paper argues that this new conceptualisation of teacher professionalism requires further, more focused, empirical study in order to explore how neoperformative teachers and school leaders articulate their vision of educational equity and social justice, and how they enact this vision in an increasingly intensified high-stakes accountability culture. (shrink)

The Nature of Classification discusses an old and generally ignored issue in the philosophy of science: natural classification. It argues for classification to be a sometimes theory-free activity in science, and discusses the existence of scientific domains, theory-dependence of observation, the inferential relations of classification and theory, and the nature of the classificatory activity in general. It focuses on biological classification, but extends the discussion to physics, psychiatry, meteorology and other special sciences.

A hypothesis on the evolutionary origin of the genetic pathway of sex determination in the nematode Caenorhabditis elegans is presented here. It is suggested that the pathway arose in steps, driven by frequency‐dependent selection for the minority sex at each step, and involving the sequential acquisition of dominant negative, neomorphic genetic switches, each one reversing the action of the previous one. A central implication is that the genetic pathway evolved in reverse order from the final step in the hierarchy up (...) to the first. The possible applicability of the model to the other well‐characterized sex determination pathway, that of Drosophila melanogaster, and to sex determination in mammals, is discussed, along with some potential implications for pathway evolution in general. Finally, the specific molecular and population genetic questions that the model raises are described and some tests are proposed. (shrink)

This study gathered preliminary baseline data on the moral development of journalists using the Defining Issues Test, an instrument based on Kohlberg's 6 stages. Results show that a sample of journalists scored 4th highest among professionals tested using the DIT. The journalists ranked behind seminarians/philosophers, medical students, and physicians but above dental students, nurses, graduate students, undergraduate college students, veterinary students, and adults in general. No significant differences were found between various groups of journalists, including men and women, and broadcast (...) and print journalists. The journalists in the study scored significantly higher on the 3 journalism-specific dilemmas than on 3 nonjournalism dilemmas. (shrink)

C.H. Waddington is today remembered chiefly as a Drosophila developmental geneticist who developed the concepts of “canalization” and “the epigenetic landscape.” In his lifetime, however, he was widely perceived primarily as a critic of Neo-Darwinian evolutionary theory. His criticisms of Neo-Darwinian evolutionary theory were focused on what he saw as unrealistic, “atomistic” models of both gene selection and trait evolution. In particular, he felt that the Neo-Darwinians badly neglected the phenomenon of extensive gene interactions and that the “randomness” of mutational (...) effects, posited in the theory, was a false postulate. This last criticism dealt with the phenomenon known today as “developmental constraints.” Although population genetics itself has evolved considerably from its form at mid-20th century, much of Waddington’s critique, it is argued here, retains cogency. Yet, he did not attempt to develop a full-fledged alternative theory himself. Perhaps most surprisingly, in retrospect, is that he did not try to marry his work on gene interactions in development with his evolutionary interests, to create a theory of “genetic networks” and their evolution. Whether evolutionary genetics today will incorporate “network thinking” as a central element or whether there will be a general retreat to the more atomistic approach offered by genomics, remains an open question. (shrink)

When does a developing human being acquire moral status? I outline three different positions based on substance ontology that attempt to solve the question by locating some morally salient event in the process of human development question. In the second section, I consider some specific empirical objections to one of these positions, refute them, and then show how similar objections and responses would generalize to the other substance-based positions on the question. The crucial finding is that all the attempts to (...) answer the question that involve substance ontology need to appeal to dispositions. (shrink)

Political character, the dynamic intersection of personality and public performance within a cultural and historical context, is appropriately the subject of news reports. The article provides journalists with an ethical rationale for covering political character while acknowledging the human need for privacy and then outlines a set of characterrelated issues that journalists should explore. It concludes with the suggestion that journalists should once again begin to cover the public record of political figures in-depth and that this public record be linked (...) with deeper, psychologically based explorations of character. (shrink)

Investigation of “out-of-body experiences” has implications for understanding both normal bodily-self integration and its vulnerabilities. Beyond reported associations between OBEs and specific brain regions, however, there have been few investigations of neurochemical systems relevant to OBEs. Ketamine, a drug used recreationally to achieve dissociative experiences, provides a real-world paradigm for investigating neurochemical effects. We investigate the strength of the association of OBEs and ketamine use relative to other common drugs of abuse. Self-report data from an online survey indicate that both (...) lifetime frequency of ketamine use and OBEs during ketamine intoxication were more strongly related to the frequency of OBEs and related phenomena than other drugs. Moreover, the apparent effects of other drugs could largely be explained by associated ketamine use. The present results, consistent with the role of NMDA receptors in OBEs, should encourage future studies of the role of neurochemical systems in OBEs. (shrink)

Finding Your Ethical Research Self introduces novice researchers to the need for ethical reflection in practice and gives them the confidence to use their knowledge and skill when, later as researchers, they are confronted by big ethical moments in the field. -/- The 12 chapters build on each other, but not in a linear way. Core ethical concepts like consent and confidentiality once established in the early chapters are later challenged. The new focus becomes how to address qualitative research ethics (...) when confidentiality and consent take on a limited form. This approach helps students understand that the application of concepts always requires thoughtful adaptation in different contexts and the book provides guidance on how to do this. Classroom/workbook exercises develop alternative solutions to create process consent, internal confidentiality, and engage reference groups, as examples. The first eight chapters allow students to develop their ethical research self before thinking through how they might address formal ethics review. Formal ethics review is deliberately not introduced until Chapter 9. Chapter 10 offers practical help to elements of review, before Chapter 11 emphasises the key message by providing examples of researchers' dilemmas in the field using vignettes and discussion. By providing these examples, students become aware that these can arise, explore how they might arise, and recognise how they might deal with them in the moment when they are unavoidable. -/- With numerous examples of ethical dilemmas and issues and questions and exercises to encourage self-reflection, this reflexive, learn-by-doing model of research ethics will be highly useful to the novice researcher, undergraduate, and postgraduate research student. (shrink)

This paper demonstrates the limited efficacy procedural ethics has for qualitative research. Ethics committee's instructions have a short shelf life given the research question qualitative researchers create is volatile; that is, likely to change due to the inductive, emergent, informant-led nature of qualitative research. Design-This article draws on extensive literature to examine the void between the original research design and the messy reality experienced in the field. We focus on how researchers can practice ethically by recognizing the need for agile (...) and responsive ethics praxis in their work. Findings-This practice describes the researcher, recognizing the initial support from an ethics committee and its limitations, but as the research gets underway assuming full responsibility for ethical considerations that emerge in the field. Practical implications-Researchers' responsibilities entail recognising the dual …. (shrink)

Kant's teleological principle is a regulative, not a constitutive, principle of reason, ordering but not creating the understanding's concepts of objects. The principle is both heuristic for suggesting explanations in terms of efficient causality and a reminder of such explanations' insufficiency. But Kant states the rough content as well as the existence of an historical pattern. Reason and understanding and philosophy and science are analogously related. Since historians disagree over which, if any, principles are used in explanations, reason, represented by (...) philosophers, intrudes so on history. Further, the falsifiability of any attempted applications leaves the teleological principle itself untouched. (shrink)

This paper argues that the EuropeanCourt of Human Rights couldserve as a model for an international court ofhuman rights to be builtupon the United Nations Committee on HumanRights. It argues that theconcerns states might have over the surrenderof a significant portion oftheir national sovereignity might be lessenedif such an internationalcourt were to incorporate the margin ofappreciation doctrine employed bythe European Court of Human Rights. Thisdoctrine is intended to respectthe customs and traditions of sovereign statesin dealing with humanrights issues, while maintaining (...) that somerights such as the right not tobe tortured will be considered as basic andwill stand independently ofthe customs and traditions of sovereignstates. (shrink)

I question the adequacy of Margaret Gilbert''s account of collectivefeelings of guilt as collective judgments which do not necessarilyhave any phenomenological components. I question whether joint commitment theory in its present form helps us to understand orresolve social conflicts.

I explore virtue and love in Maximus the Confessor’s theology with an aim to drawing an ethics from it relevant to the present day. I use a meta-ethical framework derived from contemporary virtue ethics and look at virtue as an instance of love within the context of Maximus’ cosmic theology. Virtue becomes a path that leads us towards love – who is God Himself. Virtue is thus about movement towards theosis. I describe virtue as a relationship between humans and God, (...) brought about through the mutual practice of a life of ascesis from humans and grace from God. I look at the mediatoral role of humans as microcosms gathering up the universe in an image of Christ’s activity. In particular I analyse the way that human activity is simultaneously cosmic and ascetic; personal and communal. The ethic of virtue that we pursue is always caught up in a conversation about what creation gathered in love looks like. Using a number of tools derived from Maximus’ thought, I suggest that this ethics will necessarily transform our current communities and personal practices. Recognising the cosmic dimension of personal behaviour means that our communities must be scrutinised as extensions of our actions. As an example, I critique the state as an inadequate form of loving relationship, illustrating its systemic reliance on violence and ideologies of alienation and hatred. I give examples of alternative ways of human organising drawn from anarchist thought that might better enable us to love and, more importantly, enable us to call to account failures to love. I conclude that to seek theosis after the manner Maximus describes involves recognising our personal and communal failures to love. His holistic understanding of human purpose can help us see the cosmic dimension to personal ascetic practice and consequently set our sights on a more cosmic vision of love here in the present world. (shrink)

Three recent genome‐wide studies in mice and humans have produced the most definitive map to date of genomic imprinting (gene expression that depends on parental origin) by incorporating multiple tissue types and developmental stages. Here, we explore the results of these studies in light of the kinship theory of genomic imprinting, which predicts that imprinting evolves due to differential genetic relatedness between maternal and paternal relatives. The studies produce a list of imprinted genes with around 120–180 in mice and ∼100 (...) in humans. The studies agree on broad patterns across mice and humans including the complex patterns of imprinted expression at loci like Igf2 and Grb10. We discuss how the kinship theory provides a powerful framework for hypotheses that can explain these patterns. Finally, since imprinting is rare in the genome despite predictions from the kinship theory that it might be common, we discuss evolutionary factors that could favor biallelic expression. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Philostratos records that the ephebes of Athens wore a black χλαμς to commemorate their murder of Kopreus in defence of the Herakleidai. Both the Herakleidai and a herald of Eurystheus appear in Herakleidai of Euripides, but the murder of the herald is not at issue, nor indeed is there any reference to ephebes or ephebic practice. This state of affairs will cause no surprise, for tragedy regularly selects its story-line from the wider range of the myth, and later uses to (...) which that myth may be put have no necessary bearing on the play. It is however the contention of this article that the religious and social context of Herakleidai has been neglected, and that careful reconstruction of that context from later sources, restoring to us the associations that Euripides could assume in his own day, is an essential prerequisite to any aesthetic or dramatic interpretation of the play. (shrink)

This paper focuses on the significance of the concept of noise for cognition and computation. The concept of noise was massively transformed in the twentieth century with the advent of information theory, cybernetics, and computer science, all of which provide formal accounts of information and noise centrally concerned with contingency. We show how the concept has changed from these classical formulations, through developments in mathematics (topology and topos theory), computing (interactive computing and univalent foundations), and cognitive science (predictive processing and (...) cognitive morphodynamics). Ultimately it argues for the central importance of noise not only within a topological conception of cognition and computation, but also in the transcendental-empirical torsion of image schemata and the social interactive elaboration of freedom. (shrink)

Different patterns of mitochondrial and Y-chromosome diversity have been cited as evidence of long-term patrilocality in human populations. However, what patterns are expected depends on the nature of the sampling scheme. Samples from a local region reveal only the recent demographic history of that region, whereas sampling over larger geographic scales accesses older demographic processes. A historical change in migration becomes evident first at local geographic scales, and alters global patterns of genetic diversity only after sufficient time has passed. Analysis (...) of forager populations in the ethnographic record suggests that patrilocality may not have predominated among pre-agricultural humans. The higher female migration rate inferred by some genetic studies may reflect a shift to patrilocality in association with the emergence of agriculture. A recent global survey does not show the expected effects of higher female migration, possibly because the sampling scheme used for this study is accessing pre-agricultural human migration patterns. In this paper, we show how the demographic shift associated with agriculture might affect genetic diversity over different spatial scales. We also consider the prospects for studying sex-biased migration using the X-linked and autosomal markers. These multi-locus comparisons have the potential of providing more robust estimates of sex differences than Y-linked and mitochondrial data, but only if a very large number of loci are included in the analysis. BioEssays 28: 290–300, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

The development of each of the four Malpighian tubules of Drosophila during embryogenesis requires a special cell, the tip cell, to achieve full growth. A central question concerns how the tip cell acquires its unique properties within the tubule primordium. In a recent report(1), a sequence of key gene expression events in both the tip cell and its cellular neighbours is described. The results show that there are some significant parallels between tip cell selection and the mechanisms that help select (...) neuroblasts within the developing neuroectoderm. Beyond these similarities between neural development and tip cell selection, the later differentiation of the tip cell shows some intriguing elements of neural cell differentiation. (shrink)

Over the past few years, blogging (“web logging”) has become a major social movement, and as such includes blogs by scientists about science. Blogs are highly idiosyncratic, personal and ephemeral means of public expression, and yet they contribute to the current practice and reputation of science as much as, if not more than, any popular scientific work or visual presentation. It is important, therefore, to understand this phenomenon.

This response to continuing commentary addresses brain-hand relationships in Cebus apella (as introduced in West-ergaard's commentary), the evolutionary and acquisition parallels between music and language (suggested by Lynch), and the potential behavioral linguistic consequences of the evolutionary neurobiology in Australopithecus africanus and Homo habilis (discussed by Tobias). Finally, we reiterate the importance of well informed, multidisciplinary approaches to the study of the emergence of human species-specific cognition, especially linguistic capacity.