Background The opioid epidemic has enabled rapid and unsurpassed use of big data on people with opioid use disorder to design initiatives to battle the public health crisis, generally without adequate input from impacted communities. Efforts informed by big data are saving lives, yielding significant benefits. Uses of big data may also undermine public trust in government and cause other unintended harms. Objectives We aimed to identify concerns and recommendations regarding how to use big data on opioid use in ethical (...) ways. Methods We conducted focus groups and interviews in 2019 with 39 big data stakeholders who had interest in or knowledge of the Public Health Data Warehouse maintained by the Massachusetts Department of Public Health. Results Concerns regarding big data on opioid use are rooted in potential privacy infringements due to linkage of previously distinct data systems, increased profiling and surveillance capabilities, limitless lifespan, and lack of explicit informed consent. Also problematic is the inability of affected groups to control how big data are used, the potential of big data to increase stigmatization and discrimination of those affected despite data anonymization, and uses that ignore or perpetuate biases. Participants support big data processes that protect and respect patients and society, ensure justice, and foster patient and public trust in public institutions. Recommendations for ethical big data governance offer ways to narrow the big data divide, enact shared data governance, cultivate public trust and earn social license for big data uses, and refocus ethical approaches. Conclusions Using big data to address the opioid epidemic poses ethical concerns which, if unaddressed, may undermine its benefits. Findings can inform guidelines on how to conduct ethical big data governance and in ways that protect and respect patients and society, ensure justice, and foster patient and public trust in public institutions. (shrink)

Advocates of biomimicry encourage a new industrial paradigm that ostensibly leaves behind the crude violence of Francis Bacon, the domination of nature-as-machine, and a history of toxic production processes that have given rise to a present and coming climate crisis. As part of a broader trend towards the conceptualization and development of a ‘bioeconomy’, we argue here that biomimicry produces ‘nature’ in new ways. At face value, these new approaches to valuing nature may seem less violent and exploitative. Yet, new (...) natures can and are tortured in new ways. We argue that biomimicry produces ‘nature’ through well-worn logics of resource enclosure and privatization, focusing upon two fundamental shifts in how nonhuman life is figured and put to work: (1) the production of nature as intellectual property (as opposed to raw materials); (2) the production of nature as an active subject (as opposed to a passive receptacle or vehicle). (shrink)

This book compares the range of different contemporary neo-Aristotelian moral theories. It shows that the most successful are those that remain faithful to the program proposed by Elizabeth Anscombe.

This chapter defends the account of metaphysical indeterminacy of Barnes and Williams against Eklund's objections.

In arguing about justice, different sides often accept common moral principles, but reach different conclusions about justice because they disagree about facts. I argue that motivated reasoning, epistemic injustice, and ideologies of injustice support unjust institutions by entrenching distorted representations of the world. Working from a naturalistic conception of justice as a kind of social contract, I suggest some strategies for discovering what justice demands by counteracting these biases. Moral sentiments offer vital resources to this end.

Bohmian mechanics is arguably the most naively obvious embedding imaginable of Schr¨ odinger’s equation into a completely coherent physical theory. It describes a world in which particles move in a highly non-Newtonian sort of way, one which may at first appear to have little to do with the spectrum of predictions of quantum mechanics. It turns out, however, that as a consequence of the defining dynamical equations of Bohmian mechanics, when a system has wave function ψ its configuration is typically (...) random, with probability density ρ given by |ψ|2, the quantum equilibrium distribution. It also turns out that the entire quantum formalism, operators as observables and all the rest, naturally emerges in Bohmian mechanics from the analysis of “measurements.” This analysis reveals the status of operators as observables in the description of quantum phenomena, and facilitates a clear view of the range of applicability of the usual quantum mechanical formulas. (shrink)

The most puzzling issue in the foundations of quantum mechanics is perhaps that of the status of the wave function of a system in a quantum universe. Is the wave function objective or subjective? Does it represent the physical state of the system or merely our information about the system? And if the former, does it provide a complete description of the system or only a partial description? We shall address these questions here mainly from a Bohmian perspective, and shall (...) argue that part of the difficulty in ascertaining the status of the wave function in quantum mechanics arises from the fact that there are two different sorts of wave functions involved. The most fundamental wave function is that of the universe. From it, together with the configuration of the universe, one can define the wave function of a subsystem. We argue that the fundamental wave function, the wave function of the universe, has a law-like character. (shrink)

In this paper I argue that there is a preface paradox for intention. The preface paradox for intention shows that intentions do not obey an agglomeration norm, requiring one to intend conjunctions of whatever else one intends. But what norms do intentions obey? I will argue that intentions come in degrees. These partial intentions are governed by the norms of the probability calculus. First, I will give a dispositional theory of partial intention, on which degrees of intention are the degrees (...) to which one possesses the dispositions characteristic of full intention. I will use this dispositional theory to defend probabilism about intention. Next, I will offer a more general argument for probabilism about intention. To do so, I will generalize recent decision theoretic arguments for probabilism from the case of belief to the case of intention. (shrink)

Hearing the words of Deuteronomy, the preacher is called to make clear what it means to be God's covenant community and to live according to his will rather than the dictates of the surrounding culture.

Behind every sermon lies an understanding of the nature of the Bible; by its contribution to that understanding, biblical studies can make a crucial difference for preaching.

Understanding the form and content of the Bible's hymns allows the sermon to share their principal characteristic: praise to the honor and glory of God.

The development and use of large and dynamic health data repositories designed to support research pose challenges to traditional informed consent models. We used semi-structured interviewing to elicit diverse research stakeholders' views of a model of consent appropriate to participation in initiatives that entail collection, long-term storage, and undetermined future research use of multiple types of health data. We demonstrate that, when considering health data repositories, research stakeholders replace a concept of consent as informed with one in which consent is (...) engaged. In engaged consent, a participant's ongoing relationship with a repository serves as a substitute or adjunct to information exchange at enrollment. We detail research stakeholders' views of the risks of engaged consent and suggest questions for further study about engagement and consent procedures in initiatives that aim to store data for future unspecified research purposes. (shrink)

This book is about what exceeds or resists calculation--in life and in death. Its two parts and nine chapters highlight, in their coupling of Freud and Derrida, the accidents both in and of psychoanalytic writing, and the philosophical question of what limits the openness of our horizon.

From Fall 2016 to Fall 2019 Marcelo Gleiser conducted a series of nine public dialogues between eminent scientists and humanists on challenging topics and ideas whose very definitions and meanings are disputed. Sponsored by the Institute for Cross-Disciplinary Engagement at Dartmouth College, founded by Gleiser, these events were held in theaters and universities across the US and immediately followed by workshops, open to the public, at which attendees could converse directly with participants. Great Minds Don't Think Alike collects edited versions (...) of these discussions, which set an example, in a time when public discourse is seriously threatened, of how people can engage in a fruitful exchange of ideas even when they strongly disagree. The cast of characters is stellar: David Chalmers and Antonio Damasio on consciousness, Sean Carroll and Alan Wallace on reality, Patricia Churchland and Jill Tarter on the future of intelligence, Rebecca Goldstein and Alan Lightman on faith, Jimena Canales and Paul Davies on time, Ed Boyden and Mark O'Connell on transhumanism, Elizabeth Kolbert and Siddhartha Mukherjee on immortality, and Jeremy DeSilva, David Grinspoon, and Tasneem Zehra Husain on being human. (shrink)

Bohmian trajectories have been used for various purposes, including the numerical simulation of the time-dependent Schr¨ odinger equation and the visualization of time-dependent wave functions. We review the purpose they were invented for: to serve as the foundation of quantum mechanics, i.e., to explain quantum mechanics in terms of a theory that is free of paradoxes and allows an understanding that is as clear as that of classical mechanics. Indeed, they succeed in serving that purpose in the context of a (...) theory known as Bohmian mechanics, to which this article is an introduction. (shrink)

Amartya Sen’s ethical theorizing helps feminists resolve the tensions between the claims of women’s particular perspectives and moral objectivity. His concept of ‘‘positional objectivity’’ highlights the epistemological significance of value judgments made from particular social positions, while holding that certain values may become widely shared. He shows how acknowledging positionality is consistent with affirming the universal value of democracy. This article builds on Sen’s work by proposing an analysis of democracy as a set of institutions that aims to intelligently utilize (...) positional information for shared ends. This epistemological analysis of democracy offers a way to understand the rationale for reserving political offices for women. From a political point of view, gendered positions are better thought of as an epistemological resource than as a ground of identity politics – that is, of parochial identification and solidarity. (shrink)

I begin by examining the answer to a traditional puzzle concerning supererogatory acts: if they are good to do, why are they not required? The answer often given is that they are optional acts because they cost the agent too much. This view has parallels with the traditional view of religious sacrifice, which involves offering up something or someone valuable as a gift or victim and experiencing a ‘cost’ as part of the ritual. There are problems with the idea that (...) costs justify the optional nature of supererogatory acts, however, and I suggest that these problems mirror the tensions that are found in Christian theology when a traditional view of sacrifice is adopted. (shrink)

The Russell class does not exist because the conditions purporting to specify that class are contradictory, and hence fail to specify any class. Equally, the conditions purporting to specify the Liar statement are contradictory and hence, although the Liar sentence is grammatically in order, it fails to yield a statement. Thus the common source of these and related paradoxes is contradictory (or tautologous) specifying conditions-for such conditions fail to specify. This is the diagnosis. The cure consists of seeking and destroying (...) the deep-seated preconceptions that make almost irresistible our belief in the existence of items which provably do not exist. (shrink)

In Bohmian mechanics the distribution |ψ|2 is regarded as the equilibrium distribution. We consider its uniqueness, finding that it is the unique equivariant distribution that is also a local functional of the wave function ψ.

. Interpreting children 's ideas: Creative thought or factual belief? A new look at Piaget's theory of childhood artificialism as related to religious education. British Journal of Educational Studies: Vol. 41, No. 2, pp. 164-173.

The Ethics of Economic Sanctions Economic sanctions involve the politically motivated withdrawal of customary trade or financial relations from a state, organisation or individual. They may be imposed by the United Nations, regional governmental organisations such as the European Union, or by states acting alone. Although economic sanctions have long been a feature of international … Continue reading Ethics of Economic Sanctions →.

The Ghirardi–Rimini–Weber (GRW) theory of spontaneous wave function collapse is known to provide a quantum theory without observers, in fact two different ones by using either the matter density ontology (GRWm) or the flash ontology (GRWf). Both theories are known to make predictions different from those of quantum mechanics, but the difference is so small that no decisive experiment can as yet be performed. While some testable deviations from quantum mechanics have long been known, we provide here something that has (...) until now been missing: a formalism that succinctly summarizes the empirical predictions of GRWm and GRWf. We call it the GRW formalism. Its structure is similar to that of the quantum formalism but involves different operators. In other words, we establish the validity of a general algorithm for directly computing the testable predictions of GRWm and GRWf. We further show that some well-defined quantities cannot be measured in a GRWm or GRWf world. (shrink)

In “Pox Parties for Grannies?” Malm and Navin (2020) persuasively argue that it is unjust to permit, let alone promote, avoidable harm to children by knowingly and purposefully not vaccinating them...

We will argue that clarifying the “moral core” of consent offers a common metric by which we can evaluate how well different legal frameworks are able to protect the central moral rights and interests at stake. We begin by revisiting how legal frameworks for digital consent developed in order to see where there may be common moral ground and where these different cultures diverge on the issue of protection of personal information. We then turn to ethics to clarify the central (...) interests and rights at stake in morally transformative consent, in order to provide a common basis for evaluating the different legal frameworks. Ultimately, we seek the moral core of digital consent in order to reimagine its role in international conflicts. (shrink)

At Plato’s Phaedrus 270c, Socrates asks whether one can know souls without knowing ‘the whole.’ Phaedrus answers that ‘according to Hippocrates’ the same demand on knowing the whole applies to bodies. What parallel is intended between soul-knowledge and body-knowledge and which medical passages illustrate the analogy have been much debated. Three dominant interpretations read ‘the whole’ as respectively (1) environment, (2) kosmos, and (3) individual soul or body; and adduce supporting Hippocratic passages. But none of these interpretations accounts for the (...) Phaedrus’ rhetorical method. A better reading sees the whole as the genos ‘soul,’ as the Phaedrus’ taxonomies divide that genus. (shrink)

A variety of studies show that parental absence early in life leads to deleterious effects on the developing CNS. This is thought to be largely because evolutionary-dependent stimuli are necessary for the appropriate postnatal development of the young brain, an effect sometimes termed the “experience-expectant brain,” with parents providing the necessary input for normative synaptic connections to develop and appropriate neuronal survival to occur. Principal among CNS systems affected by parental input are the monoamine systems. In the present study,N= 434 (...) rhesus monkeys (233 males, 201 females) were reared in one of two conditions: as mother-reared controls (MR;n= 269) or without adults with 24-h access to same-aged peers (PR;n= 165). When subjects were six-months-old, they underwent a separation paradigm involving 4, sequential, four-day social separations from their mothers or peers, with each separation followed by three-day reunions with their mothers or their peers. Prior to the separation paradigm, baseline cisternal CSF samples were obtained, as well as at the end of each the four social separations, and after final separation, during a recovery period. CSF was assayed for concentrations of monoamine metabolites and a blood sample was genotyped for the serotonin transporter (5-HTT) genotype. Replicating earlier landmark findings, PR subjects with thesallele exhibited lower baseline concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), when compared to PR subjects homozygous for theLallele. MR subjects were undifferentiated by genotype. PR subjects exhibited lower CSF 5-HIAA concentrations during baseline, but higher CSF 5-HIAA during social separations, when compared to MR subjects. There were rearing effects for the dopamine metabolite homovanillic acid (HVA) and for the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG), with PR subjects showing higher HVA and lower MHPG when compared to MR subjects. These findings indicate that there are long-term deficits in the response of monoamines following early maternal absence. The results of this study confirm and extend earlier findings that early parental absence has deleterious consequences for the development of the monoamine systems, and that these consequences are modulated by the 5-HTT genotype. (shrink)